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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
9
Cytoband
q34.13
Chromosome location (bp)
131576770 - 131740076
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Guanine nucleotide-releasing protein that binds to SH3 domain of CRK and GRB2/ASH. Transduces signals from CRK to activate RAS. Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1 1. Plays a role in the establishment of basal endothelial barrier function. Plays a role in nerve growth factor (NGF)-induced sustained activation of Rap1 and neurite outgrowth....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Guanine-nucleotide releasing factor
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Neurogenesis
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a human guanine nucleotide exchange factor. It transduces signals from CRK by binding the SH3 domain of CRK, and activating several members of the Ras family of GTPases. This signaling cascade that may be involved in apoptosis, integrin-mediated signal transduction, and cell transformation. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0005085[guanyl-nucleotide exchange factor activity] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005768[endosome] GO:0005769[early endosome] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0007165[signal transduction] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007264[small GTPase mediated signal transduction] GO:0007265[Ras protein signal transduction] GO:0007399[nervous system development] GO:0010976[positive regulation of neuron projection development] GO:0017124[SH3 domain binding] GO:0032486[Rap protein signal transduction] GO:0038180[nerve growth factor signaling pathway] GO:0043231[intracellular membrane-bounded organelle] GO:0043547[positive regulation of GTPase activity] GO:0061028[establishment of endothelial barrier] GO:0071320[cellular response to cAMP] GO:1901888[regulation of cell junction assembly] GO:1990090[cellular response to nerve growth factor stimulus]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0005085[guanyl-nucleotide exchange factor activity] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005768[endosome] GO:0005769[early endosome] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0007165[signal transduction] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007264[small GTPase mediated signal transduction] GO:0007265[Ras protein signal transduction] GO:0007399[nervous system development] GO:0010976[positive regulation of neuron projection development] GO:0017124[SH3 domain binding] GO:0032486[Rap protein signal transduction] GO:0038180[nerve growth factor signaling pathway] GO:0043231[intracellular membrane-bounded organelle] GO:0043547[positive regulation of GTPase activity] GO:0061028[establishment of endothelial barrier] GO:0071320[cellular response to cAMP] GO:1901888[regulation of cell junction assembly] GO:1990090[cellular response to nerve growth factor stimulus]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005085[guanyl-nucleotide exchange factor activity] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005768[endosome] GO:0005769[early endosome] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0007165[signal transduction] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007264[small GTPase mediated signal transduction] GO:0007265[Ras protein signal transduction] GO:0007399[nervous system development] GO:0010976[positive regulation of neuron projection development] GO:0017124[SH3 domain binding] GO:0032486[Rap protein signal transduction] GO:0038180[nerve growth factor signaling pathway] GO:0043231[intracellular membrane-bounded organelle] GO:0043547[positive regulation of GTPase activity] GO:0061028[establishment of endothelial barrier] GO:0071320[cellular response to cAMP] GO:1901888[regulation of cell junction assembly] GO:1990090[cellular response to nerve growth factor stimulus]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001568[blood vessel development] GO:0005085[guanyl-nucleotide exchange factor activity] GO:0007264[small GTPase mediated signal transduction] GO:0007265[Ras protein signal transduction] GO:0010976[positive regulation of neuron projection development] GO:0030670[phagocytic vesicle membrane] GO:0032991[protein-containing complex] GO:0043491[protein kinase B signaling] GO:0046328[regulation of JNK cascade] GO:0046580[negative regulation of Ras protein signal transduction] GO:0048008[platelet-derived growth factor receptor signaling pathway] GO:0048471[perinuclear region of cytoplasm] GO:0051898[negative regulation of protein kinase B signaling] GO:0060070[canonical Wnt signaling pathway] GO:0061351[neural precursor cell proliferation] GO:0070371[ERK1 and ERK2 cascade] GO:0070373[negative regulation of ERK1 and ERK2 cascade] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0090090[negative regulation of canonical Wnt signaling pathway] GO:0090630[activation of GTPase activity] GO:0098609[cell-cell adhesion] GO:1905451[positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis] GO:2000178[negative regulation of neural precursor cell proliferation]
The Human Protein Atlas project is funded
