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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes Human disease related genes Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
1
Cytoband
p36.33
Chromosome location (bp)
1335276 - 1349418
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Developmental protein
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Wnt signaling pathway
Gene summary (Entrez)i
Useful information about the gene from Entrez
DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 is a candidate gene for neuroblastomatous transformation. The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
O14640 [Direct mapping] Segment polarity protein dishevelled homolog DVL-1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Disease related genes Human disease related genes Congenital malformations Other congenital malformations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0001505[regulation of neurotransmitter levels] GO:0001932[regulation of protein phosphorylation] GO:0001933[negative regulation of protein phosphorylation] GO:0001934[positive regulation of protein phosphorylation] GO:0001947[heart looping] GO:0003151[outflow tract morphogenesis] GO:0005109[frizzled binding] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005874[microtubule] GO:0005886[plasma membrane] GO:0006355[regulation of DNA-templated transcription] GO:0006469[negative regulation of protein kinase activity] GO:0007269[neurotransmitter secretion] GO:0007409[axonogenesis] GO:0007411[axon guidance] GO:0007528[neuromuscular junction development] GO:0008013[beta-catenin binding] GO:0010976[positive regulation of neuron projection development] GO:0014069[postsynaptic density] GO:0015630[microtubule cytoskeleton] GO:0016020[membrane] GO:0016055[Wnt signaling pathway] GO:0016328[lateral plasma membrane] GO:0019899[enzyme binding] GO:0019901[protein kinase binding] GO:0021915[neural tube development] GO:0022007[convergent extension involved in neural plate elongation] GO:0022603[regulation of anatomical structure morphogenesis] GO:0030136[clathrin-coated vesicle] GO:0030424[axon] GO:0030425[dendrite] GO:0030426[growth cone] GO:0031122[cytoplasmic microtubule organization] GO:0031267[small GTPase binding] GO:0031410[cytoplasmic vesicle] GO:0032091[negative regulation of protein binding] GO:0032436[positive regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0032880[regulation of protein localization] GO:0034504[protein localization to nucleus] GO:0035176[social behavior] GO:0035372[protein localization to microtubule] GO:0035556[intracellular signal transduction] GO:0035567[non-canonical Wnt signaling pathway] GO:0042802[identical protein binding] GO:0043005[neuron projection] GO:0043025[neuronal cell body] GO:0043113[receptor clustering] GO:0043197[dendritic spine] GO:0045202[synapse] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0048668[collateral sprouting] GO:0048675[axon extension] GO:0048813[dendrite morphogenesis] GO:0050790[regulation of catalytic activity] GO:0050808[synapse organization] GO:0050821[protein stabilization] GO:0060029[convergent extension involved in organogenesis] GO:0060070[canonical Wnt signaling pathway] GO:0060071[Wnt signaling pathway, planar cell polarity pathway] GO:0060134[prepulse inhibition] GO:0060997[dendritic spine morphogenesis] GO:0071340[skeletal muscle acetylcholine-gated channel clustering] GO:0090103[cochlea morphogenesis] GO:0090179[planar cell polarity pathway involved in neural tube closure] GO:0098685[Schaffer collateral - CA1 synapse] GO:0098793[presynapse] GO:0098978[glutamatergic synapse] GO:0098992[neuronal dense core vesicle] GO:0099054[presynapse assembly] GO:0099173[postsynapse organization] GO:0099175[regulation of postsynapse organization] GO:0150012[positive regulation of neuron projection arborization] GO:1905386[positive regulation of protein localization to presynapse] GO:1990909[Wnt signalosome] GO:2000300[regulation of synaptic vesicle exocytosis] GO:2000463[positive regulation of excitatory postsynaptic potential]
O14640 [Direct mapping] Segment polarity protein dishevelled homolog DVL-1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Disease related genes Human disease related genes Congenital malformations Other congenital malformations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001505[regulation of neurotransmitter levels] GO:0001947[heart looping] GO:0003151[outflow tract morphogenesis] GO:0005109[frizzled binding] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006355[regulation of DNA-templated transcription] GO:0006469[negative regulation of protein kinase activity] GO:0007269[neurotransmitter secretion] GO:0007528[neuromuscular junction development] GO:0016020[membrane] GO:0016055[Wnt signaling pathway] GO:0016328[lateral plasma membrane] GO:0019899[enzyme binding] GO:0019901[protein kinase binding] GO:0021915[neural tube development] GO:0022603[regulation of anatomical structure morphogenesis] GO:0030426[growth cone] GO:0031410[cytoplasmic vesicle] GO:0032091[negative regulation of protein binding] GO:0032436[positive regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0032880[regulation of protein localization] GO:0034504[protein localization to nucleus] GO:0035556[intracellular signal transduction] GO:0035567[non-canonical Wnt signaling pathway] GO:0042802[identical protein binding] GO:0043005[neuron projection] GO:0043113[receptor clustering] GO:0045202[synapse] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0048813[dendrite morphogenesis] GO:0050790[regulation of catalytic activity] GO:0050808[synapse organization] GO:0050821[protein stabilization] GO:0060070[canonical Wnt signaling pathway] GO:0060071[Wnt signaling pathway, planar cell polarity pathway] GO:0090179[planar cell polarity pathway involved in neural tube closure] GO:0099054[presynapse assembly] GO:0150012[positive regulation of neuron projection arborization] GO:1905386[positive regulation of protein localization to presynapse]
A0A0J9YWZ5 [Direct mapping] Segment polarity protein dishevelled homolog DVL-1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Other congenital malformations Protein evidence (Ezkurdia et al 2014)
A0A0J9YYK1 [Direct mapping] Segment polarity protein dishevelled homolog DVL-1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Other congenital malformations Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
