GENERAL INFORMATIONi
Gene namei GATA3
Synonyms HDR
Gene descriptioni GATA binding protein 3
Protein classi Cancer-related genes
Disease related genes
Human disease related genes
Plasma proteins
Transcription factors
Predicted locationi Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi
Chromosome 10
Cytoband p14
Chromosome location (bp) 8045378 - 8075198
Number of transcriptsi 5
Ensembl ENSG00000107485 (version 109)
Entrez gene 2625
HGNC HGNC:4172
UniProt P23771 (UniProt - Evidence at protein level)
neXtProt NX_P23771
GeneCards GATA3
Antibodypedia GATA3 antibodies


PROTEIN FUNCTION
Protein function (UniProt)i Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses. Positively regulates ASB2 expression (By similarity). Coordinates macrophage transcriptional activation and UCP2-dependent metabolic reprogramming in response to IL33. Upon tissue injury, acts downstream of IL33 signaling to drive differentiation of inflammation-resolving alternatively activated macrophages. show less
Molecular function (UniProt)i Activator, DNA-binding
Biological process (UniProt)i Immunity, Innate immunity, Transcription, Transcription regulation
Ligand (UniProt)i Metal-binding, Zinc
Gene summary (Entrez)i This gene encodes a protein which belongs to the GATA family of transcription factors. The protein contains two GATA-type zinc fingers and is an important regulator of T-cell development and plays an important role in endothelial cell biology. Defects in this gene are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia. [provided by RefSeq, Nov 2009] show less
PROTEIN INFORMATIONi
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
GATA3-201
ENSP00000341619
ENST00000346208
P23771
[Direct mapping] Trans-acting T-cell-specific transcription factor GATA-3
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Frameshift Mutations
Disease related genes
Human disease related genes
   Cancers
   Cancers of the breast and female genital organs
   Congenital malformations
   Other congenital malformations
   Immune system diseases
   Allergies and autoimmune diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000976 [transcription cis-regulatory region binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0000987 [cis-regulatory region sequence-specific DNA binding]
GO:0001227 [DNA-binding transcription repressor activity, RNA polymerase II-specific]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0001709 [cell fate determination]
GO:0001817 [regulation of cytokine production]
GO:0001822 [kidney development]
GO:0001823 [mesonephros development]
GO:0002376 [immune system process]
GO:0002520 [immune system development]
GO:0003180 [aortic valve morphogenesis]
GO:0003215 [cardiac right ventricle morphogenesis]
GO:0003281 [ventricular septum development]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0006952 [defense response]
GO:0006954 [inflammatory response]
GO:0007165 [signal transduction]
GO:0008270 [zinc ion binding]
GO:0008285 [negative regulation of cell population proliferation]
GO:0008584 [male gonad development]
GO:0009615 [response to virus]
GO:0009653 [anatomical structure morphogenesis]
GO:0009967 [positive regulation of signal transduction]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0010719 [negative regulation of epithelial to mesenchymal transition]
GO:0014065 [phosphatidylinositol 3-kinase signaling]
GO:0030154 [cell differentiation]
GO:0030217 [T cell differentiation]
GO:0030225 [macrophage differentiation]
GO:0030856 [regulation of epithelial cell differentiation]
GO:0031929 [TOR signaling]
GO:0032736 [positive regulation of interleukin-13 production]
GO:0032753 [positive regulation of interleukin-4 production]
GO:0032754 [positive regulation of interleukin-5 production]
GO:0033600 [negative regulation of mammary gland epithelial cell proliferation]
GO:0035457 [cellular response to interferon-alpha]
GO:0042421 [norepinephrine biosynthetic process]
GO:0043565 [sequence-specific DNA binding]
GO:0043583 [ear development]
GO:0043627 [response to estrogen]
GO:0045064 [T-helper 2 cell differentiation]
GO:0045087 [innate immune response]
GO:0045165 [cell fate commitment]
GO:0045582 [positive regulation of T cell differentiation]
GO:0045599 [negative regulation of fat cell differentiation]
GO:0045786 [negative regulation of cell cycle]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046872 [metal ion binding]
GO:0048485 [sympathetic nervous system development]
GO:0048568 [embryonic organ development]
GO:0048646 [anatomical structure formation involved in morphogenesis]
GO:0048731 [system development]
GO:0050728 [negative regulation of inflammatory response]
GO:0050852 [T cell receptor signaling pathway]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0060037 [pharyngeal system development]
GO:0060065 [uterus development]
GO:0060231 [mesenchymal to epithelial transition]
GO:0060676 [ureteric bud formation]
GO:0061290 [canonical Wnt signaling pathway involved in metanephric kidney development]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0070888 [E-box binding]
GO:0071353 [cellular response to interleukin-4]
GO:0071356 [cellular response to tumor necrosis factor]
GO:0071837 [HMG box domain binding]
GO:0072107 [positive regulation of ureteric bud formation]
GO:0072178 [nephric duct morphogenesis]
GO:0072179 [nephric duct formation]
GO:0072182 [regulation of nephron tubule epithelial cell differentiation]
GO:0072676 [lymphocyte migration]
GO:1902895 [positive regulation of miRNA transcription]
GO:1990837 [sequence-specific double-stranded DNA binding]
GO:2000146 [negative regulation of cell motility]
GO:2000352 [negative regulation of endothelial cell apoptotic process]
GO:2000607 [negative regulation of cell proliferation involved in mesonephros development]
GO:2000611 [positive regulation of thyroid hormone generation]
GO:2000679 [positive regulation of transcription regulatory region DNA binding]
GO:2000683 [regulation of cellular response to X-ray]
GO:2000703 [negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation]
GO:2000734 [negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation]
Show all
 443 aa
47.9 kDa 		No 0
GATA3-202
ENSP00000368632
ENST00000379328
P23771
[Direct mapping] Trans-acting T-cell-specific transcription factor GATA-3
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Frameshift Mutations
Disease related genes
Human disease related genes
   Cancers
   Cancers of the breast and female genital organs
   Congenital malformations
   Other congenital malformations
   Immune system diseases
   Allergies and autoimmune diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000902 [cell morphogenesis]
GO:0000976 [transcription cis-regulatory region binding]
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0000987 [cis-regulatory region sequence-specific DNA binding]
GO:0001223 [transcription coactivator binding]
GO:0001227 [DNA-binding transcription repressor activity, RNA polymerase II-specific]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0001701 [in utero embryonic development]
GO:0001709 [cell fate determination]
GO:0001764 [neuron migration]
GO:0001806 [type IV hypersensitivity]
GO:0001817 [regulation of cytokine production]
GO:0001819 [positive regulation of cytokine production]
GO:0001822 [kidney development]
GO:0001823 [mesonephros development]
GO:0002088 [lens development in camera-type eye]
GO:0002376 [immune system process]
GO:0002520 [immune system development]
GO:0002572 [pro-T cell differentiation]
GO:0003180 [aortic valve morphogenesis]
GO:0003215 [cardiac right ventricle morphogenesis]
GO:0003281 [ventricular septum development]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005134 [interleukin-2 receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006338 [chromatin remodeling]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0006366 [transcription by RNA polymerase II]
GO:0006952 [defense response]
GO:0006954 [inflammatory response]
GO:0006959 [humoral immune response]
GO:0007165 [signal transduction]
GO:0007399 [nervous system development]
GO:0007411 [axon guidance]
GO:0008270 [zinc ion binding]
GO:0008283 [cell population proliferation]
GO:0008285 [negative regulation of cell population proliferation]
GO:0008584 [male gonad development]
GO:0009410 [response to xenobiotic stimulus]
GO:0009615 [response to virus]
GO:0009653 [anatomical structure morphogenesis]
GO:0009791 [post-embryonic development]
GO:0009967 [positive regulation of signal transduction]
GO:0010332 [response to gamma radiation]
GO:0010467 [gene expression]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0010719 [negative regulation of epithelial to mesenchymal transition]
GO:0010975 [regulation of neuron projection development]
GO:0014065 [phosphatidylinositol 3-kinase signaling]
GO:0030101 [natural killer cell activation]
GO:0030154 [cell differentiation]
GO:0030182 [neuron differentiation]
GO:0030217 [T cell differentiation]
GO:0030218 [erythrocyte differentiation]
GO:0030225 [macrophage differentiation]
GO:0030856 [regulation of epithelial cell differentiation]
GO:0031929 [TOR signaling]
GO:0032689 [negative regulation of interferon-gamma production]
GO:0032703 [negative regulation of interleukin-2 production]
GO:0032736 [positive regulation of interleukin-13 production]
GO:0032753 [positive regulation of interleukin-4 production]
GO:0032754 [positive regulation of interleukin-5 production]
GO:0033077 [T cell differentiation in thymus]
GO:0033600 [negative regulation of mammary gland epithelial cell proliferation]
GO:0035162 [embryonic hemopoiesis]
GO:0035457 [cellular response to interferon-alpha]
GO:0035799 [ureter maturation]
GO:0035898 [parathyroid hormone secretion]
GO:0042421 [norepinephrine biosynthetic process]
GO:0042472 [inner ear morphogenesis]
GO:0042802 [identical protein binding]
GO:0043523 [regulation of neuron apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0043583 [ear development]
GO:0043627 [response to estrogen]
GO:0045061 [thymic T cell selection]
GO:0045064 [T-helper 2 cell differentiation]
GO:0045087 [innate immune response]
GO:0045165 [cell fate commitment]
GO:0045471 [response to ethanol]
GO:0045582 [positive regulation of T cell differentiation]
GO:0045597 [positive regulation of cell differentiation]
GO:0045599 [negative regulation of fat cell differentiation]
GO:0045622 [regulation of T-helper cell differentiation]
GO:0045786 [negative regulation of cell cycle]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046872 [metal ion binding]
GO:0048469 [cell maturation]
GO:0048485 [sympathetic nervous system development]
GO:0048538 [thymus development]
GO:0048568 [embryonic organ development]
GO:0048589 [developmental growth]
GO:0048646 [anatomical structure formation involved in morphogenesis]
GO:0048731 [system development]
GO:0048872 [homeostasis of number of cells]
GO:0050728 [negative regulation of inflammatory response]
GO:0050852 [T cell receptor signaling pathway]
GO:0051216 [cartilage development]
GO:0051569 [regulation of histone H3-K4 methylation]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0060017 [parathyroid gland development]
GO:0060037 [pharyngeal system development]
GO:0060065 [uterus development]
GO:0060231 [mesenchymal to epithelial transition]
GO:0060374 [mast cell differentiation]
GO:0060676 [ureteric bud formation]
GO:0061085 [regulation of histone H3-K27 methylation]
GO:0061290 [canonical Wnt signaling pathway involved in metanephric kidney development]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0070888 [E-box binding]
GO:0071345 [cellular response to cytokine stimulus]
GO:0071353 [cellular response to interleukin-4]
GO:0071356 [cellular response to tumor necrosis factor]
GO:0071442 [positive regulation of histone H3-K14 acetylation]
GO:0071599 [otic vesicle development]
GO:0071773 [cellular response to BMP stimulus]
GO:0071837 [HMG box domain binding]
GO:0072107 [positive regulation of ureteric bud formation]
GO:0072178 [nephric duct morphogenesis]
GO:0072179 [nephric duct formation]
GO:0072182 [regulation of nephron tubule epithelial cell differentiation]
GO:0072197 [ureter morphogenesis]
GO:0072676 [lymphocyte migration]
GO:0090102 [cochlea development]
GO:1901536 [negative regulation of DNA demethylation]
GO:1902895 [positive regulation of miRNA transcription]
GO:1990837 [sequence-specific double-stranded DNA binding]
GO:2000114 [regulation of establishment of cell polarity]
GO:2000146 [negative regulation of cell motility]
GO:2000352 [negative regulation of endothelial cell apoptotic process]
GO:2000553 [positive regulation of T-helper 2 cell cytokine production]
GO:2000607 [negative regulation of cell proliferation involved in mesonephros development]
GO:2000611 [positive regulation of thyroid hormone generation]
GO:2000617 [positive regulation of histone H3-K9 acetylation]
GO:2000679 [positive regulation of transcription regulatory region DNA binding]
GO:2000683 [regulation of cellular response to X-ray]
GO:2000703 [negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation]
GO:2000734 [negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation]
Show all
 444 aa
48 kDa 		No 0
GATA3-203
ENSP00000515407
ENST00000461472
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Frameshift Mutations
Human disease related genes
   Cancers
   Cancers of the breast and female genital organs
   Congenital malformations
   Other congenital malformations
   Immune system diseases
   Allergies and autoimmune diseases
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005634 [nucleus]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0045582 [positive regulation of T cell differentiation]
Show all
 191 aa
20.2 kDa 		No 0
GATA3-204
ENSP00000493486
ENST00000481743
A0A2R8Y2A9
[Direct mapping] Trans-acting T-cell-specific transcription factor GATA-3
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Frameshift Mutations
Human disease related genes
   Cancers
   Cancers of the breast and female genital organs
   Congenital malformations
   Other congenital malformations
   Immune system diseases
   Allergies and autoimmune diseases
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0045582 [positive regulation of T cell differentiation]
Show all
 143 aa
15.5 kDa 		No 0
GATA3-205
ENSP00000494284
ENST00000643001
A0A2R8Y4T2
[Direct mapping] Trans-acting T-cell-specific transcription factor GATA-3
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Frameshift Mutations
Human disease related genes
   Cancers
   Cancers of the breast and female genital organs
   Congenital malformations
   Other congenital malformations
   Immune system diseases
   Allergies and autoimmune diseases
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005634 [nucleus]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0045582 [positive regulation of T cell differentiation]
Show all
 80 aa
9.1 kDa 		No 0

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