GENERAL INFORMATIONi
Gene namei MAPK8
Synonyms JNK, JNK1, PRKM8, SAPK1
Gene descriptioni Mitogen-activated protein kinase 8
Protein classi Cancer-related genes
Enzymes
RAS pathway related proteins
Predicted locationi Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi
Chromosome 10
Cytoband q11.22
Chromosome location (bp) 48306639 - 48439360
Number of transcriptsi 9
Ensembl ENSG00000107643 (version 109)
Entrez gene 5599
HGNC HGNC:6881
UniProt P45983 (UniProt - Evidence at protein level)
neXtProt NX_P45983
GeneCards MAPK8
Antibodypedia MAPK8 antibodies


PROTEIN FUNCTION
Protein function (UniProt)i Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as pro-inflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway 1. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK8/JNK1. In turn, MAPK8/JNK1 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity 2. Phosphorylates the replication licensing factor CDT1, inhibiting the interaction between CDT1 and the histone H4 acetylase HBO1 to replication origins 3. Loss of this interaction abrogates the acetylation required for replication initiation 4. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including p53/TP53 and Yes-associates protein YAP1 5. In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Contributes to the survival of erythroid cells by phosphorylating the antagonist of cell death BAD upon EPO stimulation 6. Mediates starvation-induced BCL2 phosphorylation, BCL2 dissociation from BECN1, and thus activation of autophagy 7. Phosphorylates STMN2 and hence regulates microtubule dynamics, controlling neurite elongation in cortical neurons (By similarity). In the developing brain, through its cytoplasmic activity on STMN2, negatively regulates the rate of exit from multipolar stage and of radial migration from the ventricular zone (By similarity). Phosphorylates several other substrates including heat shock factor protein 4 (HSF4), the deacetylase SIRT1, ELK1, or the E3 ligase ITCH 8, 9, 10. Phosphorylates the CLOCK-BMAL1 heterodimer and plays a role in the regulation of the circadian clock 11. Phosphorylates the heat shock transcription factor HSF1, suppressing HSF1-induced transcriptional activity 12. Phosphorylates POU5F1, which results in the inhibition of POU5F1's transcriptional activity and enhances its proteasomal degradation (By similarity). Phosphorylates JUND and this phosphorylation is inhibited in the presence of MEN1 13. In neurons, phosphorylates SYT4 which captures neuronal dense core vesicles at synapses (By similarity). Phosphorylates EIF4ENIF1/4-ET in response to oxidative stress, promoting P-body assembly 14. Phosphorylates SIRT6 in response to oxidative stress, stimulating its mono-ADP-ribosyltransferase activity 15. Phosphorylates NLRP3, promoting assembly of the NLRP3 inflammasome 16. Phosphorylates ALKBH5 in response to reactive oxygen species (ROS), promoting ALKBH5 sumoylation and inactivation 17. show less
Molecular function (UniProt)i Kinase, Serine/threonine-protein kinase, Transferase
Biological process (UniProt)i Biological rhythms
Ligand (UniProt)i ATP-binding, Nucleotide-binding
Gene summary (Entrez)i The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Apr 2016] show less
PROTEIN INFORMATIONi
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
MAPK8-201
ENSP00000353483
ENST00000360332
P45983
[Direct mapping] Mitogen-activated protein kinase 8
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004705 [JUN kinase activity]
GO:0004707 [MAP kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006979 [response to oxidative stress]
GO:0007165 [signal transduction]
GO:0007254 [JNK cascade]
GO:0007258 [JUN phosphorylation]
GO:0009411 [response to UV]
GO:0009612 [response to mechanical stimulus]
GO:0010628 [positive regulation of gene expression]
GO:0016241 [regulation of macroautophagy]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0019899 [enzyme binding]
GO:0019903 [protein phosphatase binding]
GO:0030424 [axon]
GO:0031281 [positive regulation of cyclase activity]
GO:0031343 [positive regulation of cell killing]
GO:0032091 [negative regulation of protein binding]
GO:0032880 [regulation of protein localization]
GO:0034198 [cellular response to amino acid starvation]
GO:0034599 [cellular response to oxidative stress]
GO:0034614 [cellular response to reactive oxygen species]
GO:0035033 [histone deacetylase regulator activity]
GO:0035556 [intracellular signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042752 [regulation of circadian rhythm]
GO:0042826 [histone deacetylase binding]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045202 [synapse]
GO:0048511 [rhythmic process]
GO:0051090 [regulation of DNA-binding transcription factor activity]
GO:0051247 [positive regulation of protein metabolic process]
GO:0051403 [stress-activated MAPK cascade]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071260 [cellular response to mechanical stimulus]
GO:0071276 [cellular response to cadmium ion]
GO:0090045 [positive regulation of deacetylase activity]
GO:0090398 [cellular senescence]
GO:0097441 [basal dendrite]
GO:0106310 [protein serine kinase activity]
GO:0120283 [protein serine/threonine kinase binding]
GO:1900227 [positive regulation of NLRP3 inflammasome complex assembly]
GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
GO:1902595 [regulation of DNA replication origin binding]
Show all
 308 aa
35.3 kDa 		No 0
MAPK8-203
ENSP00000363291
ENST00000374176
P45983
[Direct mapping] Mitogen-activated protein kinase 8
Show all
A1L4K2
[Target identity:100%; Query identity:100%] Stress-activated protein kinase JNK
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000166 [nucleotide binding]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004705 [JUN kinase activity]
GO:0004707 [MAP kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006979 [response to oxidative stress]
GO:0007165 [signal transduction]
GO:0007254 [JNK cascade]
GO:0007258 [JUN phosphorylation]
GO:0009411 [response to UV]
GO:0009612 [response to mechanical stimulus]
GO:0010628 [positive regulation of gene expression]
GO:0016241 [regulation of macroautophagy]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0019899 [enzyme binding]
GO:0019903 [protein phosphatase binding]
GO:0030424 [axon]
GO:0031281 [positive regulation of cyclase activity]
GO:0031343 [positive regulation of cell killing]
GO:0032091 [negative regulation of protein binding]
GO:0032880 [regulation of protein localization]
GO:0034198 [cellular response to amino acid starvation]
GO:0034599 [cellular response to oxidative stress]
GO:0034614 [cellular response to reactive oxygen species]
GO:0035033 [histone deacetylase regulator activity]
GO:0035556 [intracellular signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042752 [regulation of circadian rhythm]
GO:0042826 [histone deacetylase binding]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045202 [synapse]
GO:0048511 [rhythmic process]
GO:0051090 [regulation of DNA-binding transcription factor activity]
GO:0051247 [positive regulation of protein metabolic process]
GO:0051403 [stress-activated MAPK cascade]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071260 [cellular response to mechanical stimulus]
GO:0071276 [cellular response to cadmium ion]
GO:0090045 [positive regulation of deacetylase activity]
GO:0090398 [cellular senescence]
GO:0097441 [basal dendrite]
GO:0106310 [protein serine kinase activity]
GO:0120283 [protein serine/threonine kinase binding]
GO:1900227 [positive regulation of NLRP3 inflammasome complex assembly]
GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
GO:1902595 [regulation of DNA replication origin binding]
Show all
 427 aa
48.1 kDa 		No 0
MAPK8-204
ENSP00000363294
ENST00000374179
P45983
[Direct mapping] Mitogen-activated protein kinase 8
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004705 [JUN kinase activity]
GO:0004707 [MAP kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006979 [response to oxidative stress]
GO:0007165 [signal transduction]
GO:0007254 [JNK cascade]
GO:0007258 [JUN phosphorylation]
GO:0009411 [response to UV]
GO:0009612 [response to mechanical stimulus]
GO:0010628 [positive regulation of gene expression]
GO:0016241 [regulation of macroautophagy]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0019899 [enzyme binding]
GO:0019903 [protein phosphatase binding]
GO:0030424 [axon]
GO:0031281 [positive regulation of cyclase activity]
GO:0031343 [positive regulation of cell killing]
GO:0032091 [negative regulation of protein binding]
GO:0032880 [regulation of protein localization]
GO:0034198 [cellular response to amino acid starvation]
GO:0034599 [cellular response to oxidative stress]
GO:0034614 [cellular response to reactive oxygen species]
GO:0035033 [histone deacetylase regulator activity]
GO:0035556 [intracellular signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042752 [regulation of circadian rhythm]
GO:0042826 [histone deacetylase binding]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045202 [synapse]
GO:0048511 [rhythmic process]
GO:0051090 [regulation of DNA-binding transcription factor activity]
GO:0051247 [positive regulation of protein metabolic process]
GO:0051403 [stress-activated MAPK cascade]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071260 [cellular response to mechanical stimulus]
GO:0071276 [cellular response to cadmium ion]
GO:0090045 [positive regulation of deacetylase activity]
GO:0090398 [cellular senescence]
GO:0097441 [basal dendrite]
GO:0106310 [protein serine kinase activity]
GO:0120283 [protein serine/threonine kinase binding]
GO:1900227 [positive regulation of NLRP3 inflammasome complex assembly]
GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
GO:1902595 [regulation of DNA replication origin binding]
Show all
 384 aa
44 kDa 		No 0
MAPK8-205
ENSP00000363297
ENST00000374182
P45983
[Direct mapping] Mitogen-activated protein kinase 8
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004705 [JUN kinase activity]
GO:0004707 [MAP kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006979 [response to oxidative stress]
GO:0007165 [signal transduction]
GO:0007254 [JNK cascade]
GO:0007258 [JUN phosphorylation]
GO:0009411 [response to UV]
GO:0009612 [response to mechanical stimulus]
GO:0010628 [positive regulation of gene expression]
GO:0016241 [regulation of macroautophagy]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0019899 [enzyme binding]
GO:0019903 [protein phosphatase binding]
GO:0030424 [axon]
GO:0031281 [positive regulation of cyclase activity]
GO:0031343 [positive regulation of cell killing]
GO:0032091 [negative regulation of protein binding]
GO:0032880 [regulation of protein localization]
GO:0034198 [cellular response to amino acid starvation]
GO:0034599 [cellular response to oxidative stress]
GO:0034614 [cellular response to reactive oxygen species]
GO:0035033 [histone deacetylase regulator activity]
GO:0035556 [intracellular signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042752 [regulation of circadian rhythm]
GO:0042826 [histone deacetylase binding]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045202 [synapse]
GO:0048511 [rhythmic process]
GO:0051090 [regulation of DNA-binding transcription factor activity]
GO:0051247 [positive regulation of protein metabolic process]
GO:0051403 [stress-activated MAPK cascade]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071260 [cellular response to mechanical stimulus]
GO:0071276 [cellular response to cadmium ion]
GO:0090045 [positive regulation of deacetylase activity]
GO:0090398 [cellular senescence]
GO:0097441 [basal dendrite]
GO:0106310 [protein serine kinase activity]
GO:0120283 [protein serine/threonine kinase binding]
GO:1900227 [positive regulation of NLRP3 inflammasome complex assembly]
GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
GO:1902595 [regulation of DNA replication origin binding]
Show all
 384 aa
44.2 kDa 		No 0
MAPK8-206
ENSP00000363304
ENST00000374189
P45983
[Direct mapping] Mitogen-activated protein kinase 8
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004705 [JUN kinase activity]
GO:0004707 [MAP kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006979 [response to oxidative stress]
GO:0007165 [signal transduction]
GO:0007254 [JNK cascade]
GO:0007258 [JUN phosphorylation]
GO:0009411 [response to UV]
GO:0009612 [response to mechanical stimulus]
GO:0010628 [positive regulation of gene expression]
GO:0016241 [regulation of macroautophagy]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0019899 [enzyme binding]
GO:0019903 [protein phosphatase binding]
GO:0030424 [axon]
GO:0031281 [positive regulation of cyclase activity]
GO:0031343 [positive regulation of cell killing]
GO:0032091 [negative regulation of protein binding]
GO:0032880 [regulation of protein localization]
GO:0034198 [cellular response to amino acid starvation]
GO:0034599 [cellular response to oxidative stress]
GO:0034614 [cellular response to reactive oxygen species]
GO:0035033 [histone deacetylase regulator activity]
GO:0035556 [intracellular signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042752 [regulation of circadian rhythm]
GO:0042826 [histone deacetylase binding]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045202 [synapse]
GO:0048511 [rhythmic process]
GO:0051090 [regulation of DNA-binding transcription factor activity]
GO:0051247 [positive regulation of protein metabolic process]
GO:0051403 [stress-activated MAPK cascade]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071260 [cellular response to mechanical stimulus]
GO:0071276 [cellular response to cadmium ion]
GO:0090045 [positive regulation of deacetylase activity]
GO:0090398 [cellular senescence]
GO:0097441 [basal dendrite]
GO:0106310 [protein serine kinase activity]
GO:0120283 [protein serine/threonine kinase binding]
GO:1900227 [positive regulation of NLRP3 inflammasome complex assembly]
GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
GO:1902595 [regulation of DNA replication origin binding]
Show all
 427 aa
48.3 kDa 		No 0
MAPK8-207
ENSP00000378974
ENST00000395611
P45983
[Direct mapping] Mitogen-activated protein kinase 8
Show all
A1L4K2
[Target identity:100%; Query identity:100%] Stress-activated protein kinase JNK
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000166 [nucleotide binding]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004705 [JUN kinase activity]
GO:0004707 [MAP kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006979 [response to oxidative stress]
GO:0007165 [signal transduction]
GO:0007254 [JNK cascade]
GO:0007258 [JUN phosphorylation]
GO:0009411 [response to UV]
GO:0009612 [response to mechanical stimulus]
GO:0010628 [positive regulation of gene expression]
GO:0016241 [regulation of macroautophagy]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0019899 [enzyme binding]
GO:0019903 [protein phosphatase binding]
GO:0030424 [axon]
GO:0031281 [positive regulation of cyclase activity]
GO:0031343 [positive regulation of cell killing]
GO:0032091 [negative regulation of protein binding]
GO:0032880 [regulation of protein localization]
GO:0034198 [cellular response to amino acid starvation]
GO:0034599 [cellular response to oxidative stress]
GO:0034614 [cellular response to reactive oxygen species]
GO:0035033 [histone deacetylase regulator activity]
GO:0035556 [intracellular signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042752 [regulation of circadian rhythm]
GO:0042826 [histone deacetylase binding]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045202 [synapse]
GO:0048511 [rhythmic process]
GO:0051090 [regulation of DNA-binding transcription factor activity]
GO:0051247 [positive regulation of protein metabolic process]
GO:0051403 [stress-activated MAPK cascade]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071260 [cellular response to mechanical stimulus]
GO:0071276 [cellular response to cadmium ion]
GO:0090045 [positive regulation of deacetylase activity]
GO:0090398 [cellular senescence]
GO:0097441 [basal dendrite]
GO:0106310 [protein serine kinase activity]
GO:0120283 [protein serine/threonine kinase binding]
GO:1900227 [positive regulation of NLRP3 inflammasome complex assembly]
GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
GO:1902595 [regulation of DNA replication origin binding]
Show all
 427 aa
48.1 kDa 		No 0
MAPK8-208
ENSP00000397729
ENST00000426557
C9J762
[Direct mapping] Stress-activated protein kinase JNK
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000166 [nucleotide binding]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004707 [MAP kinase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0048511 [rhythmic process]
GO:0106310 [protein serine kinase activity]
Show all
 142 aa
16.4 kDa 		No 0
MAPK8-210
ENSP00000387936
ENST00000432379
C9J762
[Direct mapping] Stress-activated protein kinase JNK
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000166 [nucleotide binding]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004707 [MAP kinase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0048511 [rhythmic process]
GO:0106310 [protein serine kinase activity]
Show all
 142 aa
16.4 kDa 		No 0
MAPK8-215
ENSP00000496965
ENST00000476134
A0A3B3IRW7
[Direct mapping] Stress-activated protein kinase JNK
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000166 [nucleotide binding]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004707 [MAP kinase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0048511 [rhythmic process]
GO:0106310 [protein serine kinase activity]
Show all
 169 aa
19.7 kDa 		No 0

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