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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Cytoplasmic polyadenylation element binding protein 3
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
10
Cytoband
q23.32
Chromosome location (bp)
92046692 - 92291078
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Sequence-specific RNA-binding protein which acts as a translational repressor in the basal unstimulated state but, following neuronal stimulation, acts as a translational activator (By similarity). In contrast to CPEB1, does not bind to the cytoplasmic polyadenylation element (CPE), a uridine-rich sequence element within the mRNA 3'-UTR, but binds to a U-rich loop within a stem-loop structure (By similarity). Required for the consolidation and maintenance of hippocampal-based long term memory (By similarity). In the basal state, binds to the mRNA 3'-UTR of the glutamate receptors GRIA2/GLUR2 mRNA and negatively regulates their translation (By similarity). Also represses the translation of DLG4, GRIN1, GRIN2A and GRIN2B (By similarity). When activated, acts as a translational activator of GRIA1 and GRIA2 (By similarity). In the basal state, suppresses SUMO2 translation but activates it following neuronal stimulation (By similarity). Binds to the 3'-UTR of TRPV1 mRNA and represses TRPV1 translation which is required to maintain normal thermoception (By similarity). Binds actin mRNA, leading to actin translational repression in the basal state and to translational activation following neuronal stimulation (By similarity). Negatively regulates target mRNA levels by binding to TOB1 which recruits CNOT7/CAF1 to a ternary complex and this leads to target mRNA deadenylation and decay 1. In addition to its role in translation, binds to and inhibits the transcriptional activation activity of STAT5B without affecting its dimerization or DNA-binding activity. This, in turn, represses transcription of the STAT5B target gene EGFR which has been shown to play a role in enhancing learning and memory performance 2. In contrast to CPEB1, CPEB2 and CPEB4, not required for cell cycle progression 3....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Activator, Repressor, RNA-binding
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Translation regulation
Gene summary (Entrez)i
Useful information about the gene from Entrez
Enables mRNA 3'-UTR binding activity and translation factor activity, RNA binding. Involved in cellular response to amino acid stimulus; negative regulation of transcription by RNA polymerase II; and positive regulation of mRNA catabolic process. Located in several cellular components, including cytosol; midbody; and nucleoplasm. Part of CCR4-NOT complex. [provided by Alliance of Genome Resources, Apr 2022]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q8NE35 [Direct mapping] Cytoplasmic polyadenylation element-binding protein 3
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000900[mRNA regulatory element binding translation repressor activity] GO:0003676[nucleic acid binding] GO:0003723[RNA binding] GO:0003730[mRNA 3'-UTR binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006412[translation] GO:0006417[regulation of translation] GO:0007616[long-term memory] GO:0008135[translation factor activity, RNA binding] GO:0014069[postsynaptic density] GO:0017148[negative regulation of translation] GO:0030014[CCR4-NOT complex] GO:0030425[dendrite] GO:0030496[midbody] GO:0035613[RNA stem-loop binding] GO:0035925[mRNA 3'-UTR AU-rich region binding] GO:0042995[cell projection] GO:0043005[neuron projection] GO:0043022[ribosome binding] GO:0045182[translation regulator activity] GO:0045202[synapse] GO:0045727[positive regulation of translation] GO:0048167[regulation of synaptic plasticity] GO:0060213[positive regulation of nuclear-transcribed mRNA poly(A) tail shortening] GO:0060998[regulation of dendritic spine development] GO:0060999[positive regulation of dendritic spine development] GO:0061158[3'-UTR-mediated mRNA destabilization] GO:0071230[cellular response to amino acid stimulus] GO:0097440[apical dendrite] GO:0098794[postsynapse] GO:1900153[positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay] GO:1900248[negative regulation of cytoplasmic translational elongation] GO:1900365[positive regulation of mRNA polyadenylation] GO:1990124[messenger ribonucleoprotein complex] GO:2000766[negative regulation of cytoplasmic translation]
Q8NE35 [Direct mapping] Cytoplasmic polyadenylation element-binding protein 3
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Q5QP71 [Target identity:100%; Query identity:100%] Cytoplasmic polyadenylation element binding protein 3, isoform CRA_a; cDNA FLJ61637, highly similar to Homo sapiens cytoplasmic polyadenylation element binding protein 3 (CPEB3), mRNA
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000900[mRNA regulatory element binding translation repressor activity] GO:0003676[nucleic acid binding] GO:0003723[RNA binding] GO:0003730[mRNA 3'-UTR binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006412[translation] GO:0006417[regulation of translation] GO:0007616[long-term memory] GO:0008135[translation factor activity, RNA binding] GO:0014069[postsynaptic density] GO:0017148[negative regulation of translation] GO:0030014[CCR4-NOT complex] GO:0030425[dendrite] GO:0030496[midbody] GO:0035613[RNA stem-loop binding] GO:0035925[mRNA 3'-UTR AU-rich region binding] GO:0042995[cell projection] GO:0043005[neuron projection] GO:0043022[ribosome binding] GO:0045182[translation regulator activity] GO:0045202[synapse] GO:0045727[positive regulation of translation] GO:0048167[regulation of synaptic plasticity] GO:0060213[positive regulation of nuclear-transcribed mRNA poly(A) tail shortening] GO:0060998[regulation of dendritic spine development] GO:0060999[positive regulation of dendritic spine development] GO:0061158[3'-UTR-mediated mRNA destabilization] GO:0071230[cellular response to amino acid stimulus] GO:0097440[apical dendrite] GO:1900153[positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay] GO:1900248[negative regulation of cytoplasmic translational elongation] GO:1900365[positive regulation of mRNA polyadenylation] GO:1990124[messenger ribonucleoprotein complex] GO:2000766[negative regulation of cytoplasmic translation]
The Human Protein Atlas project is funded
