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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Enzymes FDA approved drug targets Metabolic proteins Plasma proteins Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
10
Cytoband
q22.3
Chromosome location (bp)
79347469 - 79355334
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding 1. Involved in regulation of the mitochondrial permeability transition pore (mPTP) 2. It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probability of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this function is debated 3. In cooperation with mitochondrial p53/TP53 is involved in activating oxidative stress-induced necrosis 4. Involved in modulation of mitochondrial membrane F(1)F(0) ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels (By similarity). Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis 5....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Isomerase, Rotamase
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Apoptosis, Necrosis
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is part of the mitochondrial permeability transition pore in the inner mitochondrial membrane. Activation of this pore is thought to be involved in the induction of apoptotic and necrotic cell death. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Enzymes ENZYME proteins Isomerase Metabolic proteins Transporters Transporter channels and pores SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins FDA approved drug targets Small molecule drugs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000413[protein peptidyl-prolyl isomerization] GO:0002931[response to ischemia] GO:0003755[peptidyl-prolyl cis-trans isomerase activity] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005743[mitochondrial inner membrane] GO:0005753[mitochondrial proton-transporting ATP synthase complex] GO:0005757[mitochondrial permeability transition pore complex] GO:0005759[mitochondrial matrix] GO:0006457[protein folding] GO:0006915[apoptotic process] GO:0006979[response to oxidative stress] GO:0008637[apoptotic mitochondrial changes] GO:0010849[regulation of proton-transporting ATPase activity, rotational mechanism] GO:0010939[regulation of necrotic cell death] GO:0012501[programmed cell death] GO:0016018[cyclosporin A binding] GO:0016020[membrane] GO:0016853[isomerase activity] GO:0032780[negative regulation of ATP-dependent activity] GO:0042277[peptide binding] GO:0042981[regulation of apoptotic process] GO:0043066[negative regulation of apoptotic process] GO:0043231[intracellular membrane-bounded organelle] GO:0046902[regulation of mitochondrial membrane permeability] GO:0070266[necroptotic process] GO:0070301[cellular response to hydrogen peroxide] GO:0071243[cellular response to arsenic-containing substance] GO:0071277[cellular response to calcium ion] GO:0090200[positive regulation of release of cytochrome c from mitochondria] GO:0090201[negative regulation of release of cytochrome c from mitochondria] GO:0090324[negative regulation of oxidative phosphorylation] GO:1902445[regulation of mitochondrial membrane permeability involved in programmed necrotic cell death] GO:1902686[mitochondrial outer membrane permeabilization involved in programmed cell death] GO:2000276[negative regulation of oxidative phosphorylation uncoupler activity] GO:2001243[negative regulation of intrinsic apoptotic signaling pathway]
The Human Protein Atlas project is funded
