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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Enzymes Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
17
Cytoband
q23.1
Chromosome location (bp)
59893046 - 59950574
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Serine/threonine-protein kinase that acts downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17. Regulates protein synthesis through phosphorylation of EIF4B, RPS6 and EEF2K, and contributes to cell survival by repressing the pro-apoptotic function of BAD 18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34. Under conditions of nutrient depletion, the inactive form associates with the EIF3 translation initiation complex 35. Upon mitogenic stimulation, phosphorylation by the mechanistic target of rapamycin complex 1 (mTORC1) leads to dissociation from the EIF3 complex and activation 36. The active form then phosphorylates and activates several substrates in the pre-initiation complex, including the EIF2B complex and the cap-binding complex component EIF4B 37. Also controls translation initiation by phosphorylating a negative regulator of EIF4A, PDCD4, targeting it for ubiquitination and subsequent proteolysis 38. Promotes initiation of the pioneer round of protein synthesis by phosphorylating POLDIP3/SKAR 39. In response to IGF1, activates translation elongation by phosphorylating EEF2 kinase (EEF2K), which leads to its inhibition and thus activation of EEF2 40. Also plays a role in feedback regulation of mTORC2 by mTORC1 by phosphorylating RICTOR, resulting in the inhibition of mTORC2 and AKT1 signaling 41,42,43. Also involved in feedback regulation of mTORC1 and mTORC2 by phosphorylating DEPTOR 44. Mediates cell survival by phosphorylating the pro-apoptotic protein BAD and suppressing its pro-apoptotic function (By similarity). Phosphorylates mitochondrial URI1 leading to dissociation of a URI1-PPP1CC complex 45. The free mitochondrial PPP1CC can then dephosphorylate RPS6KB1 at Thr-412, which is proposed to be a negative feedback mechanism for the RPS6KB1 anti-apoptotic function 46. Mediates TNF-alpha-induced insulin resistance by phosphorylating IRS1 at multiple serine residues, resulting in accelerated degradation of IRS1 47. In cells lacking functional TSC1-2 complex, constitutively phosphorylates and inhibits GSK3B 48. May be involved in cytoskeletal rearrangement through binding to neurabin (By similarity). Phosphorylates and activates the pyrimidine biosynthesis enzyme CAD, downstream of MTOR 49. Following activation by mTORC1, phosphorylates EPRS and thereby plays a key role in fatty acid uptake by adipocytes and also most probably in interferon-gamma-induced translation inhibition 50....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Apoptosis, Cell cycle, Translation regulation
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
ATP-binding, Nucleotide-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the ribosomal S6 kinase family of serine/threonine kinases. The encoded protein responds to mTOR (mammalian target of rapamycin) signaling to promote protein synthesis, cell growth, and cell proliferation. Activity of this gene has been associated with human cancer. Alternatively spliced transcript variants have been observed. The use of alternative translation start sites results in isoforms with longer or shorter N-termini which may differ in their subcellular localizations. There are two pseudogenes for this gene on chromosome 17. [provided by RefSeq, Jan 2013]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
P23443 [Direct mapping] Ribosomal protein S6 kinase beta-1
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Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000082[G1/S transition of mitotic cell cycle] GO:0000166[nucleotide binding] GO:0001662[behavioral fear response] GO:0003009[skeletal muscle contraction] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0004711[ribosomal protein S6 kinase activity] GO:0004712[protein serine/threonine/tyrosine kinase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005741[mitochondrial outer membrane] GO:0005829[cytosol] GO:0006417[regulation of translation] GO:0006468[protein phosphorylation] GO:0006915[apoptotic process] GO:0007049[cell cycle] GO:0007165[signal transduction] GO:0007281[germ cell development] GO:0007568[aging] GO:0007584[response to nutrient] GO:0007616[long-term memory] GO:0009408[response to heat] GO:0009410[response to xenobiotic stimulus] GO:0009611[response to wounding] GO:0009612[response to mechanical stimulus] GO:0009636[response to toxic substance] GO:0009749[response to glucose] GO:0009986[cell surface] GO:0010033[response to organic substance] GO:0010243[response to organonitrogen compound] GO:0014070[response to organic cyclic compound] GO:0014732[skeletal muscle atrophy] GO:0014878[response to electrical stimulus involved in regulation of muscle adaptation] GO:0014911[positive regulation of smooth muscle cell migration] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016477[cell migration] GO:0016740[transferase activity] GO:0018105[peptidyl-serine phosphorylation] GO:0030165[PDZ domain binding] GO:0031667[response to nutrient levels] GO:0031929[TOR signaling] GO:0032496[response to lipopolysaccharide] GO:0032868[response to insulin] GO:0032869[cellular response to insulin stimulus] GO:0032870[cellular response to hormone stimulus] GO:0033574[response to testosterone] GO:0033762[response to glucagon] GO:0034612[response to tumor necrosis factor] GO:0042277[peptide binding] GO:0042802[identical protein binding] GO:0043005[neuron projection] GO:0043066[negative regulation of apoptotic process] GO:0043200[response to amino acid] GO:0043201[response to leucine] GO:0043434[response to peptide hormone] GO:0043491[protein kinase B signaling] GO:0044539[long-chain fatty acid import into cell] GO:0045202[synapse] GO:0045471[response to ethanol] GO:0045727[positive regulation of translation] GO:0045931[positive regulation of mitotic cell cycle] GO:0045948[positive regulation of translational initiation] GO:0046324[regulation of glucose import] GO:0046627[negative regulation of insulin receptor signaling pathway] GO:0048015[phosphatidylinositol-mediated signaling] GO:0048471[perinuclear region of cytoplasm] GO:0048633[positive regulation of skeletal muscle tissue growth] GO:0048661[positive regulation of smooth muscle cell proliferation] GO:0050804[modulation of chemical synaptic transmission] GO:0051384[response to glucocorticoid] GO:0051721[protein phosphatase 2A binding] GO:0071346[cellular response to interferon-gamma] GO:0071363[cellular response to growth factor stimulus] GO:0071407[cellular response to organic cyclic compound] GO:0071549[cellular response to dexamethasone stimulus] GO:0098794[postsynapse] GO:0098978[glutamatergic synapse] GO:0106310[protein serine kinase activity] GO:2001237[negative regulation of extrinsic apoptotic signaling pathway]
P23443 [Direct mapping] Ribosomal protein S6 kinase beta-1
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Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
P23443 [Direct mapping] Ribosomal protein S6 kinase beta-1
Show all
Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
P23443 [Direct mapping] Ribosomal protein S6 kinase beta-1
Show all
Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
