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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
17
Cytoband
q21.32
Chromosome location (bp)
47967810 - 47981781
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Substrate adapter of E3 ligase complexes mediating ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to substrate proteins, and which is involved in various processes, such as ribosome recycling and reticulophagy (also called ER-phagy) 1,2,3,4,5,6,7,8. As part of the UREL complex, plays a key role in ribosome recycling by promoting mono-ufmylation of RPL26/uL24 subunit of the 60S ribosome 9,10. Ufmylation of RPL26/uL24 occurs on free 60S ribosomes following ribosome dissociation: it weakens the junction between post-termination 60S subunits and SEC61 translocons, promoting release and recycling of the large ribosomal subunit from the endoplasmic reticulum membrane 11,12. Ufmylation of RPL26/uL24 and subsequent 60S ribosome recycling either take place after normal termination of translation or after ribosome stalling during cotranslational translocation at the endoplasmic reticulum 13,14,15,16. Within the UREL complex, CDK5RAP3 acts as a substrate adapter that constrains UFL1 ligase activity to mono-ufmylate RPL26/uL24 at 'Lys-134' 17,18,19. The UREL complex is also involved in reticulophagy in response to endoplasmic reticulum stress by promoting ufmylation of proteins such as CYB5R3, thereby promoting lysosomal degradation of ufmylated proteins 20. Also acts as a regulator of transcription: negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation 21,22. Also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint 23,24. Through its interaction with CDKN2A/ARF and MDM2 may induce MDM2-dependent p53/TP53 ubiquitination, stabilization and activation in the nucleus, thereby promoting G1 cell cycle arrest and inhibition of cell proliferation 25. May also play a role in the rupture of the nuclear envelope during apoptosis 26. May regulate MAPK14 activity by regulating its dephosphorylation by PPM1D/WIP1 27. Required for liver development (By similarity)....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Host-virus interaction, Ubl conjugation pathway
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a protein that has been reported to function in signaling pathways governing transcriptional regulation and cell cycle progression. It may play a role in tumorigenesis and metastasis. A pseudogene of this gene is located on the long arm of chromosome 20. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, May 2013]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q96JB5 [Direct mapping] CDK5 regulatory subunit-associated protein 3
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000079[regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0001889[liver development] GO:0001933[negative regulation of protein phosphorylation] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005730[nucleolus] GO:0005737[cytoplasm] GO:0005813[centrosome] GO:0005815[microtubule organizing center] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0005874[microtubule] GO:0007095[mitotic G2 DNA damage checkpoint signaling] GO:0007346[regulation of mitotic cell cycle] GO:0007420[brain development] GO:0008283[cell population proliferation] GO:0010921[regulation of phosphatase activity] GO:0016020[membrane] GO:0019901[protein kinase binding] GO:0030262[apoptotic nuclear changes] GO:0030332[cyclin binding] GO:0030968[endoplasmic reticulum unfolded protein response] GO:0031398[positive regulation of protein ubiquitination] GO:0032088[negative regulation of NF-kappaB transcription factor activity] GO:0032991[protein-containing complex] GO:0034976[response to endoplasmic reticulum stress] GO:0042177[negative regulation of protein catabolic process] GO:0043231[intracellular membrane-bounded organelle] GO:0043407[negative regulation of MAP kinase activity] GO:0044387[negative regulation of protein kinase activity by regulation of protein phosphorylation] GO:0044389[ubiquitin-like protein ligase binding] GO:0044818[mitotic G2/M transition checkpoint] GO:0045664[regulation of neuron differentiation] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0051019[mitogen-activated protein kinase binding] GO:0051059[NF-kappaB binding] GO:0060318[definitive erythrocyte differentiation] GO:0071569[protein ufmylation] GO:0071901[negative regulation of protein serine/threonine kinase activity] GO:0097371[MDM2/MDM4 family protein binding] GO:1900182[positive regulation of protein localization to nucleus] GO:1901798[positive regulation of signal transduction by p53 class mediator]
Q96JB5 [Direct mapping] CDK5 regulatory subunit-associated protein 3
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000079[regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0001889[liver development] GO:0001933[negative regulation of protein phosphorylation] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005730[nucleolus] GO:0005737[cytoplasm] GO:0005813[centrosome] GO:0005815[microtubule organizing center] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0005874[microtubule] GO:0007095[mitotic G2 DNA damage checkpoint signaling] GO:0007346[regulation of mitotic cell cycle] GO:0007420[brain development] GO:0008283[cell population proliferation] GO:0010921[regulation of phosphatase activity] GO:0016020[membrane] GO:0019901[protein kinase binding] GO:0030262[apoptotic nuclear changes] GO:0030332[cyclin binding] GO:0030968[endoplasmic reticulum unfolded protein response] GO:0031398[positive regulation of protein ubiquitination] GO:0032088[negative regulation of NF-kappaB transcription factor activity] GO:0032991[protein-containing complex] GO:0034976[response to endoplasmic reticulum stress] GO:0042177[negative regulation of protein catabolic process] GO:0043231[intracellular membrane-bounded organelle] GO:0043407[negative regulation of MAP kinase activity] GO:0044387[negative regulation of protein kinase activity by regulation of protein phosphorylation] GO:0044389[ubiquitin-like protein ligase binding] GO:0044818[mitotic G2/M transition checkpoint] GO:0045664[regulation of neuron differentiation] GO:0051019[mitogen-activated protein kinase binding] GO:0051059[NF-kappaB binding] GO:0060318[definitive erythrocyte differentiation] GO:0071569[protein ufmylation] GO:0071901[negative regulation of protein serine/threonine kinase activity] GO:0097371[MDM2/MDM4 family protein binding] GO:1900182[positive regulation of protein localization to nucleus] GO:1901798[positive regulation of signal transduction by p53 class mediator]
The Human Protein Atlas project is funded
