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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Enzymes Metabolic proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
17
Cytoband
q21.2
Chromosome location (bp)
42113111 - 42121367
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Protein lysine acyltransferase that can act as a acetyltransferase, glutaryltransferase, succinyltransferase or malonyltransferase, depending on the context 1,2. Acts as a histone lysine succinyltransferase: catalyzes succinylation of histone H3 on 'Lys-79' (H3K79succ), with a maximum frequency around the transcription start sites of genes 3. Succinylation of histones gives a specific tag for epigenetic transcription activation 4. Association with the 2-oxoglutarate dehydrogenase complex, which provides succinyl-CoA, is required for histone succinylation 5. In different complexes, functions either as an acetyltransferase (HAT) or as a succinyltransferase: in the SAGA and ATAC complexes, acts as a histone acetyltransferase 6,7,8. Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles 9,10,11. Has a a strong preference for acetylation of H3 at 'Lys-9' (H3K9ac) 12. Acetylation of histones gives a specific tag for epigenetic transcription activation 13,14,15. Recruited by the XPC complex at promoters, where it specifically mediates acetylation of histone variant H2A.Z.1/H2A.Z, thereby promoting expression of target genes 16,17. Involved in long-term memory consolidation and synaptic plasticity: acts by promoting expression of a hippocampal gene expression network linked to neuroactive receptor signaling (By similarity). Acts as a positive regulator of T-cell activation: upon TCR stimulation, recruited to the IL2 promoter following interaction with NFATC2 and catalyzes acetylation of histone H3 at 'Lys-9' (H3K9ac), leading to promote IL2 expression (By similarity). Required for growth and differentiation of craniofacial cartilage and bone by regulating acetylation of histone H3 at 'Lys-9' (H3K9ac) (By similarity). Regulates embryonic stem cell (ESC) pluripotency and differentiation (By similarity). Also acetylates non-histone proteins, such as CEBPB, MRE11, PPARGC1A, PLK4 and TBX5 18,19,20,21,22. Involved in heart and limb development by mediating acetylation of TBX5, acetylation regulating nucleocytoplasmic shuttling of TBX5 23. Acts as a negative regulator of centrosome amplification by mediating acetylation of PLK4 24. Acts as a negative regulator of gluconeogenesis by mediating acetylation and subsequent inactivation of PPARGC1A 25,26. Also acts as a histone glutaryltransferase: catalyzes glutarylation of histone H4 on 'Lys-91' (H4K91glu), a mark that destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes 27....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Acyltransferase, Transferase
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Enzymes ENZYME proteins Transferases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000123[histone acetyltransferase complex] GO:0000124[SAGA complex] GO:0000785[chromatin] GO:0001701[in utero embryonic development] GO:0001756[somitogenesis] GO:0001819[positive regulation of cytokine production] GO:0001843[neural tube closure] GO:0003682[chromatin binding] GO:0003713[transcription coactivator activity] GO:0004402[histone acetyltransferase activity] GO:0005515[protein binding] GO:0005615[extracellular space] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005694[chromosome] GO:0005737[cytoplasm] GO:0005813[centrosome] GO:0005815[microtubule organizing center] GO:0005856[cytoskeleton] GO:0006094[gluconeogenesis] GO:0006282[regulation of DNA repair] GO:0006338[chromatin remodeling] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0007399[nervous system development] GO:0007507[heart development] GO:0007616[long-term memory] GO:0008080[N-acetyltransferase activity] GO:0010484[H3 histone acetyltransferase activity] GO:0014070[response to organic cyclic compound] GO:0016407[acetyltransferase activity] GO:0016573[histone acetylation] GO:0016578[histone deubiquitination] GO:0016740[transferase activity] GO:0016746[acyltransferase activity] GO:0016747[acyltransferase activity, transferring groups other than amino-acyl groups] GO:0018393[internal peptidyl-lysine acetylation] GO:0019903[protein phosphatase binding] GO:0021537[telencephalon development] GO:0022037[metencephalon development] GO:0030901[midbrain development] GO:0031058[positive regulation of histone modification] GO:0031063[regulation of histone deacetylation] GO:0031346[positive regulation of cell projection organization] GO:0031647[regulation of protein stability] GO:0031667[response to nutrient levels] GO:0033276[transcription factor TFTC complex] GO:0035264[multicellular organism growth] GO:0035521[monoubiquitinated histone deubiquitination] GO:0035522[monoubiquitinated histone H2A deubiquitination] GO:0042826[histone deacetylase binding] GO:0043484[regulation of RNA splicing] GO:0043966[histone H3 acetylation] GO:0043992[histone acetyltransferase activity (H3-K9 specific)] GO:0043993[histone acetyltransferase activity (H3-K18 specific)] GO:0043997[histone acetyltransferase activity (H4-K12 specific)] GO:0044154[histone H3-K14 acetylation] GO:0045252[oxoglutarate dehydrogenase complex] GO:0045589[regulation of regulatory T cell differentiation] GO:0045722[positive regulation of gluconeogenesis] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0045995[regulation of embryonic development] GO:0046600[negative regulation of centriole replication] GO:0048144[fibroblast proliferation] GO:0048167[regulation of synaptic plasticity] GO:0048312[intracellular distribution of mitochondria] GO:0050863[regulation of T cell activation] GO:0051302[regulation of cell division] GO:0051726[regulation of cell cycle] GO:0060173[limb development] GO:0061035[regulation of cartilage development] GO:0061733[peptide-lysine-N-acetyltransferase activity] GO:0071356[cellular response to tumor necrosis factor] GO:0071929[alpha-tubulin acetylation] GO:0072686[mitotic spindle] GO:0090043[regulation of tubulin deacetylation] GO:0106077[histone succinylation] GO:0106078[histone succinyltransferase activity] GO:0106227[peptidyl-lysine glutarylation] GO:0106228[peptide glutaryltransferase activity] GO:0106229[histone glutaryltransferase activity] GO:0140297[DNA-binding transcription factor binding] GO:0140672[ATAC complex] GO:1903010[regulation of bone development] GO:1990090[cellular response to nerve growth factor stimulus] GO:2000036[regulation of stem cell population maintenance] GO:2000727[positive regulation of cardiac muscle cell differentiation]
The Human Protein Atlas project is funded
