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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Enzymes FDA approved drug targets
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
17
Cytoband
q21.31
Chromosome location (bp)
44076746 - 44123702
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Serves as a corepressor of RARA and causes its deacetylation 1. In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response 2....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Chromatin regulator, Hydrolase, Repressor
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Transcription, Transcription regulation
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Metal-binding, Zinc
Gene summary (Entrez)i
Useful information about the gene from Entrez
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000118[histone deacetylase complex] GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0001222[transcription corepressor binding] GO:0004407[histone deacetylase activity] GO:0005080[protein kinase C binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005794[Golgi apparatus] GO:0005829[cytosol] GO:0006325[chromatin organization] GO:0006338[chromatin remodeling] GO:0006476[protein deacetylation] GO:0006954[inflammatory response] GO:0010830[regulation of myotube differentiation] GO:0010832[negative regulation of myotube differentiation] GO:0016575[histone deacetylation] GO:0016607[nuclear speck] GO:0016787[hydrolase activity] GO:0030183[B cell differentiation] GO:0031507[heterochromatin formation] GO:0032869[cellular response to insulin stimulus] GO:0033558[protein lysine deacetylase activity] GO:0040029[epigenetic regulation of gene expression] GO:0042113[B cell activation] GO:0042802[identical protein binding] GO:0042826[histone deacetylase binding] GO:0043393[regulation of protein binding] GO:0045892[negative regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0050896[response to stimulus] GO:0051091[positive regulation of DNA-binding transcription factor activity] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0090051[negative regulation of cell migration involved in sprouting angiogenesis] GO:0140297[DNA-binding transcription factor binding]
Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000118[histone deacetylase complex] GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0001222[transcription corepressor binding] GO:0004407[histone deacetylase activity] GO:0005080[protein kinase C binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005794[Golgi apparatus] GO:0005829[cytosol] GO:0006325[chromatin organization] GO:0006338[chromatin remodeling] GO:0006476[protein deacetylation] GO:0006954[inflammatory response] GO:0010830[regulation of myotube differentiation] GO:0010832[negative regulation of myotube differentiation] GO:0016575[histone deacetylation] GO:0016607[nuclear speck] GO:0016787[hydrolase activity] GO:0030183[B cell differentiation] GO:0031507[heterochromatin formation] GO:0032869[cellular response to insulin stimulus] GO:0033558[protein lysine deacetylase activity] GO:0040029[epigenetic regulation of gene expression] GO:0042113[B cell activation] GO:0042802[identical protein binding] GO:0042826[histone deacetylase binding] GO:0043393[regulation of protein binding] GO:0045892[negative regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0050896[response to stimulus] GO:0051091[positive regulation of DNA-binding transcription factor activity] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0090051[negative regulation of cell migration involved in sprouting angiogenesis] GO:0140297[DNA-binding transcription factor binding]
Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000118[histone deacetylase complex] GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0001222[transcription corepressor binding] GO:0004407[histone deacetylase activity] GO:0005080[protein kinase C binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005794[Golgi apparatus] GO:0005829[cytosol] GO:0006325[chromatin organization] GO:0006338[chromatin remodeling] GO:0006476[protein deacetylation] GO:0006954[inflammatory response] GO:0010830[regulation of myotube differentiation] GO:0010832[negative regulation of myotube differentiation] GO:0016575[histone deacetylation] GO:0016607[nuclear speck] GO:0016787[hydrolase activity] GO:0030183[B cell differentiation] GO:0031507[heterochromatin formation] GO:0032869[cellular response to insulin stimulus] GO:0033558[protein lysine deacetylase activity] GO:0040029[epigenetic regulation of gene expression] GO:0042113[B cell activation] GO:0042802[identical protein binding] GO:0042826[histone deacetylase binding] GO:0043393[regulation of protein binding] GO:0045892[negative regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0050896[response to stimulus] GO:0051091[positive regulation of DNA-binding transcription factor activity] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0090051[negative regulation of cell migration involved in sprouting angiogenesis] GO:0140297[DNA-binding transcription factor binding]
Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000118[histone deacetylase complex] GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0001222[transcription corepressor binding] GO:0004407[histone deacetylase activity] GO:0005080[protein kinase C binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005794[Golgi apparatus] GO:0005829[cytosol] GO:0006325[chromatin organization] GO:0006338[chromatin remodeling] GO:0006476[protein deacetylation] GO:0006954[inflammatory response] GO:0010830[regulation of myotube differentiation] GO:0010832[negative regulation of myotube differentiation] GO:0016575[histone deacetylation] GO:0016607[nuclear speck] GO:0016787[hydrolase activity] GO:0030183[B cell differentiation] GO:0031507[heterochromatin formation] GO:0032869[cellular response to insulin stimulus] GO:0033558[protein lysine deacetylase activity] GO:0040029[epigenetic regulation of gene expression] GO:0042113[B cell activation] GO:0042802[identical protein binding] GO:0042826[histone deacetylase binding] GO:0043393[regulation of protein binding] GO:0045892[negative regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0050896[response to stimulus] GO:0051091[positive regulation of DNA-binding transcription factor activity] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0090051[negative regulation of cell migration involved in sprouting angiogenesis] GO:0140297[DNA-binding transcription factor binding]
The Human Protein Atlas project is funded
