We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Disease related genes Human disease related genes Transcription factors
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
11
Cytoband
q23.2
Chromosome location (bp)
114059041 - 114256765
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Acts as a transcriptional repressor 1,2. Transcriptional repression may be mediated through recruitment of histone deacetylases to target promoters 3. May play a role in myeloid maturation and in the development and/or maintenance of other differentiated tissues. Probable substrate-recognition component of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins 4....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
DNA-binding, Repressor
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Metal-binding, Zinc
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in cell cycle progression, and interacts with a histone deacetylase. Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia (APL). Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Congenital malformations Other congenital malformations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0001222[transcription corepressor binding] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001501[skeletal system development] GO:0001673[male germ cell nucleus] GO:0001823[mesonephros development] GO:0003677[DNA binding] GO:0003690[double-stranded DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006915[apoptotic process] GO:0007417[central nervous system development] GO:0008022[protein C-terminus binding] GO:0008283[cell population proliferation] GO:0008285[negative regulation of cell population proliferation] GO:0009880[embryonic pattern specification] GO:0009952[anterior/posterior pattern specification] GO:0016567[protein ubiquitination] GO:0016604[nuclear body] GO:0016605[PML body] GO:0016607[nuclear speck] GO:0017053[transcription repressor complex] GO:0019904[protein domain specific binding] GO:0030097[hemopoiesis] GO:0030099[myeloid cell differentiation] GO:0032332[positive regulation of chondrocyte differentiation] GO:0032991[protein-containing complex] GO:0034504[protein localization to nucleus] GO:0035116[embryonic hindlimb morphogenesis] GO:0035136[forelimb morphogenesis] GO:0035137[hindlimb morphogenesis] GO:0042733[embryonic digit morphogenesis] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0043065[positive regulation of apoptotic process] GO:0043931[ossification involved in bone maturation] GO:0045600[positive regulation of fat cell differentiation] GO:0045638[negative regulation of myeloid cell differentiation] GO:0045778[positive regulation of ossification] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0048133[male germ-line stem cell asymmetric division] GO:0051138[positive regulation of NK T cell differentiation] GO:0051216[cartilage development] GO:0061036[positive regulation of cartilage development]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Congenital malformations Other congenital malformations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0001222[transcription corepressor binding] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001823[mesonephros development] GO:0003677[DNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005829[cytosol] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006915[apoptotic process] GO:0007417[central nervous system development] GO:0016567[protein ubiquitination] GO:0016604[nuclear body] GO:0016605[PML body] GO:0016607[nuclear speck] GO:0017053[transcription repressor complex] GO:0030097[hemopoiesis] GO:0030099[myeloid cell differentiation] GO:0032332[positive regulation of chondrocyte differentiation] GO:0032991[protein-containing complex] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0045600[positive regulation of fat cell differentiation] GO:0045638[negative regulation of myeloid cell differentiation] GO:0045778[positive regulation of ossification] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0051216[cartilage development] GO:0061036[positive regulation of cartilage development]
F5H6C3 [Direct mapping] Zinc finger and BTB domain-containing protein 16
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Congenital malformations Other congenital malformations Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Congenital malformations Other congenital malformations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0001222[transcription corepressor binding] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001823[mesonephros development] GO:0003677[DNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005829[cytosol] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006915[apoptotic process] GO:0007417[central nervous system development] GO:0016567[protein ubiquitination] GO:0016604[nuclear body] GO:0016605[PML body] GO:0016607[nuclear speck] GO:0017053[transcription repressor complex] GO:0030097[hemopoiesis] GO:0030099[myeloid cell differentiation] GO:0032332[positive regulation of chondrocyte differentiation] GO:0032991[protein-containing complex] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0045600[positive regulation of fat cell differentiation] GO:0045638[negative regulation of myeloid cell differentiation] GO:0045778[positive regulation of ossification] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0051216[cartilage development] GO:0061036[positive regulation of cartilage development]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Congenital malformations Other congenital malformations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0001222[transcription corepressor binding] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001823[mesonephros development] GO:0003677[DNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005829[cytosol] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006915[apoptotic process] GO:0007417[central nervous system development] GO:0016567[protein ubiquitination] GO:0016604[nuclear body] GO:0016605[PML body] GO:0016607[nuclear speck] GO:0017053[transcription repressor complex] GO:0030097[hemopoiesis] GO:0030099[myeloid cell differentiation] GO:0032332[positive regulation of chondrocyte differentiation] GO:0032991[protein-containing complex] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0045600[positive regulation of fat cell differentiation] GO:0045638[negative regulation of myeloid cell differentiation] GO:0045778[positive regulation of ossification] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0051216[cartilage development] GO:0061036[positive regulation of cartilage development]
A0A0S2Z4J5 [Direct mapping] Zinc finger and BTB domain containing 16 isoform 2; Zinc finger and BTB domain-containing protein 16
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Congenital malformations Other congenital malformations Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Congenital malformations Other congenital malformations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0001222[transcription corepressor binding] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001823[mesonephros development] GO:0003677[DNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005829[cytosol] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006915[apoptotic process] GO:0007417[central nervous system development] GO:0016567[protein ubiquitination] GO:0016604[nuclear body] GO:0016605[PML body] GO:0016607[nuclear speck] GO:0017053[transcription repressor complex] GO:0030097[hemopoiesis] GO:0030099[myeloid cell differentiation] GO:0032332[positive regulation of chondrocyte differentiation] GO:0032991[protein-containing complex] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0045600[positive regulation of fat cell differentiation] GO:0045638[negative regulation of myeloid cell differentiation] GO:0045778[positive regulation of ossification] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0051216[cartilage development] GO:0061036[positive regulation of cartilage development]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Congenital malformations Other congenital malformations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0001222[transcription corepressor binding] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001823[mesonephros development] GO:0003677[DNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005829[cytosol] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006915[apoptotic process] GO:0007417[central nervous system development] GO:0016567[protein ubiquitination] GO:0016604[nuclear body] GO:0016605[PML body] GO:0016607[nuclear speck] GO:0017053[transcription repressor complex] GO:0030097[hemopoiesis] GO:0030099[myeloid cell differentiation] GO:0032332[positive regulation of chondrocyte differentiation] GO:0032991[protein-containing complex] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0045600[positive regulation of fat cell differentiation] GO:0045638[negative regulation of myeloid cell differentiation] GO:0045778[positive regulation of ossification] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0051216[cartilage development] GO:0061036[positive regulation of cartilage development]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Congenital malformations Other congenital malformations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0001222[transcription corepressor binding] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001823[mesonephros development] GO:0003677[DNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005829[cytosol] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006915[apoptotic process] GO:0007417[central nervous system development] GO:0016567[protein ubiquitination] GO:0016604[nuclear body] GO:0016605[PML body] GO:0016607[nuclear speck] GO:0017053[transcription repressor complex] GO:0030097[hemopoiesis] GO:0030099[myeloid cell differentiation] GO:0032332[positive regulation of chondrocyte differentiation] GO:0032991[protein-containing complex] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0045600[positive regulation of fat cell differentiation] GO:0045638[negative regulation of myeloid cell differentiation] GO:0045778[positive regulation of ossification] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0051216[cartilage development] GO:0061036[positive regulation of cartilage development]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Congenital malformations Other congenital malformations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0001222[transcription corepressor binding] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001823[mesonephros development] GO:0003677[DNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005829[cytosol] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006915[apoptotic process] GO:0007417[central nervous system development] GO:0016567[protein ubiquitination] GO:0016604[nuclear body] GO:0016605[PML body] GO:0016607[nuclear speck] GO:0017053[transcription repressor complex] GO:0030097[hemopoiesis] GO:0030099[myeloid cell differentiation] GO:0032332[positive regulation of chondrocyte differentiation] GO:0032991[protein-containing complex] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0045600[positive regulation of fat cell differentiation] GO:0045638[negative regulation of myeloid cell differentiation] GO:0045778[positive regulation of ossification] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0051216[cartilage development] GO:0061036[positive regulation of cartilage development]
A0A804HJ45 [Direct mapping] Zinc finger and BTB domain-containing protein 16
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Congenital malformations Other congenital malformations Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
