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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes Human disease related genes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
11
Cytoband
p13
Chromosome location (bp)
31509755 - 31790324
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) 1. The elongator complex catalyzes the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs 2....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
tRNA processing
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a component of the six subunit elongator complex, a histone acetyltransferase complex that associates directly with RNA polymerase II during transcriptional elongation. The human gene can partially complement sensitivity phenotypes of yeast ELP4 deletion mutants. This gene has also been associated with Rolandic epilepsy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
A0A1X7SBS0 [Direct mapping] Elongator complex protein 4
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MEMSAT3 predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of eye Protein evidence (Ezkurdia et al 2014)
Q96EB1 [Direct mapping] Elongator complex protein 4
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MEMSAT3 predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Human disease related genes Congenital malformations Congenital malformations of eye Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000993[RNA polymerase II complex binding] GO:0002098[tRNA wobble uridine modification] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006368[transcription elongation by RNA polymerase II promoter] GO:0006417[regulation of translation] GO:0008023[transcription elongation factor complex] GO:0008033[tRNA processing] GO:0008607[phosphorylase kinase regulator activity] GO:0033588[elongator holoenzyme complex]
A0A1W2PP47 [Direct mapping] Elongator complex protein 4
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MEMSAT3 predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of eye Protein evidence (Ezkurdia et al 2014)
A0A1W2PQW5 [Direct mapping] Elongator complex protein 4
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of eye Protein evidence (Ezkurdia et al 2014)
A0A1W2PRF0 [Direct mapping] Elongator complex protein 4
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MEMSAT3 predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of eye Protein evidence (Ezkurdia et al 2014)
A0A1W2PPP6 [Direct mapping] Elongator complex protein 4
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MEMSAT3 predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of eye Protein evidence (Ezkurdia et al 2014)
A0A1W2PPR3 [Direct mapping] Elongator complex protein 4
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Phobius predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of eye Protein evidence (Ezkurdia et al 2014)
A0A1W2PNW2 [Direct mapping] Elongator complex protein 4
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MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of eye Protein evidence (Ezkurdia et al 2014)
A0A1W2PNY4 [Direct mapping] Elongator complex protein 4
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of eye Protein evidence (Ezkurdia et al 2014)
A0A1W2PQZ6 [Direct mapping] Elongator complex protein 4
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MEMSAT3 predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of eye Protein evidence (Ezkurdia et al 2014)
A0A1W2PNY5 [Direct mapping] Elongator complex protein 4
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MEMSAT3 predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of eye Protein evidence (Ezkurdia et al 2014)
A0A1W2PRF5 [Direct mapping] Elongator complex protein 4
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MEMSAT3 predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of eye Protein evidence (Ezkurdia et al 2014)
A0A1W2PRJ0 [Direct mapping] Elongator complex protein 4
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MEMSAT3 predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of eye Protein evidence (Ezkurdia et al 2014)
A0A1W2PS93 [Direct mapping] Elongator complex protein 4
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MEMSAT3 predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of eye Protein evidence (Ezkurdia et al 2014)
A0A1W2PR08 [Direct mapping] Elongator complex protein 4
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MEMSAT3 predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of eye Protein evidence (Ezkurdia et al 2014)
Q96EB1 [Direct mapping] Elongator complex protein 4
Show all
MEMSAT3 predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Human disease related genes Congenital malformations Congenital malformations of eye Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000993[RNA polymerase II complex binding] GO:0002098[tRNA wobble uridine modification] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006368[transcription elongation by RNA polymerase II promoter] GO:0006417[regulation of translation] GO:0008023[transcription elongation factor complex] GO:0008033[tRNA processing] GO:0008607[phosphorylase kinase regulator activity] GO:0033588[elongator holoenzyme complex]
The Human Protein Atlas project is funded
