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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
FDA approved drug targets
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
12
Cytoband
q13.3
Chromosome location (bp)
56334174 - 56340410
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Associates with IL12B to form the pro-inflammatory cytokine IL-23 that plays different roles in innate and adaptive immunity 1. Released by antigen-presenting cells such as dendritic cells or macrophages, binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R to activate JAK2 and TYK2 which then phosphorylate the receptor to form a docking site leading to the phosphorylation of STAT3 and STAT4 2,3,4. This process leads to activation of several pathways including p38 MAPK or NF-kappa-B and promotes the production of pro-inflammatory cytokines such as interleukin-17A/IL17A 5. In turn, participates in the early and effective intracellular bacterial clearance 6. Promotes the expansion and survival of T-helper 17 cells, a CD4-positive helper T-cell subset that produces IL-17, as well as other IL-17-producing cells 7....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Cytokine
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
This gene encodes a subunit of the heterodimeric cytokine interleukin 23 (IL23). IL23 is composed of this protein and the p40 subunit of interleukin 12 (IL12B). The receptor of IL23 is formed by the beta 1 subunit of IL12 (IL12RB1) and an IL23 specific subunit, IL23R. Both IL23 and IL12 can activate the transcription activator STAT4, and stimulate the production of interferon-gamma (IFNG). In contrast to IL12, which acts mainly on naive CD4(+) T cells, IL23 preferentially acts on memory CD4(+) T cells. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins DeepTMHMM predicted secreted proteins DeepSig predicted secreted proteins FDA approved drug targets Biotech drugs Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0001916[positive regulation of T cell mediated cytotoxicity] GO:0002230[positive regulation of defense response to virus by host] GO:0002376[immune system process] GO:0002827[positive regulation of T-helper 1 type immune response] GO:0005125[cytokine activity] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005788[endoplasmic reticulum lumen] GO:0006954[inflammatory response] GO:0006955[immune response] GO:0007165[signal transduction] GO:0010536[positive regulation of activation of Janus kinase activity] GO:0032693[negative regulation of interleukin-10 production] GO:0032725[positive regulation of granulocyte macrophage colony-stimulating factor production] GO:0032729[positive regulation of interferon-gamma production] GO:0032733[positive regulation of interleukin-10 production] GO:0032735[positive regulation of interleukin-12 production] GO:0032740[positive regulation of interleukin-17 production] GO:0032760[positive regulation of tumor necrosis factor production] GO:0032816[positive regulation of natural killer cell activation] GO:0032819[positive regulation of natural killer cell proliferation] GO:0034105[positive regulation of tissue remodeling] GO:0042098[T cell proliferation] GO:0042102[positive regulation of T cell proliferation] GO:0042104[positive regulation of activated T cell proliferation] GO:0042509[regulation of tyrosine phosphorylation of STAT protein] GO:0042531[positive regulation of tyrosine phosphorylation of STAT protein] GO:0043382[positive regulation of memory T cell differentiation] GO:0045087[innate immune response] GO:0045519[interleukin-23 receptor binding] GO:0045672[positive regulation of osteoclast differentiation] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0048771[tissue remodeling] GO:0050729[positive regulation of inflammatory response] GO:0050829[defense response to Gram-negative bacterium] GO:0051135[positive regulation of NK T cell activation] GO:0051142[positive regulation of NK T cell proliferation] GO:0051607[defense response to virus] GO:0070743[interleukin-23 complex] GO:0090023[positive regulation of neutrophil chemotaxis] GO:1901224[positive regulation of NIK/NF-kappaB signaling] GO:2000318[positive regulation of T-helper 17 type immune response] GO:2000330[positive regulation of T-helper 17 cell lineage commitment]
The Human Protein Atlas project is funded
