GENERAL INFORMATIONi
Gene namei ING4
Synonyms my036, p29ING4
Gene descriptioni Inhibitor of growth family member 4
Predicted locationi Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi
Chromosome 12
Cytoband p13.31
Chromosome location (bp) 6650301 - 6663142
Number of transcriptsi 9
Ensembl ENSG00000111653 (version 109)
Entrez gene 51147
HGNC HGNC:19423
UniProt Q9UNL4 (UniProt - Evidence at protein level)
neXtProt NX_Q9UNL4
GeneCards ING4
Antibodypedia ING4 antibodies


PROTEIN FUNCTION
Protein function (UniProt)i Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4 1. Through chromatin acetylation it may function in DNA replication 2. May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation 3, 4. Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA 5. May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC 6. Represses hypoxia inducible factor's (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1) 7. Can enhance apoptosis induced by serum starvation in mammary epithelial cell line HC11 (By similarity). show less
Molecular function (UniProt)i Chromatin regulator
Biological process (UniProt)i Apoptosis, Cell cycle
Ligand (UniProt)i Metal-binding, Zinc
Gene summary (Entrez)i This gene encodes a tumor suppressor protein that contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in the TP53-dependent regulatory pathway. Multiple alternatively spliced transcript variants have been observed that encode distinct proteins. [provided by RefSeq, Jul 2008] show less
PROTEIN INFORMATIONi
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
ING4-201
ENSP00000343396
ENST00000341550
Q9UNL4
[Direct mapping] Inhibitor of growth protein 4
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000123 [histone acetyltransferase complex]
GO:0001558 [regulation of cell growth]
GO:0003676 [nucleic acid binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006325 [chromatin organization]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006473 [protein acetylation]
GO:0006915 [apoptotic process]
GO:0007049 [cell cycle]
GO:0008285 [negative regulation of cell population proliferation]
GO:0016570 [histone modification]
GO:0016573 [histone acetylation]
GO:0035064 [methylated histone binding]
GO:0036408 [histone acetyltransferase activity (H3-K14 specific)]
GO:0043065 [positive regulation of apoptotic process]
GO:0043981 [histone H4-K5 acetylation]
GO:0043982 [histone H4-K8 acetylation]
GO:0043983 [histone H4-K12 acetylation]
GO:0043995 [histone acetyltransferase activity (H4-K5 specific)]
GO:0043996 [histone acetyltransferase activity (H4-K8 specific)]
GO:0043997 [histone acetyltransferase activity (H4-K12 specific)]
GO:0045111 [intermediate filament cytoskeleton]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045926 [negative regulation of growth]
GO:0046872 [metal ion binding]
GO:0051726 [regulation of cell cycle]
GO:0070776 [MOZ/MORF histone acetyltransferase complex]
GO:0140889 []
GO:1902164 [positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator]
GO:1902749 [regulation of cell cycle G2/M phase transition]
GO:2000278 [regulation of DNA biosynthetic process]
Show all
 248 aa
28.4 kDa 		No 0
ING4-202
ENSP00000380024
ENST00000396807
Q9UNL4
[Direct mapping] Inhibitor of growth protein 4
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000123 [histone acetyltransferase complex]
GO:0001558 [regulation of cell growth]
GO:0003676 [nucleic acid binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006325 [chromatin organization]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006473 [protein acetylation]
GO:0006915 [apoptotic process]
GO:0007049 [cell cycle]
GO:0008285 [negative regulation of cell population proliferation]
GO:0016570 [histone modification]
GO:0016573 [histone acetylation]
GO:0035064 [methylated histone binding]
GO:0036408 [histone acetyltransferase activity (H3-K14 specific)]
GO:0043065 [positive regulation of apoptotic process]
GO:0043981 [histone H4-K5 acetylation]
GO:0043982 [histone H4-K8 acetylation]
GO:0043983 [histone H4-K12 acetylation]
GO:0043995 [histone acetyltransferase activity (H4-K5 specific)]
GO:0043996 [histone acetyltransferase activity (H4-K8 specific)]
GO:0043997 [histone acetyltransferase activity (H4-K12 specific)]
GO:0045111 [intermediate filament cytoskeleton]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045926 [negative regulation of growth]
GO:0046872 [metal ion binding]
GO:0051726 [regulation of cell cycle]
GO:0070776 [MOZ/MORF histone acetyltransferase complex]
GO:0140889 []
GO:1902164 [positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator]
GO:1902749 [regulation of cell cycle G2/M phase transition]
GO:2000278 [regulation of DNA biosynthetic process]
Show all
 249 aa
28.5 kDa 		No 0
ING4-203
ENSP00000412705
ENST00000412586
Q9UNL4
[Direct mapping] Inhibitor of growth protein 4
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000123 [histone acetyltransferase complex]
GO:0001558 [regulation of cell growth]
GO:0003676 [nucleic acid binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006325 [chromatin organization]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006473 [protein acetylation]
GO:0006915 [apoptotic process]
GO:0007049 [cell cycle]
GO:0008285 [negative regulation of cell population proliferation]
GO:0016570 [histone modification]
GO:0016573 [histone acetylation]
GO:0035064 [methylated histone binding]
GO:0036408 [histone acetyltransferase activity (H3-K14 specific)]
GO:0043065 [positive regulation of apoptotic process]
GO:0043981 [histone H4-K5 acetylation]
GO:0043982 [histone H4-K8 acetylation]
GO:0043983 [histone H4-K12 acetylation]
GO:0043995 [histone acetyltransferase activity (H4-K5 specific)]
GO:0043996 [histone acetyltransferase activity (H4-K8 specific)]
GO:0043997 [histone acetyltransferase activity (H4-K12 specific)]
GO:0045111 [intermediate filament cytoskeleton]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045926 [negative regulation of growth]
GO:0046872 [metal ion binding]
GO:0051726 [regulation of cell cycle]
GO:0070776 [MOZ/MORF histone acetyltransferase complex]
GO:0140889 []
GO:1902164 [positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator]
GO:1902749 [regulation of cell cycle G2/M phase transition]
GO:2000278 [regulation of DNA biosynthetic process]
Show all
 246 aa
28.2 kDa 		No 0
ING4-204
ENSP00000414008
ENST00000423703
Q9UNL4
[Direct mapping] Inhibitor of growth protein 4
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000123 [histone acetyltransferase complex]
GO:0001558 [regulation of cell growth]
GO:0003676 [nucleic acid binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006325 [chromatin organization]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006473 [protein acetylation]
GO:0006915 [apoptotic process]
GO:0007049 [cell cycle]
GO:0008285 [negative regulation of cell population proliferation]
GO:0016570 [histone modification]
GO:0016573 [histone acetylation]
GO:0035064 [methylated histone binding]
GO:0036408 [histone acetyltransferase activity (H3-K14 specific)]
GO:0043065 [positive regulation of apoptotic process]
GO:0043981 [histone H4-K5 acetylation]
GO:0043982 [histone H4-K8 acetylation]
GO:0043983 [histone H4-K12 acetylation]
GO:0043995 [histone acetyltransferase activity (H4-K5 specific)]
GO:0043996 [histone acetyltransferase activity (H4-K8 specific)]
GO:0043997 [histone acetyltransferase activity (H4-K12 specific)]
GO:0045111 [intermediate filament cytoskeleton]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045926 [negative regulation of growth]
GO:0046872 [metal ion binding]
GO:0051726 [regulation of cell cycle]
GO:0070776 [MOZ/MORF histone acetyltransferase complex]
GO:0140889 []
GO:1902164 [positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator]
GO:1902749 [regulation of cell cycle G2/M phase transition]
GO:2000278 [regulation of DNA biosynthetic process]
Show all
 179 aa
20.5 kDa 		No 0
ING4-206
ENSP00000397343
ENST00000444704
Q9UNL4
[Direct mapping] Inhibitor of growth protein 4
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000123 [histone acetyltransferase complex]
GO:0001558 [regulation of cell growth]
GO:0003676 [nucleic acid binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006325 [chromatin organization]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006473 [protein acetylation]
GO:0006915 [apoptotic process]
GO:0007049 [cell cycle]
GO:0008285 [negative regulation of cell population proliferation]
GO:0016570 [histone modification]
GO:0016573 [histone acetylation]
GO:0035064 [methylated histone binding]
GO:0036408 [histone acetyltransferase activity (H3-K14 specific)]
GO:0043065 [positive regulation of apoptotic process]
GO:0043981 [histone H4-K5 acetylation]
GO:0043982 [histone H4-K8 acetylation]
GO:0043983 [histone H4-K12 acetylation]
GO:0043995 [histone acetyltransferase activity (H4-K5 specific)]
GO:0043996 [histone acetyltransferase activity (H4-K8 specific)]
GO:0043997 [histone acetyltransferase activity (H4-K12 specific)]
GO:0045111 [intermediate filament cytoskeleton]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045926 [negative regulation of growth]
GO:0046872 [metal ion binding]
GO:0051726 [regulation of cell cycle]
GO:0070776 [MOZ/MORF histone acetyltransferase complex]
GO:0140889 []
GO:1902164 [positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator]
GO:1902749 [regulation of cell cycle G2/M phase transition]
GO:2000278 [regulation of DNA biosynthetic process]
Show all
 225 aa
25.6 kDa 		No 0
ING4-207
ENSP00000415903
ENST00000446105
Q9UNL4
[Direct mapping] Inhibitor of growth protein 4
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000123 [histone acetyltransferase complex]
GO:0001558 [regulation of cell growth]
GO:0003676 [nucleic acid binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006325 [chromatin organization]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006473 [protein acetylation]
GO:0006915 [apoptotic process]
GO:0007049 [cell cycle]
GO:0008285 [negative regulation of cell population proliferation]
GO:0016570 [histone modification]
GO:0016573 [histone acetylation]
GO:0035064 [methylated histone binding]
GO:0036408 [histone acetyltransferase activity (H3-K14 specific)]
GO:0043065 [positive regulation of apoptotic process]
GO:0043981 [histone H4-K5 acetylation]
GO:0043982 [histone H4-K8 acetylation]
GO:0043983 [histone H4-K12 acetylation]
GO:0043995 [histone acetyltransferase activity (H4-K5 specific)]
GO:0043996 [histone acetyltransferase activity (H4-K8 specific)]
GO:0043997 [histone acetyltransferase activity (H4-K12 specific)]
GO:0045111 [intermediate filament cytoskeleton]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045926 [negative regulation of growth]
GO:0046872 [metal ion binding]
GO:0051726 [regulation of cell cycle]
GO:0070776 [MOZ/MORF histone acetyltransferase complex]
GO:0140889 []
GO:1902164 [positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator]
GO:1902749 [regulation of cell cycle G2/M phase transition]
GO:2000278 [regulation of DNA biosynthetic process]
Show all
 245 aa
28.1 kDa 		No 0
ING4-208
ENSP00000473635
ENST00000467678
R4GNG1
[Direct mapping] Inhibitor of growth protein 4
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0008285 [negative regulation of cell population proliferation]
GO:0016573 [histone acetylation]
GO:0070776 [MOZ/MORF histone acetyltransferase complex]
Show all
 51 aa
5.7 kDa 		No 0
ING4-217
ENSP00000437198
ENST00000493873
E9PNE3
[Direct mapping] Inhibitor of growth protein 4
Show all
   DeepTMHMM predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
 21 aa
2.2 kDa 		No 0
ING4-218
ENSP00000480978
ENST00000619641
A4KYM5
[Direct mapping] Inhibitor of growth family member 4 variant deltaEx3; Inhibitor of growth protein 4
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0008285 [negative regulation of cell population proliferation]
GO:0016573 [histone acetylation]
GO:0070776 [MOZ/MORF histone acetyltransferase complex]
Show all
 51 aa
5.8 kDa 		No 0

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