Expression of TPI1 in testis cancer - The Human Protein Atlas

TESTICULAR GERM CELL TUMOR (TCGA) - Interactive survival scatter plotⁱ

The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.

The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".

Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.

Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.

& Survival analysisⁱ

TPI1 is not prognostic in Testicular Germ Cell Tumor (TCGA)

Stage:

Survival analysis

Current cut offⁱ :

Best expression cut offⁱ : 1055.67

Median expressionⁱ : N/A

Median follow up timeⁱ : N/A

P scoreⁱ N/A

5-year survival highⁱ N/A

5-year survival lowⁱ N/A

TCGA RNA samplesⁱ

Average pTPM

1472.7

Number of samples

133

Samples

Sample	Description	pTPM
TCGA-SN-A6IS-01A	26 years, male, white, stage:Stage IS, alive, 496 days	6745.7
TCGA-2G-AALP-01A	43 years, male, white, stage:Stage IIIB, alive, 2645 days	4730.4
TCGA-XE-A8H1-01A	24 years, male, white, stage:Stage IS, alive, 209 days	3798.8
TCGA-YU-A90P-01A	25 years, male, white, stage:Stage IA, alive, 2069 days	3679.4
TCGA-W4-A7U4-01A	23 years, male, white, stage:'--, alive, 738 days	3574.4
TCGA-2G-AAFN-01A	26 years, male, white, stage:Stage IIIB, alive, 773 days	3566.6
TCGA-VF-A8A8-01A	18 years, male, white, stage:Stage IA, alive, 1131 days	3482.9
TCGA-2G-AAGK-01A	20 years, male, white, stage:Stage IS, alive, 3621 days	3072.1
TCGA-2G-AAFI-01A	41 years, male, white, stage:Stage IB, alive, 675 days	3062.9
TCGA-2G-AAKG-01A	22 years, male, white, stage:Stage I, alive, 6598 days	3010.9
TCGA-2G-AAGW-01A	38 years, male, white, stage:Stage IS, alive, 4899 days	2838.7
TCGA-2G-AAGN-01A	41 years, male, white, stage:Stage IIIB, alive, 3656 days	2726.2
TCGA-2G-AAGC-01A	28 years, male, white, stage:Stage IS, alive, 2585 days	2719.5
TCGA-SN-A84Y-01A	18 years, male, white, stage:Stage IS, alive, 524 days	2697.8
TCGA-YU-A90Y-01A	23 years, male, black or african american, stage:Stage IIIC, dead, 17 days	2684.4
TCGA-2G-AAG0-01A	23 years, male, white, stage:Stage IS, alive, 1529 days	2628.9
TCGA-2G-AAL5-01A	31 years, male, white, stage:Stage I, alive, 7437 days	2582.4
TCGA-XE-A9SE-01A	35 years, male, white, stage:Stage IA, alive, 708 days	2562.3
TCGA-2G-AAG7-01A	33 years, male, white, stage:Stage IS, alive, 2475 days	2539.1
TCGA-2G-AAFO-01A	33 years, male, white, stage:Stage IIA, alive, 685 days	2440.6
TCGA-YU-A912-01A	34 years, male, black or african american, stage:Stage IIIC, alive, 866 days	2377.1
TCGA-2G-AAFZ-01A	32 years, male, white, stage:Stage III, alive, 1353 days	2299.0
TCGA-2G-AAFM-01A	31 years, male, white, stage:Stage IIA, alive, 503 days	2276.5
TCGA-S6-A8JY-01A	27 years, male, white, stage:Stage IS, alive, 278 days	2267.6
TCGA-2G-AAKH-01A	19 years, male, white, stage:Stage II, alive, 6862 days	2181.2
TCGA-2G-AAGT-01A	30 years, male, white, stage:Stage IS, alive, 4406 days	2162.4
TCGA-XE-A8H5-01A	29 years, male, stage:Stage IS, alive, 1217 days	2157.9
TCGA-2G-AAGE-01A	21 years, male, white, stage:Stage IS, alive, 2478 days	2108.6
TCGA-2G-AAL7-01A	32 years, male, white, stage:Stage IS, alive, 3991 days	2103.3
TCGA-2G-AAH4-01A	34 years, male, white, stage:Stage II, alive, 6210 days	2092.9
TCGA-2G-AAKM-01A	14 years, male, white, stage:Stage II, dead, 6972 days	2085.6
TCGA-2G-AAGZ-01A	27 years, male, white, stage:Stage IIIA, alive, 5233 days	2074.0
TCGA-2G-AAGO-01A	41 years, male, white, stage:Stage IS, alive, 4026 days	2064.3
TCGA-X3-A8G4-01A	33 years, male, white, stage:Stage IS, alive, 856 days	2043.6
TCGA-VF-A8AD-01A	36 years, male, white, stage:Stage IB, alive, 1006 days	2034.0
TCGA-XY-A8S2-01A	67 years, male, white, stage:Stage I, alive, 672 days	2017.2
TCGA-2G-AAH2-01A	20 years, male, white, stage:Stage IS, alive, 6060 days	1990.2
TCGA-2G-AAGJ-01A	28 years, male, black or african american, stage:Stage IA, alive, 2938 days	1935.3
TCGA-2G-AAGM-01A	51 years, male, white, stage:Stage IS, alive, 3891 days	1898.9
TCGA-2G-AAG9-01A	25 years, male, white, stage:Stage IIIB, alive, 2234 days	1877.9
TCGA-2G-AAFY-01A	24 years, male, white, stage:Stage IIA, alive, 1099 days	1859.0
TCGA-XE-AAO3-01A	33 years, male, asian, stage:Stage I, alive, 2857 days	1851.9
TCGA-SN-A84X-01A	21 years, male, white, stage:Stage IS, alive, 312 days	1841.7
TCGA-WZ-A8D5-01A	38 years, male, white, stage:'--, alive, 774 days	1818.3
TCGA-2G-AAGS-01A	39 years, male, white, stage:Stage IIIB, alive, 4816 days	1756.2
TCGA-2G-AAGA-01A	38 years, male, white, stage:Stage IIA, alive, 2439 days	1690.8
TCGA-2G-AAFJ-01A	23 years, male, asian, stage:'--, alive, 792 days	1633.4
TCGA-S6-A8JW-01A	37 years, male, white, stage:Stage IS, alive, 698 days	1617.7
TCGA-2G-AAFG-01A	30 years, male, white, stage:Stage IS, alive, 6183 days	1614.7
TCGA-2G-AAFV-01A	31 years, male, white, stage:Stage IS, alive, 1389 days	1607.0
TCGA-2G-AAGP-01A	33 years, male, white, stage:Stage IIA, alive, 4018 days	1541.6
TCGA-2G-AAKL-01A	26 years, male, white, stage:Stage II, alive, 7023 days	1534.4
TCGA-YU-A94D-01A	28 years, male, stage:Stage IIIB, alive, 2167 days	1470.8
TCGA-XE-AANJ-01A	39 years, male, white, stage:Stage IS, alive, 2007 days	1440.5
TCGA-2G-AAH8-01A	45 years, male, white, stage:Stage IIIC, alive, 2248 days	1439.0
TCGA-XE-AAOJ-01A	24 years, male, white, stage:Stage IS, alive, 1550 days	1438.7
TCGA-XE-A8H4-01A	23 years, male, white, stage:Stage IA, alive, 559 days	1404.1
TCGA-2G-AAH0-01A	30 years, male, white, stage:Stage IS, alive, 5477 days	1391.0
TCGA-2G-AAGX-01A	22 years, male, white, stage:Stage IA, alive, 5514 days	1386.7
TCGA-2G-AAGG-01A	20 years, male, white, stage:Stage IIIC, alive, 2611 days	1345.7
TCGA-W4-A7U2-01A	26 years, male, white, stage:'--, alive, 1263 days	1297.5
TCGA-2G-AAGI-01A	33 years, male, white, stage:Stage IS, alive, 3137 days	1294.7
TCGA-WZ-A7V3-01A	20 years, male, white, stage:Stage I, alive, 753 days	1229.1
TCGA-2G-AAG3-01A	53 years, male, white, stage:Stage IS, alive, 1593 days	1220.7
TCGA-YU-A94I-01A	66 years, male, stage:Stage IA, alive, 536 days	1207.7
TCGA-2G-AAF6-01A	28 years, male, white, stage:Stage IS, alive, 3491 days	1199.0
TCGA-XE-AAOC-01A	31 years, male, white, stage:Stage IA, alive, 270 days	1196.9
TCGA-2G-AAHP-01A	31 years, male, white, stage:Stage IS, alive, 5667 days	1195.2
TCGA-YU-A90W-01A	45 years, male, white, stage:Stage IA, alive, 1113 days	1181.4
TCGA-2G-AAHL-01A	26 years, male, white, stage:Stage I, alive, 7081 days	1162.0
TCGA-XE-AANR-01A	23 years, male, white, stage:Stage I, alive, 14 days	1125.4
TCGA-4K-AA1G-01A	34 years, male, white, stage:Stage IS, alive, 436 days	1101.2
TCGA-2G-AAF4-01A	30 years, male, white, stage:Stage I, alive, 2315 days	1088.4
TCGA-2G-AAF8-01A	33 years, male, white, stage:Stage IA, alive, 3911 days	1084.4
TCGA-YU-AA4L-01A	27 years, male, black or african american, stage:Stage IIIC, alive, 1573 days	1083.6
TCGA-SN-A84W-01A	30 years, male, white, stage:Stage IS, alive, 293 days	1079.1
TCGA-2G-AAFL-01A	35 years, male, white, stage:Stage IB, alive, 750 days	1064.6
TCGA-2X-A9D5-01A	49 years, male, white, stage:Stage I, alive, 435 days	1055.7
TCGA-XE-AAOB-01A	27 years, male, white, stage:Stage IS, dead, 513 days	1029.2
TCGA-2G-AAG8-01A	21 years, male, white, stage:Stage IB, alive, 2289 days	955.5
TCGA-YU-AA61-01A	29 years, male, white, stage:Stage IS, alive, 864 days	949.0
TCGA-4K-AAAL-01A	31 years, male, white, stage:Stage IS, alive, 483 days	926.1
TCGA-XE-AANI-01A	37 years, male, white, stage:Stage IS, alive, 1041 days	916.9
TCGA-XE-AAO6-01A	47 years, male, white, stage:Stage IA, alive, 240 days	914.8
TCGA-SB-A76C-01A	38 years, male, white, stage:'--, alive, 42 days	914.7
TCGA-2G-AAKD-01A	18 years, male, white, stage:Stage III, alive, 6340 days	906.6
TCGA-VF-A8AE-01A	39 years, male, white, stage:Stage IA, alive, 727 days	892.3
TCGA-2G-AAHG-01A	25 years, male, white, stage:Stage I, alive, 1819 days	888.7
TCGA-YU-A90Q-01A	21 years, male, stage:Stage IB, alive, 1964 days	886.8
TCGA-SB-A6J6-01A	22 years, male, white, stage:Stage IA, alive, 413 days	870.3
TCGA-2G-AAGY-01A	28 years, male, white, stage:Stage IS, alive, 5329 days	864.1
TCGA-2G-AAGV-01A	23 years, male, white, stage:'--, alive, 4527 days	857.1
TCGA-2G-AAG6-01A	24 years, male, white, stage:Stage IS, alive, 2231 days	856.0
TCGA-VF-A8AC-01A	29 years, male, white, stage:Stage IA, alive, 1083 days	845.4
TCGA-XE-AANV-01A	52 years, male, stage:Stage IB, alive, 1701 days	828.3
TCGA-2G-AAFH-01A	38 years, male, white, stage:Stage IIB, alive, 1375 days	821.4
TCGA-WZ-A7V4-01A	28 years, male, white, stage:Stage I, alive, 894 days	820.8
TCGA-VF-A8A9-01A	31 years, male, white, stage:Stage IA, alive, 1119 days	810.3
TCGA-VF-A8AA-01A	51 years, male, white, stage:Stage I, alive, 1146 days	770.7
TCGA-2G-AAG5-01A	36 years, male, white, stage:Stage IS, alive, 2299 days	744.1
TCGA-SO-A8JP-01A	29 years, male, white, stage:Stage I, alive, 540 days	732.7
TCGA-2G-AAGF-01A	28 years, male, white, stage:Stage IS, alive, 2734 days	729.4
TCGA-W4-A7U3-01A	26 years, male, white, stage:'--, alive, 149 days	721.9
TCGA-2G-AAEW-01A	31 years, male, white, stage:Stage IS, dead, 618 days	720.8
TCGA-2G-AAEX-01A	38 years, male, white, stage:Stage IS, alive, 1259 days	704.8
TCGA-2G-AAHN-01A	32 years, male, white, stage:Stage I, alive, 6445 days	701.4
TCGA-S6-A8JX-01A	27 years, male, white, stage:Stage IB, alive, 552 days	688.6
TCGA-XY-A9T9-01A	37 years, male, white, stage:Stage IS, alive, 281 days	675.4
TCGA-XY-A89B-01A	35 years, male, white, stage:Stage IA, alive, 471 days	663.6
TCGA-XE-AAO4-01A	40 years, male, white, stage:Stage IA, alive, 367 days	660.3
TCGA-2G-AAF1-01A	28 years, male, asian, stage:Stage IS, alive, 1403 days	639.8
TCGA-WZ-A7V5-01A	27 years, male, white, stage:Stage I, alive, 1061 days	636.8
TCGA-2X-A9D6-01A	42 years, male, white, stage:Stage I, alive, 607 days	631.6
TCGA-XE-AAOD-01A	39 years, male, white, stage:Stage IB, alive, 2058 days	593.9
TCGA-2G-AAHT-01A	32 years, male, white, stage:Stage IS, alive, 542 days	593.5
TCGA-2G-AAHA-01A	48 years, male, white, stage:Stage IB, alive, 3349 days	533.0
TCGA-4K-AA1I-01A	26 years, male, white, stage:Stage IA, alive, 3 days	503.9
TCGA-VF-A8AB-01A	31 years, male, black or african american, stage:Stage IA, alive, 760 days	497.8
TCGA-YU-A90S-01A	26 years, male, white, stage:Stage IA, alive, 971 days	475.5
TCGA-4K-AA1H-01A	26 years, male, white, stage:Stage IA, alive, 518 days	449.4
TCGA-ZM-AA0E-01A	39 years, male, white, stage:Stage IA, alive, 811 days	447.6
TCGA-ZM-AA0H-01A	50 years, male, white, stage:Stage IS, alive, 1736 days	402.1
TCGA-ZM-AA0N-01A	44 years, male, white, stage:Stage IB, alive, 634 days	402.0
TCGA-2G-AAH3-01A	20 years, male, white, stage:Stage I, alive, 1822 days	374.7
TCGA-XE-AAOF-01A	50 years, male, asian, stage:Stage IA, alive, 1268 days	370.6
TCGA-ZM-AA06-01A	45 years, male, white, stage:Stage IB, alive, 1498 days	370.3
TCGA-ZM-AA0D-01A	34 years, male, white, stage:Stage IA, alive, 848 days	362.9
TCGA-2G-AAFE-01A	37 years, male, white, stage:Stage IIA, alive, 4702 days	359.1
TCGA-ZM-AA0B-01A	32 years, male, white, stage:Stage IA, alive, 838 days	332.1
TCGA-2G-AAHC-01A	33 years, male, white, stage:Stage IS, alive, 5539 days	277.8
TCGA-ZM-AA0F-01A	35 years, male, white, stage:Stage IA, alive, 681 days	264.9
TCGA-XE-AAOL-01A	38 years, male, black or african american, stage:Stage I, alive, 13 days	232.7
TCGA-ZM-AA05-01A	36 years, male, white, stage:Stage IIC, alive, 1126 days	115.5
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TESTIS CANCER - Protein expressionⁱ A mouse-over function shows sample information and annotation data. Click on an image to view it in a full screen mode. Samples can be filtered based on level of antibody staining by selecting one or several of the following categories: high, medium, low and not detected. The assay and annotation is described here. Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.

Antibody stainingⁱ Antibody staining in the annotated cell types in the current human tissue is reported as not detected, low, medium, or high, based on conventional immunohistochemistry profiling in selected tissues. This score is based on the combination of the staining intensity and fraction of stained cells. Each image is clickable and will lead to virtual microscopy that enables deeper exploration of all samples and also displays staining intensity scores, fraction scores and subcellular localization as well as patient and tissue information for each sample.	Antibody HPA050924	Antibody HPA053568
Staining
High
Medium
Low
Not detected
Intensity
Strong
Moderate
Weak
Negative
Quantity
>75%
75%-25%
<25%
None
Location
Nuclear
Cytoplasmic/membranous
Cytoplasmic/membranous,nuclear
None
Seminoma, NOS
Carcinoma, Embryonal, NOS
Seminoma, NOS Carcinoma, Embryonal, NOS
Carcinoma, Embryonal, NOS Teratoma, malignant, NOS