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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
RHO family interacting cell polarization regulator 2
Protein classi
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes Human disease related genes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
6
Cytoband
p22.3
Chromosome location (bp)
24804282 - 25042170
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Acts as an inhibitor of the small GTPase RHOA and plays several roles in the regulation of myoblast and hair cell differentiation, lymphocyte T proliferation and neutrophil polarization 1,2,3,4,5,6. Inhibits chemokine-induced T lymphocyte responses, such as cell adhesion, polarization and migration 7. Involved also in the regulation of neutrophil polarization, chemotaxis and adhesion (By similarity). Required for normal development of inner and outer hair cell stereocilia within the cochlea of the inner ear (By similarity). Plays a role for maintaining the structural organization of the basal domain of stereocilia (By similarity). Involved in mechanosensory hair cell function (By similarity). Required for normal hearing 8....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Developmental protein, Signal transduction inhibitor
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
This gene encodes an atypical inhibitor of the small G protein RhoA. Inhibition of RhoA activity by the encoded protein mediates myoblast fusion and polarization of T cells and neutrophils. The encoded protein is a component of hair cell stereocilia that is essential for hearing. A splice site mutation in this gene results in hearing loss in human patients. [provided by RefSeq, Sep 2016]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Human disease related genes Nervous system diseases Ear disease Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005856[cytoskeleton] GO:0005886[plasma membrane] GO:0006935[chemotaxis] GO:0007155[cell adhesion] GO:0007162[negative regulation of cell adhesion] GO:0007517[muscle organ development] GO:0007605[sensory perception of sound] GO:0009968[negative regulation of signal transduction] GO:0016020[membrane] GO:0016324[apical plasma membrane] GO:0030154[cell differentiation] GO:0030175[filopodium] GO:0032420[stereocilium] GO:0035024[negative regulation of Rho protein signal transduction] GO:0042130[negative regulation of T cell proliferation] GO:0042995[cell projection] GO:0045663[positive regulation of myoblast differentiation] GO:0048741[skeletal muscle fiber development] GO:0051491[positive regulation of filopodium assembly] GO:0060171[stereocilium membrane] GO:0071889[14-3-3 protein binding] GO:0090023[positive regulation of neutrophil chemotaxis] GO:1901741[positive regulation of myoblast fusion] GO:1903904[negative regulation of establishment of T cell polarity] GO:1905872[negative regulation of protein localization to cell leading edge] GO:1990869[cellular response to chemokine] GO:2000114[regulation of establishment of cell polarity] GO:2000391[positive regulation of neutrophil extravasation] GO:2000405[negative regulation of T cell migration] GO:2001107[negative regulation of Rho guanyl-nucleotide exchange factor activity]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Human disease related genes Nervous system diseases Ear disease Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005856[cytoskeleton] GO:0005886[plasma membrane] GO:0006935[chemotaxis] GO:0007155[cell adhesion] GO:0007162[negative regulation of cell adhesion] GO:0007517[muscle organ development] GO:0007605[sensory perception of sound] GO:0009968[negative regulation of signal transduction] GO:0016020[membrane] GO:0016324[apical plasma membrane] GO:0030154[cell differentiation] GO:0030175[filopodium] GO:0032420[stereocilium] GO:0035024[negative regulation of Rho protein signal transduction] GO:0042130[negative regulation of T cell proliferation] GO:0042995[cell projection] GO:0045663[positive regulation of myoblast differentiation] GO:0048741[skeletal muscle fiber development] GO:0051491[positive regulation of filopodium assembly] GO:0051726[regulation of cell cycle] GO:0060171[stereocilium membrane] GO:0071889[14-3-3 protein binding] GO:0090023[positive regulation of neutrophil chemotaxis] GO:1901673[regulation of mitotic spindle assembly] GO:1901741[positive regulation of myoblast fusion] GO:1903904[negative regulation of establishment of T cell polarity] GO:1905872[negative regulation of protein localization to cell leading edge] GO:1990869[cellular response to chemokine] GO:2000114[regulation of establishment of cell polarity] GO:2000391[positive regulation of neutrophil extravasation] GO:2000405[negative regulation of T cell migration] GO:2001107[negative regulation of Rho guanyl-nucleotide exchange factor activity]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Ear disease Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Ear disease Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Ear disease Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Human disease related genes Nervous system diseases Ear disease Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005856[cytoskeleton] GO:0005886[plasma membrane] GO:0006935[chemotaxis] GO:0007155[cell adhesion] GO:0007162[negative regulation of cell adhesion] GO:0007517[muscle organ development] GO:0007605[sensory perception of sound] GO:0009968[negative regulation of signal transduction] GO:0016020[membrane] GO:0016324[apical plasma membrane] GO:0030154[cell differentiation] GO:0030175[filopodium] GO:0032420[stereocilium] GO:0035024[negative regulation of Rho protein signal transduction] GO:0042130[negative regulation of T cell proliferation] GO:0042995[cell projection] GO:0045663[positive regulation of myoblast differentiation] GO:0048741[skeletal muscle fiber development] GO:0051491[positive regulation of filopodium assembly] GO:0060171[stereocilium membrane] GO:0071889[14-3-3 protein binding] GO:0090023[positive regulation of neutrophil chemotaxis] GO:1901741[positive regulation of myoblast fusion] GO:1903904[negative regulation of establishment of T cell polarity] GO:1905872[negative regulation of protein localization to cell leading edge] GO:1990869[cellular response to chemokine] GO:2000114[regulation of establishment of cell polarity] GO:2000391[positive regulation of neutrophil extravasation] GO:2000405[negative regulation of T cell migration] GO:2001107[negative regulation of Rho guanyl-nucleotide exchange factor activity]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Human disease related genes Nervous system diseases Ear disease Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005856[cytoskeleton] GO:0005886[plasma membrane] GO:0006935[chemotaxis] GO:0007155[cell adhesion] GO:0007162[negative regulation of cell adhesion] GO:0007517[muscle organ development] GO:0007605[sensory perception of sound] GO:0009968[negative regulation of signal transduction] GO:0016020[membrane] GO:0016324[apical plasma membrane] GO:0030154[cell differentiation] GO:0030175[filopodium] GO:0032420[stereocilium] GO:0035024[negative regulation of Rho protein signal transduction] GO:0042130[negative regulation of T cell proliferation] GO:0042995[cell projection] GO:0045663[positive regulation of myoblast differentiation] GO:0048741[skeletal muscle fiber development] GO:0051491[positive regulation of filopodium assembly] GO:0051726[regulation of cell cycle] GO:0060171[stereocilium membrane] GO:0071889[14-3-3 protein binding] GO:0090023[positive regulation of neutrophil chemotaxis] GO:1901673[regulation of mitotic spindle assembly] GO:1901741[positive regulation of myoblast fusion] GO:1903904[negative regulation of establishment of T cell polarity] GO:1905872[negative regulation of protein localization to cell leading edge] GO:1990869[cellular response to chemokine] GO:2000114[regulation of establishment of cell polarity] GO:2000391[positive regulation of neutrophil extravasation] GO:2000405[negative regulation of T cell migration] GO:2001107[negative regulation of Rho guanyl-nucleotide exchange factor activity]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Ear disease Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737[cytoplasm] GO:0005856[cytoskeleton] GO:0005886[plasma membrane] GO:0006935[chemotaxis] GO:0007155[cell adhesion] GO:0007162[negative regulation of cell adhesion] GO:0007517[muscle organ development] GO:0007605[sensory perception of sound] GO:0009968[negative regulation of signal transduction] GO:0016020[membrane] GO:0016324[apical plasma membrane] GO:0030154[cell differentiation] GO:0030175[filopodium] GO:0032420[stereocilium] GO:0035024[negative regulation of Rho protein signal transduction] GO:0042802[identical protein binding] GO:0042995[cell projection] GO:0045184[establishment of protein localization] GO:0048741[skeletal muscle fiber development] GO:0051260[protein homooligomerization] GO:0051491[positive regulation of filopodium assembly] GO:0060088[auditory receptor cell stereocilium organization] GO:0060171[stereocilium membrane] GO:0071260[cellular response to mechanical stimulus] GO:0090023[positive regulation of neutrophil chemotaxis] GO:1905872[negative regulation of protein localization to cell leading edge] GO:1990869[cellular response to chemokine] GO:2000114[regulation of establishment of cell polarity] GO:2000391[positive regulation of neutrophil extravasation] GO:2001107[negative regulation of Rho guanyl-nucleotide exchange factor activity]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Ear disease Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Human disease related genes Nervous system diseases Ear disease Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005856[cytoskeleton] GO:0005886[plasma membrane] GO:0006935[chemotaxis] GO:0007155[cell adhesion] GO:0007162[negative regulation of cell adhesion] GO:0007517[muscle organ development] GO:0007605[sensory perception of sound] GO:0009968[negative regulation of signal transduction] GO:0016020[membrane] GO:0016324[apical plasma membrane] GO:0030154[cell differentiation] GO:0030175[filopodium] GO:0032420[stereocilium] GO:0035024[negative regulation of Rho protein signal transduction] GO:0042130[negative regulation of T cell proliferation] GO:0042995[cell projection] GO:0045663[positive regulation of myoblast differentiation] GO:0048741[skeletal muscle fiber development] GO:0051491[positive regulation of filopodium assembly] GO:0051726[regulation of cell cycle] GO:0060171[stereocilium membrane] GO:0071889[14-3-3 protein binding] GO:0090023[positive regulation of neutrophil chemotaxis] GO:1901673[regulation of mitotic spindle assembly] GO:1901741[positive regulation of myoblast fusion] GO:1903904[negative regulation of establishment of T cell polarity] GO:1905872[negative regulation of protein localization to cell leading edge] GO:1990869[cellular response to chemokine] GO:2000114[regulation of establishment of cell polarity] GO:2000391[positive regulation of neutrophil extravasation] GO:2000405[negative regulation of T cell migration] GO:2001107[negative regulation of Rho guanyl-nucleotide exchange factor activity]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Ear disease Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Ear disease Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Ear disease Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Ear disease Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
