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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
6
Cytoband
q25.2
Chromosome location (bp)
152970519 - 152983579
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Regulator of APC activity during mitotic and meiotic cell cycle 1,2,3,4,5,6. During mitotic cell cycle plays a role as both substrate and inhibitor of APC-FZR1 complex 7,8,9,10,11,12,13. During G1 phase, plays a role as substrate of APC-FZR1 complex E3 ligase 14. Then switches as an inhibitor of APC-FZR1 complex during S and G2 leading to cell-cycle commitment 15. As APC inhibitor, prevents the degradation of APC substrates at multiple levels: by interacting with APC and blocking access of APC substrates to the D-box coreceptor, formed by FZR1 and ANAPC10; by suppressing ubiquitin ligation and chain elongation by APC by preventing the UBE2C and UBE2S activities 16,17,18. Plays a role in genome integrity preservation by coordinating DNA replication with mitosis through APC inhibition in interphase to stabilize CCNA2 and GMNN in order to promote mitosis and prevent rereplication and DNA damage-induced cellular senescence 19,20,21. During oocyte maturation, plays a role in meiosis through inactivation of APC-FZR1 complex. Inhibits APC through RPS6KA2 interaction that increases FBXO5 affiniy for CDC20 leading to the metaphase arrest of the second meiotic division before fertilization (By similarity). Controls entry into the first meiotic division through inactivation of APC-FZR1 complex (By similarity). Promotes migration and osteogenic differentiation of mesenchymal stem cells 22....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Metal-binding, Zinc
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is similar to xenopus early mitotic inhibitor-1 (Emi1), which is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Dec 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0001556[oocyte maturation] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005819[spindle] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0006275[regulation of DNA replication] GO:0007049[cell cycle] GO:0007057[spindle assembly involved in female meiosis I] GO:0007088[regulation of mitotic nuclear division] GO:0007346[regulation of mitotic cell cycle] GO:0008284[positive regulation of cell population proliferation] GO:0010948[negative regulation of cell cycle process] GO:0010971[positive regulation of G2/M transition of mitotic cell cycle] GO:0010997[anaphase-promoting complex binding] GO:0016050[vesicle organization] GO:0016567[protein ubiquitination] GO:0019901[protein kinase binding] GO:0032876[negative regulation of DNA endoreduplication] GO:0040020[regulation of meiotic nuclear division] GO:0045669[positive regulation of osteoblast differentiation] GO:0045835[negative regulation of meiotic nuclear division] GO:0045841[negative regulation of mitotic metaphase/anaphase transition] GO:0046785[microtubule polymerization] GO:0046872[metal ion binding] GO:0051225[spindle assembly] GO:0051301[cell division] GO:0051444[negative regulation of ubiquitin-protein transferase activity] GO:0070169[positive regulation of biomineral tissue development] GO:0072687[meiotic spindle] GO:0140678[molecular function inhibitor activity] GO:1904667[negative regulation of ubiquitin protein ligase activity] GO:1905322[positive regulation of mesenchymal stem cell migration] GO:1990948[ubiquitin ligase inhibitor activity] GO:2000773[negative regulation of cellular senescence] GO:2001021[negative regulation of response to DNA damage stimulus]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005819[spindle] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0006275[regulation of DNA replication] GO:0007049[cell cycle] GO:0007088[regulation of mitotic nuclear division] GO:0007346[regulation of mitotic cell cycle] GO:0008284[positive regulation of cell population proliferation] GO:0010948[negative regulation of cell cycle process] GO:0010971[positive regulation of G2/M transition of mitotic cell cycle] GO:0010997[anaphase-promoting complex binding] GO:0016567[protein ubiquitination] GO:0019901[protein kinase binding] GO:0032876[negative regulation of DNA endoreduplication] GO:0045669[positive regulation of osteoblast differentiation] GO:0045835[negative regulation of meiotic nuclear division] GO:0045841[negative regulation of mitotic metaphase/anaphase transition] GO:0046872[metal ion binding] GO:0051301[cell division] GO:0051444[negative regulation of ubiquitin-protein transferase activity] GO:0070169[positive regulation of biomineral tissue development] GO:0072687[meiotic spindle] GO:0140678[molecular function inhibitor activity] GO:1904667[negative regulation of ubiquitin protein ligase activity] GO:1905322[positive regulation of mesenchymal stem cell migration] GO:1990948[ubiquitin ligase inhibitor activity] GO:2000773[negative regulation of cellular senescence] GO:2001021[negative regulation of response to DNA damage stimulus]
The Human Protein Atlas project is funded
