GENERAL INFORMATIONi
Gene namei PPARD
Synonyms FAAR, NR1C2, NUC1, NUCII, PPARB
Gene descriptioni Peroxisome proliferator activated receptor delta
Protein classi FDA approved drug targets
Nuclear receptors
Transcription factors
Predicted locationi Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi
Chromosome 6
Cytoband p21.31
Chromosome location (bp) 35342558 - 35428191
Number of transcriptsi 5
Ensembl ENSG00000112033 (version 109)
Entrez gene 5467
HGNC HGNC:9235
UniProt Q03181 (UniProt - Evidence at protein level)
neXtProt NX_Q03181
GeneCards PPARD
Antibodypedia PPARD antibodies


PROTEIN FUNCTION
Protein function (UniProt)i Ligand-activated transcription factor key mediator of energy metabolism in adipose tissues 1. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand. show less
Molecular function (UniProt)i Activator, DNA-binding, Receptor
Biological process (UniProt)i Transcription, Transcription regulation
Ligand (UniProt)i Metal-binding, Zinc
Gene summary (Entrez)i This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. The encoded protein is thought to function as an integrator of transcriptional repression and nuclear receptor signaling. It may inhibit the ligand-induced transcriptional activity of peroxisome proliferator activated receptors alpha and gamma, though evidence for this effect is inconsistent. Expression of this gene in colorectal cancer cells may be variable but is typically relatively low. Knockout studies in mice suggested a role for this protein in myelination of the corpus callosum, lipid metabolism, differentiation, and epidermal cell proliferation. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. [provided by RefSeq, Aug 2017] show less
PROTEIN INFORMATIONi
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
PPARD-201
ENSP00000310928
ENST00000311565
Q03181
[Direct mapping] Peroxisome proliferator-activated receptor delta
Show all
A0A024RCW6
[Target identity:100%; Query identity:100%] Peroxisome proliferative activated receptor, delta, isoform CRA_a
Show all
Nuclear receptors
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Zinc-coordinating DNA-binding domains
FDA approved drug targets
   Small molecule drugs
Mapped to neXtProt
   neXtProt - Evidence at protein level
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001223 [transcription coactivator binding]
GO:0001227 [DNA-binding transcription repressor activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0003707 [nuclear steroid receptor activity]
GO:0004879 [nuclear receptor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006006 [glucose metabolic process]
GO:0006091 [generation of precursor metabolites and energy]
GO:0006351 [DNA-templated transcription]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0006629 [lipid metabolic process]
GO:0006631 [fatty acid metabolic process]
GO:0006635 [fatty acid beta-oxidation]
GO:0006915 [apoptotic process]
GO:0007154 [cell communication]
GO:0007566 [embryo implantation]
GO:0008203 [cholesterol metabolic process]
GO:0008270 [zinc ion binding]
GO:0008283 [cell population proliferation]
GO:0008289 [lipid binding]
GO:0008366 [axon ensheathment]
GO:0009062 [fatty acid catabolic process]
GO:0009755 [hormone-mediated signaling pathway]
GO:0010887 [negative regulation of cholesterol storage]
GO:0015908 [fatty acid transport]
GO:0019216 [regulation of lipid metabolic process]
GO:0030154 [cell differentiation]
GO:0030522 [intracellular receptor signaling pathway]
GO:0033993 [response to lipid]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045600 [positive regulation of fat cell differentiation]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045923 [positive regulation of fatty acid metabolic process]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046697 [decidualization]
GO:0046872 [metal ion binding]
GO:0050728 [negative regulation of inflammatory response]
GO:0051716 [cellular response to stimulus]
GO:0070539 [linoleic acid binding]
GO:0097190 [apoptotic signaling pathway]
GO:0140297 [DNA-binding transcription factor binding]
GO:1902894 [negative regulation of miRNA transcription]
GO:1904659 [glucose transmembrane transport]
GO:1990837 [sequence-specific double-stranded DNA binding]
Show all
 441 aa
49.9 kDa 		No 0
PPARD-202
ENSP00000337063
ENST00000337400
Q03181
[Direct mapping] Peroxisome proliferator-activated receptor delta
Show all
F1D8S7
[Target identity:100%; Query identity:100%] Peroxisome proliferative activated receptor, delta, isoform CRA_b; Peroxisome proliferator-activated nuclear receptor beta/delta variant 2
Show all
Nuclear receptors
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Zinc-coordinating DNA-binding domains
FDA approved drug targets
   Small molecule drugs
Mapped to neXtProt
   neXtProt - Evidence at protein level
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001223 [transcription coactivator binding]
GO:0001227 [DNA-binding transcription repressor activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0003707 [nuclear steroid receptor activity]
GO:0004879 [nuclear receptor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006006 [glucose metabolic process]
GO:0006091 [generation of precursor metabolites and energy]
GO:0006351 [DNA-templated transcription]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0006629 [lipid metabolic process]
GO:0006631 [fatty acid metabolic process]
GO:0006635 [fatty acid beta-oxidation]
GO:0006915 [apoptotic process]
GO:0007154 [cell communication]
GO:0007566 [embryo implantation]
GO:0008203 [cholesterol metabolic process]
GO:0008270 [zinc ion binding]
GO:0008283 [cell population proliferation]
GO:0008289 [lipid binding]
GO:0008366 [axon ensheathment]
GO:0009062 [fatty acid catabolic process]
GO:0009755 [hormone-mediated signaling pathway]
GO:0010887 [negative regulation of cholesterol storage]
GO:0015908 [fatty acid transport]
GO:0019216 [regulation of lipid metabolic process]
GO:0030154 [cell differentiation]
GO:0030522 [intracellular receptor signaling pathway]
GO:0033993 [response to lipid]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045600 [positive regulation of fat cell differentiation]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045923 [positive regulation of fatty acid metabolic process]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046697 [decidualization]
GO:0046872 [metal ion binding]
GO:0050728 [negative regulation of inflammatory response]
GO:0051716 [cellular response to stimulus]
GO:0070539 [linoleic acid binding]
GO:0097190 [apoptotic signaling pathway]
GO:0140297 [DNA-binding transcription factor binding]
GO:1902894 [negative regulation of miRNA transcription]
GO:1904659 [glucose transmembrane transport]
GO:1990837 [sequence-specific double-stranded DNA binding]
Show all
 361 aa
40.4 kDa 		No 0
PPARD-203
ENSP00000353916
ENST00000360694
Q03181
[Direct mapping] Peroxisome proliferator-activated receptor delta
Show all
A0A024RCW6
[Target identity:100%; Query identity:100%] Peroxisome proliferative activated receptor, delta, isoform CRA_a
Show all
Nuclear receptors
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Zinc-coordinating DNA-binding domains
FDA approved drug targets
   Small molecule drugs
Mapped to neXtProt
   neXtProt - Evidence at protein level
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001223 [transcription coactivator binding]
GO:0001227 [DNA-binding transcription repressor activity, RNA polymerase II-specific]
GO:0001890 [placenta development]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0003707 [nuclear steroid receptor activity]
GO:0004879 [nuclear receptor activity]
GO:0005504 [fatty acid binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006006 [glucose metabolic process]
GO:0006029 [proteoglycan metabolic process]
GO:0006091 [generation of precursor metabolites and energy]
GO:0006351 [DNA-templated transcription]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0006629 [lipid metabolic process]
GO:0006631 [fatty acid metabolic process]
GO:0006635 [fatty acid beta-oxidation]
GO:0006776 [vitamin A metabolic process]
GO:0006915 [apoptotic process]
GO:0007154 [cell communication]
GO:0007507 [heart development]
GO:0007566 [embryo implantation]
GO:0008203 [cholesterol metabolic process]
GO:0008270 [zinc ion binding]
GO:0008283 [cell population proliferation]
GO:0008289 [lipid binding]
GO:0008366 [axon ensheathment]
GO:0008654 [phospholipid biosynthetic process]
GO:0009062 [fatty acid catabolic process]
GO:0009749 [response to glucose]
GO:0009755 [hormone-mediated signaling pathway]
GO:0010033 [response to organic substance]
GO:0010628 [positive regulation of gene expression]
GO:0010887 [negative regulation of cholesterol storage]
GO:0014065 [phosphatidylinositol 3-kinase signaling]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0014823 [response to activity]
GO:0014842 [regulation of skeletal muscle satellite cell proliferation]
GO:0014912 [negative regulation of smooth muscle cell migration]
GO:0015908 [fatty acid transport]
GO:0019216 [regulation of lipid metabolic process]
GO:0019395 [fatty acid oxidation]
GO:0030154 [cell differentiation]
GO:0030308 [negative regulation of cell growth]
GO:0030522 [intracellular receptor signaling pathway]
GO:0031589 [cell-substrate adhesion]
GO:0032966 [negative regulation of collagen biosynthetic process]
GO:0033189 [response to vitamin A]
GO:0033993 [response to lipid]
GO:0035774 [positive regulation of insulin secretion involved in cellular response to glucose stimulus]
GO:0042060 [wound healing]
GO:0042127 [regulation of cell population proliferation]
GO:0042311 [vasodilation]
GO:0043066 [negative regulation of apoptotic process]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043415 [positive regulation of skeletal muscle tissue regeneration]
GO:0043565 [sequence-specific DNA binding]
GO:0043616 [keratinocyte proliferation]
GO:0045598 [regulation of fat cell differentiation]
GO:0045600 [positive regulation of fat cell differentiation]
GO:0045662 [negative regulation of myoblast differentiation]
GO:0045684 [positive regulation of epidermis development]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045923 [positive regulation of fatty acid metabolic process]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046321 [positive regulation of fatty acid oxidation]
GO:0046697 [decidualization]
GO:0046872 [metal ion binding]
GO:0048662 [negative regulation of smooth muscle cell proliferation]
GO:0050673 [epithelial cell proliferation]
GO:0050678 [regulation of epithelial cell proliferation]
GO:0050680 [negative regulation of epithelial cell proliferation]
GO:0050728 [negative regulation of inflammatory response]
GO:0051059 [NF-kappaB binding]
GO:0051546 [keratinocyte migration]
GO:0051716 [cellular response to stimulus]
GO:0060612 [adipose tissue development]
GO:0070341 [fat cell proliferation]
GO:0070346 [positive regulation of fat cell proliferation]
GO:0070539 [linoleic acid binding]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071456 [cellular response to hypoxia]
GO:0097190 [apoptotic signaling pathway]
GO:0140297 [DNA-binding transcription factor binding]
GO:1902894 [negative regulation of miRNA transcription]
GO:1904659 [glucose transmembrane transport]
GO:1990837 [sequence-specific double-stranded DNA binding]
GO:2000288 [positive regulation of myoblast proliferation]
Show all
 441 aa
49.9 kDa 		No 0
PPARD-204
ENSP00000413314
ENST00000418635
Q03181
[Direct mapping] Peroxisome proliferator-activated receptor delta
Show all
Nuclear receptors
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Zinc-coordinating DNA-binding domains
FDA approved drug targets
   Small molecule drugs
Mapped to neXtProt
   neXtProt - Evidence at protein level
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001223 [transcription coactivator binding]
GO:0001227 [DNA-binding transcription repressor activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0003707 [nuclear steroid receptor activity]
GO:0004879 [nuclear receptor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006006 [glucose metabolic process]
GO:0006091 [generation of precursor metabolites and energy]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0006629 [lipid metabolic process]
GO:0006631 [fatty acid metabolic process]
GO:0006635 [fatty acid beta-oxidation]
GO:0006915 [apoptotic process]
GO:0007154 [cell communication]
GO:0007566 [embryo implantation]
GO:0008203 [cholesterol metabolic process]
GO:0008270 [zinc ion binding]
GO:0008283 [cell population proliferation]
GO:0008289 [lipid binding]
GO:0008366 [axon ensheathment]
GO:0009062 [fatty acid catabolic process]
GO:0009755 [hormone-mediated signaling pathway]
GO:0010887 [negative regulation of cholesterol storage]
GO:0015908 [fatty acid transport]
GO:0019216 [regulation of lipid metabolic process]
GO:0030154 [cell differentiation]
GO:0030522 [intracellular receptor signaling pathway]
GO:0033993 [response to lipid]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045600 [positive regulation of fat cell differentiation]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045923 [positive regulation of fatty acid metabolic process]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046697 [decidualization]
GO:0046872 [metal ion binding]
GO:0050728 [negative regulation of inflammatory response]
GO:0051716 [cellular response to stimulus]
GO:0070539 [linoleic acid binding]
GO:0097190 [apoptotic signaling pathway]
GO:0140297 [DNA-binding transcription factor binding]
GO:1902894 [negative regulation of miRNA transcription]
GO:1904659 [glucose transmembrane transport]
GO:1990837 [sequence-specific double-stranded DNA binding]
Show all
 343 aa
38.9 kDa 		No 0
PPARD-205
ENSP00000414372
ENST00000448077
Q03181
[Direct mapping] Peroxisome proliferator-activated receptor delta
Show all
Nuclear receptors
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Zinc-coordinating DNA-binding domains
FDA approved drug targets
   Small molecule drugs
Mapped to neXtProt
   neXtProt - Evidence at protein level
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001223 [transcription coactivator binding]
GO:0001227 [DNA-binding transcription repressor activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0003707 [nuclear steroid receptor activity]
GO:0004879 [nuclear receptor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006006 [glucose metabolic process]
GO:0006091 [generation of precursor metabolites and energy]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0006629 [lipid metabolic process]
GO:0006631 [fatty acid metabolic process]
GO:0006635 [fatty acid beta-oxidation]
GO:0006915 [apoptotic process]
GO:0007154 [cell communication]
GO:0007566 [embryo implantation]
GO:0008203 [cholesterol metabolic process]
GO:0008270 [zinc ion binding]
GO:0008283 [cell population proliferation]
GO:0008289 [lipid binding]
GO:0008366 [axon ensheathment]
GO:0009062 [fatty acid catabolic process]
GO:0009755 [hormone-mediated signaling pathway]
GO:0010887 [negative regulation of cholesterol storage]
GO:0015908 [fatty acid transport]
GO:0019216 [regulation of lipid metabolic process]
GO:0030154 [cell differentiation]
GO:0030522 [intracellular receptor signaling pathway]
GO:0033993 [response to lipid]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045600 [positive regulation of fat cell differentiation]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045923 [positive regulation of fatty acid metabolic process]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046697 [decidualization]
GO:0046872 [metal ion binding]
GO:0050728 [negative regulation of inflammatory response]
GO:0051716 [cellular response to stimulus]
GO:0070539 [linoleic acid binding]
GO:0097190 [apoptotic signaling pathway]
GO:0140297 [DNA-binding transcription factor binding]
GO:1902894 [negative regulation of miRNA transcription]
GO:1904659 [glucose transmembrane transport]
GO:1990837 [sequence-specific double-stranded DNA binding]
Show all
 402 aa
45.8 kDa 		No 0

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