Expression of RPS12 in urothelial cancer

BLADDER UROTHELIAL CARCINOMA (TCGA) - Interactive survival scatter plotⁱ

The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.

The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".

Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.

Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.

& Survival analysisⁱ

RPS12 is not prognostic in Bladder Urothelial Carcinoma (TCGA)

Stage:

Survival analysis

Current cut offⁱ :

Best expression cut offⁱ : 1772.07

Median expressionⁱ : N/A

Median follow up timeⁱ : N/A

P scoreⁱ N/A

5-year survival highⁱ N/A

5-year survival lowⁱ N/A

TCGA RNA samplesⁱ

Average pTPM

2921.8

Number of samples

169

Samples

Sample	Description	pTPM
TCGA-BT-A0S7-01A	75 years, male, white, stage:Stage III, dead, 200 days	10344.3
TCGA-XF-A9ST-01A	68 years, male, white, stage:Stage III, dead, 128 days	8724.2
TCGA-YC-A9TC-01A	71 years, male, white, stage:Stage IV, dead, 20 days	6663.0
TCGA-XF-AAMH-01A	80 years, male, white, stage:Stage IV, dead, 344 days	6652.3
TCGA-XF-AAN4-01A	77 years, female, white, stage:Stage III, dead, 823 days	6641.8
TCGA-XF-A9SU-01A	74 years, female, white, stage:Stage IV, dead, 182 days	6416.8
TCGA-ZF-A9RN-01A	67 years, female, white, stage:Stage III, dead, 615 days	6399.7
TCGA-G2-AA3C-01A	66 years, male, white, stage:Stage IV, dead, 211 days	6347.7
TCGA-GU-A767-01A	81 years, male, white, stage:Stage IV, dead, 144 days	6223.3
TCGA-GV-A40E-01A	75 years, male, white, stage:Stage II, dead, 261 days	6143.5
TCGA-ZF-AA5N-01A	62 years, female, white, stage:Stage IV, dead, 168 days	6085.7
TCGA-XF-A9T2-01A	54 years, male, white, stage:Stage III, dead, 575 days	6025.4
TCGA-XF-A9SL-01A	69 years, male, white, stage:Stage IV, dead, 2020 days	5893.8
TCGA-XF-A9SW-01A	85 years, male, white, stage:Stage IV, dead, 362 days	5599.4
TCGA-XF-A9T8-01A	64 years, male, white, stage:Stage III, dead, 418 days	5466.6
TCGA-GC-A3BM-01A	70 years, male, white, stage:Stage II, dead, 651 days	5357.7
TCGA-XF-AAN8-01A	74 years, female, white, stage:Stage III, dead, 118 days	5255.0
TCGA-FD-A5BT-01A	84 years, male, white, stage:Stage III, dead, 328 days	4944.2
TCGA-XF-A9SX-01A	63 years, female, white, stage:Stage IV, dead, 719 days	4710.7
TCGA-G2-A2EL-01A	77 years, male, white, stage:Stage II, dead, 819 days	4639.1
TCGA-C4-A0F7-01A	77 years, male, stage:Stage IV, dead, 62 days	4600.8
TCGA-DK-A3IM-01A	76 years, male, white, stage:Stage III, dead, 248 days	4588.2
TCGA-GU-A42Q-01A	67 years, male, white, stage:Stage III, dead, 344 days	4562.2
TCGA-CU-A0YO-01A	84 years, male, white, stage:Stage IV, dead, 149 days	4309.7
TCGA-ZF-AA52-01A	70 years, male, white, stage:Stage III, dead, 1077 days	4281.3
TCGA-4Z-AA7S-01A	66 years, male, black or african american, stage:Stage III, dead, 1064 days	4235.6
TCGA-FJ-A871-01A	49 years, male, white, stage:Stage III, dead, 272 days	4065.8
TCGA-BT-A20X-01A	56 years, male, white, stage:Stage IV, dead, 251 days	4061.8
TCGA-E7-A541-01A	66 years, male, white, stage:Stage II, dead, 778 days	4039.6
TCGA-FJ-A3ZE-01A	65 years, male, white, stage:Stage IV, dead, 324 days	3871.0
TCGA-UY-A78N-01A	80 years, male, white, stage:Stage IV, dead, 2641 days	3870.1
TCGA-ZF-AA4N-01A	74 years, male, white, stage:Stage II, dead, 88 days	3810.7
TCGA-FD-A5BX-01A	82 years, male, white, stage:Stage IV, dead, 173 days	3795.9
TCGA-FD-A3SO-01A	68 years, male, white, stage:Stage IV, dead, 168 days	3753.5
TCGA-XF-AAME-01A	64 years, female, white, stage:Stage II, dead, 2828 days	3738.0
TCGA-4Z-AA81-01A	80 years, male, white, stage:Stage II, dead, 1270 days	3697.0
TCGA-XF-A9SJ-01A	83 years, male, white, stage:Stage IV, dead, 98 days	3691.1
TCGA-HQ-A5ND-01A	78 years, male, stage:Stage IV, dead, 274 days	3672.8
TCGA-2F-A9KP-01A	66 years, male, white, stage:Stage IV, dead, 364 days	3632.2
TCGA-4Z-AA7N-01A	65 years, male, white, stage:Stage III, dead, 1367 days	3575.8
TCGA-CU-A0YR-01A	83 years, male, white, stage:Stage IV, dead, 460 days	3455.8
TCGA-XF-A9SV-01A	82 years, male, white, stage:Stage IV, dead, 388 days	3433.6
TCGA-CU-A72E-01A	76 years, male, white, stage:Stage IV, dead, 413 days	3428.3
TCGA-ZF-A9RD-01A	75 years, female, white, stage:Stage IV, dead, 408 days	3395.9
TCGA-ZF-AA56-01A	79 years, female, white, stage:Stage III, dead, 259 days	3370.2
TCGA-K4-A5RI-01A	67 years, female, white, stage:Stage III, dead, 356 days	3363.8
TCGA-XF-AAN1-01A	75 years, female, stage:Stage III, dead, 941 days	3324.1
TCGA-FD-A3B4-01A	55 years, female, black or african american, stage:Stage III, dead, 510 days	3248.4
TCGA-FD-A3SS-01A	66 years, male, white, stage:Stage IV, dead, 391 days	3234.9
TCGA-XF-AAN7-01A	60 years, male, white, stage:Stage IV, dead, 565 days	3233.7
TCGA-FD-A6TF-01A	80 years, female, white, stage:Stage IV, dead, 69 days	3195.5
TCGA-UY-A78M-01A	81 years, female, asian, stage:Stage IV, dead, 690 days	3185.1
TCGA-DK-A3IU-01A	58 years, male, white, stage:Stage II, dead, 706 days	3151.2
TCGA-K4-A4AC-01A	83 years, male, white, stage:Stage II, dead, 278 days	3138.3
TCGA-XF-A9SZ-01A	79 years, male, white, stage:Stage IV, dead, 859 days	3122.1
TCGA-SY-A9G0-01A	82 years, male, white, stage:Stage IV, dead, 1008 days	3107.7
TCGA-S5-A6DX-01A	83 years, male, white, stage:Stage IV, dead, 56 days	3101.0
TCGA-XF-AAN2-01A	73 years, male, white, stage:Stage II, dead, 1869 days	3049.8
TCGA-ZF-A9R9-01A	58 years, male, white, stage:Stage IV, dead, 864 days	3031.0
TCGA-FD-A62P-01A	76 years, male, white, stage:Stage II, dead, 191 days	3012.2
TCGA-BL-A13J-01A	65 years, male, white, stage:Stage IV, dead, 81 days	3009.7
TCGA-ZF-AA54-01A	71 years, male, white, stage:Stage III, dead, 590 days	2984.1
TCGA-FD-A3B6-01A	75 years, male, white, stage:Stage II, dead, 1005 days	2982.6
TCGA-4Z-AA80-01A	73 years, male, white, stage:Stage II, dead, 19 days	2961.0
TCGA-E7-A3X6-01A	70 years, male, white, stage:Stage II, dead, 904 days	2960.2
TCGA-2F-A9KO-01A	63 years, male, white, stage:Stage IV, dead, 734 days	2957.2
TCGA-XF-A8HI-01A	57 years, female, white, stage:Stage IV, dead, 544 days	2937.5
TCGA-BT-A20N-01A	72 years, male, stage:Stage III, dead, 795 days	2851.1
TCGA-GU-AATO-01A	75 years, male, white, stage:Stage IV, dead, 324 days	2840.0
TCGA-FD-A6TD-01A	77 years, male, white, stage:Stage III, dead, 386 days	2825.2
TCGA-BT-A0YX-01A	70 years, female, white, stage:Stage III, dead, 400 days	2784.2
TCGA-FD-A6TH-01A	63 years, male, white, stage:Stage IV, dead, 131 days	2779.5
TCGA-GU-AATQ-01A	68 years, male, white, stage:Stage III, dead, 213 days	2776.2
TCGA-FD-A3B3-01A	74 years, female, white, stage:Stage III, dead, 974 days	2775.4
TCGA-DK-AA6W-01A	78 years, male, white, stage:Stage II, dead, 415 days	2774.0
TCGA-E5-A4TZ-01A	64 years, male, white, stage:Stage IV, dead, 467 days	2762.8
TCGA-E7-A97P-01A	73 years, male, asian, stage:Stage II, dead, 437 days	2755.2
TCGA-DK-A1A3-01A	60 years, male, white, stage:Stage IV, dead, 665 days	2733.3
TCGA-XF-AAMT-01A	75 years, female, white, stage:Stage IV, dead, 90 days	2658.6
TCGA-BT-A20W-01A	71 years, male, white, stage:Stage II, dead, 254 days	2648.9
TCGA-XF-A9SH-01A	65 years, female, asian, stage:Stage II, dead, 1971 days	2641.7
TCGA-XF-AAMW-01A	79 years, female, white, stage:Stage IV, dead, 253 days	2633.6
TCGA-FD-A3B5-01A	86 years, male, black or african american, stage:Stage IV, dead, 272 days	2626.3
TCGA-DK-A3X2-01A	85 years, male, white, stage:Stage IV, dead, 547 days	2626.2
TCGA-XF-AAN0-01A	68 years, male, white, stage:Stage IV, dead, 1718 days	2601.5
TCGA-FD-A62O-01A	74 years, male, white, stage:Stage IV, dead, 216 days	2578.7
TCGA-BT-A20V-01A	59 years, female, black or african american, stage:Stage IV, dead, 154 days	2570.3
TCGA-5N-A9KM-01A	73 years, female, white, stage:Stage III, dead, 530 days	2569.6
TCGA-DK-A1AB-01A	74 years, female, white, stage:Stage IV, dead, 508 days	2540.3
TCGA-FD-A3B7-01A	66 years, male, black or african american, stage:Stage III, dead, 122 days	2531.8
TCGA-BT-A3PK-01A	80 years, male, white, stage:Stage II, dead, 303 days	2476.8
TCGA-4Z-AA7Q-01A	79 years, male, white, stage:Stage III, dead, 510 days	2458.6
TCGA-G2-A2EO-01A	69 years, male, white, stage:Stage III, dead, 1804 days	2443.7
TCGA-5N-A9KI-01A	76 years, female, white, stage:Stage III, dead, 76 days	2429.2
TCGA-DK-A3IN-01A	72 years, male, white, stage:Stage III, dead, 250 days	2397.5
TCGA-ZF-A9R3-01A	53 years, female, white, stage:Stage II, dead, 949 days	2387.0
TCGA-BL-A3JM-01A	62 years, male, white, stage:Stage III, dead, 205 days	2358.5
TCGA-DK-AA6L-01A	48 years, male, white, stage:Stage IV, dead, 1163 days	2328.0
TCGA-FD-A3SJ-01A	59 years, male, white, stage:Stage IV, dead, 739 days	2327.8
TCGA-DK-A2I2-01A	63 years, female, white, stage:Stage IV, dead, 237 days	2327.6
TCGA-HQ-A5NE-01A	57 years, male, stage:Stage III, dead, 370 days	2316.8
TCGA-FD-A43Y-01A	65 years, male, white, stage:Stage III, dead, 474 days	2285.2
TCGA-XF-A8HG-01A	69 years, male, white, stage:Stage III, dead, 467 days	2279.8
TCGA-BT-A20O-01A	75 years, male, white, stage:Stage III, dead, 370 days	2242.8
TCGA-DK-A3IQ-01A	74 years, male, white, stage:Stage III, dead, 539 days	2219.9
TCGA-XF-AAMX-01A	87 years, female, black or african american, stage:Stage III, dead, 206 days	2214.8
TCGA-GU-A762-01A	87 years, male, white, stage:Stage IV, dead, 232 days	2214.0
TCGA-G2-A2ES-01A	85 years, male, white, stage:Stage II, dead, 1004 days	2205.2
TCGA-CU-A0YN-01A	60 years, male, white, stage:Stage III, dead, 393 days	2204.6
TCGA-C4-A0EZ-01A	69 years, female, stage:Stage IV, dead, 273 days	2203.9
TCGA-FD-A5BZ-01A	77 years, female, white, stage:Stage IV, dead, 835 days	2203.0
TCGA-ZF-A9RE-01A	78 years, female, white, stage:Stage II, dead, 106 days	2196.7
TCGA-FD-A3SM-01A	70 years, male, white, stage:Stage IV, dead, 547 days	2182.8
TCGA-4Z-AA82-01A	59 years, male, black or african american, stage:Stage IV, dead, 1556 days	2137.3
TCGA-ZF-AA4U-01A	70 years, male, white, stage:Stage III, dead, 262 days	2097.1
TCGA-G2-A3IB-01A	66 years, male, black or african american, stage:Stage II, dead, 220 days	2093.7
TCGA-DK-A1A5-01A	79 years, male, white, stage:Stage II, dead, 65 days	2070.1
TCGA-UY-A78K-01A	60 years, male, white, stage:Stage IV, dead, 536 days	2018.5
TCGA-CU-A5W6-01A	70 years, male, white, stage:Stage III, dead, 56 days	1996.1
TCGA-2F-A9KW-01A	67 years, female, white, stage:Stage III, dead, 254 days	1980.2
TCGA-BT-A20Q-01A	73 years, male, white, stage:Stage IV, dead, 593 days	1978.0
TCGA-G2-A2EC-01A	58 years, female, black or african american, stage:Stage II, dead, 696 days	1970.1
TCGA-FD-A5C0-01A	61 years, male, white, stage:Stage IV, dead, 550 days	1966.7
TCGA-FD-A3N5-01A	69 years, male, black or african american, stage:Stage II, dead, 685 days	1917.6
TCGA-CF-A47T-01A	58 years, female, asian, stage:Stage II, dead, 385 days	1917.5
TCGA-XF-A9SP-01A	59 years, male, white, stage:Stage III, dead, 454 days	1886.7
TCGA-BT-A20J-01A	75 years, male, white, stage:Stage II, dead, 579 days	1885.3
TCGA-G2-A3IE-01A	51 years, male, white, stage:Stage II, dead, 612 days	1871.1
TCGA-XF-AAML-01A	75 years, male, white, stage:Stage II, dead, 232 days	1850.7
TCGA-GU-A42P-01A	72 years, male, white, stage:Stage IV, dead, 332 days	1830.7
TCGA-BT-A20T-01A	63 years, male, white, stage:Stage IV, dead, 453 days	1809.5
TCGA-FD-A6TG-01A	73 years, male, white, stage:Stage IV, dead, 93 days	1801.5
TCGA-4Z-AA86-01A	66 years, male, black or african american, stage:Stage IV, dead, 311 days	1801.3
TCGA-FD-A6TI-01A	73 years, male, white, stage:Stage IV, dead, 294 days	1795.6
TCGA-BT-A2LB-01A	73 years, female, white, stage:Stage III, dead, 492 days	1776.4
TCGA-XF-A9SK-01A	65 years, male, white, stage:Stage IV, dead, 486 days	1767.7
TCGA-GV-A3QH-01A	67 years, male, white, stage:Stage II, dead, 258 days	1720.2
TCGA-XF-A8HF-01A	80 years, male, white, stage:Stage III, dead, 2954 days	1712.2
TCGA-CF-A9FL-01A	85 years, male, asian, stage:Stage III, dead, 565 days	1632.4
TCGA-XF-A8HH-01A	61 years, female, white, stage:Stage IV, dead, 57 days	1613.2
TCGA-FJ-A3Z9-01A	72 years, male, white, stage:'--, dead, 385 days	1612.2
TCGA-FD-A3SR-01A	68 years, male, white, stage:Stage IV, dead, 602 days	1610.7
TCGA-FD-A3SQ-01A	62 years, male, white, stage:Stage IV, dead, 1423 days	1604.6
TCGA-FD-A62S-01A	60 years, female, black or african american, stage:Stage III, dead, 406 days	1599.9
TCGA-BT-A3PH-01A	76 years, male, white, stage:Stage IV, dead, 142 days	1593.3
TCGA-BT-A20U-01A	70 years, female, white, stage:Stage III, dead, 455 days	1590.5
TCGA-FD-A5BV-01A	47 years, female, white, stage:Stage III, dead, 163 days	1577.2
TCGA-GV-A3JV-01A	66 years, male, white, stage:Stage IV, dead, 434 days	1541.8
TCGA-2F-A9KR-01A	59 years, female, stage:Stage III, dead, 3183 days	1486.1
TCGA-ZF-AA4R-01A	67 years, male, white, stage:Stage IV, dead, 1036 days	1484.5
TCGA-BT-A20P-01A	81 years, female, white, stage:Stage III, dead, 544 days	1414.5
TCGA-ZF-AA4T-01A	65 years, male, white, stage:Stage IV, dead, 599 days	1412.5
TCGA-GC-A3I6-01A	45 years, male, white, stage:Stage III, dead, 630 days	1403.2
TCGA-E7-A4XJ-01A	66 years, male, asian, stage:Stage II, dead, 68 days	1389.0
TCGA-ZF-A9R0-01A	82 years, male, white, stage:Stage III, dead, 680 days	1372.1
TCGA-DK-AA6Q-01A	61 years, female, white, stage:Stage IV, dead, 413 days	1297.6
TCGA-BL-A13I-01A	57 years, female, white, stage:Stage III, dead, 223 days	1293.2
TCGA-DK-AA75-01A	82 years, male, white, stage:Stage III, dead, 340 days	1277.0
TCGA-BT-A2LD-01A	78 years, female, white, stage:Stage IV, dead, 623 days	1272.1
TCGA-DK-A3IL-01A	79 years, female, white, stage:Stage IV, dead, 413 days	1173.5
TCGA-GU-A42R-01A	68 years, male, white, stage:Stage IV, dead, 577 days	1170.8
TCGA-XF-AAMZ-01A	81 years, female, white, stage:Stage IV, dead, 1348 days	1167.9
TCGA-XF-AAMJ-01A	70 years, male, asian, stage:Stage III, dead, 1670 days	1150.4
TCGA-FD-A3SL-01A	60 years, male, white, stage:Stage IV, dead, 712 days	1062.1
TCGA-4Z-AA7R-01A	73 years, male, black or african american, stage:Stage IV, dead, 522 days	1056.5
TCGA-DK-A2HX-01A	80 years, female, white, stage:Stage IV, dead, 1420 days	1052.1
TCGA-XF-A8HC-01A	79 years, male, asian, stage:Stage IV, dead, 200 days	992.7
TCGA-GV-A3QF-01A	79 years, male, white, stage:Stage IV, dead, 617 days	891.1
TCGA-DK-A3IK-01A	87 years, male, white, stage:Stage IV, dead, 146 days	789.7
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UROTHELIAL CANCER - Protein expressionⁱ A mouse-over function shows sample information and annotation data. Click on an image to view it in a full screen mode. Samples can be filtered based on level of antibody staining by selecting one or several of the following categories: high, medium, low and not detected. The assay and annotation is described here. Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.

Antibody stainingⁱ Antibody staining in the annotated cell types in the current human tissue is reported as not detected, low, medium, or high, based on conventional immunohistochemistry profiling in selected tissues. This score is based on the combination of the staining intensity and fraction of stained cells. Each image is clickable and will lead to virtual microscopy that enables deeper exploration of all samples and also displays staining intensity scores, fraction scores and subcellular localization as well as patient and tissue information for each sample.	Antibody HPA006124
Staining
High
Medium
Low
Not detected
Intensity
Strong
Moderate
Weak
Negative
Quantity
>75%
75%-25%
<25%
None
Location
Nuclear
Cytoplasmic/membranous
Cytoplasmic/membranous,nuclear
None
Urothelial carcinoma, Low grade
Urothelial carcinoma, High grade