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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Transcription factors
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
6
Cytoband
p21.1
Chromosome location (bp)
43171269 - 43181506
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Together with MRTFA transcription coactivator, controls expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration. The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. Required for cardiac differentiation and maturation....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Activator, Developmental protein, DNA-binding
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Transcription, Transcription regulation
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a ubiquitous nuclear protein that stimulates both cell proliferation and differentiation. It is a member of the MADS (MCM1, Agamous, Deficiens, and SRF) box superfamily of transcription factors. This protein binds to the serum response element (SRE) in the promoter region of target genes. This protein regulates the activity of many immediate-early genes, for example c-fos, and thereby participates in cell cycle regulation, apoptosis, cell growth, and cell differentiation. This gene is the downstream target of many pathways; for example, the mitogen-activated protein kinase pathway (MAPK) that acts through the ternary complex factors (TCFs). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors alpha-Helices exposed by beta-structures Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014)
Show all
GO:0000785[chromatin] GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0000987[cis-regulatory region sequence-specific DNA binding] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001569[branching involved in blood vessel morphogenesis] GO:0001666[response to hypoxia] GO:0001701[in utero embryonic development] GO:0001707[mesoderm formation] GO:0001764[neuron migration] GO:0001829[trophectodermal cell differentiation] GO:0001947[heart looping] GO:0002011[morphogenesis of an epithelial sheet] GO:0002042[cell migration involved in sprouting angiogenesis] GO:0002521[leukocyte differentiation] GO:0003677[DNA binding] GO:0003682[chromatin binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006366[transcription by RNA polymerase II] GO:0007015[actin filament organization] GO:0007160[cell-matrix adhesion] GO:0007369[gastrulation] GO:0007507[heart development] GO:0007616[long-term memory] GO:0008285[negative regulation of cell population proliferation] GO:0008306[associative learning] GO:0009636[response to toxic substance] GO:0009725[response to hormone] GO:0010669[epithelial structure maintenance] GO:0010736[serum response element binding] GO:0021766[hippocampus development] GO:0022028[tangential migration from the subventricular zone to the olfactory bulb] GO:0030036[actin cytoskeleton organization] GO:0030038[contractile actin filament bundle assembly] GO:0030155[regulation of cell adhesion] GO:0030168[platelet activation] GO:0030220[platelet formation] GO:0030336[negative regulation of cell migration] GO:0030878[thyroid gland development] GO:0030900[forebrain development] GO:0031175[neuron projection development] GO:0031490[chromatin DNA binding] GO:0034097[response to cytokine] GO:0035855[megakaryocyte development] GO:0035912[dorsal aorta morphogenesis] GO:0042803[protein homodimerization activity] GO:0042826[histone deacetylase binding] GO:0043149[stress fiber assembly] GO:0043565[sequence-specific DNA binding] GO:0043589[skin morphogenesis] GO:0045059[positive thymic T cell selection] GO:0045214[sarcomere organization] GO:0045597[positive regulation of cell differentiation] GO:0045773[positive regulation of axon extension] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0045987[positive regulation of smooth muscle contraction] GO:0046016[positive regulation of transcription by glucose] GO:0046716[muscle cell cellular homeostasis] GO:0046847[filopodium assembly] GO:0046983[protein dimerization activity] GO:0048513[animal organ development] GO:0048538[thymus development] GO:0048589[developmental growth] GO:0048666[neuron development] GO:0048675[axon extension] GO:0048821[erythrocyte development] GO:0051091[positive regulation of DNA-binding transcription factor activity] GO:0051150[regulation of smooth muscle cell differentiation] GO:0051491[positive regulation of filopodium assembly] GO:0055003[cardiac myofibril assembly] GO:0060055[angiogenesis involved in wound healing] GO:0060218[hematopoietic stem cell differentiation] GO:0060261[positive regulation of transcription initiation by RNA polymerase II] GO:0060292[long-term synaptic depression] GO:0060324[face development] GO:0060347[heart trabecula formation] GO:0060379[cardiac muscle cell myoblast differentiation] GO:0060425[lung morphogenesis] GO:0060532[bronchus cartilage development] GO:0060534[trachea cartilage development] GO:0060947[cardiac vascular smooth muscle cell differentiation] GO:0061029[eyelid development in camera-type eye] GO:0061145[lung smooth muscle development] GO:0061436[establishment of skin barrier] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0070830[bicellular tight junction assembly] GO:0070878[primary miRNA binding] GO:0071333[cellular response to glucose stimulus] GO:0090009[primitive streak formation] GO:0090136[epithelial cell-cell adhesion] GO:0090398[cellular senescence] GO:0098609[cell-cell adhesion] GO:0140297[DNA-binding transcription factor binding] GO:1900222[negative regulation of amyloid-beta clearance] GO:1902894[negative regulation of miRNA transcription] GO:1902895[positive regulation of miRNA transcription] GO:1990837[sequence-specific double-stranded DNA binding]
The Human Protein Atlas project is funded
