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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
5
Cytoband
q12.3
Chromosome location (bp)
65883128 - 66082546
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state 1. Inhibits NOD2-dependent NF-kappa-B signaling and pro-inflammatory cytokine secretion 2....show less
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene is a member of the leucine-rich repeat and PDZ domain (LAP) family. The encoded protein contains 17 leucine-rich repeats and one PDZ domain. It binds to the unphosphorylated form of the ERBB2 protein and regulates ERBB2 function and localization. It has also been shown to affect the Ras signaling pathway by disrupting Ras-Raf interaction. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0005102[signaling receptor binding] GO:0005176[ErbB-2 class receptor binding] GO:0005200[structural constituent of cytoskeleton] GO:0005515[protein binding] GO:0005604[basement membrane] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005886[plasma membrane] GO:0006605[protein targeting] GO:0007155[cell adhesion] GO:0007165[signal transduction] GO:0007173[epidermal growth factor receptor signaling pathway] GO:0007229[integrin-mediated signaling pathway] GO:0009925[basal plasma membrane] GO:0016020[membrane] GO:0016323[basolateral plasma membrane] GO:0016607[nuclear speck] GO:0030054[cell junction] GO:0030056[hemidesmosome] GO:0031965[nuclear membrane] GO:0032088[negative regulation of NF-kappaB transcription factor activity] GO:0032495[response to muramyl dipeptide] GO:0032496[response to lipopolysaccharide] GO:0045104[intermediate filament cytoskeleton organization] GO:0045175[basal protein localization] GO:0045197[establishment or maintenance of epithelial cell apical/basal polarity] GO:0046579[positive regulation of Ras protein signal transduction] GO:0070161[anchoring junction] GO:0070433[negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway] GO:0071356[cellular response to tumor necrosis factor] GO:0071638[negative regulation of monocyte chemotactic protein-1 production] GO:0098794[postsynapse] GO:0098978[glutamatergic synapse] GO:0099072[regulation of postsynaptic membrane neurotransmitter receptor levels]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005102[signaling receptor binding] GO:0005176[ErbB-2 class receptor binding] GO:0005200[structural constituent of cytoskeleton] GO:0005515[protein binding] GO:0005604[basement membrane] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005886[plasma membrane] GO:0007155[cell adhesion] GO:0007165[signal transduction] GO:0007173[epidermal growth factor receptor signaling pathway] GO:0007229[integrin-mediated signaling pathway] GO:0009925[basal plasma membrane] GO:0016020[membrane] GO:0016323[basolateral plasma membrane] GO:0016607[nuclear speck] GO:0030054[cell junction] GO:0030056[hemidesmosome] GO:0031965[nuclear membrane] GO:0032088[negative regulation of NF-kappaB transcription factor activity] GO:0032495[response to muramyl dipeptide] GO:0032496[response to lipopolysaccharide] GO:0045104[intermediate filament cytoskeleton organization] GO:0045175[basal protein localization] GO:0045197[establishment or maintenance of epithelial cell apical/basal polarity] GO:0046579[positive regulation of Ras protein signal transduction] GO:0070161[anchoring junction] GO:0070433[negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway] GO:0071356[cellular response to tumor necrosis factor]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005102[signaling receptor binding] GO:0005176[ErbB-2 class receptor binding] GO:0005200[structural constituent of cytoskeleton] GO:0005515[protein binding] GO:0005604[basement membrane] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005886[plasma membrane] GO:0007155[cell adhesion] GO:0007165[signal transduction] GO:0007173[epidermal growth factor receptor signaling pathway] GO:0007229[integrin-mediated signaling pathway] GO:0009925[basal plasma membrane] GO:0016020[membrane] GO:0016323[basolateral plasma membrane] GO:0016607[nuclear speck] GO:0030054[cell junction] GO:0030056[hemidesmosome] GO:0031965[nuclear membrane] GO:0032088[negative regulation of NF-kappaB transcription factor activity] GO:0032495[response to muramyl dipeptide] GO:0032496[response to lipopolysaccharide] GO:0045104[intermediate filament cytoskeleton organization] GO:0045175[basal protein localization] GO:0045197[establishment or maintenance of epithelial cell apical/basal polarity] GO:0046579[positive regulation of Ras protein signal transduction] GO:0070161[anchoring junction] GO:0070433[negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway] GO:0071356[cellular response to tumor necrosis factor]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005102[signaling receptor binding] GO:0005176[ErbB-2 class receptor binding] GO:0005200[structural constituent of cytoskeleton] GO:0005515[protein binding] GO:0005604[basement membrane] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005886[plasma membrane] GO:0007155[cell adhesion] GO:0007165[signal transduction] GO:0007173[epidermal growth factor receptor signaling pathway] GO:0007229[integrin-mediated signaling pathway] GO:0009925[basal plasma membrane] GO:0016020[membrane] GO:0016323[basolateral plasma membrane] GO:0016607[nuclear speck] GO:0030054[cell junction] GO:0030056[hemidesmosome] GO:0031965[nuclear membrane] GO:0032088[negative regulation of NF-kappaB transcription factor activity] GO:0032495[response to muramyl dipeptide] GO:0032496[response to lipopolysaccharide] GO:0045104[intermediate filament cytoskeleton organization] GO:0045175[basal protein localization] GO:0045197[establishment or maintenance of epithelial cell apical/basal polarity] GO:0046579[positive regulation of Ras protein signal transduction] GO:0070161[anchoring junction] GO:0070433[negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway] GO:0071356[cellular response to tumor necrosis factor]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005102[signaling receptor binding] GO:0005176[ErbB-2 class receptor binding] GO:0005200[structural constituent of cytoskeleton] GO:0005515[protein binding] GO:0005604[basement membrane] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005886[plasma membrane] GO:0007155[cell adhesion] GO:0007165[signal transduction] GO:0007173[epidermal growth factor receptor signaling pathway] GO:0007229[integrin-mediated signaling pathway] GO:0009925[basal plasma membrane] GO:0016020[membrane] GO:0016323[basolateral plasma membrane] GO:0016607[nuclear speck] GO:0030054[cell junction] GO:0030056[hemidesmosome] GO:0031965[nuclear membrane] GO:0032088[negative regulation of NF-kappaB transcription factor activity] GO:0032495[response to muramyl dipeptide] GO:0032496[response to lipopolysaccharide] GO:0045104[intermediate filament cytoskeleton organization] GO:0045175[basal protein localization] GO:0045197[establishment or maintenance of epithelial cell apical/basal polarity] GO:0046579[positive regulation of Ras protein signal transduction] GO:0070161[anchoring junction] GO:0070433[negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway] GO:0071356[cellular response to tumor necrosis factor]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005102[signaling receptor binding] GO:0005176[ErbB-2 class receptor binding] GO:0005200[structural constituent of cytoskeleton] GO:0005515[protein binding] GO:0005604[basement membrane] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005886[plasma membrane] GO:0007155[cell adhesion] GO:0007165[signal transduction] GO:0007173[epidermal growth factor receptor signaling pathway] GO:0007229[integrin-mediated signaling pathway] GO:0009925[basal plasma membrane] GO:0016020[membrane] GO:0016323[basolateral plasma membrane] GO:0016607[nuclear speck] GO:0030054[cell junction] GO:0030056[hemidesmosome] GO:0031965[nuclear membrane] GO:0032088[negative regulation of NF-kappaB transcription factor activity] GO:0032495[response to muramyl dipeptide] GO:0032496[response to lipopolysaccharide] GO:0045104[intermediate filament cytoskeleton organization] GO:0045175[basal protein localization] GO:0045197[establishment or maintenance of epithelial cell apical/basal polarity] GO:0046579[positive regulation of Ras protein signal transduction] GO:0070161[anchoring junction] GO:0070433[negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway] GO:0071356[cellular response to tumor necrosis factor]
The Human Protein Atlas project is funded
