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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Enzymes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
5
Cytoband
q35.3
Chromosome location (bp)
180494379 - 180578358
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Poly(A) nuclease with 3'-5' RNase activity. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in mRNA decay mediated by the major-protein-coding determinant of instability (mCRD) of the FOS gene in the cytoplasm. In the presence of ZNF335, enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA. The increase of ligand-dependent ESR1-mediated transcription is much smaller, if any. Mediates cell proliferation and cell survival and prevents cellular senescence....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Magnesium, Metal-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes the catalytic component of the CCR4-NOT core transcriptional regulation complex. The encoded protein has a 3'-5' RNase activity and prefers polyadenylated substrates. The CCR4-NOT complex plays a role in many cellular processes, including miRNA-mediated repression, mRNA degradation, and transcriptional regulation. [provided by RefSeq, Dec 2014]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000175[3'-5'-exoribonuclease activity] GO:0000289[nuclear-transcribed mRNA poly(A) tail shortening] GO:0003723[RNA binding] GO:0003824[catalytic activity] GO:0004518[nuclease activity] GO:0004527[exonuclease activity] GO:0004532[exoribonuclease activity] GO:0004535[poly(A)-specific ribonuclease activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006417[regulation of translation] GO:0008284[positive regulation of cell population proliferation] GO:0010606[positive regulation of cytoplasmic mRNA processing body assembly] GO:0016020[membrane] GO:0016787[hydrolase activity] GO:0030014[CCR4-NOT complex] GO:0030374[nuclear receptor coactivator activity] GO:0031047[gene silencing by RNA] GO:0035195[miRNA-mediated gene silencing] GO:0043928[exonucleolytic catabolism of deadenylated mRNA] GO:0045893[positive regulation of DNA-templated transcription] GO:0046872[metal ion binding] GO:0070966[nuclear-transcribed mRNA catabolic process, no-go decay] GO:0090305[nucleic acid phosphodiester bond hydrolysis] GO:0090503[RNA phosphodiester bond hydrolysis, exonucleolytic]
Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000175[3'-5'-exoribonuclease activity] GO:0000289[nuclear-transcribed mRNA poly(A) tail shortening] GO:0003723[RNA binding] GO:0003824[catalytic activity] GO:0004518[nuclease activity] GO:0004527[exonuclease activity] GO:0004532[exoribonuclease activity] GO:0004535[poly(A)-specific ribonuclease activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006417[regulation of translation] GO:0008284[positive regulation of cell population proliferation] GO:0010606[positive regulation of cytoplasmic mRNA processing body assembly] GO:0016020[membrane] GO:0016787[hydrolase activity] GO:0030014[CCR4-NOT complex] GO:0030374[nuclear receptor coactivator activity] GO:0031047[gene silencing by RNA] GO:0035195[miRNA-mediated gene silencing] GO:0043928[exonucleolytic catabolism of deadenylated mRNA] GO:0045893[positive regulation of DNA-templated transcription] GO:0046872[metal ion binding] GO:0070966[nuclear-transcribed mRNA catabolic process, no-go decay] GO:0090305[nucleic acid phosphodiester bond hydrolysis] GO:0090503[RNA phosphodiester bond hydrolysis, exonucleolytic]
Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000175[3'-5'-exoribonuclease activity] GO:0000289[nuclear-transcribed mRNA poly(A) tail shortening] GO:0003723[RNA binding] GO:0003824[catalytic activity] GO:0004518[nuclease activity] GO:0004527[exonuclease activity] GO:0004532[exoribonuclease activity] GO:0004535[poly(A)-specific ribonuclease activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006417[regulation of translation] GO:0008284[positive regulation of cell population proliferation] GO:0010606[positive regulation of cytoplasmic mRNA processing body assembly] GO:0016020[membrane] GO:0016787[hydrolase activity] GO:0030014[CCR4-NOT complex] GO:0030374[nuclear receptor coactivator activity] GO:0031047[gene silencing by RNA] GO:0035195[miRNA-mediated gene silencing] GO:0043928[exonucleolytic catabolism of deadenylated mRNA] GO:0045893[positive regulation of DNA-templated transcription] GO:0046872[metal ion binding] GO:0070966[nuclear-transcribed mRNA catabolic process, no-go decay] GO:0090305[nucleic acid phosphodiester bond hydrolysis] GO:0090503[RNA phosphodiester bond hydrolysis, exonucleolytic]
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