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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
5
Cytoband
q31.1
Chromosome location (bp)
134148935 - 134176964
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5, CEP68 and probably NFKB2 1. SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1. SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO11) directs ubiquitination of BCL6 and DTL but does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(CCNF) directs ubiquitination of CCP110. SCF(FBXL3) and SCF(FBXL21) direct ubiquitination of CRY1 and CRY2. SCF(FBXO9) directs ubiquitination of TTI1 and TELO2. SCF(FBXO10) directs ubiquitination of BCL2....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Host-virus interaction, Ubl conjugation pathway
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a component of SCF complexes, which are composed of this protein, cullin 1, a ring-box protein, and one member of the F-box family of proteins. This protein binds directly to the F-box motif found in F-box proteins. SCF complexes are involved in the regulated ubiquitination of specific protein substrates, which targets them for degradation by the proteosome. Specific F-box proteins recognize different target protein(s), and many specific SCF substrates have been identified including regulators of cell cycle progression and development. Studies have also characterized the protein as an RNA polymerase II elongation factor. Alternative splicing of this gene results in two transcript variants. A related pseudogene has been identified on chromosome 7. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
P63208 [Direct mapping] S-phase kinase-associated protein 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000209[protein polyubiquitination] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005813[centrosome] GO:0005829[cytosol] GO:0006338[chromatin remodeling] GO:0006511[ubiquitin-dependent protein catabolic process] GO:0006513[protein monoubiquitination] GO:0008013[beta-catenin binding] GO:0016567[protein ubiquitination] GO:0019005[SCF ubiquitin ligase complex] GO:0019904[protein domain specific binding] GO:0031146[SCF-dependent proteasomal ubiquitin-dependent protein catabolic process] GO:0031467[Cul7-RING ubiquitin ligase complex] GO:0031519[PcG protein complex] GO:0051457[maintenance of protein location in nucleus] GO:0070936[protein K48-linked ubiquitination] GO:0097602[cullin family protein binding] GO:1904668[positive regulation of ubiquitin protein ligase activity] GO:1990444[F-box domain binding] GO:1990756[ubiquitin ligase-substrate adaptor activity]
P63208 [Direct mapping] S-phase kinase-associated protein 1
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209[protein polyubiquitination] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006338[chromatin remodeling] GO:0006511[ubiquitin-dependent protein catabolic process] GO:0008013[beta-catenin binding] GO:0016567[protein ubiquitination] GO:0019005[SCF ubiquitin ligase complex] GO:0019904[protein domain specific binding] GO:0031146[SCF-dependent proteasomal ubiquitin-dependent protein catabolic process] GO:0031467[Cul7-RING ubiquitin ligase complex] GO:0031519[PcG protein complex] GO:0051457[maintenance of protein location in nucleus] GO:0097602[cullin family protein binding] GO:1904668[positive regulation of ubiquitin protein ligase activity] GO:1990444[F-box domain binding] GO:1990756[ubiquitin ligase-substrate adaptor activity]
P63208 [Direct mapping] S-phase kinase-associated protein 1
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209[protein polyubiquitination] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006338[chromatin remodeling] GO:0006511[ubiquitin-dependent protein catabolic process] GO:0008013[beta-catenin binding] GO:0016567[protein ubiquitination] GO:0019005[SCF ubiquitin ligase complex] GO:0019904[protein domain specific binding] GO:0031146[SCF-dependent proteasomal ubiquitin-dependent protein catabolic process] GO:0031467[Cul7-RING ubiquitin ligase complex] GO:0031519[PcG protein complex] GO:0051457[maintenance of protein location in nucleus] GO:0097602[cullin family protein binding] GO:1904668[positive regulation of ubiquitin protein ligase activity] GO:1990444[F-box domain binding] GO:1990756[ubiquitin ligase-substrate adaptor activity]
P63208 [Direct mapping] S-phase kinase-associated protein 1
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209[protein polyubiquitination] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006338[chromatin remodeling] GO:0006511[ubiquitin-dependent protein catabolic process] GO:0008013[beta-catenin binding] GO:0016567[protein ubiquitination] GO:0019005[SCF ubiquitin ligase complex] GO:0019904[protein domain specific binding] GO:0031146[SCF-dependent proteasomal ubiquitin-dependent protein catabolic process] GO:0031467[Cul7-RING ubiquitin ligase complex] GO:0031519[PcG protein complex] GO:0051457[maintenance of protein location in nucleus] GO:0097602[cullin family protein binding] GO:1904668[positive regulation of ubiquitin protein ligase activity] GO:1990444[F-box domain binding] GO:1990756[ubiquitin ligase-substrate adaptor activity]
The Human Protein Atlas project is funded
