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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes FDA approved drug targets Human disease related genes Nuclear receptors Plasma proteins Transcription factors
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
5
Cytoband
q31.3
Chromosome location (bp)
143277931 - 143435512
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Receptor for glucocorticoids (GC) 1,2. Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors 3. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling 4. Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay 5. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth (By similarity)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Nuclear receptors Phobius predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Endocrine and metabolic diseases Adrenal gland diseases Musculoskeletal diseases Skeletal diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001046[core promoter sequence-specific DNA binding] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0003723[RNA binding] GO:0004879[nuclear receptor activity] GO:0004883[nuclear glucocorticoid receptor activity] GO:0005496[steroid binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005759[mitochondrial matrix] GO:0005815[microtubule organizing center] GO:0005819[spindle] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0006325[chromatin organization] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006915[apoptotic process] GO:0007049[cell cycle] GO:0007059[chromosome segregation] GO:0007165[signal transduction] GO:0008270[zinc ion binding] GO:0008289[lipid binding] GO:0016607[nuclear speck] GO:0019901[protein kinase binding] GO:0030518[intracellular steroid hormone receptor signaling pathway] GO:0032991[protein-containing complex] GO:0042921[glucocorticoid receptor signaling pathway] GO:0043402[glucocorticoid mediated signaling pathway] GO:0043565[sequence-specific DNA binding] GO:0045202[synapse] GO:0045892[negative regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0051301[cell division] GO:0051879[Hsp90 protein binding] GO:0071383[cellular response to steroid hormone stimulus] GO:0071385[cellular response to glucocorticoid stimulus] GO:0071549[cellular response to dexamethasone stimulus] GO:0071560[cellular response to transforming growth factor beta stimulus] GO:0140677[molecular function activator activity] GO:1902895[positive regulation of miRNA transcription] GO:1990239[steroid hormone binding] GO:1990837[sequence-specific double-stranded DNA binding]
Nuclear receptors Phobius predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Endocrine and metabolic diseases Adrenal gland diseases Musculoskeletal diseases Skeletal diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001046[core promoter sequence-specific DNA binding] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0003723[RNA binding] GO:0004879[nuclear receptor activity] GO:0004883[nuclear glucocorticoid receptor activity] GO:0005496[steroid binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005759[mitochondrial matrix] GO:0005815[microtubule organizing center] GO:0005819[spindle] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0006325[chromatin organization] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006915[apoptotic process] GO:0007049[cell cycle] GO:0007059[chromosome segregation] GO:0007165[signal transduction] GO:0008270[zinc ion binding] GO:0008289[lipid binding] GO:0016607[nuclear speck] GO:0019901[protein kinase binding] GO:0030518[intracellular steroid hormone receptor signaling pathway] GO:0032991[protein-containing complex] GO:0042921[glucocorticoid receptor signaling pathway] GO:0043402[glucocorticoid mediated signaling pathway] GO:0043565[sequence-specific DNA binding] GO:0045202[synapse] GO:0045892[negative regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0051301[cell division] GO:0051879[Hsp90 protein binding] GO:0071383[cellular response to steroid hormone stimulus] GO:0071385[cellular response to glucocorticoid stimulus] GO:0071549[cellular response to dexamethasone stimulus] GO:0071560[cellular response to transforming growth factor beta stimulus] GO:0140677[molecular function activator activity] GO:1902895[positive regulation of miRNA transcription] GO:1990239[steroid hormone binding] GO:1990837[sequence-specific double-stranded DNA binding]
Nuclear receptors Phobius predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Endocrine and metabolic diseases Adrenal gland diseases Musculoskeletal diseases Skeletal diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001046[core promoter sequence-specific DNA binding] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0003723[RNA binding] GO:0004879[nuclear receptor activity] GO:0004883[nuclear glucocorticoid receptor activity] GO:0005496[steroid binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005759[mitochondrial matrix] GO:0005815[microtubule organizing center] GO:0005819[spindle] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0006111[regulation of gluconeogenesis] GO:0006325[chromatin organization] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006915[apoptotic process] GO:0007049[cell cycle] GO:0007059[chromosome segregation] GO:0007165[signal transduction] GO:0008211[glucocorticoid metabolic process] GO:0008270[zinc ion binding] GO:0008289[lipid binding] GO:0010467[gene expression] GO:0014004[microglia differentiation] GO:0016020[membrane] GO:0016607[nuclear speck] GO:0019901[protein kinase binding] GO:0030325[adrenal gland development] GO:0030518[intracellular steroid hormone receptor signaling pathway] GO:0031946[regulation of glucocorticoid biosynthetic process] GO:0032991[protein-containing complex] GO:0035249[synaptic transmission, glutamatergic] GO:0042711[maternal behavior] GO:0042802[identical protein binding] GO:0042921[glucocorticoid receptor signaling pathway] GO:0043402[glucocorticoid mediated signaling pathway] GO:0043525[positive regulation of neuron apoptotic process] GO:0043565[sequence-specific DNA binding] GO:0045202[synapse] GO:0045892[negative regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0048708[astrocyte differentiation] GO:0051301[cell division] GO:0051879[Hsp90 protein binding] GO:0060603[mammary gland duct morphogenesis] GO:0061744[motor behavior] GO:0071383[cellular response to steroid hormone stimulus] GO:0071385[cellular response to glucocorticoid stimulus] GO:0071549[cellular response to dexamethasone stimulus] GO:0071560[cellular response to transforming growth factor beta stimulus] GO:0140677[molecular function activator activity] GO:0150076[neuroinflammatory response] GO:1902895[positive regulation of miRNA transcription] GO:1990239[steroid hormone binding] GO:1990837[sequence-specific double-stranded DNA binding]
Nuclear receptors Phobius predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Endocrine and metabolic diseases Adrenal gland diseases Musculoskeletal diseases Skeletal diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001046[core promoter sequence-specific DNA binding] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0003723[RNA binding] GO:0004879[nuclear receptor activity] GO:0004883[nuclear glucocorticoid receptor activity] GO:0005496[steroid binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005759[mitochondrial matrix] GO:0005815[microtubule organizing center] GO:0005819[spindle] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0006325[chromatin organization] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006915[apoptotic process] GO:0007049[cell cycle] GO:0007059[chromosome segregation] GO:0007165[signal transduction] GO:0008270[zinc ion binding] GO:0008289[lipid binding] GO:0016607[nuclear speck] GO:0019901[protein kinase binding] GO:0030518[intracellular steroid hormone receptor signaling pathway] GO:0032991[protein-containing complex] GO:0042921[glucocorticoid receptor signaling pathway] GO:0043402[glucocorticoid mediated signaling pathway] GO:0043565[sequence-specific DNA binding] GO:0045202[synapse] GO:0045892[negative regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0051301[cell division] GO:0051879[Hsp90 protein binding] GO:0071383[cellular response to steroid hormone stimulus] GO:0071385[cellular response to glucocorticoid stimulus] GO:0071549[cellular response to dexamethasone stimulus] GO:0071560[cellular response to transforming growth factor beta stimulus] GO:0140677[molecular function activator activity] GO:1902895[positive regulation of miRNA transcription] GO:1990239[steroid hormone binding] GO:1990837[sequence-specific double-stranded DNA binding]
Nuclear receptors Phobius predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Endocrine and metabolic diseases Adrenal gland diseases Musculoskeletal diseases Skeletal diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001046[core promoter sequence-specific DNA binding] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0003723[RNA binding] GO:0004879[nuclear receptor activity] GO:0004883[nuclear glucocorticoid receptor activity] GO:0005496[steroid binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005759[mitochondrial matrix] GO:0005815[microtubule organizing center] GO:0005819[spindle] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0006325[chromatin organization] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006915[apoptotic process] GO:0007049[cell cycle] GO:0007059[chromosome segregation] GO:0007165[signal transduction] GO:0008270[zinc ion binding] GO:0008289[lipid binding] GO:0016607[nuclear speck] GO:0019901[protein kinase binding] GO:0030518[intracellular steroid hormone receptor signaling pathway] GO:0032991[protein-containing complex] GO:0042921[glucocorticoid receptor signaling pathway] GO:0043402[glucocorticoid mediated signaling pathway] GO:0043565[sequence-specific DNA binding] GO:0045202[synapse] GO:0045892[negative regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0051301[cell division] GO:0051879[Hsp90 protein binding] GO:0071383[cellular response to steroid hormone stimulus] GO:0071385[cellular response to glucocorticoid stimulus] GO:0071549[cellular response to dexamethasone stimulus] GO:0071560[cellular response to transforming growth factor beta stimulus] GO:0140677[molecular function activator activity] GO:1902895[positive regulation of miRNA transcription] GO:1990239[steroid hormone binding] GO:1990837[sequence-specific double-stranded DNA binding]
Nuclear receptors Phobius predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Endocrine and metabolic diseases Adrenal gland diseases Musculoskeletal diseases Skeletal diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001046[core promoter sequence-specific DNA binding] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0003723[RNA binding] GO:0004879[nuclear receptor activity] GO:0004883[nuclear glucocorticoid receptor activity] GO:0005496[steroid binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005759[mitochondrial matrix] GO:0005815[microtubule organizing center] GO:0005819[spindle] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0006325[chromatin organization] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006915[apoptotic process] GO:0007049[cell cycle] GO:0007059[chromosome segregation] GO:0007165[signal transduction] GO:0008270[zinc ion binding] GO:0008289[lipid binding] GO:0016607[nuclear speck] GO:0019901[protein kinase binding] GO:0030518[intracellular steroid hormone receptor signaling pathway] GO:0032991[protein-containing complex] GO:0042921[glucocorticoid receptor signaling pathway] GO:0043402[glucocorticoid mediated signaling pathway] GO:0043565[sequence-specific DNA binding] GO:0045202[synapse] GO:0045892[negative regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0051301[cell division] GO:0051879[Hsp90 protein binding] GO:0071383[cellular response to steroid hormone stimulus] GO:0071385[cellular response to glucocorticoid stimulus] GO:0071549[cellular response to dexamethasone stimulus] GO:0071560[cellular response to transforming growth factor beta stimulus] GO:0140677[molecular function activator activity] GO:1902895[positive regulation of miRNA transcription] GO:1990239[steroid hormone binding] GO:1990837[sequence-specific double-stranded DNA binding]
SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Endocrine and metabolic diseases Adrenal gland diseases Musculoskeletal diseases Skeletal diseases Protein evidence (Ezkurdia et al 2014)
Q3MSN4 [Direct mapping] Glucocorticoid receptor; Nuclear receptor subfamily 3, group C, member 1 (Glucocorticoid receptor)
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SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Endocrine and metabolic diseases Adrenal gland diseases Musculoskeletal diseases Skeletal diseases Protein evidence (Ezkurdia et al 2014)
Nuclear receptors Phobius predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Endocrine and metabolic diseases Adrenal gland diseases Musculoskeletal diseases Skeletal diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001046[core promoter sequence-specific DNA binding] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0003723[RNA binding] GO:0004879[nuclear receptor activity] GO:0004883[nuclear glucocorticoid receptor activity] GO:0005496[steroid binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005759[mitochondrial matrix] GO:0005815[microtubule organizing center] GO:0005819[spindle] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0006325[chromatin organization] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006915[apoptotic process] GO:0007049[cell cycle] GO:0007059[chromosome segregation] GO:0007165[signal transduction] GO:0008270[zinc ion binding] GO:0008289[lipid binding] GO:0016607[nuclear speck] GO:0019901[protein kinase binding] GO:0030518[intracellular steroid hormone receptor signaling pathway] GO:0032991[protein-containing complex] GO:0042921[glucocorticoid receptor signaling pathway] GO:0043402[glucocorticoid mediated signaling pathway] GO:0043565[sequence-specific DNA binding] GO:0045202[synapse] GO:0045892[negative regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0051301[cell division] GO:0051879[Hsp90 protein binding] GO:0071383[cellular response to steroid hormone stimulus] GO:0071385[cellular response to glucocorticoid stimulus] GO:0071549[cellular response to dexamethasone stimulus] GO:0071560[cellular response to transforming growth factor beta stimulus] GO:0140677[molecular function activator activity] GO:1902895[positive regulation of miRNA transcription] GO:1990239[steroid hormone binding] GO:1990837[sequence-specific double-stranded DNA binding]
Nuclear receptors Phobius predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Endocrine and metabolic diseases Adrenal gland diseases Musculoskeletal diseases Skeletal diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001046[core promoter sequence-specific DNA binding] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0003723[RNA binding] GO:0004879[nuclear receptor activity] GO:0004883[nuclear glucocorticoid receptor activity] GO:0005496[steroid binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005759[mitochondrial matrix] GO:0005815[microtubule organizing center] GO:0005819[spindle] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0006325[chromatin organization] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006915[apoptotic process] GO:0007049[cell cycle] GO:0007059[chromosome segregation] GO:0007165[signal transduction] GO:0008270[zinc ion binding] GO:0008289[lipid binding] GO:0016607[nuclear speck] GO:0019901[protein kinase binding] GO:0030518[intracellular steroid hormone receptor signaling pathway] GO:0032991[protein-containing complex] GO:0042921[glucocorticoid receptor signaling pathway] GO:0043402[glucocorticoid mediated signaling pathway] GO:0043565[sequence-specific DNA binding] GO:0045202[synapse] GO:0045892[negative regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0051301[cell division] GO:0051879[Hsp90 protein binding] GO:0071383[cellular response to steroid hormone stimulus] GO:0071385[cellular response to glucocorticoid stimulus] GO:0071549[cellular response to dexamethasone stimulus] GO:0071560[cellular response to transforming growth factor beta stimulus] GO:0140677[molecular function activator activity] GO:1902895[positive regulation of miRNA transcription] GO:1990239[steroid hormone binding] GO:1990837[sequence-specific double-stranded DNA binding]
Q3MSN4 [Direct mapping] Glucocorticoid receptor; Nuclear receptor subfamily 3, group C, member 1 (Glucocorticoid receptor)
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SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Endocrine and metabolic diseases Adrenal gland diseases Musculoskeletal diseases Skeletal diseases Protein evidence (Ezkurdia et al 2014)
Q3MSN4 [Direct mapping] Glucocorticoid receptor; Nuclear receptor subfamily 3, group C, member 1 (Glucocorticoid receptor)
Show all
SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Endocrine and metabolic diseases Adrenal gland diseases Musculoskeletal diseases Skeletal diseases Protein evidence (Ezkurdia et al 2014)
Q3MSN4 [Direct mapping] Glucocorticoid receptor; Nuclear receptor subfamily 3, group C, member 1 (Glucocorticoid receptor)
Show all
SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Endocrine and metabolic diseases Adrenal gland diseases Musculoskeletal diseases Skeletal diseases Protein evidence (Ezkurdia et al 2014)
Phobius predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Endocrine and metabolic diseases Adrenal gland diseases Musculoskeletal diseases Skeletal diseases Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
