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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Disease related genes Enzymes Metabolic proteins Potential drug targets
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
3
Cytoband
p24.3
Chromosome location (bp)
20040446 - 20154404
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Functions as a histone acetyltransferase (HAT) to promote transcriptional activation 1. Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles 2. Has a a strong preference for acetylation of H3 at 'Lys-9' (H3K9ac) 3. Also acetylates non-histone proteins, such as ACLY, MAPRE1/EB1, PLK4, RRP9/U3-55K and TBX5 4,5,6,7,8,9,10. Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A 11. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-BMAL1 and CLOCK-BMAL1 heterodimers 12. Involved in heart and limb development by mediating acetylation of TBX5, acetylation regulating nucleocytoplasmic shuttling of TBX5 13. Acts as a negative regulator of centrosome amplification by mediating acetylation of PLK4 14. Acetylates RRP9/U3-55K, a core subunit of the U3 snoRNP complex, impairing pre-rRNA processing 15. Acetylates MAPRE1/EB1, promoting dynamic kinetochore-microtubule interactions in early mitosis 16. Also acetylates spermidine 17....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Activator, Acyltransferase, Transferase
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation, including c-jun and the adenoviral oncoprotein E1A. The protein encoded by this gene associates with p300/CBP. It has in vitro and in vivo binding activity with CBP and p300, and competes with E1A for binding sites in p300/CBP. It has histone acetyl transferase activity with core histones and nucleosome core particles, indicating that this protein plays a direct role in transcriptional regulation. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Enzymes ENZYME proteins Transferases Metabolic proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000123[histone acetyltransferase complex] GO:0000124[SAGA complex] GO:0000776[kinetochore] GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0003682[chromatin binding] GO:0003712[transcription coregulator activity] GO:0003713[transcription coactivator activity] GO:0004145[diamine N-acetyltransferase activity] GO:0004402[histone acetyltransferase activity] GO:0004468[lysine N-acetyltransferase activity, acting on acetyl phosphate as donor] GO:0004861[cyclin-dependent protein serine/threonine kinase inhibitor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005813[centrosome] GO:0005815[microtubule organizing center] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0006094[gluconeogenesis] GO:0006282[regulation of DNA repair] GO:0006338[chromatin remodeling] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006473[protein acetylation] GO:0007049[cell cycle] GO:0007507[heart development] GO:0008285[negative regulation of cell population proliferation] GO:0010484[H3 histone acetyltransferase activity] GO:0010835[regulation of protein ADP-ribosylation] GO:0016407[acetyltransferase activity] GO:0016573[histone acetylation] GO:0016740[transferase activity] GO:0016746[acyltransferase activity] GO:0016747[acyltransferase activity, transferring groups other than amino-acyl groups] GO:0018076[N-terminal peptidyl-lysine acetylation] GO:0018393[internal peptidyl-lysine acetylation] GO:0018394[peptidyl-lysine acetylation] GO:0019901[protein kinase binding] GO:0031063[regulation of histone deacetylation] GO:0031672[A band] GO:0031674[I band] GO:0032869[cellular response to insulin stimulus] GO:0032991[protein-containing complex] GO:0035521[monoubiquitinated histone deubiquitination] GO:0035522[monoubiquitinated histone H2A deubiquitination] GO:0042641[actomyosin] GO:0042826[histone deacetylase binding] GO:0043484[regulation of RNA splicing] GO:0043966[histone H3 acetylation] GO:0043992[histone acetyltransferase activity (H3-K9 specific)] GO:0044154[histone H3-K14 acetylation] GO:0045722[positive regulation of gluconeogenesis] GO:0045736[negative regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0045815[transcriptional initiation-coupled chromatin remodeling] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0045995[regulation of embryonic development] GO:0046600[negative regulation of centriole replication] GO:0048511[rhythmic process] GO:0051302[regulation of cell division] GO:0051726[regulation of cell cycle] GO:0060173[limb development] GO:0061733[peptide-lysine-N-acetyltransferase activity] GO:0072686[mitotic spindle] GO:0090043[regulation of tubulin deacetylation] GO:0140297[DNA-binding transcription factor binding] GO:0140672[ATAC complex] GO:1902425[positive regulation of attachment of mitotic spindle microtubules to kinetochore] GO:2000233[negative regulation of rRNA processing]
The Human Protein Atlas project is funded
