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MORC1
HPA
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  • MORC1
PROTEIN SUMMARY GENE INFORMATION RNA DATA ANTIBODY DATA
GENERAL INFORMATIONi

General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.

Gene namei

Official gene symbol, which is typically a short form of the gene name, according to HGNC.

MORC1
Synonyms CT33, MORC, ZCW6
Gene descriptioni

Full gene name according to HGNC.

MORC family CW-type zinc finger 1
Predicted locationi

All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.

  • Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.

  • Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).

The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.

Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi

Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.

Chromosome 3
Cytoband q13.13
Chromosome location (bp) 108958248 - 109118134
Number of transcriptsi

Number of protein-coding transcripts from the gene as defined by Ensembl.

2
Ensembl ENSG00000114487 (version 109)
Entrez gene 27136
HGNC HGNC:7198
UniProt Q86VD1 (UniProt - Evidence at transcript level)
neXtProt NX_Q86VD1
GeneCards MORC1
Antibodypedia MORC1 antibodies


PROTEIN FUNCTION
Protein function (UniProt)i

Useful information about the protein provided by UniProt.

Required for spermatogenesis (By similarity). Essential for de novo DNA methylation and silencing of transposable elements in the male embryonic germ cells (By similarity).... show less
Molecular function (UniProt)i

Keywords assigned by UniProt to proteins due to their particular molecular function.

Developmental protein
Biological process (UniProt)i

Keywords assigned by UniProt to proteins because they are involved in a particular biological process.

Differentiation, RNA-mediated gene silencing, Spermatogenesis
Ligand (UniProt)i

Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.

Metal-binding, Zinc
Gene summary (Entrez)i

Useful information about the gene from Entrez

This gene encodes the human homolog of mouse morc and like the mouse protein it is testis-specific. Mouse studies support a testis-specific function since only male knockout mice are infertile; infertility is the only apparent defect. These studies further support a role for this protein early in spermatogenesis, possibly by affecting entry into apoptosis because testis from knockout mice show greatly increased numbers of apoptotic cells. [provided by RefSeq, Jan 2009]... show less
PROTEIN INFORMATIONi

The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.

The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.

The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.

The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)
Transmembrane regions
(predicted)
MORC1-201
ENSP00000232603
ENST00000232603
Q86VD1
[Direct mapping] MORC family CW-type zinc finger protein 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Show all
GO:0001662 [behavioral fear response]
GO:0001673 [male germ cell nucleus]
GO:0005634 [nucleus]
GO:0007283 [spermatogenesis]
GO:0008270 [zinc ion binding]
GO:0010529 [negative regulation of transposition]
GO:0010629 [negative regulation of gene expression]
GO:0030154 [cell differentiation]
GO:0031047 [gene silencing by RNA]
GO:0032196 [transposition]
GO:0040029 [epigenetic regulation of gene expression]
GO:0043046 [DNA methylation involved in gamete generation]
GO:0044026 [DNA hypermethylation]
GO:0046872 [metal ion binding]
GO:2000143 [negative regulation of DNA-templated transcription initiation]
Show all
984 aa
112.9 kDa
No 0
MORC1-202
ENSP00000417282
ENST00000483760
Q86VD1
[Direct mapping] MORC family CW-type zinc finger protein 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Mapped to neXtProt
   neXtProt - Evidence at protein level
Show all
GO:0005634 [nucleus]
GO:0007283 [spermatogenesis]
GO:0008270 [zinc ion binding]
GO:0030154 [cell differentiation]
GO:0031047 [gene silencing by RNA]
GO:0046872 [metal ion binding]
Show all
963 aa
110.6 kDa
No 0

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