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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
3
Cytoband
q29
Chromosome location (bp)
196935402 - 196942594
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus via its interaction with ALYREF/THOC4/ALY, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC) via its interaction with UPF1, promoting the interaction between UPF1 and UPF2. The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with SRRT/ARS2, thereby being required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of PARN, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, NCBP2/CBP20 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires NCBP1/CBP80 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure. The conventional cap-binding complex with NCBP2 binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus 1....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
RNA-binding
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
The product of this gene is a component of the nuclear cap-binding protein complex (CBC), which binds to the monomethylated 5' cap of nascent pre-mRNA in the nucleoplasm. The encoded protein has an RNP domain commonly found in RNA binding proteins, and contains the cap-binding activity. The CBC promotes pre-mRNA splicing, 3'-end processing, RNA nuclear export, and nonsense-mediated mRNA decay. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
P52298 [Direct mapping] Nuclear cap-binding protein subunit 2
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Transporters Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000184[nuclear-transcribed mRNA catabolic process, nonsense-mediated decay] GO:0000339[RNA cap binding] GO:0000340[RNA 7-methylguanosine cap binding] GO:0000380[alternative mRNA splicing, via spliceosome] GO:0000398[mRNA splicing, via spliceosome] GO:0002191[cap-dependent translational initiation] GO:0003676[nucleic acid binding] GO:0003677[DNA binding] GO:0003723[RNA binding] GO:0003729[mRNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005845[mRNA cap binding complex] GO:0005846[nuclear cap binding complex] GO:0006397[mRNA processing] GO:0006406[mRNA export from nucleus] GO:0006408[snRNA export from nucleus] GO:0006417[regulation of translation] GO:0006446[regulation of translational initiation] GO:0008334[histone mRNA metabolic process] GO:0008380[RNA splicing] GO:0017069[snRNA binding] GO:0031047[gene silencing by RNA] GO:0031053[primary miRNA processing] GO:0031124[mRNA 3'-end processing] GO:0031442[positive regulation of mRNA 3'-end processing] GO:0032968[positive regulation of transcription elongation by RNA polymerase II] GO:0034518[RNA cap binding complex] GO:0035195[miRNA-mediated gene silencing] GO:0042789[mRNA transcription by RNA polymerase II] GO:0045292[mRNA cis splicing, via spliceosome] GO:0046833[positive regulation of RNA export from nucleus] GO:0051028[mRNA transport] GO:0098789[pre-mRNA cleavage required for polyadenylation] GO:1901409[positive regulation of phosphorylation of RNA polymerase II C-terminal domain]
P52298 [Direct mapping] Nuclear cap-binding protein subunit 2
Show all
Transporters Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000184[nuclear-transcribed mRNA catabolic process, nonsense-mediated decay] GO:0000339[RNA cap binding] GO:0000340[RNA 7-methylguanosine cap binding] GO:0000380[alternative mRNA splicing, via spliceosome] GO:0000398[mRNA splicing, via spliceosome] GO:0002191[cap-dependent translational initiation] GO:0003676[nucleic acid binding] GO:0003677[DNA binding] GO:0003723[RNA binding] GO:0003729[mRNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005845[mRNA cap binding complex] GO:0005846[nuclear cap binding complex] GO:0006397[mRNA processing] GO:0006406[mRNA export from nucleus] GO:0006408[snRNA export from nucleus] GO:0006417[regulation of translation] GO:0006446[regulation of translational initiation] GO:0008334[histone mRNA metabolic process] GO:0008380[RNA splicing] GO:0017069[snRNA binding] GO:0031047[gene silencing by RNA] GO:0031053[primary miRNA processing] GO:0031124[mRNA 3'-end processing] GO:0031442[positive regulation of mRNA 3'-end processing] GO:0032968[positive regulation of transcription elongation by RNA polymerase II] GO:0034518[RNA cap binding complex] GO:0035195[miRNA-mediated gene silencing] GO:0042789[mRNA transcription by RNA polymerase II] GO:0045292[mRNA cis splicing, via spliceosome] GO:0046833[positive regulation of RNA export from nucleus] GO:0051028[mRNA transport] GO:0098789[pre-mRNA cleavage required for polyadenylation] GO:1901409[positive regulation of phosphorylation of RNA polymerase II C-terminal domain]
P52298 [Direct mapping] Nuclear cap-binding protein subunit 2
Show all
Transporters Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000184[nuclear-transcribed mRNA catabolic process, nonsense-mediated decay] GO:0000339[RNA cap binding] GO:0000340[RNA 7-methylguanosine cap binding] GO:0000380[alternative mRNA splicing, via spliceosome] GO:0000398[mRNA splicing, via spliceosome] GO:0002191[cap-dependent translational initiation] GO:0003676[nucleic acid binding] GO:0003677[DNA binding] GO:0003723[RNA binding] GO:0003729[mRNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005845[mRNA cap binding complex] GO:0005846[nuclear cap binding complex] GO:0006397[mRNA processing] GO:0006406[mRNA export from nucleus] GO:0006408[snRNA export from nucleus] GO:0006417[regulation of translation] GO:0006446[regulation of translational initiation] GO:0008334[histone mRNA metabolic process] GO:0008380[RNA splicing] GO:0017069[snRNA binding] GO:0031047[gene silencing by RNA] GO:0031053[primary miRNA processing] GO:0031124[mRNA 3'-end processing] GO:0031442[positive regulation of mRNA 3'-end processing] GO:0032968[positive regulation of transcription elongation by RNA polymerase II] GO:0034518[RNA cap binding complex] GO:0035195[miRNA-mediated gene silencing] GO:0042789[mRNA transcription by RNA polymerase II] GO:0045292[mRNA cis splicing, via spliceosome] GO:0046833[positive regulation of RNA export from nucleus] GO:0051028[mRNA transport] GO:0098789[pre-mRNA cleavage required for polyadenylation] GO:1901409[positive regulation of phosphorylation of RNA polymerase II C-terminal domain]
The Human Protein Atlas project is funded
