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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Disease related genes Plasma proteins Transcription factors
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
3
Cytoband
p13
Chromosome location (bp)
70954693 - 71583978
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Transcriptional repressor 1,2. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential (By similarity). Plays an important role in the specification and differentiation of lung epithelium. Acts cooperatively with FOXP4 to regulate lung secretory epithelial cell fate and regeneration by restricting the goblet cell lineage program; the function may involve regulation of AGR2. Essential transcriptional regulator of B-cell development. Involved in regulation of cardiac muscle cell proliferation. Involved in the columnar organization of spinal motor neurons. Promotes the formation of the lateral motor neuron column (LMC) and the preganglionic motor column (PGC) and is required for respective appropriate motor axon projections. The segment-appropriate generation of spinal cord motor columns requires cooperation with other Hox proteins. Can regulate PITX3 promoter activity; may promote midbrain identity in embryonic stem cell-derived dopamine neurons by regulating PITX3. Negatively regulates the differentiation of T follicular helper cells T(FH)s. Involved in maintenance of hair follicle stem cell quiescence; the function probably involves regulation of FGF18 (By similarity). Represses transcription of various pro-apoptotic genes and cooperates with NF-kappa B-signaling in promoting B-cell expansion by inhibition of caspase-dependent apoptosis 3. Binds to CSF1R promoter elements and is involved in regulation of monocyte differentiation and macrophage functions; repression of CSF1R in monocytes seems to involve NCOR2 as corepressor 4,5,6. Involved in endothelial cell proliferation, tube formation and migration indicative for a role in angiogenesis; the role in neovascularization seems to implicate suppression of SEMA5B 7. Can negatively regulate androgen receptor signaling 8. Acts as a transcriptional activator of the FBXL7 promoter; this activity is regulated by AURKA 9....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
DNA-binding, Repressor
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Transcription, Transcription regulation
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Metal-binding, Zinc
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Helix-turn-helix domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001046[core promoter sequence-specific DNA binding] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0002903[negative regulation of B cell apoptotic process] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006974[cellular response to DNA damage stimulus] GO:0010468[regulation of gene expression] GO:0010595[positive regulation of endothelial cell migration] GO:0010629[negative regulation of gene expression] GO:0030316[osteoclast differentiation] GO:0032496[response to lipopolysaccharide] GO:0032651[regulation of interleukin-1 beta production] GO:0032655[regulation of interleukin-12 production] GO:0032680[regulation of tumor necrosis factor production] GO:0032745[positive regulation of interleukin-21 production] GO:0036035[osteoclast development] GO:0042116[macrophage activation] GO:0042117[monocyte activation] GO:0042118[endothelial cell activation] GO:0042802[identical protein binding] GO:0043565[sequence-specific DNA binding] GO:0043621[protein self-association] GO:0045655[regulation of monocyte differentiation] GO:0045892[negative regulation of DNA-templated transcription] GO:0046872[metal ion binding] GO:0048661[positive regulation of smooth muscle cell proliferation] GO:0050681[nuclear androgen receptor binding] GO:0050727[regulation of inflammatory response] GO:0050861[positive regulation of B cell receptor signaling pathway] GO:0060766[negative regulation of androgen receptor signaling pathway] GO:0061470[T follicular helper cell differentiation] GO:1900424[regulation of defense response to bacterium] GO:1901256[regulation of macrophage colony-stimulating factor production] GO:1901509[regulation of endothelial tube morphogenesis] GO:1990837[sequence-specific double-stranded DNA binding] GO:2000341[regulation of chemokine (C-X-C motif) ligand 2 production]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Helix-turn-helix domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001046[core promoter sequence-specific DNA binding] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0002903[negative regulation of B cell apoptotic process] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006974[cellular response to DNA damage stimulus] GO:0010468[regulation of gene expression] GO:0010595[positive regulation of endothelial cell migration] GO:0010629[negative regulation of gene expression] GO:0030316[osteoclast differentiation] GO:0032496[response to lipopolysaccharide] GO:0032651[regulation of interleukin-1 beta production] GO:0032655[regulation of interleukin-12 production] GO:0032680[regulation of tumor necrosis factor production] GO:0032745[positive regulation of interleukin-21 production] GO:0036035[osteoclast development] GO:0042116[macrophage activation] GO:0042117[monocyte activation] GO:0042118[endothelial cell activation] GO:0042802[identical protein binding] GO:0043565[sequence-specific DNA binding] GO:0043621[protein self-association] GO:0045655[regulation of monocyte differentiation] GO:0045892[negative regulation of DNA-templated transcription] GO:0046872[metal ion binding] GO:0048661[positive regulation of smooth muscle cell proliferation] GO:0050681[nuclear androgen receptor binding] GO:0050727[regulation of inflammatory response] GO:0050861[positive regulation of B cell receptor signaling pathway] GO:0060766[negative regulation of androgen receptor signaling pathway] GO:0061470[T follicular helper cell differentiation] GO:1900424[regulation of defense response to bacterium] GO:1901256[regulation of macrophage colony-stimulating factor production] GO:1901509[regulation of endothelial tube morphogenesis] GO:1990837[sequence-specific double-stranded DNA binding] GO:2000341[regulation of chemokine (C-X-C motif) ligand 2 production]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
A0A3B3ITZ4 [Direct mapping] Forkhead box protein P1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
A0A087X2G3 [Direct mapping] Forkhead box protein P1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Helix-turn-helix domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001046[core promoter sequence-specific DNA binding] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0002903[negative regulation of B cell apoptotic process] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006974[cellular response to DNA damage stimulus] GO:0010468[regulation of gene expression] GO:0010595[positive regulation of endothelial cell migration] GO:0010629[negative regulation of gene expression] GO:0030316[osteoclast differentiation] GO:0032496[response to lipopolysaccharide] GO:0032651[regulation of interleukin-1 beta production] GO:0032655[regulation of interleukin-12 production] GO:0032680[regulation of tumor necrosis factor production] GO:0032745[positive regulation of interleukin-21 production] GO:0036035[osteoclast development] GO:0042116[macrophage activation] GO:0042117[monocyte activation] GO:0042118[endothelial cell activation] GO:0042802[identical protein binding] GO:0043565[sequence-specific DNA binding] GO:0043621[protein self-association] GO:0045655[regulation of monocyte differentiation] GO:0045892[negative regulation of DNA-templated transcription] GO:0046872[metal ion binding] GO:0048661[positive regulation of smooth muscle cell proliferation] GO:0050681[nuclear androgen receptor binding] GO:0050727[regulation of inflammatory response] GO:0050861[positive regulation of B cell receptor signaling pathway] GO:0060766[negative regulation of androgen receptor signaling pathway] GO:0061470[T follicular helper cell differentiation] GO:1900424[regulation of defense response to bacterium] GO:1901256[regulation of macrophage colony-stimulating factor production] GO:1901509[regulation of endothelial tube morphogenesis] GO:1990837[sequence-specific double-stranded DNA binding] GO:2000341[regulation of chemokine (C-X-C motif) ligand 2 production]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
A0A0B4J2F3 [Direct mapping] Forkhead box protein P1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Helix-turn-helix domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001046[core promoter sequence-specific DNA binding] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0002903[negative regulation of B cell apoptotic process] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006974[cellular response to DNA damage stimulus] GO:0010468[regulation of gene expression] GO:0010595[positive regulation of endothelial cell migration] GO:0010629[negative regulation of gene expression] GO:0030316[osteoclast differentiation] GO:0032496[response to lipopolysaccharide] GO:0032651[regulation of interleukin-1 beta production] GO:0032655[regulation of interleukin-12 production] GO:0032680[regulation of tumor necrosis factor production] GO:0032745[positive regulation of interleukin-21 production] GO:0036035[osteoclast development] GO:0042116[macrophage activation] GO:0042117[monocyte activation] GO:0042118[endothelial cell activation] GO:0042802[identical protein binding] GO:0043565[sequence-specific DNA binding] GO:0043621[protein self-association] GO:0045655[regulation of monocyte differentiation] GO:0045892[negative regulation of DNA-templated transcription] GO:0046872[metal ion binding] GO:0048661[positive regulation of smooth muscle cell proliferation] GO:0050681[nuclear androgen receptor binding] GO:0050727[regulation of inflammatory response] GO:0050861[positive regulation of B cell receptor signaling pathway] GO:0060766[negative regulation of androgen receptor signaling pathway] GO:0061470[T follicular helper cell differentiation] GO:1900424[regulation of defense response to bacterium] GO:1901256[regulation of macrophage colony-stimulating factor production] GO:1901509[regulation of endothelial tube morphogenesis] GO:1990837[sequence-specific double-stranded DNA binding] GO:2000341[regulation of chemokine (C-X-C motif) ligand 2 production]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Helix-turn-helix domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001046[core promoter sequence-specific DNA binding] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0002903[negative regulation of B cell apoptotic process] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006974[cellular response to DNA damage stimulus] GO:0010468[regulation of gene expression] GO:0010595[positive regulation of endothelial cell migration] GO:0010629[negative regulation of gene expression] GO:0030316[osteoclast differentiation] GO:0032496[response to lipopolysaccharide] GO:0032651[regulation of interleukin-1 beta production] GO:0032655[regulation of interleukin-12 production] GO:0032680[regulation of tumor necrosis factor production] GO:0032745[positive regulation of interleukin-21 production] GO:0036035[osteoclast development] GO:0042116[macrophage activation] GO:0042117[monocyte activation] GO:0042118[endothelial cell activation] GO:0042802[identical protein binding] GO:0043565[sequence-specific DNA binding] GO:0043621[protein self-association] GO:0045655[regulation of monocyte differentiation] GO:0045892[negative regulation of DNA-templated transcription] GO:0046872[metal ion binding] GO:0048661[positive regulation of smooth muscle cell proliferation] GO:0050681[nuclear androgen receptor binding] GO:0050727[regulation of inflammatory response] GO:0050861[positive regulation of B cell receptor signaling pathway] GO:0060766[negative regulation of androgen receptor signaling pathway] GO:0061470[T follicular helper cell differentiation] GO:1900424[regulation of defense response to bacterium] GO:1901256[regulation of macrophage colony-stimulating factor production] GO:1901509[regulation of endothelial tube morphogenesis] GO:1990837[sequence-specific double-stranded DNA binding] GO:2000341[regulation of chemokine (C-X-C motif) ligand 2 production]
A0A0B4J2F3 [Direct mapping] Forkhead box protein P1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
A0A3B3IT26 [Direct mapping] Forkhead box protein P1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Helix-turn-helix domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001046[core promoter sequence-specific DNA binding] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0002903[negative regulation of B cell apoptotic process] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006974[cellular response to DNA damage stimulus] GO:0010468[regulation of gene expression] GO:0010595[positive regulation of endothelial cell migration] GO:0010629[negative regulation of gene expression] GO:0030316[osteoclast differentiation] GO:0032496[response to lipopolysaccharide] GO:0032651[regulation of interleukin-1 beta production] GO:0032655[regulation of interleukin-12 production] GO:0032680[regulation of tumor necrosis factor production] GO:0032745[positive regulation of interleukin-21 production] GO:0036035[osteoclast development] GO:0042116[macrophage activation] GO:0042117[monocyte activation] GO:0042118[endothelial cell activation] GO:0042802[identical protein binding] GO:0043565[sequence-specific DNA binding] GO:0043621[protein self-association] GO:0045655[regulation of monocyte differentiation] GO:0045892[negative regulation of DNA-templated transcription] GO:0046872[metal ion binding] GO:0048661[positive regulation of smooth muscle cell proliferation] GO:0050681[nuclear androgen receptor binding] GO:0050727[regulation of inflammatory response] GO:0050861[positive regulation of B cell receptor signaling pathway] GO:0060766[negative regulation of androgen receptor signaling pathway] GO:0061470[T follicular helper cell differentiation] GO:1900424[regulation of defense response to bacterium] GO:1901256[regulation of macrophage colony-stimulating factor production] GO:1901509[regulation of endothelial tube morphogenesis] GO:1990837[sequence-specific double-stranded DNA binding] GO:2000341[regulation of chemokine (C-X-C motif) ligand 2 production]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Helix-turn-helix domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001046[core promoter sequence-specific DNA binding] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0002903[negative regulation of B cell apoptotic process] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006974[cellular response to DNA damage stimulus] GO:0010468[regulation of gene expression] GO:0010595[positive regulation of endothelial cell migration] GO:0010629[negative regulation of gene expression] GO:0030316[osteoclast differentiation] GO:0032496[response to lipopolysaccharide] GO:0032651[regulation of interleukin-1 beta production] GO:0032655[regulation of interleukin-12 production] GO:0032680[regulation of tumor necrosis factor production] GO:0032745[positive regulation of interleukin-21 production] GO:0036035[osteoclast development] GO:0042116[macrophage activation] GO:0042117[monocyte activation] GO:0042118[endothelial cell activation] GO:0042802[identical protein binding] GO:0043565[sequence-specific DNA binding] GO:0043621[protein self-association] GO:0045655[regulation of monocyte differentiation] GO:0045892[negative regulation of DNA-templated transcription] GO:0046872[metal ion binding] GO:0048661[positive regulation of smooth muscle cell proliferation] GO:0050681[nuclear androgen receptor binding] GO:0050727[regulation of inflammatory response] GO:0050861[positive regulation of B cell receptor signaling pathway] GO:0060766[negative regulation of androgen receptor signaling pathway] GO:0061470[T follicular helper cell differentiation] GO:1900424[regulation of defense response to bacterium] GO:1901256[regulation of macrophage colony-stimulating factor production] GO:1901509[regulation of endothelial tube morphogenesis] GO:1990837[sequence-specific double-stranded DNA binding] GO:2000341[regulation of chemokine (C-X-C motif) ligand 2 production]
A0A3B3IST0 [Direct mapping] Forkhead box protein P1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Helix-turn-helix domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001046[core promoter sequence-specific DNA binding] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0002903[negative regulation of B cell apoptotic process] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006974[cellular response to DNA damage stimulus] GO:0010468[regulation of gene expression] GO:0010595[positive regulation of endothelial cell migration] GO:0010629[negative regulation of gene expression] GO:0030316[osteoclast differentiation] GO:0032496[response to lipopolysaccharide] GO:0032651[regulation of interleukin-1 beta production] GO:0032655[regulation of interleukin-12 production] GO:0032680[regulation of tumor necrosis factor production] GO:0032745[positive regulation of interleukin-21 production] GO:0036035[osteoclast development] GO:0042116[macrophage activation] GO:0042117[monocyte activation] GO:0042118[endothelial cell activation] GO:0042802[identical protein binding] GO:0043565[sequence-specific DNA binding] GO:0043621[protein self-association] GO:0045655[regulation of monocyte differentiation] GO:0045892[negative regulation of DNA-templated transcription] GO:0046872[metal ion binding] GO:0048661[positive regulation of smooth muscle cell proliferation] GO:0050681[nuclear androgen receptor binding] GO:0050727[regulation of inflammatory response] GO:0050861[positive regulation of B cell receptor signaling pathway] GO:0060766[negative regulation of androgen receptor signaling pathway] GO:0061470[T follicular helper cell differentiation] GO:1900424[regulation of defense response to bacterium] GO:1901256[regulation of macrophage colony-stimulating factor production] GO:1901509[regulation of endothelial tube morphogenesis] GO:1990837[sequence-specific double-stranded DNA binding] GO:2000341[regulation of chemokine (C-X-C motif) ligand 2 production]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Helix-turn-helix domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001046[core promoter sequence-specific DNA binding] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0002903[negative regulation of B cell apoptotic process] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006974[cellular response to DNA damage stimulus] GO:0010468[regulation of gene expression] GO:0010595[positive regulation of endothelial cell migration] GO:0010629[negative regulation of gene expression] GO:0030316[osteoclast differentiation] GO:0032496[response to lipopolysaccharide] GO:0032651[regulation of interleukin-1 beta production] GO:0032655[regulation of interleukin-12 production] GO:0032680[regulation of tumor necrosis factor production] GO:0032745[positive regulation of interleukin-21 production] GO:0036035[osteoclast development] GO:0042116[macrophage activation] GO:0042117[monocyte activation] GO:0042118[endothelial cell activation] GO:0042802[identical protein binding] GO:0043565[sequence-specific DNA binding] GO:0043621[protein self-association] GO:0045655[regulation of monocyte differentiation] GO:0045892[negative regulation of DNA-templated transcription] GO:0046872[metal ion binding] GO:0048661[positive regulation of smooth muscle cell proliferation] GO:0050681[nuclear androgen receptor binding] GO:0050727[regulation of inflammatory response] GO:0050861[positive regulation of B cell receptor signaling pathway] GO:0060766[negative regulation of androgen receptor signaling pathway] GO:0061470[T follicular helper cell differentiation] GO:1900424[regulation of defense response to bacterium] GO:1901256[regulation of macrophage colony-stimulating factor production] GO:1901509[regulation of endothelial tube morphogenesis] GO:1990837[sequence-specific double-stranded DNA binding] GO:2000341[regulation of chemokine (C-X-C motif) ligand 2 production]
A0A3B3IT66 [Direct mapping] Forkhead box protein P1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
A0A3B3ITZ4 [Direct mapping] Forkhead box protein P1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
A0A0B4J2F3 [Direct mapping] Forkhead box protein P1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
A0A3B3ISQ7 [Direct mapping] Forkhead box protein P1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
A0A3B3IUB6 [Direct mapping] Forkhead box protein P1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
A0A3B3IS87 [Direct mapping] Forkhead box protein P1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Helix-turn-helix domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001046[core promoter sequence-specific DNA binding] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0002903[negative regulation of B cell apoptotic process] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006974[cellular response to DNA damage stimulus] GO:0010468[regulation of gene expression] GO:0010595[positive regulation of endothelial cell migration] GO:0010629[negative regulation of gene expression] GO:0021756[striatum development] GO:0030316[osteoclast differentiation] GO:0030900[forebrain development] GO:0032496[response to lipopolysaccharide] GO:0032651[regulation of interleukin-1 beta production] GO:0032655[regulation of interleukin-12 production] GO:0032680[regulation of tumor necrosis factor production] GO:0032745[positive regulation of interleukin-21 production] GO:0033574[response to testosterone] GO:0036035[osteoclast development] GO:0042116[macrophage activation] GO:0042117[monocyte activation] GO:0042118[endothelial cell activation] GO:0042802[identical protein binding] GO:0043565[sequence-specific DNA binding] GO:0043621[protein self-association] GO:0045655[regulation of monocyte differentiation] GO:0045892[negative regulation of DNA-templated transcription] GO:0046872[metal ion binding] GO:0048661[positive regulation of smooth muscle cell proliferation] GO:0050681[nuclear androgen receptor binding] GO:0050727[regulation of inflammatory response] GO:0050861[positive regulation of B cell receptor signaling pathway] GO:0060766[negative regulation of androgen receptor signaling pathway] GO:0061052[negative regulation of cell growth involved in cardiac muscle cell development] GO:0061470[T follicular helper cell differentiation] GO:0071356[cellular response to tumor necrosis factor] GO:1900424[regulation of defense response to bacterium] GO:1901256[regulation of macrophage colony-stimulating factor production] GO:1901509[regulation of endothelial tube morphogenesis] GO:1905206[positive regulation of hydrogen peroxide-induced cell death] GO:1990837[sequence-specific double-stranded DNA binding] GO:2000341[regulation of chemokine (C-X-C motif) ligand 2 production]
A0A3B3IT66 [Direct mapping] Forkhead box protein P1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
A0A3B3IST0 [Direct mapping] Forkhead box protein P1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Helix-turn-helix domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001046[core promoter sequence-specific DNA binding] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0002903[negative regulation of B cell apoptotic process] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006974[cellular response to DNA damage stimulus] GO:0010468[regulation of gene expression] GO:0010595[positive regulation of endothelial cell migration] GO:0010629[negative regulation of gene expression] GO:0030316[osteoclast differentiation] GO:0032496[response to lipopolysaccharide] GO:0032651[regulation of interleukin-1 beta production] GO:0032655[regulation of interleukin-12 production] GO:0032680[regulation of tumor necrosis factor production] GO:0032745[positive regulation of interleukin-21 production] GO:0036035[osteoclast development] GO:0042116[macrophage activation] GO:0042117[monocyte activation] GO:0042118[endothelial cell activation] GO:0042802[identical protein binding] GO:0043565[sequence-specific DNA binding] GO:0043621[protein self-association] GO:0045655[regulation of monocyte differentiation] GO:0045892[negative regulation of DNA-templated transcription] GO:0046872[metal ion binding] GO:0048661[positive regulation of smooth muscle cell proliferation] GO:0050681[nuclear androgen receptor binding] GO:0050727[regulation of inflammatory response] GO:0050861[positive regulation of B cell receptor signaling pathway] GO:0060766[negative regulation of androgen receptor signaling pathway] GO:0061470[T follicular helper cell differentiation] GO:1900424[regulation of defense response to bacterium] GO:1901256[regulation of macrophage colony-stimulating factor production] GO:1901509[regulation of endothelial tube morphogenesis] GO:1990837[sequence-specific double-stranded DNA binding] GO:2000341[regulation of chemokine (C-X-C motif) ligand 2 production]
A0A3B3IRW5 [Direct mapping] Forkhead box protein P1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Helix-turn-helix domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001046[core promoter sequence-specific DNA binding] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0002903[negative regulation of B cell apoptotic process] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006974[cellular response to DNA damage stimulus] GO:0010468[regulation of gene expression] GO:0010595[positive regulation of endothelial cell migration] GO:0010629[negative regulation of gene expression] GO:0030316[osteoclast differentiation] GO:0032496[response to lipopolysaccharide] GO:0032651[regulation of interleukin-1 beta production] GO:0032655[regulation of interleukin-12 production] GO:0032680[regulation of tumor necrosis factor production] GO:0032745[positive regulation of interleukin-21 production] GO:0036035[osteoclast development] GO:0042116[macrophage activation] GO:0042117[monocyte activation] GO:0042118[endothelial cell activation] GO:0042802[identical protein binding] GO:0043565[sequence-specific DNA binding] GO:0043621[protein self-association] GO:0045655[regulation of monocyte differentiation] GO:0045892[negative regulation of DNA-templated transcription] GO:0046872[metal ion binding] GO:0048661[positive regulation of smooth muscle cell proliferation] GO:0050681[nuclear androgen receptor binding] GO:0050727[regulation of inflammatory response] GO:0050861[positive regulation of B cell receptor signaling pathway] GO:0060766[negative regulation of androgen receptor signaling pathway] GO:0061470[T follicular helper cell differentiation] GO:1900424[regulation of defense response to bacterium] GO:1901256[regulation of macrophage colony-stimulating factor production] GO:1901509[regulation of endothelial tube morphogenesis] GO:1990837[sequence-specific double-stranded DNA binding] GO:2000341[regulation of chemokine (C-X-C motif) ligand 2 production]
A0A3B3IRL7 [Direct mapping] Forkhead box protein P1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
A0A3B3IRW5 [Direct mapping] Forkhead box protein P1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
A0A3B3IRY1 [Direct mapping] Forkhead box protein P1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
A0A3B3IT66 [Direct mapping] Forkhead box protein P1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
