GENERAL INFORMATIONi
Gene namei EIF4G1
Synonyms EIF4F, EIF4G, p220, PARK18
Gene descriptioni Eukaryotic translation initiation factor 4 gamma 1
Protein classi Cancer-related genes
Disease related genes
Human disease related genes
Plasma proteins
Predicted locationi Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi
Chromosome 3
Cytoband q27.1
Chromosome location (bp) 184314495 - 184335358
Number of transcriptsi 26
Ensembl ENSG00000114867 (version 109)
Entrez gene 1981
HGNC HGNC:3296
UniProt Q04637 (UniProt - Evidence at protein level)
neXtProt NX_Q04637
GeneCards EIF4G1
Antibodypedia EIF4G1 antibodies


PROTEIN FUNCTION
Protein function (UniProt)i Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome 1. Exists in two complexes, either with EIF1 or with EIF4E (mutually exclusive) 2. Together with EIF1, is required for leaky scanning, in particular for avoiding cap-proximal start codon 3. Together with EIF4E, antagonizes the scanning promoted by EIF1-EIF4G1 and locates the start codon (through a TISU element) without scanning 4. As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation 5. show less
Molecular function (UniProt)i Initiation factor, RNA-binding, Translational shunt
Biological process (UniProt)i Host-virus interaction, Protein biosynthesis, Translation regulation
Gene summary (Entrez)i The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5'-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage. [provided by RefSeq, Aug 2010] show less
PROTEIN INFORMATIONi
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
EIF4G1-201
ENSP00000343450
ENST00000342981
Q04637
[Direct mapping] Eukaryotic translation initiation factor 4 gamma 1
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002191 [cap-dependent translational initiation]
GO:0003723 [RNA binding]
GO:0003729 [mRNA binding]
GO:0003743 [translation initiation factor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005844 [polysome]
GO:0006412 [translation]
GO:0006413 [translational initiation]
GO:0006417 [regulation of translation]
GO:0006446 [regulation of translational initiation]
GO:0008135 [translation factor activity, RNA binding]
GO:0008190 [eukaryotic initiation factor 4E binding]
GO:0010494 [cytoplasmic stress granule]
GO:0010507 [negative regulation of autophagy]
GO:0010801 [negative regulation of peptidyl-threonine phosphorylation]
GO:0010942 [positive regulation of cell death]
GO:0016020 [membrane]
GO:0016281 [eukaryotic translation initiation factor 4F complex]
GO:0030307 [positive regulation of cell growth]
GO:0031369 [translation initiation factor binding]
GO:0031669 [cellular response to nutrient levels]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0034645 [cellular macromolecule biosynthetic process]
GO:0035278 [miRNA-mediated gene silencing by inhibition of translation]
GO:0036493 [positive regulation of translation in response to endoplasmic reticulum stress]
GO:0042802 [identical protein binding]
GO:0051247 [positive regulation of protein metabolic process]
GO:0060090 [molecular adaptor activity]
GO:0060964 [regulation of miRNA-mediated gene silencing]
GO:0080135 [regulation of cellular response to stress]
GO:0097009 [energy homeostasis]
GO:1900087 [positive regulation of G1/S transition of mitotic cell cycle]
GO:1901215 [negative regulation of neuron death]
GO:1905537 [positive regulation of eukaryotic translation initiation factor 4F complex assembly]
GO:1905606 [regulation of presynapse assembly]
GO:1905612 [positive regulation of mRNA cap binding]
GO:1905696 [regulation of polysome binding]
Show all
 1600 aa
175.6 kDa 		No 0
EIF4G1-202
ENSP00000316879
ENST00000346169
Q04637
[Direct mapping] Eukaryotic translation initiation factor 4 gamma 1
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001662 [behavioral fear response]
GO:0002191 [cap-dependent translational initiation]
GO:0003723 [RNA binding]
GO:0003729 [mRNA binding]
GO:0003743 [translation initiation factor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005844 [polysome]
GO:0006412 [translation]
GO:0006413 [translational initiation]
GO:0006417 [regulation of translation]
GO:0006446 [regulation of translational initiation]
GO:0008135 [translation factor activity, RNA binding]
GO:0008190 [eukaryotic initiation factor 4E binding]
GO:0010494 [cytoplasmic stress granule]
GO:0010507 [negative regulation of autophagy]
GO:0010801 [negative regulation of peptidyl-threonine phosphorylation]
GO:0010942 [positive regulation of cell death]
GO:0016020 [membrane]
GO:0016281 [eukaryotic translation initiation factor 4F complex]
GO:0030182 [neuron differentiation]
GO:0030307 [positive regulation of cell growth]
GO:0030324 [lung development]
GO:0031369 [translation initiation factor binding]
GO:0031669 [cellular response to nutrient levels]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0034645 [cellular macromolecule biosynthetic process]
GO:0035278 [miRNA-mediated gene silencing by inhibition of translation]
GO:0036493 [positive regulation of translation in response to endoplasmic reticulum stress]
GO:0042802 [identical protein binding]
GO:0045471 [response to ethanol]
GO:0045666 [positive regulation of neuron differentiation]
GO:0051247 [positive regulation of protein metabolic process]
GO:0060090 [molecular adaptor activity]
GO:0060964 [regulation of miRNA-mediated gene silencing]
GO:0080135 [regulation of cellular response to stress]
GO:0097009 [energy homeostasis]
GO:0098794 [postsynapse]
GO:1900087 [positive regulation of G1/S transition of mitotic cell cycle]
GO:1901215 [negative regulation of neuron death]
GO:1905537 [positive regulation of eukaryotic translation initiation factor 4F complex assembly]
GO:1905606 [regulation of presynapse assembly]
GO:1905612 [positive regulation of mRNA cap binding]
GO:1905696 [regulation of polysome binding]
Show all
 1599 aa
175.5 kDa 		No 0
EIF4G1-203
ENSP00000317600
ENST00000350481
Q04637
[Direct mapping] Eukaryotic translation initiation factor 4 gamma 1
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002191 [cap-dependent translational initiation]
GO:0003723 [RNA binding]
GO:0003729 [mRNA binding]
GO:0003743 [translation initiation factor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005844 [polysome]
GO:0006412 [translation]
GO:0006413 [translational initiation]
GO:0006417 [regulation of translation]
GO:0006446 [regulation of translational initiation]
GO:0008135 [translation factor activity, RNA binding]
GO:0008190 [eukaryotic initiation factor 4E binding]
GO:0010494 [cytoplasmic stress granule]
GO:0010507 [negative regulation of autophagy]
GO:0010801 [negative regulation of peptidyl-threonine phosphorylation]
GO:0010942 [positive regulation of cell death]
GO:0016020 [membrane]
GO:0016281 [eukaryotic translation initiation factor 4F complex]
GO:0030307 [positive regulation of cell growth]
GO:0031369 [translation initiation factor binding]
GO:0031669 [cellular response to nutrient levels]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0034645 [cellular macromolecule biosynthetic process]
GO:0035278 [miRNA-mediated gene silencing by inhibition of translation]
GO:0036493 [positive regulation of translation in response to endoplasmic reticulum stress]
GO:0042802 [identical protein binding]
GO:0051247 [positive regulation of protein metabolic process]
GO:0060090 [molecular adaptor activity]
GO:0060964 [regulation of miRNA-mediated gene silencing]
GO:0080135 [regulation of cellular response to stress]
GO:0097009 [energy homeostasis]
GO:1900087 [positive regulation of G1/S transition of mitotic cell cycle]
GO:1901215 [negative regulation of neuron death]
GO:1905537 [positive regulation of eukaryotic translation initiation factor 4F complex assembly]
GO:1905606 [regulation of presynapse assembly]
GO:1905612 [positive regulation of mRNA cap binding]
GO:1905696 [regulation of polysome binding]
Show all
 1435 aa
158.5 kDa 		No 0
EIF4G1-204
ENSP00000338020
ENST00000352767
Q04637
[Direct mapping] Eukaryotic translation initiation factor 4 gamma 1
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002191 [cap-dependent translational initiation]
GO:0003723 [RNA binding]
GO:0003729 [mRNA binding]
GO:0003743 [translation initiation factor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005844 [polysome]
GO:0006412 [translation]
GO:0006413 [translational initiation]
GO:0006417 [regulation of translation]
GO:0006446 [regulation of translational initiation]
GO:0008135 [translation factor activity, RNA binding]
GO:0008190 [eukaryotic initiation factor 4E binding]
GO:0010494 [cytoplasmic stress granule]
GO:0010507 [negative regulation of autophagy]
GO:0010801 [negative regulation of peptidyl-threonine phosphorylation]
GO:0010942 [positive regulation of cell death]
GO:0016020 [membrane]
GO:0016281 [eukaryotic translation initiation factor 4F complex]
GO:0030307 [positive regulation of cell growth]
GO:0031369 [translation initiation factor binding]
GO:0031669 [cellular response to nutrient levels]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0034645 [cellular macromolecule biosynthetic process]
GO:0035278 [miRNA-mediated gene silencing by inhibition of translation]
GO:0036493 [positive regulation of translation in response to endoplasmic reticulum stress]
GO:0042802 [identical protein binding]
GO:0051247 [positive regulation of protein metabolic process]
GO:0060090 [molecular adaptor activity]
GO:0060964 [regulation of miRNA-mediated gene silencing]
GO:0080135 [regulation of cellular response to stress]
GO:0097009 [energy homeostasis]
GO:1900087 [positive regulation of G1/S transition of mitotic cell cycle]
GO:1901215 [negative regulation of neuron death]
GO:1905537 [positive regulation of eukaryotic translation initiation factor 4F complex assembly]
GO:1905606 [regulation of presynapse assembly]
GO:1905612 [positive regulation of mRNA cap binding]
GO:1905696 [regulation of polysome binding]
Show all
 1606 aa
176.2 kDa 		No 0
EIF4G1-205
ENSP00000371767
ENST00000382330
Q04637
[Direct mapping] Eukaryotic translation initiation factor 4 gamma 1
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002191 [cap-dependent translational initiation]
GO:0003723 [RNA binding]
GO:0003729 [mRNA binding]
GO:0003743 [translation initiation factor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005844 [polysome]
GO:0006412 [translation]
GO:0006413 [translational initiation]
GO:0006417 [regulation of translation]
GO:0006446 [regulation of translational initiation]
GO:0008135 [translation factor activity, RNA binding]
GO:0008190 [eukaryotic initiation factor 4E binding]
GO:0010494 [cytoplasmic stress granule]
GO:0010507 [negative regulation of autophagy]
GO:0010801 [negative regulation of peptidyl-threonine phosphorylation]
GO:0010942 [positive regulation of cell death]
GO:0016020 [membrane]
GO:0016281 [eukaryotic translation initiation factor 4F complex]
GO:0030307 [positive regulation of cell growth]
GO:0031369 [translation initiation factor binding]
GO:0031669 [cellular response to nutrient levels]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0034645 [cellular macromolecule biosynthetic process]
GO:0035278 [miRNA-mediated gene silencing by inhibition of translation]
GO:0036493 [positive regulation of translation in response to endoplasmic reticulum stress]
GO:0042802 [identical protein binding]
GO:0051247 [positive regulation of protein metabolic process]
GO:0060090 [molecular adaptor activity]
GO:0060964 [regulation of miRNA-mediated gene silencing]
GO:0080135 [regulation of cellular response to stress]
GO:0097009 [energy homeostasis]
GO:1900087 [positive regulation of G1/S transition of mitotic cell cycle]
GO:1901215 [negative regulation of neuron death]
GO:1905537 [positive regulation of eukaryotic translation initiation factor 4F complex assembly]
GO:1905606 [regulation of presynapse assembly]
GO:1905612 [positive regulation of mRNA cap binding]
GO:1905696 [regulation of polysome binding]
Show all
 1606 aa
176.2 kDa 		No 0
EIF4G1-206
ENSP00000376320
ENST00000392537
Q04637
[Direct mapping] Eukaryotic translation initiation factor 4 gamma 1
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002191 [cap-dependent translational initiation]
GO:0003723 [RNA binding]
GO:0003729 [mRNA binding]
GO:0003743 [translation initiation factor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005844 [polysome]
GO:0006412 [translation]
GO:0006413 [translational initiation]
GO:0006417 [regulation of translation]
GO:0006446 [regulation of translational initiation]
GO:0008135 [translation factor activity, RNA binding]
GO:0008190 [eukaryotic initiation factor 4E binding]
GO:0010494 [cytoplasmic stress granule]
GO:0010507 [negative regulation of autophagy]
GO:0010801 [negative regulation of peptidyl-threonine phosphorylation]
GO:0010942 [positive regulation of cell death]
GO:0016020 [membrane]
GO:0016281 [eukaryotic translation initiation factor 4F complex]
GO:0030307 [positive regulation of cell growth]
GO:0031369 [translation initiation factor binding]
GO:0031669 [cellular response to nutrient levels]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0034645 [cellular macromolecule biosynthetic process]
GO:0035278 [miRNA-mediated gene silencing by inhibition of translation]
GO:0036493 [positive regulation of translation in response to endoplasmic reticulum stress]
GO:0042802 [identical protein binding]
GO:0051247 [positive regulation of protein metabolic process]
GO:0060090 [molecular adaptor activity]
GO:0060964 [regulation of miRNA-mediated gene silencing]
GO:0080135 [regulation of cellular response to stress]
GO:0097009 [energy homeostasis]
GO:1900087 [positive regulation of G1/S transition of mitotic cell cycle]
GO:1901215 [negative regulation of neuron death]
GO:1905537 [positive regulation of eukaryotic translation initiation factor 4F complex assembly]
GO:1905606 [regulation of presynapse assembly]
GO:1905612 [positive regulation of mRNA cap binding]
GO:1905696 [regulation of polysome binding]
Show all
 1512 aa
166.6 kDa 		No 0
EIF4G1-207
ENSP00000395974
ENST00000411531
E7EUU4
[Direct mapping] Eukaryotic translation initiation factor 4 gamma 1
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0003729 [mRNA binding]
GO:0003743 [translation initiation factor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006412 [translation]
GO:0006413 [translational initiation]
GO:0008190 [eukaryotic initiation factor 4E binding]
Show all
 1560 aa
171.6 kDa 		No 0
EIF4G1-209
ENSP00000391935
ENST00000414031
Q04637
[Direct mapping] Eukaryotic translation initiation factor 4 gamma 1
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002191 [cap-dependent translational initiation]
GO:0003723 [RNA binding]
GO:0003729 [mRNA binding]
GO:0003743 [translation initiation factor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005844 [polysome]
GO:0006412 [translation]
GO:0006413 [translational initiation]
GO:0006417 [regulation of translation]
GO:0006446 [regulation of translational initiation]
GO:0008135 [translation factor activity, RNA binding]
GO:0008190 [eukaryotic initiation factor 4E binding]
GO:0010494 [cytoplasmic stress granule]
GO:0010507 [negative regulation of autophagy]
GO:0010801 [negative regulation of peptidyl-threonine phosphorylation]
GO:0010942 [positive regulation of cell death]
GO:0016020 [membrane]
GO:0016281 [eukaryotic translation initiation factor 4F complex]
GO:0030307 [positive regulation of cell growth]
GO:0031369 [translation initiation factor binding]
GO:0031669 [cellular response to nutrient levels]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0034645 [cellular macromolecule biosynthetic process]
GO:0035278 [miRNA-mediated gene silencing by inhibition of translation]
GO:0036493 [positive regulation of translation in response to endoplasmic reticulum stress]
GO:0042802 [identical protein binding]
GO:0051247 [positive regulation of protein metabolic process]
GO:0060090 [molecular adaptor activity]
GO:0060964 [regulation of miRNA-mediated gene silencing]
GO:0080135 [regulation of cellular response to stress]
GO:0097009 [energy homeostasis]
GO:1900087 [positive regulation of G1/S transition of mitotic cell cycle]
GO:1901215 [negative regulation of neuron death]
GO:1905537 [positive regulation of eukaryotic translation initiation factor 4F complex assembly]
GO:1905606 [regulation of presynapse assembly]
GO:1905612 [positive regulation of mRNA cap binding]
GO:1905696 [regulation of polysome binding]
Show all
 1559 aa
171.5 kDa 		No 0
EIF4G1-210
ENSP00000413159
ENST00000421110
C9K073
[Direct mapping] Eukaryotic translation initiation factor 4 gamma 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0003729 [mRNA binding]
GO:0003743 [translation initiation factor activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006413 [translational initiation]
Show all
 869 aa
93.4 kDa 		No 0
EIF4G1-212
ENSP00000416255
ENST00000424196
Q04637
[Direct mapping] Eukaryotic translation initiation factor 4 gamma 1
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002191 [cap-dependent translational initiation]
GO:0003723 [RNA binding]
GO:0003729 [mRNA binding]
GO:0003743 [translation initiation factor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005844 [polysome]
GO:0006412 [translation]
GO:0006413 [translational initiation]
GO:0006417 [regulation of translation]
GO:0006446 [regulation of translational initiation]
GO:0008135 [translation factor activity, RNA binding]
GO:0008190 [eukaryotic initiation factor 4E binding]
GO:0010494 [cytoplasmic stress granule]
GO:0010507 [negative regulation of autophagy]
GO:0010801 [negative regulation of peptidyl-threonine phosphorylation]
GO:0010942 [positive regulation of cell death]
GO:0016020 [membrane]
GO:0016281 [eukaryotic translation initiation factor 4F complex]
GO:0030307 [positive regulation of cell growth]
GO:0031369 [translation initiation factor binding]
GO:0031669 [cellular response to nutrient levels]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0034645 [cellular macromolecule biosynthetic process]
GO:0035278 [miRNA-mediated gene silencing by inhibition of translation]
GO:0036493 [positive regulation of translation in response to endoplasmic reticulum stress]
GO:0042802 [identical protein binding]
GO:0051247 [positive regulation of protein metabolic process]
GO:0060090 [molecular adaptor activity]
GO:0060964 [regulation of miRNA-mediated gene silencing]
GO:0080135 [regulation of cellular response to stress]
GO:0097009 [energy homeostasis]
GO:1900087 [positive regulation of G1/S transition of mitotic cell cycle]
GO:1901215 [negative regulation of neuron death]
GO:1905537 [positive regulation of eukaryotic translation initiation factor 4F complex assembly]
GO:1905606 [regulation of presynapse assembly]
GO:1905612 [positive regulation of mRNA cap binding]
GO:1905696 [regulation of polysome binding]
Show all
 1606 aa
176.2 kDa 		No 0
EIF4G1-213
ENSP00000403269
ENST00000426123
C9JF13
[Direct mapping] Eukaryotic translation initiation factor 4 gamma 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0003729 [mRNA binding]
GO:0003743 [translation initiation factor activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006413 [translational initiation]
Show all
 903 aa
98.2 kDa 		No 0
EIF4G1-214
ENSP00000411214
ENST00000427141
C9J987
[Direct mapping] Eukaryotic translation initiation factor 4 gamma 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003729 [mRNA binding]
GO:0003743 [translation initiation factor activity]
Show all
 92 aa
9.9 kDa 		No 0
EIF4G1-215
ENSP00000409545
ENST00000427607
C9JSU8
[Direct mapping] Eukaryotic translation initiation factor 4 gamma 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003729 [mRNA binding]
GO:0003743 [translation initiation factor activity]
Show all
 163 aa
16.9 kDa 		No 0
EIF4G1-216
ENSP00000407682
ENST00000427845
E9PGM1
[Direct mapping] Eukaryotic translation initiation factor 4 gamma 1
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0003729 [mRNA binding]
GO:0003743 [translation initiation factor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006412 [translation]
GO:0006413 [translational initiation]
GO:0008190 [eukaryotic initiation factor 4E binding]
Show all
 1513 aa
166.7 kDa 		No 0
EIF4G1-217
ENSP00000411707
ENST00000428387
C9J556
[Direct mapping] Eukaryotic translation initiation factor 4 gamma 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003729 [mRNA binding]
GO:0003743 [translation initiation factor activity]
Show all
 143 aa
14.8 kDa 		No 0
EIF4G1-218
ENSP00000411826
ENST00000434061
Q04637
[Direct mapping] Eukaryotic translation initiation factor 4 gamma 1
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002191 [cap-dependent translational initiation]
GO:0003723 [RNA binding]
GO:0003729 [mRNA binding]
GO:0003743 [translation initiation factor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005844 [polysome]
GO:0006412 [translation]
GO:0006413 [translational initiation]
GO:0006417 [regulation of translation]
GO:0006446 [regulation of translational initiation]
GO:0008135 [translation factor activity, RNA binding]
GO:0008190 [eukaryotic initiation factor 4E binding]
GO:0010494 [cytoplasmic stress granule]
GO:0010507 [negative regulation of autophagy]
GO:0010801 [negative regulation of peptidyl-threonine phosphorylation]
GO:0010942 [positive regulation of cell death]
GO:0016020 [membrane]
GO:0016281 [eukaryotic translation initiation factor 4F complex]
GO:0030307 [positive regulation of cell growth]
GO:0031369 [translation initiation factor binding]
GO:0031669 [cellular response to nutrient levels]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0034645 [cellular macromolecule biosynthetic process]
GO:0035278 [miRNA-mediated gene silencing by inhibition of translation]
GO:0036493 [positive regulation of translation in response to endoplasmic reticulum stress]
GO:0042802 [identical protein binding]
GO:0051247 [positive regulation of protein metabolic process]
GO:0060090 [molecular adaptor activity]
GO:0060964 [regulation of miRNA-mediated gene silencing]
GO:0080135 [regulation of cellular response to stress]
GO:0097009 [energy homeostasis]
GO:1900087 [positive regulation of G1/S transition of mitotic cell cycle]
GO:1901215 [negative regulation of neuron death]
GO:1905537 [positive regulation of eukaryotic translation initiation factor 4F complex assembly]
GO:1905606 [regulation of presynapse assembly]
GO:1905612 [positive regulation of mRNA cap binding]
GO:1905696 [regulation of polysome binding]
Show all
 1404 aa
154.9 kDa 		No 0
EIF4G1-219
ENSP00000404754
ENST00000435046
A0A7I2Y1C3
[Direct mapping] Eukaryotic translation initiation factor 4 gamma 1
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0003729 [mRNA binding]
GO:0003743 [translation initiation factor activity]
GO:0005515 [protein binding]
GO:0006412 [translation]
GO:0006413 [translational initiation]
Show all
 1577 aa
173.1 kDa 		No 0
EIF4G1-220
ENSP00000407240
ENST00000440448
C9JWH9
[Direct mapping] Eukaryotic translation initiation factor 4 gamma 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003729 [mRNA binding]
GO:0003743 [translation initiation factor activity]
Show all
 143 aa
14.8 kDa 		No 0
EIF4G1-221
ENSP00000399858
ENST00000441154
E7EX73
[Direct mapping] Eukaryotic translation initiation factor 4 gamma 1
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0003729 [mRNA binding]
GO:0003743 [translation initiation factor activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006412 [translation]
GO:0006413 [translational initiation]
Show all
 1436 aa
158.6 kDa 		No 0
EIF4G1-223
ENSP00000407244
ENST00000444134
C9JWH7
[Direct mapping] Eukaryotic translation initiation factor 4 gamma 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003729 [mRNA binding]
GO:0003743 [translation initiation factor activity]
Show all
 127 aa
13 kDa 		No 0
EIF4G1-224
ENSP00000398145
ENST00000444861
C9J6B6
[Direct mapping] Eukaryotic translation initiation factor 4 gamma 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0003729 [mRNA binding]
GO:0003743 [translation initiation factor activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006413 [translational initiation]
Show all
 757 aa
82.5 kDa 		No 0
EIF4G1-225
ENSP00000392908
ENST00000448284
H7C044
[Direct mapping] Eukaryotic translation initiation factor 4 gamma 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0003729 [mRNA binding]
GO:0003743 [translation initiation factor activity]
GO:0005515 [protein binding]
GO:0006413 [translational initiation]
Show all
 226 aa
24.7 kDa 		No 0
EIF4G1-226
ENSP00000391412
ENST00000450424
C9J2Z7
[Direct mapping] Eukaryotic translation initiation factor 4 gamma 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0003729 [mRNA binding]
GO:0003743 [translation initiation factor activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006413 [translational initiation]
Show all
 833 aa
89.1 kDa 		No 0
EIF4G1-227
ENSP00000415842
ENST00000455679
C9JIH5
[Direct mapping] Eukaryotic translation initiation factor 4 gamma 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003729 [mRNA binding]
GO:0003743 [translation initiation factor activity]
Show all
 87 aa
9.2 kDa 		No 0
EIF4G1-228
ENSP00000415943
ENST00000456033
C9JHW9
[Direct mapping] Eukaryotic translation initiation factor 4 gamma 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003729 [mRNA binding]
GO:0003743 [translation initiation factor activity]
Show all
 160 aa
17 kDa 		No 0
EIF4G1-229
ENSP00000399969
ENST00000457456
C9JWW9
[Direct mapping] Eukaryotic translation initiation factor 4 gamma 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003729 [mRNA binding]
GO:0003743 [translation initiation factor activity]
GO:0005829 [cytosol]
Show all
 285 aa
29.3 kDa 		No 0

Contact

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The Human Protein Atlas

The Human Protein Atlas project is funded
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contact@proteinatlas.org