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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Human disease related genes Plasma proteins Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
2
Cytoband
q14.1
Chromosome location (bp)
112773925 - 112784493
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Cytokine constitutively present intracellularly in nearly all resting non-hematopoietic cells that plays an important role in inflammation and bridges the innate and adaptive immune systems 1. After binding to its receptor IL1R1 together with its accessory protein IL1RAP, forms the high affinity interleukin-1 receptor complex 2,3. Signaling involves the recruitment of adapter molecules such as MYD88, IRAK1 or IRAK4 4. In turn, mediates the activation of NF-kappa-B and the three MAPK pathways p38, p42/p44 and JNK pathways 5. Within the cell, acts as an alarmin and cell death results in its liberation in the extracellular space after disruption of the cell membrane to induce inflammation and alert the host to injury or damage 6. In addition to its role as a danger signal, which occurs when the cytokine is passively released by cell necrosis, directly senses DNA damage and acts as a signal for genotoxic stress without loss of cell integrity 7....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Cytokine, Mitogen, Pyrogen
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Inflammatory response
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Transporters Transporter channels and pores Predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Candidate cancer biomarkers Human disease related genes Immune system diseases Allergies and autoimmune diseases Skin diseases Skin and soft tissue diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001660[fever generation] GO:0001666[response to hypoxia] GO:0001819[positive regulation of cytokine production] GO:0002248[connective tissue replacement involved in inflammatory response wound healing] GO:0002526[acute inflammatory response] GO:0005125[cytokine activity] GO:0005149[interleukin-1 receptor binding] GO:0005507[copper ion binding] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006883[cellular sodium ion homeostasis] GO:0006915[apoptotic process] GO:0006954[inflammatory response] GO:0006955[immune response] GO:0007283[spermatogenesis] GO:0007507[heart development] GO:0008285[negative regulation of cell population proliferation] GO:0009408[response to heat] GO:0009986[cell surface] GO:0010033[response to organic substance] GO:0010193[response to ozone] GO:0010243[response to organonitrogen compound] GO:0010332[response to gamma radiation] GO:0010575[positive regulation of vascular endothelial growth factor production] GO:0010628[positive regulation of gene expression] GO:0010893[positive regulation of steroid biosynthetic process] GO:0014070[response to organic cyclic compound] GO:0019221[cytokine-mediated signaling pathway] GO:0031424[keratinization] GO:0032308[positive regulation of prostaglandin secretion] GO:0032496[response to lipopolysaccharide] GO:0032743[positive regulation of interleukin-2 production] GO:0032755[positive regulation of interleukin-6 production] GO:0032760[positive regulation of tumor necrosis factor production] GO:0032874[positive regulation of stress-activated MAPK cascade] GO:0032956[regulation of actin cytoskeleton organization] GO:0033092[positive regulation of immature T cell proliferation in thymus] GO:0033591[response to L-ascorbic acid] GO:0034605[cellular response to heat] GO:0035234[ectopic germ cell programmed cell death] GO:0042060[wound healing] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0045766[positive regulation of angiogenesis] GO:0045840[positive regulation of mitotic nuclear division] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046330[positive regulation of JNK cascade] GO:0046688[response to copper ion] GO:0050714[positive regulation of protein secretion] GO:0050999[regulation of nitric-oxide synthase activity] GO:0051781[positive regulation of cell division] GO:0051930[regulation of sensory perception of pain] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0071222[cellular response to lipopolysaccharide] GO:0097192[extrinsic apoptotic signaling pathway in absence of ligand] GO:1902624[positive regulation of neutrophil migration] GO:1904445[negative regulation of establishment of Sertoli cell barrier] GO:2001240[negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
The Human Protein Atlas project is funded
