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The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.
The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".
Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.
Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.
& Survival analysisi
Kaplan-Meier plots summarize results from analysis of correlation between mRNA expression level and patient survival. Patients were divided based on level of expression into one of the two groups "low" (under cut off) or "high" (over cut off). X-axis shows time for survival (years) and y-axis shows the probability of survival, where 1.0 corresponds to 100 percent.
FN1 is not prognostic in Pancreatic Adenocarcinoma (TCGA)
Stage:
Survival analysis
Current cut offi
Current cut-off shows the cut-off (FPKM) currently selected. It may be changed manually. When the current cut-off is changed, the vertical dashed line indicating cut-off, the interactive survival scatter plot and the Kaplan-Meier curve will be automatically adjusted to show results accordingly.
:
Best expression cut offi
Based on the FPKM value of each gene, patients were classified into two groups and association between prognosis (survival) and gene expression (FPKM) was examined. The best expression cut-off refers the FPKM value that yields maximal difference with regard to survival between the two groups at the lowest log-rank P-value. Best expression cut-off was selected based on survival analysis .
When clicking on this number, the vertical dashed line indicating cut-off, the interactive survival plot, and the Kaplan-Meier curve will be adjusted to show results based on the best expression cut-off.
Median expression refers to the median FPKM value calculated based on the gene expression (FPKM) data from all patients in this dataset. When clicking on this number, the vertical dashed line indicating cut-off, the interactive survival plot, and the Kaplan-Meier curve will be adjusted to show results based on the median expression.
Median follow up time refers to the median time (years) after diagnosis with this type of cancer, based on clinical data from all patients in this dataset.
: N/A
P scorei
Log-rank P value for Kaplan-Meier plot showing results from analysis of correlation between mRNA expression level and patient survival.
N/A
5-year survival highi
5-year survival for patients with higher expression than the expression cutoff.
For melanoma and glioma, 3-year survival is shown.
N/A
5-year survival lowi
5-year survival for patients with lower expression than the expression cutoff.
For melanoma and glioma, 3-year survival is shown.
N/A
TCGA RNA samplesi
RNA-seq data is reported as average FPKM (number Fragments Per Kilobase of exon per Million reads), generated by the The Cancer Genome Atlas (TCGA) .
Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. FPKM values of the individual samples are presented next to the box plot.
Average pTPM
979.8
Number of samples
176
Samples
Sample
Description
pTPM
TCGA-IB-7893-01A
64 years, male, white, stage:Stage IIA, dead, 117 days
7371.6
TCGA-HZ-8005-01A
81 years, male, white, stage:Stage IIB, dead, 120 days
6292.8
TCGA-IB-A5SS-01A
64 years, female, white, stage:Stage IIB, dead, 460 days
5984.0
TCGA-IB-7646-01A
60 years, male, white, stage:Stage IIB, dead, 145 days
5329.2
TCGA-FB-AAPS-01A
62 years, female, white, stage:Stage IIB, alive, 228 days
3931.4
TCGA-IB-7890-01A
73 years, male, stage:Stage IB, dead, 598 days
3642.4
TCGA-HZ-7922-01A
61 years, female, white, stage:Stage IIB, alive, 4 days
3509.1
TCGA-HZ-7925-01A
66 years, male, white, stage:Stage IIB, dead, 614 days
3252.2
TCGA-HZ-8636-01A
58 years, female, white, stage:Stage IV, dead, 545 days
2810.8
TCGA-HV-AA8V-01A
50 years, male, asian, stage:Stage IIB, alive, 920 days
2700.9
TCGA-H6-8124-01A
56 years, female, white, stage:Stage IIB, alive, 392 days
2560.8
TCGA-IB-7885-01A
78 years, female, white, stage:Stage IIB, alive, 1257 days
2554.6
TCGA-3A-A9IC-01A
61 years, female, white, stage:Stage IIB, dead, 738 days
2386.2
TCGA-IB-AAUS-01A
84 years, female, white, stage:Stage IIB, alive, 225 days
2273.8
TCGA-M8-A5N4-01A
48 years, female, stage:Stage IIA, alive, 584 days
2116.6
TCGA-XD-AAUG-01A
66 years, female, white, stage:Stage IV, alive, 420 days
2102.0
TCGA-IB-AAUV-01A
49 years, male, white, stage:Stage IIB, alive, 404 days
2007.0
TCGA-IB-A5SQ-01A
56 years, female, white, stage:Stage IB, dead, 219 days
1982.6
TCGA-2J-AAB8-01A
71 years, male, white, stage:Stage IIB, alive, 80 days
1878.5
TCGA-RB-A7B8-01A
81 years, female, white, stage:Stage IIB, dead, 466 days
1840.2
TCGA-IB-7887-01A
62 years, female, white, stage:Stage IIB, dead, 110 days
1826.5
TCGA-US-A774-01A
76 years, female, white, stage:Stage IIB, dead, 695 days
1816.7
TCGA-HZ-A77Q-01A
55 years, female, white, stage:Stage IIB, alive, 33 days
1815.6
TCGA-XD-AAUL-01A
56 years, male, white, stage:Stage IIA, alive, 498 days
1802.0
TCGA-YH-A8SY-01A
73 years, female, white, stage:'--, alive, 388 days
1798.8
TCGA-L1-A7W4-01A
48 years, female, white, stage:Stage IIB, dead, 278 days
1785.7
TCGA-3A-A9IU-01A
65 years, male, white, stage:Stage IIB, dead, 458 days
1709.1
TCGA-2J-AABU-01A
56 years, male, white, stage:Stage IIB, dead, 277 days
1698.0
TCGA-3A-A9J0-01A
75 years, male, white, stage:Stage IIB, alive, 743 days
1678.6
TCGA-FB-A7DR-01A
48 years, male, asian, stage:Stage IIA, dead, 353 days
1668.8
TCGA-IB-7886-01A
80 years, male, white, stage:Stage IIB, dead, 123 days
1628.0
TCGA-2J-AAB6-01A
75 years, male, white, stage:Stage IIA, dead, 293 days
1590.5
TCGA-2J-AABE-01A
73 years, male, white, stage:Stage IIA, alive, 676 days
1577.9
TCGA-HZ-8315-01A
54 years, female, white, stage:Stage IIA, dead, 299 days
1566.8
TCGA-3A-A9IB-01A
69 years, female, white, stage:Stage IIB, dead, 224 days
1544.8
TCGA-IB-7645-01A
44 years, female, stage:Stage IIB, dead, 1502 days
1530.4
TCGA-3A-A9I7-01A
45 years, male, black or african american, stage:Stage IIB, alive, 1323 days
1395.3
TCGA-2J-AABO-01A
43 years, male, white, stage:Stage IIB, alive, 440 days
1388.8
TCGA-IB-7654-01A
80 years, male, white, stage:Stage IIB, dead, 476 days
1386.3
TCGA-IB-7651-01A
64 years, female, white, stage:Stage IIB, dead, 603 days
1370.0
TCGA-IB-8127-01A
59 years, male, white, stage:Stage IIB, alive, 522 days
1369.9
TCGA-3A-A9IZ-01A
47 years, male, white, stage:Stage IIB, dead, 308 days
1325.5
TCGA-PZ-A5RE-01A
44 years, female, white, stage:Stage IIB, dead, 470 days
1311.0
TCGA-US-A77E-01A
73 years, male, white, stage:Stage IIB, dead, 430 days
1293.2
TCGA-YB-A89D-01A
59 years, male, white, stage:Stage IIB, alive, 350 days
1292.4
TCGA-HV-A5A4-01A
72 years, female, asian, stage:Stage IIA, alive, 232 days
1276.5
TCGA-FB-A545-01A
72 years, female, white, stage:Stage IIB, dead, 732 days
1249.9
TCGA-XN-A8T3-01A
67 years, male, white, stage:Stage IB, alive, 951 days
1244.2
TCGA-HV-A5A3-01A
50 years, male, asian, stage:Stage IIA, dead, 128 days
1226.6
TCGA-IB-A5SO-01A
71 years, male, white, stage:Stage IIB, dead, 365 days
1223.9
TCGA-F2-A44G-01A
79 years, female, white, stage:Stage IIB, dead, 233 days
1218.1
TCGA-FB-AAPZ-01A
54 years, male, white, stage:Stage IIB, alive, 716 days
1182.8
TCGA-2J-AABI-01A
55 years, female, white, stage:Stage IIA, alive, 969 days
1125.1
TCGA-IB-A7LX-01A
57 years, male, white, stage:Stage IIB, dead, 250 days
1123.6
TCGA-2L-AAQA-01A
76 years, male, white, stage:Stage IIB, dead, 143 days
1104.9
TCGA-F2-7276-01A
64 years, male, white, stage:Stage IIB, dead, 216 days
1102.8
TCGA-HZ-7919-01A
52 years, female, white, stage:Stage IIB, dead, 593 days
1063.5
TCGA-IB-AAUQ-01A
50 years, male, white, stage:Stage IIB, dead, 183 days
1045.9
TCGA-F2-A44H-01A
65 years, male, white, stage:Stage IIA, alive, 586 days
1038.8
TCGA-IB-A5ST-01A
64 years, female, white, stage:Stage IIB, alive, 635 days
1020.0
TCGA-HZ-7918-01A
72 years, male, white, stage:Stage IIB, alive, 969 days
1008.0
TCGA-IB-7652-01A
49 years, female, asian, stage:Stage IIB, alive, 1116 days
998.8
TCGA-HV-A5A6-01A
65 years, female, asian, stage:Stage IIB, dead, 2036 days
991.2
TCGA-F2-A8YN-01A
76 years, male, white, stage:Stage IIA, alive, 517 days
963.3
TCGA-HZ-A49G-01A
58 years, female, white, stage:Stage IIB, alive, 660 days
938.1
TCGA-S4-A8RP-01A
77 years, female, white, stage:Stage IIB, dead, 702 days
928.2
TCGA-F2-6879-01A
57 years, male, white, stage:Stage IIB, dead, 334 days
908.1
TCGA-IB-AAUN-01A
74 years, female, white, stage:Stage IB, dead, 144 days
875.0
TCGA-IB-7891-01A
49 years, female, white, stage:Stage IIB, dead, 913 days
855.5
TCGA-XD-AAUI-01A
50 years, female, white, stage:Stage IIB, dead, 366 days
855.5
TCGA-HZ-7923-01A
65 years, male, white, stage:Stage IIA, alive, 314 days
844.6
TCGA-2J-AABP-01A
58 years, female, white, stage:Stage IIB, alive, 463 days
836.4
TCGA-HZ-8002-01A
61 years, male, white, stage:Stage IIB, dead, 366 days
826.3
TCGA-2J-AABA-01A
55 years, male, white, stage:Stage IIB, dead, 607 days
821.1
TCGA-HV-A5A5-01A
61 years, female, asian, stage:Stage IIB, alive, 289 days
816.5
TCGA-2J-AAB9-01A
70 years, female, white, stage:Stage IIB, dead, 627 days
809.2
TCGA-F2-7273-01A
54 years, male, black or african american, stage:Stage IIB, dead, 592 days
807.6
TCGA-HZ-A77P-01A
77 years, male, white, stage:Stage IIB, alive, 330 days
791.5
TCGA-IB-AAUP-01A
68 years, male, white, stage:Stage IIB, alive, 431 days
786.2
TCGA-IB-AAUT-01A
65 years, male, white, stage:Stage IIB, alive, 287 days
767.5
TCGA-FB-A4P5-01A
69 years, female, white, stage:Stage IIB, dead, 179 days
741.6
TCGA-2J-AABT-01A
72 years, female, white, stage:Stage IIB, alive, 319 days
719.8
TCGA-IB-7888-01A
66 years, female, black or african american, stage:Stage IIA, dead, 1332 days
714.1
TCGA-2J-AABR-01A
60 years, female, white, stage:Stage IIA, alive, 438 days
688.3
TCGA-HZ-8637-01A
76 years, female, white, stage:Stage IIB, dead, 517 days
678.8
TCGA-HZ-A77O-01A
77 years, female, white, stage:Stage IIB, dead, 160 days
677.8
TCGA-IB-AAUU-01A
35 years, male, white, stage:Stage IIB, alive, 245 days
658.8
TCGA-3A-A9IV-01A
59 years, female, white, stage:Stage IB, alive, 1103 days
657.5
TCGA-2J-AABF-01A
73 years, male, white, stage:Stage IIB, dead, 691 days
652.9
TCGA-H6-A45N-01A
88 years, female, white, stage:Stage IIB, dead, 397 days
648.2
TCGA-IB-7897-01A
53 years, female, white, stage:Stage IIB, dead, 486 days
642.9
TCGA-HZ-A4BH-01A
75 years, male, white, stage:Stage IIB, alive, 194 days
621.8
TCGA-FB-AAPQ-01A
65 years, male, white, stage:Stage IIB, dead, 1130 days
619.2
TCGA-HZ-8001-01A
69 years, male, white, stage:Stage III, alive, 706 days
608.1
TCGA-HZ-8003-01A
65 years, female, white, stage:Stage IIB, dead, 596 days
604.9
TCGA-RB-AA9M-01A
43 years, male, white, stage:Stage IIB, alive, 286 days
589.4
TCGA-FB-A4P6-01A
54 years, male, white, stage:Stage IIB, alive, 767 days
579.4
TCGA-2L-AAQE-01A
56 years, male, white, stage:Stage IIB, dead, 684 days
563.0
TCGA-3A-A9IX-01A
40 years, male, white, stage:Stage IA, alive, 1037 days
562.6
TCGA-IB-7649-01A
73 years, female, stage:Stage IIB, dead, 467 days
558.1
TCGA-2J-AABH-01A
61 years, male, white, stage:Stage IIA, alive, 1287 days
557.0
TCGA-IB-7644-01A
65 years, female, white, stage:Stage IV, dead, 394 days
552.7
TCGA-IB-AAUR-01A
67 years, male, white, stage:Stage IIB, alive, 338 days
536.1
TCGA-3E-AAAZ-01A
71 years, male, white, stage:Stage IIA, dead, 2182 days
522.8
TCGA-3A-A9IH-01A
66 years, female, white, stage:Stage IA, alive, 1021 days
517.4
TCGA-FB-AAQ0-01A
68 years, male, white, stage:Stage IIA, dead, 473 days
500.6
TCGA-2J-AAB4-01A
48 years, male, white, stage:Stage IIB, alive, 729 days
486.2
TCGA-US-A77J-01A
81 years, female, white, stage:Stage IIB, dead, 568 days
477.9
TCGA-HZ-A49I-01A
77 years, male, white, stage:Stage IIB, dead, 308 days
459.7
TCGA-FB-AAQ6-01A
85 years, male, white, stage:Stage IA, dead, 244 days
454.4
TCGA-HZ-A4BK-01A
72 years, male, white, stage:Stage IIB, alive, 657 days
452.3
TCGA-HZ-7926-01A
57 years, male, black or african american, stage:Stage IIB, dead, 518 days
446.7
TCGA-XN-A8T5-01A
53 years, female, white, stage:Stage IB, alive, 720 days
443.0
TCGA-2J-AAB1-01A
65 years, male, white, stage:Stage IIB, dead, 66 days
441.4
TCGA-IB-A6UF-01A
63 years, male, white, stage:Stage IIB, alive, 666 days
440.8
TCGA-IB-A7M4-01A
81 years, male, white, stage:Stage IIB, alive, 483 days
431.4
TCGA-S4-A8RO-01A
75 years, female, white, stage:Stage IIB, alive, 525 days
412.6
TCGA-Q3-A5QY-01A
58 years, male, white, stage:Stage IIB, alive, 416 days
391.4
TCGA-FB-AAQ2-01A
81 years, female, white, stage:Stage IIB, dead, 153 days
387.7
TCGA-FB-A78T-01A
71 years, female, white, stage:Stage IIB, dead, 375 days
375.3
TCGA-F2-A7TX-01A
77 years, male, white, stage:Stage IIB, dead, 95 days
374.4
TCGA-3E-AAAY-01A
67 years, male, white, stage:Stage IIB, alive, 2285 days
362.0
TCGA-2L-AAQJ-01A
49 years, female, white, stage:Stage III, dead, 394 days
358.0
TCGA-LB-A9Q5-01A
63 years, female, white, stage:Stage IIB, dead, 313 days
353.8
TCGA-Q3-AA2A-01A
64 years, female, white, stage:Stage IB, alive, 95 days
337.4
TCGA-FB-AAPY-01A
71 years, male, white, stage:Stage IIB, dead, 1059 days
332.7
TCGA-HZ-8519-01A
73 years, male, white, stage:Stage IA, alive, 454 days
328.7
TCGA-HZ-7920-01A
71 years, male, white, stage:Stage IB, dead, 236 days
324.3
TCGA-HV-AA8X-01A
75 years, female, asian, stage:Stage IIB, dead, 532 days
323.7
TCGA-3A-A9I9-01A
67 years, male, white, stage:Stage IIA, dead, 634 days
300.2
TCGA-H8-A6C1-01A
53 years, male, white, stage:Stage IIA, alive, 671 days
296.7
TCGA-3A-A9I5-01A
57 years, male, white, stage:'--, alive, 1794 days
294.9
TCGA-FB-A5VM-01A
74 years, male, white, stage:Stage IB, dead, 498 days
281.8
TCGA-2L-AAQI-01A
66 years, male, white, stage:Stage IIB, dead, 103 days
275.6
TCGA-HZ-8317-01A
69 years, female, white, stage:Stage IIB, dead, 378 days
269.2
TCGA-XD-AAUH-01A
57 years, female, white, stage:Stage IIB, alive, 395 days
266.8
TCGA-HZ-A8P1-01A
81 years, male, white, stage:Stage IB, alive, 7 days
248.2
TCGA-RL-AAAS-01A
60 years, female, white, stage:Stage IB, alive, 9 days
244.3
TCGA-IB-7889-01A
85 years, female, white, stage:Stage IIB, dead, 481 days
244.2
TCGA-FB-AAQ1-01A
49 years, male, white, stage:Stage IIB, dead, 123 days
239.7
TCGA-S4-A8RM-01A
67 years, male, white, stage:Stage IIB, alive, 737 days
238.4
TCGA-LB-A8F3-01A
64 years, female, black or african american, stage:Stage IIA, alive, 379 days
225.4
TCGA-IB-AAUO-01A
64 years, female, white, stage:Stage IIB, dead, 239 days
202.1
TCGA-IB-AAUM-01A
76 years, male, white, stage:Stage IIB, alive, 8 days
199.3
TCGA-Z5-AAPL-01A
74 years, female, white, stage:Stage IIA, alive, 467 days
191.3
TCGA-HZ-A9TJ-01A
70 years, male, white, stage:Stage IV, alive, 603 days
178.8
TCGA-IB-8126-01A
79 years, female, white, stage:Stage III, alive, 462 days
171.4
TCGA-OE-A75W-01A
75 years, male, white, stage:Stage IIA, dead, 267 days
171.3
TCGA-3A-A9IO-01A
55 years, male, white, stage:'--, alive, 1942 days
157.7
TCGA-IB-A6UG-01A
65 years, male, white, stage:Stage IIB, dead, 41 days
152.4
TCGA-2L-AAQL-01A
82 years, male, white, stage:Stage IIB, dead, 292 days
150.9
TCGA-IB-AAUW-01A
63 years, female, white, stage:Stage IIB, dead, 230 days
150.4
TCGA-LB-A7SX-01A
74 years, female, black or african american, stage:Stage IIB, dead, 393 days
145.0
TCGA-HZ-7289-01A
77 years, male, white, stage:Stage IIB, dead, 661 days
137.8
TCGA-HV-A7OL-01A
70 years, male, asian, stage:Stage IIA, alive, 252 days
129.1
TCGA-3A-A9IN-01A
62 years, female, white, stage:Stage IB, alive, 2084 days
124.6
TCGA-HZ-7924-01A
60 years, female, white, stage:Stage IIA, alive, 840 days
122.1
TCGA-HZ-8638-01A
84 years, female, white, stage:Stage IA, dead, 151 days
115.6
TCGA-FB-AAPU-01A
41 years, female, asian, stage:Stage IIA, dead, 381 days
114.7
TCGA-HZ-A49H-01A
68 years, female, white, stage:Stage IIB, alive, 491 days
114.0
TCGA-IB-A5SP-01A
77 years, male, white, stage:Stage IIA, alive, 482 days
105.4
TCGA-2L-AAQM-01A
52 years, male, white, stage:Stage IIB, alive, 1383 days
94.2
TCGA-FB-AAQ3-01A
65 years, female, white, stage:Stage IIB, dead, 31 days
93.8
TCGA-YY-A8LH-01A
61 years, female, white, stage:Stage IIB, alive, 2016 days
83.2
TCGA-2J-AABK-01A
71 years, male, white, stage:Stage IIB, alive, 484 days
59.8
TCGA-US-A77G-01A
64 years, male, white, stage:Stage IIB, dead, 12 days
56.8
TCGA-3A-A9IL-01A
39 years, female, white, stage:Stage I, alive, 2741 days
54.6
TCGA-US-A779-01A
54 years, female, white, stage:Stage IIB, dead, 511 days
46.3
TCGA-3A-A9IS-01A
67 years, male, white, stage:Stage IB, alive, 998 days
44.8
TCGA-US-A776-01A
61 years, male, white, stage:Stage IIA, alive, 1216 days
39.2
TCGA-FB-AAPP-01A
71 years, male, white, stage:Stage IIB, dead, 485 days
27.7
TCGA-3A-A9IR-01A
64 years, female, white, stage:Stage IB, alive, 1542 days
25.4
TCGA-3A-A9IJ-01A
65 years, male, white, stage:Stage IB, alive, 1854 days
12.1
TCGA-F2-6880-01A
70 years, male, white, stage:Stage IIB, alive, 295 days
7.0
TCGA-2J-AABV-01A
74 years, male, white, stage:Stage IIB, dead, 652 days
6.5
TCGA-HV-A7OP-01A
72 years, male, asian, stage:Stage IIB, alive, 978 days
The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.
The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".
Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.
Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.
& Survival analysisi
Kaplan-Meier plots summarize results from analysis of correlation between mRNA expression level and patient survival. Patients were divided based on level of expression into one of the two groups "low" (under cut off) or "high" (over cut off). X-axis shows time for survival (years) and y-axis shows the probability of survival, where 1.0 corresponds to 100 percent.
FN1 is not prognostic in Pancreatic Adenocarcinoma (validation)
Stage:
Survival analysis
Current cut offi
Current cut-off shows the cut-off (FPKM) currently selected. It may be changed manually. When the current cut-off is changed, the vertical dashed line indicating cut-off, the interactive survival scatter plot and the Kaplan-Meier curve will be automatically adjusted to show results accordingly.
:
Best expression cut offi
Based on the FPKM value of each gene, patients were classified into two groups and association between prognosis (survival) and gene expression (FPKM) was examined. The best expression cut-off refers the FPKM value that yields maximal difference with regard to survival between the two groups at the lowest log-rank P-value. Best expression cut-off was selected based on survival analysis .
When clicking on this number, the vertical dashed line indicating cut-off, the interactive survival plot, and the Kaplan-Meier curve will be adjusted to show results based on the best expression cut-off.
Median expression refers to the median FPKM value calculated based on the gene expression (FPKM) data from all patients in this dataset. When clicking on this number, the vertical dashed line indicating cut-off, the interactive survival plot, and the Kaplan-Meier curve will be adjusted to show results based on the median expression.
Median follow up time refers to the median time (years) after diagnosis with this type of cancer, based on clinical data from all patients in this dataset.
: N/A
P scorei
Log-rank P value for Kaplan-Meier plot showing results from analysis of correlation between mRNA expression level and patient survival.
N/A
5-year survival highi
5-year survival for patients with higher expression than the expression cutoff.
For melanoma and glioma, 3-year survival is shown.
N/A
5-year survival lowi
5-year survival for patients with lower expression than the expression cutoff.
For melanoma and glioma, 3-year survival is shown.
N/A
TCGA RNA samplesi
RNA-seq data is reported as average FPKM (number Fragments Per Kilobase of exon per Million reads), generated by the The Cancer Genome Atlas (TCGA) .
Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. FPKM values of the individual samples are presented next to the box plot.
Average pTPM
1561.1
Number of samples
80
Samples
Sample
Description
pTPM
DO34240
72 years, male, NA, stage:, dead, 236 days
9126.1
DO34728
77 years, female, NA, stage:, alive, 508 days
6346.8
DO33472
75 years, female, NA, stage:, dead, 388 days
5654.1
DO34448
79 years, female, NA, stage:, dead, 719 days
4835.6
DO49183
51 years, female, NA, stage:, dead, 429 days
4681.1
DO49170
67 years, male, NA, stage:, alive, 197 days
4538.9
DO34600
77 years, male, NA, stage:, dead, 537 days
3861.6
DO33336
67 years, female, NA, stage:, dead, 451 days
3777.6
DO32863
60 years, male, NA, stage:, dead, 715 days
3414.0
DO33480
52 years, male, NA, stage:, alive, 1054 days
3308.9
DO49204
67 years, male, NA, stage:, dead, 156 days
3204.5
DO49185
55 years, male, NA, stage:, alive, 179 days
3160.6
DO34905
64 years, male, NA, stage:, alive, 1142 days
3121.5
DO34504
37 years, male, NA, stage:, dead, 257 days
2608.7
DO49199
52 years, male, NA, stage:, dead, 1095 days
2389.5
DO49166
40 years, female, NA, stage:, alive, 222 days
2337.2
DO49080
60 years, male, NA, stage:, alive, 83 days
2327.9
DO33376
62 years, female, NA, stage:, alive, 909 days
2288.7
DO49129
50 years, male, NA, stage:, alive, 337 days
2150.2
DO34312
58 years, female, NA, stage:, dead, 226 days
2065.2
DO49184
56 years, male, NA, stage:, dead, 455 days
2057.2
DO33168
80 years, female, NA, stage:, dead, 8 days
1873.7
DO49130
76 years, female, NA, stage:, alive, 351 days
1801.3
DO34849
86 years, female, NA, stage:, dead, 272 days
1656.2
DO33368
81 years, male, NA, stage:, dead, 98 days
1648.9
DO33512
female, NA, stage:, dead, 499 days
1609.2
DO32878
69 years, female, NA, stage:, dead, 260 days
1575.7
DO33408
68 years, female, NA, stage:, alive, 909 days
1537.1
DO34640
49 years, female, NA, stage:, dead, 287 days
1528.7
DO33552
70 years, female, NA, stage:, alive, 873 days
1362.9
DO33544
83 years, female, NA, stage:, dead, 412 days
1331.9
DO49168
58 years, male, NA, stage:, alive, 149 days
1301.3
DO34680
75 years, male, NA, stage:, dead, 99 days
1279.2
DO49079
50 years, male, NA, stage:, dead, 332 days
1247.6
DO32829
78 years, female, NA, stage:T2N0MX, dead, 1874 days
1177.8
DO34801
60 years, male, NA, stage:, alive, 626 days
1147.6
DO32875
69 years, male, NA, stage:, dead, 348 days
1086.0
DO49113
46 years, female, NA, stage:, alive, 413 days
1032.9
DO34368
64 years, female, NA, stage:, dead, 537 days
1017.3
DO34793
56 years, male, NA, stage:, dead, 427 days
992.8
DO34720
68 years, male, NA, stage:, alive, 555 days
965.9
DO49087
68 years, female, NA, stage:, dead, 260 days
897.3
DO49178
58 years, male, NA, stage:, dead, 27 days
882.6
DO34432
82 years, female, NA, stage:, dead, 400 days
875.7
DO34656
61 years, female, NA, stage:, alive, 834 days
861.2
DO33344
70 years, male, NA, stage:, dead, 361 days
807.3
DO33600
77 years, female, NA, stage:, alive, 854 days
789.3
DO32860
57 years, male, NA, stage:, dead, 1259 days
785.6
DO34608
72 years, female, NA, stage:, dead, 709 days
780.3
DO34288
83 years, female, NA, stage:, dead, 220 days
753.1
DO49193
60 years, male, NA, stage:, dead, 1 days
752.3
DO33984
64 years, male, NA, stage:, alive, 847 days
747.7
DO34696
75 years, male, NA, stage:, alive, 689 days
741.9
DO49138
74 years, male, NA, stage:, dead, 230 days
736.8
DO34785
67 years, female, NA, stage:, alive, 721 days
721.9
DO32900
51 years, male, NA, stage:, dead, 768 days
712.2
DO49090
77 years, female, NA, stage:, dead, 152 days
710.6
DO49074
49 years, male, NA, stage:, dead, 168 days
705.4
DO33488
61 years, male, NA, stage:, alive, 844 days
700.0
DO33128
72 years, male, NA, stage:, dead, 423 days
677.2
DO49181
77 years, male, NA, stage:, dead, 1534 days
508.7
DO49172
60 years, female, NA, stage:, dead, 1021 days
488.5
DO49135
65 years, male, NA, stage:, alive, 270 days
469.4
DO49164
70 years, male, NA, stage:, alive, 272 days
458.6
DO49133
55 years, female, NA, stage:, alive, 188 days
408.7
DO34264
63 years, female, NA, stage:, dead, 1144 days
387.2
DO49078
79 years, male, NA, stage:, dead, 465 days
381.5
DO49198
61 years, female, NA, stage:, dead, 251 days
376.1
DO49127
77 years, female, NA, stage:, alive, 392 days
373.7
DO34736
78 years, female, NA, stage:, dead, 203 days
281.7
DO33400
76 years, female, NA, stage:, alive, 1043 days
266.2
DO49137
67 years, female, NA, stage:, alive, 232 days
245.2
DO49076
64 years, male, NA, stage:, dead, 480 days
231.4
DO34817
72 years, female, NA, stage:, alive, 540 days
215.8
DO33392
70 years, male, NA, stage:, alive, 1014 days
202.2
DO49175
68 years, male, NA, stage:, dead, 414 days
163.8
DO34809
74 years, female, NA, stage:, dead, 297 days
149.5
DO34336
70 years, female, NA, stage:, alive, 743 days
110.0
DO34961
71 years, male, NA, stage:, dead, 632 days
74.9
DO34616
68 years, female, NA, stage:, alive, 666 days
28.0
Show allShow less
PANCREATIC DUCTAL ADENOCARCINOMA - Protein relative expression (CPTAC)
Number of samples
235
Samples
Sample ID
Sample type
nRPX
CPT0236340004
Tumor
2.0
CPT0226490004
Tumor
1.4
CPT0011520003
Tumor
1.4
CPT0083270003
Tumor
1.4
CPT0063570003
Tumor
1.3
CPT0226650004
Tumor
1.3
CPT0208840004
Tumor
1.1
CPT0248590004
Tumor
1.0
CPT0081470004
Tumor
1.0
CPT0124360003
Tumor
1.0
CPT0185920004
Tumor
0.9
CPT0198700005
Tumor
0.9
CPT0226600004
Tumor
0.9
CPT0094230004
Tumor
0.9
CPT0081360004
Tumor
0.9
WU-PDA1
Tumor
0.9
CPT0089720003
Tumor
0.8
CPT0207780004
Tumor
0.8
CPT0124500004
Tumor
0.8
CPT0109010004
Tumor
0.8
CPT0247040003
Tumor
0.8
CPT0077860003
Tumor
0.8
CPT0227930004
Tumor
0.8
CPT0088320003
Tumor
0.7
CPT0081060004
Tumor
0.7
CPT0108400003
Tumor
0.7
CPT0064090003
Tumor
0.7
CPT0237910004
Tumor
0.7
CPT0091660003
Tumor
0.7
CPT0094740004
Tumor
0.6
CPT0170240004
Tumor
0.6
CPT0226570004
Tumor
0.6
CPT0125130003
Tumor
0.5
CPT0019410004
Tumor
0.5
CPT0065570003
Tumor
0.5
CPT0246720003
Tumor
0.5
CPT0078000003
Tumor
0.5
CPT0161770004
Tumor
0.4
CPT0019300004
Tumor
0.4
CPT0254680003
Tumor
0.4
CPT0208690004
Tumor
0.4
CPT0237840004
Tumor
0.4
CPT0064520004
Tumor
0.3
CPT0001730017
Tumor
0.3
CPT0246990003
Tumor
0.3
CPT0239100009
Tumor
0.3
CPT0088180004
Tumor
0.3
CPT0238610009
Tumor
0.3
CPT0094180003
Tumor
0.3
CPT0161990005
Tumor
0.3
CPT0276010003
Tumor
0.3
CPT0077930004
Tumor
0.3
CPT0197420004
Tumor
0.2
CPT0124610004
Tumor
0.2
CPT0093930004
Tumor
0.2
CPT0162760003
Tumor
0.2
CPT0008750003
Tumor
0.2
CPT0238040005
Tumor
0.2
CPT0092630003
Tumor
0.2
CPT0209310004
Tumor
0.1
CPT0008800003
Tumor
0.1
CPT0183750005
Tumor
0.1
CPT0183450005
Tumor
0.1
CPT0246810003
Tumor
0.1
CPT0238530005
Tumor
0.1
CPT0123860003
Tumor
0.1
CPT0139000004
Tumor
0.1
CPT0207980005
Tumor
0.0
CPT0264150003
Tumor
0.0
CPT0246840003
Tumor
0.0
CPT0094030003
Tumor
0.0
CPT0166760004
Tumor
0.0
CPT0217700004
Tumor
0.0
CPT0235230004
Tumor
-0.1
CPT0014040003
Tumor
-0.1
CPT0123650003
Tumor
-0.1
KoreanReference1
Tumor
-0.1
CPT0123440003
Tumor
-0.1
CPT0086190004
Tumor
-0.1
CPT0124530003
Normal
-0.1
KoreanReference2
Tumor
-0.1
CPT0077790004
Tumor
-0.1
CPT0109300004
Tumor
-0.2
KoreanReference3
Tumor
-0.2
CPT0064110003
Normal
-0.2
CPT0094130004
Tumor
-0.2
CPT0078090004
Tumor
-0.2
CPT0238820005
Tumor
-0.2
CPT0246940003
Tumor
-0.2
CPT0236560004
Tumor
-0.2
CPT0246210004
Tumor
-0.2
CPT0001750003
Normal
-0.3
CPT0207990004
Normal
-0.3
CPT0125090003
Tumor
-0.3
CPT0126160004
Tumor
-0.3
CPT0236700005
Tumor
-0.3
CPT0174700004
Tumor
-0.3
CPT0237270005
Tumor
-0.3
CPT0123750003
Tumor
-0.3
CPT0236780005
Tumor
-0.3
CPT0123890003
Normal
-0.3
CPT0238710004
Tumor
-0.3
CPT0218200004
Tumor
-0.3
CPT0108930003
Tumor
-0.3
CPT0187930005
Tumor
-0.4
CPT0221470005
Tumor
-0.4
CPT0208550005
Tumor
-0.4
CPT0086210003
Normal
-0.4
CPT0063970004
Tumor
-0.4
CPT0248410004
Tumor
-0.4
CPT0124980004
Tumor
-0.4
CPT0017040004
Tumor
-0.4
CPT0138990003
Normal
-0.4
CPT0238920004
Tumor
-0.4
CPT0123460003
Normal
-0.4
CPT0066020003
Normal
-0.5
CPT0109200004
Tumor
-0.5
CPT0162660004
Tumor
-0.5
CPT0239920004
Normal
-0.5
CPT0226760004
Tumor
-0.5
CPT0197440004
Normal
-0.5
CPT0077880003
Normal
-0.5
CPT0124410004
Tumor
-0.5
CPT0226530004
Tumor
-0.5
CPT0239910004
Tumor
-0.5
CPT0093980004
Tumor
-0.5
CPT0088260004
Tumor
-0.6
CPT0203850004
Tumor
-0.6
CPT0065640003
Tumor
-0.6
CPT0246950003
Normal
-0.6
CPT0078160004
Tumor
-0.6
CPT0198910005
Tumor
-0.6
CPT0123990003
Tumor
-0.6
CPT0011540003
Normal
-0.6
CPT0174800003
Normal
-0.7
CPT0224460004
Tumor
-0.7
CPT0236360004
Normal
-0.7
CPT0127270003
Tumor
-0.7
CPT0238440005
Tumor
-0.7
CPT0093860003
Tumor
-0.7
CPT0248620003
Normal
-0.7
CPT0162670004
Normal
-0.7
CPT0209640005
Tumor
-0.7
CPT0064570003
Normal
-0.7
CPT0127290003
Normal
-0.8
CPT0078250003
Tumor
-0.8
CPT0078030003
Normal
-0.8
CPT0187550004
Tumor
-0.8
CPT0094940004
Tumor
-0.8
CPT0089750004
Normal
-0.8
CPT0246260004
Tumor
-0.8
CPT0093880003
Normal
-0.8
CPT0017130003
Normal
-0.8
CPT0094630004
Tumor
-0.8
CPT0078180003
Normal
-0.8
CPT0246220004
Normal
-0.9
CPT0247000003
Normal
-0.9
CPT0123770003
Normal
-0.9
CPT0125010003
Normal
-0.9
CPT0108960003
Normal
-0.9
CPT0000250017
Tumor
-0.9
CPT0241510004
Normal
-0.9
CPT0221240004
Tumor
-0.9
C3L-00401-04
Normal
-0.9
CPT0077950003
Normal
-0.9
C3N-02573-03
Normal
-0.9
CPT0183770004
Normal
-0.9
CPT0162780004
Normal
-0.9
CPT0238640004
Normal
-1.0
CPT0226610004
Normal
-1.0
CPT0124000003
Normal
-1.0
CPT0355180003
Normal
-1.0
CPT0025760003
Normal
-1.0
CPT0236800004
Normal
-1.0
CPT0081260004
Tumor
-1.0
C3N-00709-06
Normal
-1.0
CPT0170260004
Normal
-1.0
C3L-03632-04
Normal
-1.0
CPT0186040004
Tumor
-1.0
CPT0247090003
Tumor
-1.0
CPT0276030003
Normal
-1.0
CPT0241320005
Tumor
-1.0
CPT0198420004
Tumor
-1.1
CPT0087890004
Tumor
-1.1
CPT0025750003
Tumor
-1.1
CPT0221250004
Normal
-1.1
CPT0091680003
Normal
-1.1
CPT0226680005
Tumor
-1.1
CPT0238740004
Normal
-1.2
CPT0063580003
Normal
-1.2
C3L-00189-04
Normal
-1.2
CPT0123670003
Normal
-1.2
CPT0077810003
Normal
-1.2
CPT0241500004
Tumor
-1.2
CPT0187540004
Normal
-1.2
CPT0218220004
Normal
-1.2
CPT0237920004
Normal
-1.3
CPT0208850004
Normal
-1.3
CPT0208710004
Normal
-1.3
CPT0238940004
Normal
-1.3
CPT0237850004
Normal
-1.4
CPT0239140004
Normal
-1.4
CPT0355200003
Normal
-1.5
CPT0248440003
Normal
-1.5
CPT0209650004
Normal
-1.5
CPT0166780004
Normal
-1.6
CPT0236710004
Normal
-1.7
CPT0347760002
Normal
-1.7
CPT0198440004
Normal
-1.9
CPT0355190003
Normal
-2.0
CPT0347850002
Normal
-2.0
CPT0198930003
Normal
-2.1
CPT0347820002
Normal
-2.1
CPT0347790002
Normal
-2.2
CPT0347880002
Normal
-2.3
CPT0247050003
Normal
N/A
CPT0108410003
Normal
N/A
CPT0248320003
Normal
N/A
CPT0166650006
Tumor
N/A
CPT0224470004
Normal
N/A
C3L-01687-04
Normal
N/A
CPT0138890003
Normal
N/A
CPT0109110004
Tumor
N/A
WU-pooled sample
Tumor
N/A
CPT0014060003
Normal
N/A
CPT0109130003
Normal
N/A
CPT0138900004
Tumor
N/A
CPT0166680004
Normal
N/A
CPT0094760003
Normal
N/A
CPT0186050004
Normal
N/A
CPT0237290004
Normal
N/A
CPT0264180003
Normal
N/A
CPT0063990003
Normal
N/A
CPT0126200003
Normal
N/A
CPT0198730004
Normal
N/A
Show allShow less
PANCREATIC CANCER - Protein expressioni
A mouse-over function shows sample information and annotation data. Click on an image to view it in a full screen mode. Samples can be filtered based on level of antibody staining by selecting one or several of the following categories: high, medium, low and not detected. The assay and annotation is described here.
Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.
Antibody stainingi
Antibody staining in the annotated cell types in the current human tissue is reported as not detected, low, medium, or high, based on conventional immunohistochemistry profiling in selected tissues. This score is based on the combination of the staining intensity and fraction of stained cells.
Each image is clickable and will lead to virtual microscopy that enables deeper exploration of all samples and also displays staining intensity scores, fraction scores and subcellular localization as well as patient and tissue information for each sample.
The Human Protein Atlas project is funded
