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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Human disease related genes Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
2
Cytoband
q35
Chromosome location (bp)
215360440 - 215436073
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin 1,2,3,4. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape 5,6,7,8. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization (By similarity). Participates in the regulation of type I collagen deposition by osteoblasts (By similarity). Acts as a ligand for the LILRB4 receptor, inhibiting FCGR1A/CD64-mediated monocyte activation 9....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Heparin-binding
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. The encoded preproprotein is proteolytically processed to generate the mature protein. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants, at least one of which encodes an isoform that undergoes proteolytic processing. The full-length nature of some variants has not been determined. [provided by RefSeq, Jan 2016]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins DeepTMHMM predicted secreted proteins DeepSig predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutational cancer driver genes Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Biotech drugs Human disease related genes Congenital malformations Congenital malformations of the musculoskeletal system Urinary system diseases Kidney diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0001525[angiogenesis] GO:0001932[regulation of protein phosphorylation] GO:0002020[protease binding] GO:0005102[signaling receptor binding] GO:0005178[integrin binding] GO:0005201[extracellular matrix structural constituent] GO:0005515[protein binding] GO:0005518[collagen binding] GO:0005576[extracellular region] GO:0005577[fibrinogen complex] GO:0005615[extracellular space] GO:0005788[endoplasmic reticulum lumen] GO:0005793[endoplasmic reticulum-Golgi intermediate compartment] GO:0005886[plasma membrane] GO:0006953[acute-phase response] GO:0007044[cell-substrate junction assembly] GO:0007155[cell adhesion] GO:0007160[cell-matrix adhesion] GO:0007229[integrin-mediated signaling pathway] GO:0007399[nervous system development] GO:0007507[heart development] GO:0008022[protein C-terminus binding] GO:0008201[heparin binding] GO:0008284[positive regulation of cell population proliferation] GO:0008360[regulation of cell shape] GO:0009611[response to wounding] GO:0010628[positive regulation of gene expression] GO:0014068[positive regulation of phosphatidylinositol 3-kinase signaling] GO:0018149[peptide cross-linking] GO:0019899[enzyme binding] GO:0031012[extracellular matrix] GO:0031093[platelet alpha granule lumen] GO:0033622[integrin activation] GO:0034446[substrate adhesion-dependent cell spreading] GO:0035987[endodermal cell differentiation] GO:0042802[identical protein binding] GO:0043394[proteoglycan binding] GO:0048146[positive regulation of fibroblast proliferation] GO:0051087[chaperone binding] GO:0051702[biological process involved in interaction with symbiont] GO:0062023[collagen-containing extracellular matrix] GO:0070062[extracellular exosome] GO:0070372[regulation of ERK1 and ERK2 cascade] GO:0070527[platelet aggregation] GO:0071635[negative regulation of transforming growth factor beta production] GO:0072378[blood coagulation, fibrin clot formation] GO:0072562[blood microparticle] GO:0097718[disordered domain specific binding] GO:0110165[cellular anatomical entity] GO:0150102[negative regulation of monocyte activation] GO:1901166[neural crest cell migration involved in autonomic nervous system development] GO:1904237[positive regulation of substrate-dependent cell migration, cell attachment to substrate]
Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins DeepTMHMM predicted secreted proteins DeepSig predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutational cancer driver genes Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Biotech drugs Human disease related genes Congenital malformations Congenital malformations of the musculoskeletal system Urinary system diseases Kidney diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525[angiogenesis] GO:0001932[regulation of protein phosphorylation] GO:0002020[protease binding] GO:0005102[signaling receptor binding] GO:0005178[integrin binding] GO:0005201[extracellular matrix structural constituent] GO:0005515[protein binding] GO:0005518[collagen binding] GO:0005576[extracellular region] GO:0005577[fibrinogen complex] GO:0005615[extracellular space] GO:0005788[endoplasmic reticulum lumen] GO:0005793[endoplasmic reticulum-Golgi intermediate compartment] GO:0005886[plasma membrane] GO:0006953[acute-phase response] GO:0007044[cell-substrate junction assembly] GO:0007155[cell adhesion] GO:0007160[cell-matrix adhesion] GO:0007229[integrin-mediated signaling pathway] GO:0007399[nervous system development] GO:0007507[heart development] GO:0008022[protein C-terminus binding] GO:0008201[heparin binding] GO:0008284[positive regulation of cell population proliferation] GO:0008360[regulation of cell shape] GO:0009611[response to wounding] GO:0010628[positive regulation of gene expression] GO:0014068[positive regulation of phosphatidylinositol 3-kinase signaling] GO:0018149[peptide cross-linking] GO:0019899[enzyme binding] GO:0031012[extracellular matrix] GO:0031093[platelet alpha granule lumen] GO:0033622[integrin activation] GO:0034446[substrate adhesion-dependent cell spreading] GO:0035987[endodermal cell differentiation] GO:0042802[identical protein binding] GO:0043394[proteoglycan binding] GO:0048146[positive regulation of fibroblast proliferation] GO:0051087[chaperone binding] GO:0051702[biological process involved in interaction with symbiont] GO:0062023[collagen-containing extracellular matrix] GO:0070062[extracellular exosome] GO:0070372[regulation of ERK1 and ERK2 cascade] GO:0070527[platelet aggregation] GO:0071635[negative regulation of transforming growth factor beta production] GO:0072378[blood coagulation, fibrin clot formation] GO:0072562[blood microparticle] GO:0097718[disordered domain specific binding] GO:0110165[cellular anatomical entity] GO:0150102[negative regulation of monocyte activation] GO:1901166[neural crest cell migration involved in autonomic nervous system development] GO:1904237[positive regulation of substrate-dependent cell migration, cell attachment to substrate]
Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins DeepTMHMM predicted secreted proteins DeepSig predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutational cancer driver genes Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Biotech drugs Human disease related genes Congenital malformations Congenital malformations of the musculoskeletal system Urinary system diseases Kidney diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525[angiogenesis] GO:0001932[regulation of protein phosphorylation] GO:0002020[protease binding] GO:0005102[signaling receptor binding] GO:0005178[integrin binding] GO:0005201[extracellular matrix structural constituent] GO:0005515[protein binding] GO:0005518[collagen binding] GO:0005576[extracellular region] GO:0005577[fibrinogen complex] GO:0005604[basement membrane] GO:0005615[extracellular space] GO:0005788[endoplasmic reticulum lumen] GO:0005793[endoplasmic reticulum-Golgi intermediate compartment] GO:0005886[plasma membrane] GO:0006953[acute-phase response] GO:0007044[cell-substrate junction assembly] GO:0007155[cell adhesion] GO:0007160[cell-matrix adhesion] GO:0007161[calcium-independent cell-matrix adhesion] GO:0007229[integrin-mediated signaling pathway] GO:0007399[nervous system development] GO:0007507[heart development] GO:0008022[protein C-terminus binding] GO:0008201[heparin binding] GO:0008284[positive regulation of cell population proliferation] GO:0008360[regulation of cell shape] GO:0009611[response to wounding] GO:0010628[positive regulation of gene expression] GO:0014068[positive regulation of phosphatidylinositol 3-kinase signaling] GO:0016324[apical plasma membrane] GO:0016504[peptidase activator activity] GO:0018149[peptide cross-linking] GO:0019899[enzyme binding] GO:0031012[extracellular matrix] GO:0031093[platelet alpha granule lumen] GO:0033622[integrin activation] GO:0034446[substrate adhesion-dependent cell spreading] GO:0035987[endodermal cell differentiation] GO:0042060[wound healing] GO:0042802[identical protein binding] GO:0043394[proteoglycan binding] GO:0045773[positive regulation of axon extension] GO:0048146[positive regulation of fibroblast proliferation] GO:0051087[chaperone binding] GO:0051702[biological process involved in interaction with symbiont] GO:0062023[collagen-containing extracellular matrix] GO:0070062[extracellular exosome] GO:0070372[regulation of ERK1 and ERK2 cascade] GO:0070527[platelet aggregation] GO:0071635[negative regulation of transforming growth factor beta production] GO:0072378[blood coagulation, fibrin clot formation] GO:0072562[blood microparticle] GO:0097718[disordered domain specific binding] GO:0110165[cellular anatomical entity] GO:0150102[negative regulation of monocyte activation] GO:1901166[neural crest cell migration involved in autonomic nervous system development] GO:1904237[positive regulation of substrate-dependent cell migration, cell attachment to substrate]
Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins DeepTMHMM predicted secreted proteins DeepSig predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutational cancer driver genes Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Biotech drugs Human disease related genes Congenital malformations Congenital malformations of the musculoskeletal system Urinary system diseases Kidney diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525[angiogenesis] GO:0001932[regulation of protein phosphorylation] GO:0002020[protease binding] GO:0005102[signaling receptor binding] GO:0005178[integrin binding] GO:0005201[extracellular matrix structural constituent] GO:0005515[protein binding] GO:0005518[collagen binding] GO:0005576[extracellular region] GO:0005577[fibrinogen complex] GO:0005615[extracellular space] GO:0005788[endoplasmic reticulum lumen] GO:0005793[endoplasmic reticulum-Golgi intermediate compartment] GO:0005886[plasma membrane] GO:0006953[acute-phase response] GO:0007044[cell-substrate junction assembly] GO:0007155[cell adhesion] GO:0007160[cell-matrix adhesion] GO:0007229[integrin-mediated signaling pathway] GO:0007399[nervous system development] GO:0007507[heart development] GO:0008022[protein C-terminus binding] GO:0008201[heparin binding] GO:0008284[positive regulation of cell population proliferation] GO:0008360[regulation of cell shape] GO:0009611[response to wounding] GO:0010628[positive regulation of gene expression] GO:0014068[positive regulation of phosphatidylinositol 3-kinase signaling] GO:0018149[peptide cross-linking] GO:0019899[enzyme binding] GO:0031012[extracellular matrix] GO:0031093[platelet alpha granule lumen] GO:0033622[integrin activation] GO:0034446[substrate adhesion-dependent cell spreading] GO:0035987[endodermal cell differentiation] GO:0042802[identical protein binding] GO:0043394[proteoglycan binding] GO:0048146[positive regulation of fibroblast proliferation] GO:0051087[chaperone binding] GO:0051702[biological process involved in interaction with symbiont] GO:0062023[collagen-containing extracellular matrix] GO:0070062[extracellular exosome] GO:0070372[regulation of ERK1 and ERK2 cascade] GO:0070527[platelet aggregation] GO:0071635[negative regulation of transforming growth factor beta production] GO:0072378[blood coagulation, fibrin clot formation] GO:0072562[blood microparticle] GO:0097718[disordered domain specific binding] GO:0110165[cellular anatomical entity] GO:0150102[negative regulation of monocyte activation] GO:1901166[neural crest cell migration involved in autonomic nervous system development] GO:1904237[positive regulation of substrate-dependent cell migration, cell attachment to substrate]
Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins DeepTMHMM predicted secreted proteins DeepSig predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutational cancer driver genes Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Biotech drugs Human disease related genes Congenital malformations Congenital malformations of the musculoskeletal system Urinary system diseases Kidney diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525[angiogenesis] GO:0001932[regulation of protein phosphorylation] GO:0002020[protease binding] GO:0005102[signaling receptor binding] GO:0005178[integrin binding] GO:0005201[extracellular matrix structural constituent] GO:0005515[protein binding] GO:0005518[collagen binding] GO:0005576[extracellular region] GO:0005577[fibrinogen complex] GO:0005615[extracellular space] GO:0005788[endoplasmic reticulum lumen] GO:0005793[endoplasmic reticulum-Golgi intermediate compartment] GO:0005886[plasma membrane] GO:0006953[acute-phase response] GO:0007044[cell-substrate junction assembly] GO:0007155[cell adhesion] GO:0007160[cell-matrix adhesion] GO:0007229[integrin-mediated signaling pathway] GO:0007399[nervous system development] GO:0007507[heart development] GO:0008022[protein C-terminus binding] GO:0008201[heparin binding] GO:0008284[positive regulation of cell population proliferation] GO:0008360[regulation of cell shape] GO:0009611[response to wounding] GO:0010628[positive regulation of gene expression] GO:0014068[positive regulation of phosphatidylinositol 3-kinase signaling] GO:0018149[peptide cross-linking] GO:0019899[enzyme binding] GO:0031012[extracellular matrix] GO:0031093[platelet alpha granule lumen] GO:0033622[integrin activation] GO:0034446[substrate adhesion-dependent cell spreading] GO:0035987[endodermal cell differentiation] GO:0042802[identical protein binding] GO:0043394[proteoglycan binding] GO:0048146[positive regulation of fibroblast proliferation] GO:0051087[chaperone binding] GO:0051702[biological process involved in interaction with symbiont] GO:0062023[collagen-containing extracellular matrix] GO:0070062[extracellular exosome] GO:0070372[regulation of ERK1 and ERK2 cascade] GO:0070527[platelet aggregation] GO:0071635[negative regulation of transforming growth factor beta production] GO:0072378[blood coagulation, fibrin clot formation] GO:0072562[blood microparticle] GO:0097718[disordered domain specific binding] GO:0110165[cellular anatomical entity] GO:0150102[negative regulation of monocyte activation] GO:1901166[neural crest cell migration involved in autonomic nervous system development] GO:1904237[positive regulation of substrate-dependent cell migration, cell attachment to substrate]
Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins DeepTMHMM predicted secreted proteins DeepSig predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutational cancer driver genes Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Biotech drugs Human disease related genes Congenital malformations Congenital malformations of the musculoskeletal system Urinary system diseases Kidney diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525[angiogenesis] GO:0001932[regulation of protein phosphorylation] GO:0002020[protease binding] GO:0005102[signaling receptor binding] GO:0005178[integrin binding] GO:0005201[extracellular matrix structural constituent] GO:0005515[protein binding] GO:0005518[collagen binding] GO:0005576[extracellular region] GO:0005577[fibrinogen complex] GO:0005615[extracellular space] GO:0005788[endoplasmic reticulum lumen] GO:0005793[endoplasmic reticulum-Golgi intermediate compartment] GO:0005886[plasma membrane] GO:0006953[acute-phase response] GO:0007044[cell-substrate junction assembly] GO:0007155[cell adhesion] GO:0007160[cell-matrix adhesion] GO:0007229[integrin-mediated signaling pathway] GO:0007399[nervous system development] GO:0007507[heart development] GO:0008022[protein C-terminus binding] GO:0008201[heparin binding] GO:0008284[positive regulation of cell population proliferation] GO:0008360[regulation of cell shape] GO:0009611[response to wounding] GO:0010628[positive regulation of gene expression] GO:0014068[positive regulation of phosphatidylinositol 3-kinase signaling] GO:0018149[peptide cross-linking] GO:0019899[enzyme binding] GO:0031012[extracellular matrix] GO:0031093[platelet alpha granule lumen] GO:0033622[integrin activation] GO:0034446[substrate adhesion-dependent cell spreading] GO:0035987[endodermal cell differentiation] GO:0042802[identical protein binding] GO:0043394[proteoglycan binding] GO:0048146[positive regulation of fibroblast proliferation] GO:0051087[chaperone binding] GO:0051702[biological process involved in interaction with symbiont] GO:0062023[collagen-containing extracellular matrix] GO:0070062[extracellular exosome] GO:0070372[regulation of ERK1 and ERK2 cascade] GO:0070527[platelet aggregation] GO:0071635[negative regulation of transforming growth factor beta production] GO:0072378[blood coagulation, fibrin clot formation] GO:0072562[blood microparticle] GO:0097718[disordered domain specific binding] GO:0110165[cellular anatomical entity] GO:0150102[negative regulation of monocyte activation] GO:1901166[neural crest cell migration involved in autonomic nervous system development] GO:1904237[positive regulation of substrate-dependent cell migration, cell attachment to substrate]
Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins DeepTMHMM predicted secreted proteins DeepSig predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutational cancer driver genes Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Biotech drugs Human disease related genes Congenital malformations Congenital malformations of the musculoskeletal system Urinary system diseases Kidney diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525[angiogenesis] GO:0001932[regulation of protein phosphorylation] GO:0002020[protease binding] GO:0005102[signaling receptor binding] GO:0005178[integrin binding] GO:0005201[extracellular matrix structural constituent] GO:0005515[protein binding] GO:0005518[collagen binding] GO:0005576[extracellular region] GO:0005577[fibrinogen complex] GO:0005615[extracellular space] GO:0005788[endoplasmic reticulum lumen] GO:0005793[endoplasmic reticulum-Golgi intermediate compartment] GO:0005886[plasma membrane] GO:0006953[acute-phase response] GO:0007044[cell-substrate junction assembly] GO:0007155[cell adhesion] GO:0007160[cell-matrix adhesion] GO:0007229[integrin-mediated signaling pathway] GO:0007399[nervous system development] GO:0007507[heart development] GO:0008022[protein C-terminus binding] GO:0008201[heparin binding] GO:0008284[positive regulation of cell population proliferation] GO:0008360[regulation of cell shape] GO:0009611[response to wounding] GO:0010628[positive regulation of gene expression] GO:0014068[positive regulation of phosphatidylinositol 3-kinase signaling] GO:0018149[peptide cross-linking] GO:0019899[enzyme binding] GO:0031012[extracellular matrix] GO:0031093[platelet alpha granule lumen] GO:0033622[integrin activation] GO:0034446[substrate adhesion-dependent cell spreading] GO:0035987[endodermal cell differentiation] GO:0042802[identical protein binding] GO:0043394[proteoglycan binding] GO:0048146[positive regulation of fibroblast proliferation] GO:0051087[chaperone binding] GO:0051702[biological process involved in interaction with symbiont] GO:0062023[collagen-containing extracellular matrix] GO:0070062[extracellular exosome] GO:0070372[regulation of ERK1 and ERK2 cascade] GO:0070527[platelet aggregation] GO:0071635[negative regulation of transforming growth factor beta production] GO:0072378[blood coagulation, fibrin clot formation] GO:0072562[blood microparticle] GO:0097718[disordered domain specific binding] GO:0110165[cellular anatomical entity] GO:0150102[negative regulation of monocyte activation] GO:1901166[neural crest cell migration involved in autonomic nervous system development] GO:1904237[positive regulation of substrate-dependent cell migration, cell attachment to substrate]
Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins DeepTMHMM predicted secreted proteins DeepSig predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutational cancer driver genes Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Biotech drugs Human disease related genes Congenital malformations Congenital malformations of the musculoskeletal system Urinary system diseases Kidney diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001525[angiogenesis] GO:0001932[regulation of protein phosphorylation] GO:0002020[protease binding] GO:0005102[signaling receptor binding] GO:0005178[integrin binding] GO:0005201[extracellular matrix structural constituent] GO:0005515[protein binding] GO:0005518[collagen binding] GO:0005576[extracellular region] GO:0005577[fibrinogen complex] GO:0005615[extracellular space] GO:0005788[endoplasmic reticulum lumen] GO:0005793[endoplasmic reticulum-Golgi intermediate compartment] GO:0005886[plasma membrane] GO:0006953[acute-phase response] GO:0007044[cell-substrate junction assembly] GO:0007155[cell adhesion] GO:0007160[cell-matrix adhesion] GO:0007229[integrin-mediated signaling pathway] GO:0007399[nervous system development] GO:0007507[heart development] GO:0008022[protein C-terminus binding] GO:0008201[heparin binding] GO:0008284[positive regulation of cell population proliferation] GO:0008360[regulation of cell shape] GO:0009611[response to wounding] GO:0010628[positive regulation of gene expression] GO:0014068[positive regulation of phosphatidylinositol 3-kinase signaling] GO:0018149[peptide cross-linking] GO:0019899[enzyme binding] GO:0031012[extracellular matrix] GO:0031093[platelet alpha granule lumen] GO:0033622[integrin activation] GO:0034446[substrate adhesion-dependent cell spreading] GO:0035987[endodermal cell differentiation] GO:0042802[identical protein binding] GO:0043394[proteoglycan binding] GO:0048146[positive regulation of fibroblast proliferation] GO:0051087[chaperone binding] GO:0051702[biological process involved in interaction with symbiont] GO:0062023[collagen-containing extracellular matrix] GO:0070062[extracellular exosome] GO:0070372[regulation of ERK1 and ERK2 cascade] GO:0070527[platelet aggregation] GO:0071635[negative regulation of transforming growth factor beta production] GO:0072378[blood coagulation, fibrin clot formation] GO:0072562[blood microparticle] GO:0097718[disordered domain specific binding] GO:0110165[cellular anatomical entity] GO:0150102[negative regulation of monocyte activation] GO:1901166[neural crest cell migration involved in autonomic nervous system development] GO:1904237[positive regulation of substrate-dependent cell migration, cell attachment to substrate]
Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins DeepTMHMM predicted secreted proteins DeepSig predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutational cancer driver genes Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Biotech drugs Human disease related genes Congenital malformations Congenital malformations of the musculoskeletal system Urinary system diseases Kidney diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525[angiogenesis] GO:0001932[regulation of protein phosphorylation] GO:0002020[protease binding] GO:0005102[signaling receptor binding] GO:0005178[integrin binding] GO:0005201[extracellular matrix structural constituent] GO:0005515[protein binding] GO:0005518[collagen binding] GO:0005576[extracellular region] GO:0005577[fibrinogen complex] GO:0005615[extracellular space] GO:0005788[endoplasmic reticulum lumen] GO:0005793[endoplasmic reticulum-Golgi intermediate compartment] GO:0005886[plasma membrane] GO:0006953[acute-phase response] GO:0007044[cell-substrate junction assembly] GO:0007155[cell adhesion] GO:0007160[cell-matrix adhesion] GO:0007229[integrin-mediated signaling pathway] GO:0007399[nervous system development] GO:0007507[heart development] GO:0008022[protein C-terminus binding] GO:0008201[heparin binding] GO:0008284[positive regulation of cell population proliferation] GO:0008360[regulation of cell shape] GO:0009611[response to wounding] GO:0010628[positive regulation of gene expression] GO:0014068[positive regulation of phosphatidylinositol 3-kinase signaling] GO:0018149[peptide cross-linking] GO:0019899[enzyme binding] GO:0031012[extracellular matrix] GO:0031093[platelet alpha granule lumen] GO:0033622[integrin activation] GO:0034446[substrate adhesion-dependent cell spreading] GO:0035987[endodermal cell differentiation] GO:0042802[identical protein binding] GO:0043394[proteoglycan binding] GO:0048146[positive regulation of fibroblast proliferation] GO:0051087[chaperone binding] GO:0051702[biological process involved in interaction with symbiont] GO:0062023[collagen-containing extracellular matrix] GO:0070062[extracellular exosome] GO:0070372[regulation of ERK1 and ERK2 cascade] GO:0070527[platelet aggregation] GO:0071635[negative regulation of transforming growth factor beta production] GO:0072378[blood coagulation, fibrin clot formation] GO:0072562[blood microparticle] GO:0097718[disordered domain specific binding] GO:0110165[cellular anatomical entity] GO:0150102[negative regulation of monocyte activation] GO:1901166[neural crest cell migration involved in autonomic nervous system development] GO:1904237[positive regulation of substrate-dependent cell migration, cell attachment to substrate]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes Human disease related genes Congenital malformations Congenital malformations of the musculoskeletal system Urinary system diseases Kidney diseases Protein evidence (Ezkurdia et al 2014)
Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins DeepTMHMM predicted secreted proteins DeepSig predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutational cancer driver genes Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Biotech drugs Human disease related genes Congenital malformations Congenital malformations of the musculoskeletal system Urinary system diseases Kidney diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0001525[angiogenesis] GO:0001932[regulation of protein phosphorylation] GO:0002020[protease binding] GO:0005102[signaling receptor binding] GO:0005178[integrin binding] GO:0005201[extracellular matrix structural constituent] GO:0005515[protein binding] GO:0005518[collagen binding] GO:0005576[extracellular region] GO:0005577[fibrinogen complex] GO:0005615[extracellular space] GO:0005788[endoplasmic reticulum lumen] GO:0005793[endoplasmic reticulum-Golgi intermediate compartment] GO:0005886[plasma membrane] GO:0006953[acute-phase response] GO:0007044[cell-substrate junction assembly] GO:0007155[cell adhesion] GO:0007160[cell-matrix adhesion] GO:0007229[integrin-mediated signaling pathway] GO:0007399[nervous system development] GO:0007507[heart development] GO:0008022[protein C-terminus binding] GO:0008201[heparin binding] GO:0008284[positive regulation of cell population proliferation] GO:0008360[regulation of cell shape] GO:0009611[response to wounding] GO:0010628[positive regulation of gene expression] GO:0014068[positive regulation of phosphatidylinositol 3-kinase signaling] GO:0018149[peptide cross-linking] GO:0019899[enzyme binding] GO:0031012[extracellular matrix] GO:0031093[platelet alpha granule lumen] GO:0033622[integrin activation] GO:0034446[substrate adhesion-dependent cell spreading] GO:0035987[endodermal cell differentiation] GO:0042802[identical protein binding] GO:0043394[proteoglycan binding] GO:0048146[positive regulation of fibroblast proliferation] GO:0051087[chaperone binding] GO:0051702[biological process involved in interaction with symbiont] GO:0062023[collagen-containing extracellular matrix] GO:0070062[extracellular exosome] GO:0070372[regulation of ERK1 and ERK2 cascade] GO:0070527[platelet aggregation] GO:0071635[negative regulation of transforming growth factor beta production] GO:0072378[blood coagulation, fibrin clot formation] GO:0072562[blood microparticle] GO:0097718[disordered domain specific binding] GO:0110165[cellular anatomical entity] GO:0150102[negative regulation of monocyte activation] GO:1901166[neural crest cell migration involved in autonomic nervous system development] GO:1904237[positive regulation of substrate-dependent cell migration, cell attachment to substrate]
Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins DeepTMHMM predicted secreted proteins DeepSig predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutational cancer driver genes Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Biotech drugs Human disease related genes Congenital malformations Congenital malformations of the musculoskeletal system Urinary system diseases Kidney diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0001525[angiogenesis] GO:0001932[regulation of protein phosphorylation] GO:0002020[protease binding] GO:0005102[signaling receptor binding] GO:0005178[integrin binding] GO:0005201[extracellular matrix structural constituent] GO:0005515[protein binding] GO:0005518[collagen binding] GO:0005576[extracellular region] GO:0005577[fibrinogen complex] GO:0005615[extracellular space] GO:0005788[endoplasmic reticulum lumen] GO:0005793[endoplasmic reticulum-Golgi intermediate compartment] GO:0005886[plasma membrane] GO:0006953[acute-phase response] GO:0007044[cell-substrate junction assembly] GO:0007155[cell adhesion] GO:0007160[cell-matrix adhesion] GO:0007229[integrin-mediated signaling pathway] GO:0007399[nervous system development] GO:0007507[heart development] GO:0008022[protein C-terminus binding] GO:0008201[heparin binding] GO:0008284[positive regulation of cell population proliferation] GO:0008360[regulation of cell shape] GO:0009611[response to wounding] GO:0010628[positive regulation of gene expression] GO:0014068[positive regulation of phosphatidylinositol 3-kinase signaling] GO:0018149[peptide cross-linking] GO:0019899[enzyme binding] GO:0031012[extracellular matrix] GO:0031093[platelet alpha granule lumen] GO:0033622[integrin activation] GO:0034446[substrate adhesion-dependent cell spreading] GO:0035987[endodermal cell differentiation] GO:0042802[identical protein binding] GO:0043394[proteoglycan binding] GO:0048146[positive regulation of fibroblast proliferation] GO:0051087[chaperone binding] GO:0051702[biological process involved in interaction with symbiont] GO:0062023[collagen-containing extracellular matrix] GO:0070062[extracellular exosome] GO:0070372[regulation of ERK1 and ERK2 cascade] GO:0070527[platelet aggregation] GO:0071635[negative regulation of transforming growth factor beta production] GO:0072378[blood coagulation, fibrin clot formation] GO:0072562[blood microparticle] GO:0097718[disordered domain specific binding] GO:0110165[cellular anatomical entity] GO:0150102[negative regulation of monocyte activation] GO:1901166[neural crest cell migration involved in autonomic nervous system development] GO:1904237[positive regulation of substrate-dependent cell migration, cell attachment to substrate]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes Human disease related genes Congenital malformations Congenital malformations of the musculoskeletal system Urinary system diseases Kidney diseases Protein evidence (Ezkurdia et al 2014)
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