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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Signal transducer and activator of transcription 1
Protein classi
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes Human disease related genes Plasma proteins Transcription factors
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
2
Cytoband
q32.2
Chromosome location (bp)
190908460 - 191020960
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors 1,2,3,4,5,6,7. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus 8,9. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN-stimulated genes (ISG), which drive the cell in an antiviral state 10,11. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated 12. It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state 13. Becomes activated in response to KITLG/SCF and KIT signaling 14. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4 15. Involved in food tolerance in small intestine: associates with the Gasdermin-D, p13 cleavage product (13 kDa GSDMD) and promotes transcription of CIITA, inducing type 1 regulatory T (Tr1) cells in upper small intestine (By similarity)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Activator, DNA-binding
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. The protein encoded by this gene can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. The protein plays an important role in immune responses to viral, fungal and mycobacterial pathogens. Mutations in this gene are associated with Immunodeficiency 31B, 31A, and 31C. [provided by RefSeq, Jun 2020]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
P42224 [Direct mapping] Signal transducer and activator of transcription 1-alpha/beta
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Immunoglobulin fold Disease related genes Human disease related genes Immune system diseases Primary immunodeficiency Other immune system diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000979[RNA polymerase II core promoter sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001222[transcription corepressor binding] GO:0001223[transcription coactivator binding] GO:0001937[negative regulation of endothelial cell proliferation] GO:0002053[positive regulation of mesenchymal cell proliferation] GO:0002230[positive regulation of defense response to virus by host] GO:0003340[negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis] GO:0003677[DNA binding] GO:0003690[double-stranded DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005164[tumor necrosis factor receptor binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005730[nucleolus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006355[regulation of DNA-templated transcription] GO:0006952[defense response] GO:0007165[signal transduction] GO:0007259[receptor signaling pathway via JAK-STAT] GO:0007584[response to nutrient] GO:0008015[blood circulation] GO:0008284[positive regulation of cell population proliferation] GO:0009410[response to xenobiotic stimulus] GO:0009612[response to mechanical stimulus] GO:0010742[macrophage derived foam cell differentiation] GO:0014070[response to organic cyclic compound] GO:0016525[negative regulation of angiogenesis] GO:0016922[nuclear receptor binding] GO:0019221[cytokine-mediated signaling pathway] GO:0019899[enzyme binding] GO:0030424[axon] GO:0030425[dendrite] GO:0031730[CCR5 chemokine receptor binding] GO:0032727[positive regulation of interferon-alpha production] GO:0032869[cellular response to insulin stimulus] GO:0032991[protein-containing complex] GO:0033209[tumor necrosis factor-mediated signaling pathway] GO:0034097[response to cytokine] GO:0034341[response to type II interferon] GO:0035035[histone acetyltransferase binding] GO:0035456[response to interferon-beta] GO:0035458[cellular response to interferon-beta] GO:0042127[regulation of cell population proliferation] GO:0042393[histone binding] GO:0042542[response to hydrogen peroxide] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0042981[regulation of apoptotic process] GO:0043124[negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043434[response to peptide hormone] GO:0043565[sequence-specific DNA binding] GO:0044389[ubiquitin-like protein ligase binding] GO:0045296[cadherin binding] GO:0045648[positive regulation of erythrocyte differentiation] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046725[negative regulation by virus of viral protein levels in host cell] GO:0048471[perinuclear region of cytoplasm] GO:0048661[positive regulation of smooth muscle cell proliferation] GO:0051591[response to cAMP] GO:0051607[defense response to virus] GO:0051721[protein phosphatase 2A binding] GO:0051770[positive regulation of nitric-oxide synthase biosynthetic process] GO:0060333[type II interferon-mediated signaling pathway] GO:0060337[type I interferon signaling pathway] GO:0061326[renal tubule development] GO:0070106[interleukin-27-mediated signaling pathway] GO:0070721[ISGF3 complex] GO:0071345[cellular response to cytokine stimulus] GO:0071346[cellular response to interferon-gamma] GO:0071407[cellular response to organic cyclic compound] GO:0072136[metanephric mesenchymal cell proliferation involved in metanephros development] GO:0072162[metanephric mesenchymal cell differentiation] GO:0072308[negative regulation of metanephric nephron tubule epithelial cell differentiation] GO:0090575[RNA polymerase II transcription regulator complex] GO:1990841[promoter-specific chromatin binding]
P42224 [Direct mapping] Signal transducer and activator of transcription 1-alpha/beta
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Immunoglobulin fold Disease related genes Human disease related genes Immune system diseases Primary immunodeficiency Other immune system diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000979[RNA polymerase II core promoter sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001222[transcription corepressor binding] GO:0001223[transcription coactivator binding] GO:0001937[negative regulation of endothelial cell proliferation] GO:0002053[positive regulation of mesenchymal cell proliferation] GO:0002230[positive regulation of defense response to virus by host] GO:0003340[negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis] GO:0003677[DNA binding] GO:0003690[double-stranded DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005164[tumor necrosis factor receptor binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005730[nucleolus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006355[regulation of DNA-templated transcription] GO:0006952[defense response] GO:0007165[signal transduction] GO:0007259[receptor signaling pathway via JAK-STAT] GO:0008015[blood circulation] GO:0010742[macrophage derived foam cell differentiation] GO:0016525[negative regulation of angiogenesis] GO:0016922[nuclear receptor binding] GO:0019221[cytokine-mediated signaling pathway] GO:0019899[enzyme binding] GO:0030424[axon] GO:0030425[dendrite] GO:0032727[positive regulation of interferon-alpha production] GO:0032991[protein-containing complex] GO:0033209[tumor necrosis factor-mediated signaling pathway] GO:0034097[response to cytokine] GO:0034341[response to type II interferon] GO:0035035[histone acetyltransferase binding] GO:0035456[response to interferon-beta] GO:0035458[cellular response to interferon-beta] GO:0042127[regulation of cell population proliferation] GO:0042393[histone binding] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0042981[regulation of apoptotic process] GO:0043124[negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043434[response to peptide hormone] GO:0044389[ubiquitin-like protein ligase binding] GO:0045296[cadherin binding] GO:0045648[positive regulation of erythrocyte differentiation] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046725[negative regulation by virus of viral protein levels in host cell] GO:0048471[perinuclear region of cytoplasm] GO:0048661[positive regulation of smooth muscle cell proliferation] GO:0051591[response to cAMP] GO:0051607[defense response to virus] GO:0060333[type II interferon-mediated signaling pathway] GO:0060337[type I interferon signaling pathway] GO:0061326[renal tubule development] GO:0070106[interleukin-27-mediated signaling pathway] GO:0070721[ISGF3 complex] GO:0071346[cellular response to interferon-gamma] GO:0072136[metanephric mesenchymal cell proliferation involved in metanephros development] GO:0072162[metanephric mesenchymal cell differentiation] GO:0072308[negative regulation of metanephric nephron tubule epithelial cell differentiation] GO:0090575[RNA polymerase II transcription regulator complex] GO:1990841[promoter-specific chromatin binding]
J3KPM9 [Direct mapping] Signal transducer and activator of transcription
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Immune system diseases Primary immunodeficiency Other immune system diseases Protein evidence (Ezkurdia et al 2014)
P42224 [Direct mapping] Signal transducer and activator of transcription 1-alpha/beta
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Immunoglobulin fold Disease related genes Human disease related genes Immune system diseases Primary immunodeficiency Other immune system diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000979[RNA polymerase II core promoter sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001222[transcription corepressor binding] GO:0001223[transcription coactivator binding] GO:0001937[negative regulation of endothelial cell proliferation] GO:0002053[positive regulation of mesenchymal cell proliferation] GO:0002230[positive regulation of defense response to virus by host] GO:0003340[negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis] GO:0003677[DNA binding] GO:0003690[double-stranded DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005164[tumor necrosis factor receptor binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005730[nucleolus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006355[regulation of DNA-templated transcription] GO:0006952[defense response] GO:0007165[signal transduction] GO:0007259[receptor signaling pathway via JAK-STAT] GO:0008015[blood circulation] GO:0010742[macrophage derived foam cell differentiation] GO:0016525[negative regulation of angiogenesis] GO:0016922[nuclear receptor binding] GO:0019221[cytokine-mediated signaling pathway] GO:0019899[enzyme binding] GO:0030424[axon] GO:0030425[dendrite] GO:0032727[positive regulation of interferon-alpha production] GO:0032991[protein-containing complex] GO:0033209[tumor necrosis factor-mediated signaling pathway] GO:0034097[response to cytokine] GO:0034341[response to type II interferon] GO:0035035[histone acetyltransferase binding] GO:0035456[response to interferon-beta] GO:0035458[cellular response to interferon-beta] GO:0042127[regulation of cell population proliferation] GO:0042393[histone binding] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0042981[regulation of apoptotic process] GO:0043124[negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043434[response to peptide hormone] GO:0044389[ubiquitin-like protein ligase binding] GO:0045296[cadherin binding] GO:0045648[positive regulation of erythrocyte differentiation] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046725[negative regulation by virus of viral protein levels in host cell] GO:0048471[perinuclear region of cytoplasm] GO:0048661[positive regulation of smooth muscle cell proliferation] GO:0051591[response to cAMP] GO:0051607[defense response to virus] GO:0060333[type II interferon-mediated signaling pathway] GO:0060337[type I interferon signaling pathway] GO:0061326[renal tubule development] GO:0070106[interleukin-27-mediated signaling pathway] GO:0070721[ISGF3 complex] GO:0071346[cellular response to interferon-gamma] GO:0072136[metanephric mesenchymal cell proliferation involved in metanephros development] GO:0072162[metanephric mesenchymal cell differentiation] GO:0072308[negative regulation of metanephric nephron tubule epithelial cell differentiation] GO:0090575[RNA polymerase II transcription regulator complex] GO:1990841[promoter-specific chromatin binding]
E7EPD2 [Direct mapping] Signal transducer and activator of transcription 1-alpha/beta
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Immune system diseases Primary immunodeficiency Other immune system diseases Protein evidence (Ezkurdia et al 2014)
E9PH66 [Direct mapping] Signal transducer and activator of transcription 1-alpha/beta
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Immune system diseases Primary immunodeficiency Other immune system diseases Protein evidence (Ezkurdia et al 2014)
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GO:0003700[DNA-binding transcription factor activity] GO:0006355[regulation of DNA-templated transcription] GO:0007165[signal transduction]
E7ENM1 [Direct mapping] Signal transducer and activator of transcription 1-alpha/beta
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Immune system diseases Primary immunodeficiency Other immune system diseases Protein evidence (Ezkurdia et al 2014)
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GO:0003700[DNA-binding transcription factor activity] GO:0006355[regulation of DNA-templated transcription] GO:0007165[signal transduction]
P42224 [Direct mapping] Signal transducer and activator of transcription 1-alpha/beta
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Immunoglobulin fold Disease related genes Human disease related genes Immune system diseases Primary immunodeficiency Other immune system diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000979[RNA polymerase II core promoter sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001222[transcription corepressor binding] GO:0001223[transcription coactivator binding] GO:0001937[negative regulation of endothelial cell proliferation] GO:0002053[positive regulation of mesenchymal cell proliferation] GO:0002230[positive regulation of defense response to virus by host] GO:0003340[negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis] GO:0003677[DNA binding] GO:0003690[double-stranded DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005164[tumor necrosis factor receptor binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005730[nucleolus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006355[regulation of DNA-templated transcription] GO:0006952[defense response] GO:0007165[signal transduction] GO:0007259[receptor signaling pathway via JAK-STAT] GO:0008015[blood circulation] GO:0010742[macrophage derived foam cell differentiation] GO:0016525[negative regulation of angiogenesis] GO:0016922[nuclear receptor binding] GO:0019221[cytokine-mediated signaling pathway] GO:0019899[enzyme binding] GO:0030424[axon] GO:0030425[dendrite] GO:0032727[positive regulation of interferon-alpha production] GO:0032991[protein-containing complex] GO:0033209[tumor necrosis factor-mediated signaling pathway] GO:0034097[response to cytokine] GO:0034341[response to type II interferon] GO:0035035[histone acetyltransferase binding] GO:0035456[response to interferon-beta] GO:0035458[cellular response to interferon-beta] GO:0042127[regulation of cell population proliferation] GO:0042393[histone binding] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0042981[regulation of apoptotic process] GO:0043124[negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043434[response to peptide hormone] GO:0044389[ubiquitin-like protein ligase binding] GO:0045296[cadherin binding] GO:0045648[positive regulation of erythrocyte differentiation] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046725[negative regulation by virus of viral protein levels in host cell] GO:0048471[perinuclear region of cytoplasm] GO:0048661[positive regulation of smooth muscle cell proliferation] GO:0051591[response to cAMP] GO:0051607[defense response to virus] GO:0060333[type II interferon-mediated signaling pathway] GO:0060337[type I interferon signaling pathway] GO:0061326[renal tubule development] GO:0070106[interleukin-27-mediated signaling pathway] GO:0070721[ISGF3 complex] GO:0071346[cellular response to interferon-gamma] GO:0072136[metanephric mesenchymal cell proliferation involved in metanephros development] GO:0072162[metanephric mesenchymal cell differentiation] GO:0072308[negative regulation of metanephric nephron tubule epithelial cell differentiation] GO:0090575[RNA polymerase II transcription regulator complex] GO:1990841[promoter-specific chromatin binding]
A0A669KB68 [Direct mapping] Signal transducer and activator of transcription
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Immune system diseases Primary immunodeficiency Other immune system diseases Protein evidence (Ezkurdia et al 2014)
A0A669KB56 [Direct mapping] Signal transducer and activator of transcription
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Immune system diseases Primary immunodeficiency Other immune system diseases Protein evidence (Ezkurdia et al 2014)
P42224 [Direct mapping] Signal transducer and activator of transcription 1-alpha/beta
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Immunoglobulin fold Disease related genes Human disease related genes Immune system diseases Primary immunodeficiency Other immune system diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000979[RNA polymerase II core promoter sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001222[transcription corepressor binding] GO:0001223[transcription coactivator binding] GO:0001937[negative regulation of endothelial cell proliferation] GO:0002053[positive regulation of mesenchymal cell proliferation] GO:0002230[positive regulation of defense response to virus by host] GO:0003340[negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis] GO:0003677[DNA binding] GO:0003690[double-stranded DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005164[tumor necrosis factor receptor binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005730[nucleolus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006355[regulation of DNA-templated transcription] GO:0006952[defense response] GO:0007165[signal transduction] GO:0007259[receptor signaling pathway via JAK-STAT] GO:0008015[blood circulation] GO:0010742[macrophage derived foam cell differentiation] GO:0016525[negative regulation of angiogenesis] GO:0016922[nuclear receptor binding] GO:0019221[cytokine-mediated signaling pathway] GO:0019899[enzyme binding] GO:0030424[axon] GO:0030425[dendrite] GO:0032727[positive regulation of interferon-alpha production] GO:0032991[protein-containing complex] GO:0033209[tumor necrosis factor-mediated signaling pathway] GO:0034097[response to cytokine] GO:0034341[response to type II interferon] GO:0035035[histone acetyltransferase binding] GO:0035456[response to interferon-beta] GO:0035458[cellular response to interferon-beta] GO:0042127[regulation of cell population proliferation] GO:0042393[histone binding] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0042981[regulation of apoptotic process] GO:0043124[negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043434[response to peptide hormone] GO:0044389[ubiquitin-like protein ligase binding] GO:0045296[cadherin binding] GO:0045648[positive regulation of erythrocyte differentiation] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046725[negative regulation by virus of viral protein levels in host cell] GO:0048471[perinuclear region of cytoplasm] GO:0048661[positive regulation of smooth muscle cell proliferation] GO:0051591[response to cAMP] GO:0051607[defense response to virus] GO:0060333[type II interferon-mediated signaling pathway] GO:0060337[type I interferon signaling pathway] GO:0061326[renal tubule development] GO:0070106[interleukin-27-mediated signaling pathway] GO:0070721[ISGF3 complex] GO:0071346[cellular response to interferon-gamma] GO:0072136[metanephric mesenchymal cell proliferation involved in metanephros development] GO:0072162[metanephric mesenchymal cell differentiation] GO:0072308[negative regulation of metanephric nephron tubule epithelial cell differentiation] GO:0090575[RNA polymerase II transcription regulator complex] GO:1990841[promoter-specific chromatin binding]
A0A669KBA4 [Direct mapping] Signal transducer and activator of transcription
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Immune system diseases Primary immunodeficiency Other immune system diseases Protein evidence (Ezkurdia et al 2014)
A0A669KB68 [Direct mapping] Signal transducer and activator of transcription
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Immune system diseases Primary immunodeficiency Other immune system diseases Protein evidence (Ezkurdia et al 2014)
A0A669KB53 [Direct mapping] Signal transducer and activator of transcription
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Immune system diseases Primary immunodeficiency Other immune system diseases Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Immune system diseases Primary immunodeficiency Other immune system diseases Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Immune system diseases Primary immunodeficiency Other immune system diseases Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Immune system diseases Primary immunodeficiency Other immune system diseases Protein evidence (Ezkurdia et al 2014)
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GO:0003700[DNA-binding transcription factor activity] GO:0006355[regulation of DNA-templated transcription] GO:0007165[signal transduction]
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