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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
2
Cytoband
q12.2
Chromosome location (bp)
105357712 - 105438513
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation. Negatively regulates the calcineurin/NFAT signaling pathway in cardiomyocytes 1....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Transcription, Transcription regulation
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Metal-binding, Zinc
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. This protein is thought to have a role in the assembly of extracellular membranes. Also, this gene is down-regulated during transformation of normal myoblasts to rhabdomyosarcoma cells and the encoded protein may function as a link between presenilin-2 and an intracellular signaling pathway. Multiple alternatively spliced variants encoding different isoforms have been identified. [provided by RefSeq, Jan 2016]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q14192 [Direct mapping] Four and a half LIM domains protein 2
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Q6I9R8 [Target identity:100%; Query identity:100%] FHL2 protein; Four and a half LIM domains 2; HCG28013, isoform CRA_a; cDNA, FLJ94468, Homo sapiens four and a half LIM domains 2 (FHL2), mRNA
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Q14192 [Direct mapping] Four and a half LIM domains protein 2
Show all
Q6I9R8 [Target identity:100%; Query identity:100%] FHL2 protein; Four and a half LIM domains 2; HCG28013, isoform CRA_a; cDNA, FLJ94468, Homo sapiens four and a half LIM domains 2 (FHL2), mRNA
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Q14192 [Direct mapping] Four and a half LIM domains protein 2
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Q14192 [Direct mapping] Four and a half LIM domains protein 2
Show all
Q6I9R8 [Target identity:100%; Query identity:100%] FHL2 protein; Four and a half LIM domains 2; HCG28013, isoform CRA_a; cDNA, FLJ94468, Homo sapiens four and a half LIM domains 2 (FHL2), mRNA
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Q14192 [Direct mapping] Four and a half LIM domains protein 2
Show all
Q6I9R8 [Target identity:100%; Query identity:100%] FHL2 protein; Four and a half LIM domains 2; HCG28013, isoform CRA_a; cDNA, FLJ94468, Homo sapiens four and a half LIM domains 2 (FHL2), mRNA
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Q14192 [Direct mapping] Four and a half LIM domains protein 2
Show all
Q6I9R8 [Target identity:100%; Query identity:100%] FHL2 protein; Four and a half LIM domains 2; HCG28013, isoform CRA_a; cDNA, FLJ94468, Homo sapiens four and a half LIM domains 2 (FHL2), mRNA
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Q14192 [Direct mapping] Four and a half LIM domains protein 2
Show all
Q6I9R8 [Target identity:100%; Query identity:100%] FHL2 protein; Four and a half LIM domains 2; HCG28013, isoform CRA_a; cDNA, FLJ94468, Homo sapiens four and a half LIM domains 2 (FHL2), mRNA
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Q14192 [Direct mapping] Four and a half LIM domains protein 2
Show all
Q6I9R8 [Target identity:100%; Query identity:100%] FHL2 protein; Four and a half LIM domains 2; HCG28013, isoform CRA_a; cDNA, FLJ94468, Homo sapiens four and a half LIM domains 2 (FHL2), mRNA
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Q14192 [Direct mapping] Four and a half LIM domains protein 2
Show all
Q6I9R8 [Target identity:100%; Query identity:100%] FHL2 protein; Four and a half LIM domains 2; HCG28013, isoform CRA_a; cDNA, FLJ94468, Homo sapiens four and a half LIM domains 2 (FHL2), mRNA
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0001649[osteoblast differentiation] GO:0003712[transcription coregulator activity] GO:0003714[transcription corepressor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005925[focal adhesion] GO:0006351[DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0008134[transcription factor binding] GO:0009725[response to hormone] GO:0030018[Z disc] GO:0042802[identical protein binding] GO:0043066[negative regulation of apoptotic process] GO:0043425[bHLH transcription factor binding] GO:0046872[metal ion binding] GO:0055014[atrial cardiac muscle cell development] GO:0055015[ventricular cardiac muscle cell development] GO:0060347[heart trabecula formation] GO:0070885[negative regulation of calcineurin-NFAT signaling cascade]
The Human Protein Atlas project is funded
