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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Transcription factors
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
2
Cytoband
p25.1
Chromosome location (bp)
8678845 - 8684461
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. Restricts the CLOCK and BMAL1 localization to the cytoplasm. Plays a role in both the input and output pathways of the circadian clock: in the input component, is involved in modulating the magnitude of photic entrainment and in the output component, contributes to the regulation of a variety of liver clock-controlled genes involved in lipid metabolism....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Developmental protein, Repressor
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
The protein encoded by this gene belongs to the inhibitor of DNA binding family, members of which are transcriptional regulators that contain a helix-loop-helix (HLH) domain but not a basic domain. Members of the inhibitor of DNA binding family inhibit the functions of basic helix-loop-helix transcription factors in a dominant-negative manner by suppressing their heterodimerization partners through the HLH domains. This protein may play a role in negatively regulating cell differentiation. A pseudogene of this gene is located on chromosome 3. [provided by RefSeq, Aug 2011]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q02363 [Direct mapping] DNA-binding protein inhibitor ID-2
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Q53T66 [Target identity:100%; Query identity:100%] Cell growth-inhibiting gene 8; Inhibitor of DNA binding 2, dominant negative helix-loop-helix protein, isoform CRA_a; Uncharacterized protein ID2; cDNA, FLJ92261, highly similar to Homo sapiens inhibitor of DNA binding 2, dominant negative helix-loop-helix protein (ID2), mRNA
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Basic domains Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000791[euchromatin] GO:0003166[bundle of His development] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0007507[heart development] GO:0007623[circadian rhythm] GO:0010628[positive regulation of gene expression] GO:0010629[negative regulation of gene expression] GO:0019216[regulation of lipid metabolic process] GO:0021772[olfactory bulb development] GO:0030154[cell differentiation] GO:0032922[circadian regulation of gene expression] GO:0032991[protein-containing complex] GO:0033598[mammary gland epithelial cell proliferation] GO:0042752[regulation of circadian rhythm] GO:0043153[entrainment of circadian clock by photoperiod] GO:0043353[enucleate erythrocyte differentiation] GO:0043433[negative regulation of DNA-binding transcription factor activity] GO:0044325[transmembrane transporter binding] GO:0045475[locomotor rhythm] GO:0045578[negative regulation of B cell differentiation] GO:0045600[positive regulation of fat cell differentiation] GO:0045651[positive regulation of macrophage differentiation] GO:0045664[regulation of neuron differentiation] GO:0045777[positive regulation of blood pressure] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0046983[protein dimerization activity] GO:0048511[rhythmic process] GO:0048557[embryonic digestive tract morphogenesis] GO:0048661[positive regulation of smooth muscle cell proliferation] GO:0048663[neuron fate commitment] GO:0048711[positive regulation of astrocyte differentiation] GO:0051148[negative regulation of muscle cell differentiation] GO:0060749[mammary gland alveolus development] GO:0061030[epithelial cell differentiation involved in mammary gland alveolus development] GO:0061031[endodermal digestive tract morphogenesis] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0071931[positive regulation of transcription involved in G1/S transition of mitotic cell cycle] GO:0090398[cellular senescence] GO:0140416[transcription regulator inhibitor activity] GO:2000045[regulation of G1/S transition of mitotic cell cycle] GO:2000177[regulation of neural precursor cell proliferation]
Q02363 [Direct mapping] DNA-binding protein inhibitor ID-2
Show all
Q53T66 [Target identity:100%; Query identity:100%] Cell growth-inhibiting gene 8; Inhibitor of DNA binding 2, dominant negative helix-loop-helix protein, isoform CRA_a; Uncharacterized protein ID2; cDNA, FLJ92261, highly similar to Homo sapiens inhibitor of DNA binding 2, dominant negative helix-loop-helix protein (ID2), mRNA
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Basic domains Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000791[euchromatin] GO:0003166[bundle of His development] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0007507[heart development] GO:0007623[circadian rhythm] GO:0010628[positive regulation of gene expression] GO:0010629[negative regulation of gene expression] GO:0019216[regulation of lipid metabolic process] GO:0021772[olfactory bulb development] GO:0030154[cell differentiation] GO:0032922[circadian regulation of gene expression] GO:0032991[protein-containing complex] GO:0033598[mammary gland epithelial cell proliferation] GO:0042752[regulation of circadian rhythm] GO:0043153[entrainment of circadian clock by photoperiod] GO:0043353[enucleate erythrocyte differentiation] GO:0043433[negative regulation of DNA-binding transcription factor activity] GO:0044325[transmembrane transporter binding] GO:0045475[locomotor rhythm] GO:0045578[negative regulation of B cell differentiation] GO:0045600[positive regulation of fat cell differentiation] GO:0045651[positive regulation of macrophage differentiation] GO:0045664[regulation of neuron differentiation] GO:0045777[positive regulation of blood pressure] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0046983[protein dimerization activity] GO:0048511[rhythmic process] GO:0048557[embryonic digestive tract morphogenesis] GO:0048661[positive regulation of smooth muscle cell proliferation] GO:0048663[neuron fate commitment] GO:0048711[positive regulation of astrocyte differentiation] GO:0051148[negative regulation of muscle cell differentiation] GO:0060749[mammary gland alveolus development] GO:0061030[epithelial cell differentiation involved in mammary gland alveolus development] GO:0061031[endodermal digestive tract morphogenesis] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0071931[positive regulation of transcription involved in G1/S transition of mitotic cell cycle] GO:0090398[cellular senescence] GO:0140416[transcription regulator inhibitor activity] GO:2000045[regulation of G1/S transition of mitotic cell cycle] GO:2000177[regulation of neural precursor cell proliferation]
Q02363 [Direct mapping] DNA-binding protein inhibitor ID-2
Show all
Q53T66 [Target identity:100%; Query identity:100%] Cell growth-inhibiting gene 8; Inhibitor of DNA binding 2, dominant negative helix-loop-helix protein, isoform CRA_a; Uncharacterized protein ID2; cDNA, FLJ92261, highly similar to Homo sapiens inhibitor of DNA binding 2, dominant negative helix-loop-helix protein (ID2), mRNA
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Basic domains Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000791[euchromatin] GO:0003166[bundle of His development] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0007507[heart development] GO:0007623[circadian rhythm] GO:0010628[positive regulation of gene expression] GO:0010629[negative regulation of gene expression] GO:0019216[regulation of lipid metabolic process] GO:0021772[olfactory bulb development] GO:0030154[cell differentiation] GO:0032922[circadian regulation of gene expression] GO:0032991[protein-containing complex] GO:0033598[mammary gland epithelial cell proliferation] GO:0042752[regulation of circadian rhythm] GO:0043153[entrainment of circadian clock by photoperiod] GO:0043353[enucleate erythrocyte differentiation] GO:0043433[negative regulation of DNA-binding transcription factor activity] GO:0044325[transmembrane transporter binding] GO:0045475[locomotor rhythm] GO:0045578[negative regulation of B cell differentiation] GO:0045600[positive regulation of fat cell differentiation] GO:0045651[positive regulation of macrophage differentiation] GO:0045664[regulation of neuron differentiation] GO:0045777[positive regulation of blood pressure] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0046983[protein dimerization activity] GO:0048511[rhythmic process] GO:0048557[embryonic digestive tract morphogenesis] GO:0048661[positive regulation of smooth muscle cell proliferation] GO:0048663[neuron fate commitment] GO:0048711[positive regulation of astrocyte differentiation] GO:0051148[negative regulation of muscle cell differentiation] GO:0060749[mammary gland alveolus development] GO:0061030[epithelial cell differentiation involved in mammary gland alveolus development] GO:0061031[endodermal digestive tract morphogenesis] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0071931[positive regulation of transcription involved in G1/S transition of mitotic cell cycle] GO:0090398[cellular senescence] GO:0140416[transcription regulator inhibitor activity] GO:2000045[regulation of G1/S transition of mitotic cell cycle] GO:2000177[regulation of neural precursor cell proliferation]
The Human Protein Atlas project is funded
