GENERAL INFORMATIONi
Gene namei ATF2
Synonyms CRE-BP1, CREB2, HB16, TREB7
Gene descriptioni Activating transcription factor 2
Protein classi Transcription factors
Predicted locationi Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi
Chromosome 2
Cytoband q31.1
Chromosome location (bp) 175072250 - 175168382
Number of transcriptsi 10
Ensembl ENSG00000115966 (version 109)
Entrez gene 1386
HGNC HGNC:784
UniProt P15336 (UniProt - Evidence at protein level)
neXtProt NX_P15336
GeneCards ATF2
Antibodypedia ATF2 antibodies


PROTEIN FUNCTION
Protein function (UniProt)i Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro 1. In concert with CUL3 and RBX1, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type. show less
Molecular function (UniProt)i Activator, DNA-binding
Biological process (UniProt)i DNA damage, Transcription, Transcription regulation
Ligand (UniProt)i Metal-binding, Zinc
Gene summary (Entrez)i This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. It forms a homodimer or a heterodimer with c-Jun and stimulates CRE-dependent transcription. This protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. The encoded protein may also be involved in cell's DNA damage response independent of its role in transcriptional regulation. Several alternatively spliced transcript variants have been found for this gene [provided by RefSeq, Jan 2014] show less
PROTEIN INFORMATIONi
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
ATF2-201
ENSP00000264110
ENST00000264110
P15336
[Direct mapping] Cyclic AMP-dependent transcription factor ATF-2
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Basic domains
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000165 [MAPK cascade]
GO:0000785 [chromatin]
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0000987 [cis-regulatory region sequence-specific DNA binding]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0001701 [in utero embryonic development]
GO:0001865 [NK T cell differentiation]
GO:0001889 [liver development]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0002244 [hematopoietic progenitor cell differentiation]
GO:0003151 [outflow tract morphogenesis]
GO:0003360 [brainstem development]
GO:0003418 [growth plate cartilage chondrocyte differentiation]
GO:0003419 [growth plate cartilage chondrocyte proliferation]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0004402 [histone acetyltransferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0006606 [protein import into nucleus]
GO:0006915 [apoptotic process]
GO:0006970 [response to osmotic stress]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007033 [vacuole organization]
GO:0007254 [JNK cascade]
GO:0007507 [heart development]
GO:0008140 [cAMP response element binding protein binding]
GO:0009414 [response to water deprivation]
GO:0010467 [gene expression]
GO:0010485 [histone H4 acetyltransferase activity]
GO:0010628 [positive regulation of gene expression]
GO:0014070 [response to organic cyclic compound]
GO:0016020 [membrane]
GO:0016525 [negative regulation of angiogenesis]
GO:0016602 [CCAAT-binding factor complex]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0019901 [protein kinase binding]
GO:0021742 [abducens nucleus development]
GO:0021743 [hypoglossal nucleus development]
GO:0021754 [facial nucleus development]
GO:0030509 [BMP signaling pathway]
GO:0031573 [mitotic intra-S DNA damage checkpoint signaling]
GO:0032915 [positive regulation of transforming growth factor beta2 production]
GO:0034599 [cellular response to oxidative stress]
GO:0035497 [cAMP response element binding]
GO:0035861 [site of double-strand break]
GO:0038066 [p38MAPK cascade]
GO:0042789 [mRNA transcription by RNA polymerase II]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043522 [leucine zipper domain binding]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0043967 [histone H4 acetylation]
GO:0043969 [histone H2B acetylation]
GO:0044013 [H2B histone acetyltransferase activity]
GO:0044255 [cellular lipid metabolic process]
GO:0044877 [protein-containing complex binding]
GO:0045815 [transcriptional initiation-coupled chromatin remodeling]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046872 [metal ion binding]
GO:0046982 [protein heterodimerization activity]
GO:0050680 [negative regulation of epithelial cell proliferation]
GO:0050872 [white fat cell differentiation]
GO:0051091 [positive regulation of DNA-binding transcription factor activity]
GO:0060052 [neurofilament cytoskeleton organization]
GO:0060245 [detection of cell density]
GO:0060612 [adipose tissue development]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0072740 [cellular response to anisomycin]
GO:0090575 [RNA polymerase II transcription regulator complex]
GO:0097049 [motor neuron apoptotic process]
GO:0097186 [amelogenesis]
GO:0097284 [hepatocyte apoptotic process]
GO:0098586 [cellular response to virus]
GO:0110024 [positive regulation of cardiac muscle myoblast proliferation]
GO:1901522 [positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus]
GO:1902110 [positive regulation of mitochondrial membrane permeability involved in apoptotic process]
GO:1902562 [H4 histone acetyltransferase complex]
GO:1902742 [apoptotic process involved in development]
GO:1990144 [intrinsic apoptotic signaling pathway in response to hypoxia]
GO:1990253 [cellular response to leucine starvation]
GO:1990837 [sequence-specific double-stranded DNA binding]
GO:1990841 [promoter-specific chromatin binding]
Show all
 505 aa
54.5 kDa 		No 0
ATF2-202
ENSP00000340576
ENST00000345739
P15336
[Direct mapping] Cyclic AMP-dependent transcription factor ATF-2
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Basic domains
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0000987 [cis-regulatory region sequence-specific DNA binding]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0004402 [histone acetyltransferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0006970 [response to osmotic stress]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0008140 [cAMP response element binding protein binding]
GO:0010485 [histone H4 acetyltransferase activity]
GO:0010628 [positive regulation of gene expression]
GO:0016020 [membrane]
GO:0016525 [negative regulation of angiogenesis]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0019901 [protein kinase binding]
GO:0031573 [mitotic intra-S DNA damage checkpoint signaling]
GO:0035497 [cAMP response element binding]
GO:0035861 [site of double-strand break]
GO:0042802 [identical protein binding]
GO:0044013 [H2B histone acetyltransferase activity]
GO:0045815 [transcriptional initiation-coupled chromatin remodeling]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046872 [metal ion binding]
GO:0051091 [positive regulation of DNA-binding transcription factor activity]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0090575 [RNA polymerase II transcription regulator complex]
GO:0110024 [positive regulation of cardiac muscle myoblast proliferation]
GO:1902110 [positive regulation of mitochondrial membrane permeability involved in apoptotic process]
GO:1902562 [H4 histone acetyltransferase complex]
GO:1990253 [cellular response to leucine starvation]
GO:1990837 [sequence-specific double-stranded DNA binding]
GO:1990841 [promoter-specific chromatin binding]
Show all
 447 aa
48 kDa 		No 0
ATF2-203
ENSP00000376327
ENST00000392544
P15336
[Direct mapping] Cyclic AMP-dependent transcription factor ATF-2
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Basic domains
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0000987 [cis-regulatory region sequence-specific DNA binding]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0004402 [histone acetyltransferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0006970 [response to osmotic stress]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0008140 [cAMP response element binding protein binding]
GO:0010485 [histone H4 acetyltransferase activity]
GO:0010628 [positive regulation of gene expression]
GO:0016020 [membrane]
GO:0016525 [negative regulation of angiogenesis]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0019901 [protein kinase binding]
GO:0031573 [mitotic intra-S DNA damage checkpoint signaling]
GO:0035497 [cAMP response element binding]
GO:0035861 [site of double-strand break]
GO:0042802 [identical protein binding]
GO:0044013 [H2B histone acetyltransferase activity]
GO:0045815 [transcriptional initiation-coupled chromatin remodeling]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046872 [metal ion binding]
GO:0051091 [positive regulation of DNA-binding transcription factor activity]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0090575 [RNA polymerase II transcription regulator complex]
GO:0110024 [positive regulation of cardiac muscle myoblast proliferation]
GO:1902110 [positive regulation of mitochondrial membrane permeability involved in apoptotic process]
GO:1902562 [H4 histone acetyltransferase complex]
GO:1990253 [cellular response to leucine starvation]
GO:1990837 [sequence-specific double-stranded DNA binding]
GO:1990841 [promoter-specific chromatin binding]
Show all
 505 aa
54.5 kDa 		No 0
ATF2-204
ENSP00000386326
ENST00000409437
B8ZZU6
[Direct mapping] Cyclic AMP-dependent transcription factor ATF-2
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
Show all
 389 aa
42.3 kDa 		No 0
ATF2-205
ENSP00000386282
ENST00000409499
P15336
[Direct mapping] Cyclic AMP-dependent transcription factor ATF-2
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Basic domains
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0000987 [cis-regulatory region sequence-specific DNA binding]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0004402 [histone acetyltransferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0006970 [response to osmotic stress]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0008140 [cAMP response element binding protein binding]
GO:0010485 [histone H4 acetyltransferase activity]
GO:0010628 [positive regulation of gene expression]
GO:0016020 [membrane]
GO:0016525 [negative regulation of angiogenesis]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0019901 [protein kinase binding]
GO:0031573 [mitotic intra-S DNA damage checkpoint signaling]
GO:0035497 [cAMP response element binding]
GO:0035861 [site of double-strand break]
GO:0042802 [identical protein binding]
GO:0044013 [H2B histone acetyltransferase activity]
GO:0045815 [transcriptional initiation-coupled chromatin remodeling]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046872 [metal ion binding]
GO:0051091 [positive regulation of DNA-binding transcription factor activity]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0090575 [RNA polymerase II transcription regulator complex]
GO:0110024 [positive regulation of cardiac muscle myoblast proliferation]
GO:1902110 [positive regulation of mitochondrial membrane permeability involved in apoptotic process]
GO:1902562 [H4 histone acetyltransferase complex]
GO:1990253 [cellular response to leucine starvation]
GO:1990837 [sequence-specific double-stranded DNA binding]
GO:1990841 [promoter-specific chromatin binding]
Show all
 144 aa
15.4 kDa 		No 0
ATF2-206
ENSP00000387093
ENST00000409635
P15336
[Direct mapping] Cyclic AMP-dependent transcription factor ATF-2
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Basic domains
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0000987 [cis-regulatory region sequence-specific DNA binding]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0004402 [histone acetyltransferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0006970 [response to osmotic stress]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0008140 [cAMP response element binding protein binding]
GO:0010485 [histone H4 acetyltransferase activity]
GO:0010628 [positive regulation of gene expression]
GO:0016020 [membrane]
GO:0016525 [negative regulation of angiogenesis]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0019901 [protein kinase binding]
GO:0031573 [mitotic intra-S DNA damage checkpoint signaling]
GO:0035497 [cAMP response element binding]
GO:0035861 [site of double-strand break]
GO:0042802 [identical protein binding]
GO:0044013 [H2B histone acetyltransferase activity]
GO:0045815 [transcriptional initiation-coupled chromatin remodeling]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046872 [metal ion binding]
GO:0051091 [positive regulation of DNA-binding transcription factor activity]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0090575 [RNA polymerase II transcription regulator complex]
GO:0110024 [positive regulation of cardiac muscle myoblast proliferation]
GO:1902110 [positive regulation of mitochondrial membrane permeability involved in apoptotic process]
GO:1902562 [H4 histone acetyltransferase complex]
GO:1990253 [cellular response to leucine starvation]
GO:1990837 [sequence-specific double-stranded DNA binding]
GO:1990841 [promoter-specific chromatin binding]
Show all
 447 aa
48 kDa 		No 0
ATF2-207
ENSP00000386526
ENST00000409833
P15336
[Direct mapping] Cyclic AMP-dependent transcription factor ATF-2
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Basic domains
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0000987 [cis-regulatory region sequence-specific DNA binding]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0004402 [histone acetyltransferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0006970 [response to osmotic stress]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0008140 [cAMP response element binding protein binding]
GO:0010485 [histone H4 acetyltransferase activity]
GO:0010628 [positive regulation of gene expression]
GO:0016020 [membrane]
GO:0016525 [negative regulation of angiogenesis]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0019901 [protein kinase binding]
GO:0031573 [mitotic intra-S DNA damage checkpoint signaling]
GO:0035497 [cAMP response element binding]
GO:0035861 [site of double-strand break]
GO:0042802 [identical protein binding]
GO:0044013 [H2B histone acetyltransferase activity]
GO:0045815 [transcriptional initiation-coupled chromatin remodeling]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046872 [metal ion binding]
GO:0051091 [positive regulation of DNA-binding transcription factor activity]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0090575 [RNA polymerase II transcription regulator complex]
GO:0110024 [positive regulation of cardiac muscle myoblast proliferation]
GO:1902110 [positive regulation of mitochondrial membrane permeability involved in apoptotic process]
GO:1902562 [H4 histone acetyltransferase complex]
GO:1990253 [cellular response to leucine starvation]
GO:1990837 [sequence-specific double-stranded DNA binding]
GO:1990841 [promoter-specific chromatin binding]
Show all
 209 aa
23 kDa 		No 0
ATF2-212
ENSP00000407911
ENST00000426833
P15336
[Direct mapping] Cyclic AMP-dependent transcription factor ATF-2
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Basic domains
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0000987 [cis-regulatory region sequence-specific DNA binding]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0004402 [histone acetyltransferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0006970 [response to osmotic stress]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0008140 [cAMP response element binding protein binding]
GO:0010485 [histone H4 acetyltransferase activity]
GO:0010628 [positive regulation of gene expression]
GO:0016020 [membrane]
GO:0016525 [negative regulation of angiogenesis]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0019901 [protein kinase binding]
GO:0031573 [mitotic intra-S DNA damage checkpoint signaling]
GO:0035497 [cAMP response element binding]
GO:0035861 [site of double-strand break]
GO:0042802 [identical protein binding]
GO:0044013 [H2B histone acetyltransferase activity]
GO:0045815 [transcriptional initiation-coupled chromatin remodeling]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046872 [metal ion binding]
GO:0051091 [positive regulation of DNA-binding transcription factor activity]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0090575 [RNA polymerase II transcription regulator complex]
GO:0110024 [positive regulation of cardiac muscle myoblast proliferation]
GO:1902110 [positive regulation of mitochondrial membrane permeability involved in apoptotic process]
GO:1902562 [H4 histone acetyltransferase complex]
GO:1990253 [cellular response to leucine starvation]
GO:1990837 [sequence-specific double-stranded DNA binding]
GO:1990841 [promoter-specific chromatin binding]
Show all
 487 aa
52.3 kDa 		No 0
ATF2-215
ENSP00000406995
ENST00000435004
H7C2N6
[Direct mapping] Cyclic AMP-dependent transcription factor ATF-2
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [DNA-binding transcription factor activity]
GO:0005634 [nucleus]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
Show all
 265 aa
30 kDa 		No 0
ATF2-217
ENSP00000416854
ENST00000437522
C9JCI8
[Direct mapping] Cyclic AMP-dependent transcription factor ATF-2
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [DNA-binding transcription factor activity]
GO:0005634 [nucleus]
GO:0006357 [regulation of transcription by RNA polymerase II]
Show all
 189 aa
20.3 kDa 		No 0

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