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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes Human disease related genes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
2
Cytoband
q33.1
Chromosome location (bp)
202206182 - 202238599
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Covalently attached to the voltage-gated potassium channel KCNB1; this modulates the gating characteristics of KCNB1 1. Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development. Covalently attached to ZFHX3 2....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Host-virus interaction, Ubl conjugation pathway
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last four amino acids of the carboxy-terminus have been cleaved off. Several pseudogenes have been reported for this gene. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
P63165 [Direct mapping] Small ubiquitin-related modifier 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Human disease related genes Congenital malformations Congenital malformations of face and neck Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0003723[RNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005643[nuclear pore] GO:0005654[nucleoplasm] GO:0005730[nucleolus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006281[DNA repair] GO:0008076[voltage-gated potassium channel complex] GO:0008134[transcription factor binding] GO:0010621[negative regulation of transcription by transcription factor localization] GO:0015459[potassium channel regulator activity] GO:0016020[membrane] GO:0016604[nuclear body] GO:0016605[PML body] GO:0016607[nuclear speck] GO:0016925[protein sumoylation] GO:0019899[enzyme binding] GO:0031334[positive regulation of protein-containing complex assembly] GO:0031386[protein tag] GO:0031625[ubiquitin protein ligase binding] GO:0031965[nuclear membrane] GO:0032436[positive regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0032880[regulation of protein localization] GO:0034605[cellular response to heat] GO:0042308[negative regulation of protein import into nucleus] GO:0043392[negative regulation of DNA binding] GO:0043433[negative regulation of DNA-binding transcription factor activity] GO:0044388[small protein activating enzyme binding] GO:0044389[ubiquitin-like protein ligase binding] GO:0045759[negative regulation of action potential] GO:0045892[negative regulation of DNA-templated transcription] GO:0050821[protein stabilization] GO:0060021[roof of mouth development] GO:0071276[cellular response to cadmium ion] GO:0097165[nuclear stress granule] GO:1902260[negative regulation of delayed rectifier potassium channel activity] GO:1990381[ubiquitin-specific protease binding]
P63165 [Direct mapping] Small ubiquitin-related modifier 1
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A0A024R3Z2 [Target identity:100%; Query identity:100%] Small ubiquitin-related modifier
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Human disease related genes Congenital malformations Congenital malformations of face and neck Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0003723[RNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005643[nuclear pore] GO:0005654[nucleoplasm] GO:0005730[nucleolus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006281[DNA repair] GO:0008076[voltage-gated potassium channel complex] GO:0008134[transcription factor binding] GO:0010621[negative regulation of transcription by transcription factor localization] GO:0015459[potassium channel regulator activity] GO:0016020[membrane] GO:0016604[nuclear body] GO:0016605[PML body] GO:0016607[nuclear speck] GO:0016925[protein sumoylation] GO:0019899[enzyme binding] GO:0031334[positive regulation of protein-containing complex assembly] GO:0031386[protein tag] GO:0031625[ubiquitin protein ligase binding] GO:0031965[nuclear membrane] GO:0032436[positive regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0032880[regulation of protein localization] GO:0034605[cellular response to heat] GO:0042308[negative regulation of protein import into nucleus] GO:0043392[negative regulation of DNA binding] GO:0043433[negative regulation of DNA-binding transcription factor activity] GO:0044388[small protein activating enzyme binding] GO:0044389[ubiquitin-like protein ligase binding] GO:0045759[negative regulation of action potential] GO:0045892[negative regulation of DNA-templated transcription] GO:0050821[protein stabilization] GO:0060021[roof of mouth development] GO:0071276[cellular response to cadmium ion] GO:0097165[nuclear stress granule] GO:1902260[negative regulation of delayed rectifier potassium channel activity] GO:1990381[ubiquitin-specific protease binding]
P63165 [Direct mapping] Small ubiquitin-related modifier 1
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A0A024R3Z2 [Target identity:100%; Query identity:100%] Small ubiquitin-related modifier
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Human disease related genes Congenital malformations Congenital malformations of face and neck Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001741[XY body] GO:0003723[RNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005643[nuclear pore] GO:0005654[nucleoplasm] GO:0005730[nucleolus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006281[DNA repair] GO:0006355[regulation of DNA-templated transcription] GO:0008076[voltage-gated potassium channel complex] GO:0008134[transcription factor binding] GO:0010621[negative regulation of transcription by transcription factor localization] GO:0015459[potassium channel regulator activity] GO:0016020[membrane] GO:0016604[nuclear body] GO:0016605[PML body] GO:0016607[nuclear speck] GO:0016925[protein sumoylation] GO:0019899[enzyme binding] GO:0030578[PML body organization] GO:0031334[positive regulation of protein-containing complex assembly] GO:0031386[protein tag] GO:0031625[ubiquitin protein ligase binding] GO:0031647[regulation of protein stability] GO:0031965[nuclear membrane] GO:0032436[positive regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0032880[regulation of protein localization] GO:0034605[cellular response to heat] GO:0042308[negative regulation of protein import into nucleus] GO:0043392[negative regulation of DNA binding] GO:0043433[negative regulation of DNA-binding transcription factor activity] GO:0044388[small protein activating enzyme binding] GO:0044389[ubiquitin-like protein ligase binding] GO:0045759[negative regulation of action potential] GO:0045892[negative regulation of DNA-templated transcription] GO:0050821[protein stabilization] GO:0060021[roof of mouth development] GO:0071276[cellular response to cadmium ion] GO:0086004[regulation of cardiac muscle cell contraction] GO:0090204[protein localization to nuclear pore] GO:0097165[nuclear stress granule] GO:1901896[positive regulation of ATPase-coupled calcium transmembrane transporter activity] GO:1902260[negative regulation of delayed rectifier potassium channel activity] GO:1903169[regulation of calcium ion transmembrane transport] GO:1990381[ubiquitin-specific protease binding]
B8ZZJ0 [Direct mapping] Small ubiquitin-related modifier 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of face and neck Protein evidence (Ezkurdia et al 2014)
B8ZZ67 [Direct mapping] SMT3 suppressor of mif two 3 homolog 1 (Yeast), isoform CRA_b; Small ubiquitin-related modifier 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of face and neck Protein evidence (Ezkurdia et al 2014)
B8ZZN6 [Direct mapping] Small ubiquitin-related modifier 1
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SCAMPI predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of face and neck Protein evidence (Ezkurdia et al 2014)
B8ZZ67 [Direct mapping] SMT3 suppressor of mif two 3 homolog 1 (Yeast), isoform CRA_b; Small ubiquitin-related modifier 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of face and neck Protein evidence (Ezkurdia et al 2014)
B9A032 [Direct mapping] Small ubiquitin-related modifier 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of face and neck Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
