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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
1
Cytoband
p36.23
Chromosome location (bp)
8004404 - 8026309
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development (By similarity)....show less
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096[GTPase activator activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0007175[negative regulation of epidermal growth factor-activated receptor activity] GO:0016020[membrane] GO:0017124[SH3 domain binding] GO:0019900[kinase binding] GO:0019901[protein kinase binding] GO:0031234[extrinsic component of cytoplasmic side of plasma membrane] GO:0031267[small GTPase binding] GO:0031953[negative regulation of protein autophosphorylation] GO:0032691[negative regulation of interleukin-1 beta production] GO:0032720[negative regulation of tumor necrosis factor production] GO:0032869[cellular response to insulin stimulus] GO:0032966[negative regulation of collagen biosynthetic process] GO:0036120[cellular response to platelet-derived growth factor stimulus] GO:0042059[negative regulation of epidermal growth factor receptor signaling pathway] GO:0043589[skin morphogenesis] GO:0045616[regulation of keratinocyte differentiation] GO:0048286[lung alveolus development] GO:0050732[negative regulation of peptidyl-tyrosine phosphorylation] GO:0060426[lung vasculature development] GO:0060428[lung epithelium development] GO:0061469[regulation of type B pancreatic cell proliferation] GO:0070373[negative regulation of ERK1 and ERK2 cascade] GO:0071364[cellular response to epidermal growth factor stimulus] GO:0071474[cellular hyperosmotic response] GO:0071549[cellular response to dexamethasone stimulus] GO:1903243[negative regulation of cardiac muscle hypertrophy in response to stress]
DeepTMHMM predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
