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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Enzymes FDA approved drug targets Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
1
Cytoband
Chromosome location (bp)
32292083 - 32333635
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) 1,2,3. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events 4,5. Histone deacetylases act via the formation of large multiprotein complexes 6,7. Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin 8,9. As part of the SIN3B complex is recruited downstream of the constitutively active genes transcriptional start sites through interaction with histones and mitigates histone acetylation and RNA polymerase II progression within transcribed regions contributing to the regulation of transcription 10. Also functions as a deacetylase for non-histone targets, such as NR1D2, RELA, SP1, SP3, STAT3 and TSHZ3 11,12,13,14,15. Deacetylates SP proteins, SP1 and SP3, and regulates their function 16,17. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons 18. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation 19. Deacetylates TSHZ3 and regulates its transcriptional repressor activity 20. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B 21. Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity 22. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development (By similarity). Involved in CIART-mediated transcriptional repression of the circadian transcriptional activator: CLOCK-BMAL1 heterodimer (By similarity). Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex or CRY1 through histone deacetylation (By similarity). In addition to protein deacetylase activity, also has protein-lysine deacylase activity: acts as a protein decrotonylase by mediating decrotonylation ((2E)-butenoyl) of histones 23....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Chromatin regulator, Hydrolase, Repressor
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins FDA approved drug targets Small molecule drugs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000118[histone deacetylase complex] GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000792[heterochromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000979[RNA polymerase II core promoter sequence-specific DNA binding] GO:0001046[core promoter sequence-specific DNA binding] GO:0001222[transcription corepressor binding] GO:0002039[p53 binding] GO:0003677[DNA binding] GO:0003682[chromatin binding] GO:0003714[transcription corepressor activity] GO:0004407[histone deacetylase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005667[transcription regulator complex] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006325[chromatin organization] GO:0006338[chromatin remodeling] GO:0006346[DNA methylation-dependent heterochromatin formation] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006476[protein deacetylation] GO:0007492[endoderm development] GO:0007623[circadian rhythm] GO:0008284[positive regulation of cell population proliferation] GO:0009913[epidermal cell differentiation] GO:0010628[positive regulation of gene expression] GO:0010629[negative regulation of gene expression] GO:0016575[histone deacetylation] GO:0016580[Sin3 complex] GO:0016581[NuRD complex] GO:0016787[hydrolase activity] GO:0017053[transcription repressor complex] GO:0019213[deacetylase activity] GO:0019899[enzyme binding] GO:0021766[hippocampus development] GO:0030182[neuron differentiation] GO:0030336[negative regulation of cell migration] GO:0030512[negative regulation of transforming growth factor beta receptor signaling pathway] GO:0031492[nucleosomal DNA binding] GO:0032922[circadian regulation of gene expression] GO:0032991[protein-containing complex] GO:0033558[protein lysine deacetylase activity] GO:0035851[Krueppel-associated box domain binding] GO:0036120[cellular response to platelet-derived growth factor stimulus] GO:0042475[odontogenesis of dentin-containing tooth] GO:0042659[regulation of cell fate specification] GO:0042733[embryonic digit morphogenesis] GO:0042826[histone deacetylase binding] GO:0043025[neuronal cell body] GO:0043066[negative regulation of apoptotic process] GO:0043124[negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043922[negative regulation by host of viral transcription] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0047485[protein N-terminus binding] GO:0048511[rhythmic process] GO:0048661[positive regulation of smooth muscle cell proliferation] GO:0048709[oligodendrocyte differentiation] GO:0048714[positive regulation of oligodendrocyte differentiation] GO:0051059[NF-kappaB binding] GO:0052548[regulation of endopeptidase activity] GO:0060766[negative regulation of androgen receptor signaling pathway] GO:0060789[hair follicle placode formation] GO:0061029[eyelid development in camera-type eye] GO:0061198[fungiform papilla formation] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0070888[E-box binding] GO:0070932[histone H3 deacetylation] GO:0070933[histone H4 deacetylation] GO:0090090[negative regulation of canonical Wnt signaling pathway] GO:0140297[DNA-binding transcription factor binding] GO:0160008[protein decrotonylase activity] GO:0160009[histone decrotonylase activity] GO:1900221[regulation of amyloid-beta clearance] GO:1902455[negative regulation of stem cell population maintenance] GO:1902459[positive regulation of stem cell population maintenance] GO:1990841[promoter-specific chromatin binding] GO:2000273[positive regulation of signaling receptor activity] GO:2000736[regulation of stem cell differentiation] GO:2001243[negative regulation of intrinsic apoptotic signaling pathway]
The Human Protein Atlas project is funded
