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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
1
Cytoband
p31.3
Chromosome location (bp)
67685201 - 67688334
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
In T-cells, functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity (By similarity). Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Cell cycle, DNA damage, Growth arrest
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Dec 2010]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
P24522 [Direct mapping] Growth arrest and DNA damage-inducible protein GADD45 alpha
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level
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GO:0000079[regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0006281[DNA repair] GO:0006915[apoptotic process] GO:0006974[cellular response to DNA damage stimulus] GO:0007049[cell cycle] GO:0016607[nuclear speck] GO:0019900[kinase binding] GO:0033140[negative regulation of peptidyl-serine phosphorylation of STAT protein] GO:0042770[signal transduction in response to DNA damage] GO:0042803[protein homodimerization activity] GO:0043065[positive regulation of apoptotic process] GO:0043537[negative regulation of blood vessel endothelial cell migration] GO:0046330[positive regulation of JNK cascade] GO:0046982[protein heterodimerization activity] GO:0047485[protein N-terminus binding] GO:0051726[regulation of cell cycle] GO:0071260[cellular response to mechanical stimulus] GO:0071479[cellular response to ionizing radiation] GO:0071901[negative regulation of protein serine/threonine kinase activity] GO:1900745[positive regulation of p38MAPK cascade] GO:2000379[positive regulation of reactive oxygen species metabolic process]
P24522 [Direct mapping] Growth arrest and DNA damage-inducible protein GADD45 alpha
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000079[regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0006281[DNA repair] GO:0006469[negative regulation of protein kinase activity] GO:0006915[apoptotic process] GO:0006974[cellular response to DNA damage stimulus] GO:0007049[cell cycle] GO:0007098[centrosome cycle] GO:0016525[negative regulation of angiogenesis] GO:0016607[nuclear speck] GO:0019900[kinase binding] GO:0033140[negative regulation of peptidyl-serine phosphorylation of STAT protein] GO:0042770[signal transduction in response to DNA damage] GO:0042803[protein homodimerization activity] GO:0043065[positive regulation of apoptotic process] GO:0043537[negative regulation of blood vessel endothelial cell migration] GO:0046330[positive regulation of JNK cascade] GO:0046982[protein heterodimerization activity] GO:0047485[protein N-terminus binding] GO:0051726[regulation of cell cycle] GO:0071260[cellular response to mechanical stimulus] GO:0071479[cellular response to ionizing radiation] GO:0071901[negative regulation of protein serine/threonine kinase activity] GO:1900745[positive regulation of p38MAPK cascade] GO:1990841[promoter-specific chromatin binding] GO:2000379[positive regulation of reactive oxygen species metabolic process]
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