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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
1
Cytoband
q31.2
Chromosome location (bp)
192809039 - 192812275
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form 1,2. It is involved in the negative regulation of the angiotensin-activated signaling pathway 3. Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ. Plays a role in regulating the constriction and relaxation of vascular smooth muscle (By similarity). Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein 4....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
GTPase activation, Signal transduction inhibitor
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Cell cycle, Translation regulation
Gene summary (Entrez)i
Useful information about the gene from Entrez
Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 2 belongs to this family. The protein acts as a mediator of myeloid differentiation and may play a role in leukemogenesis. [provided by RefSeq, Aug 2009]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
P41220 [Direct mapping] Regulator of G-protein signaling 2
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A0A024R939 [Target identity:100%; Query identity:100%] Regulator of G-protein signaling 2
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0001965[G-protein alpha-subunit binding] GO:0001975[response to amphetamine] GO:0003924[GTPase activity] GO:0005096[GTPase activator activity] GO:0005515[protein binding] GO:0005516[calmodulin binding] GO:0005634[nucleus] GO:0005730[nucleolus] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006417[regulation of translation] GO:0007049[cell cycle] GO:0007186[G protein-coupled receptor signaling pathway] GO:0007283[spermatogenesis] GO:0007420[brain development] GO:0008277[regulation of G protein-coupled receptor signaling pathway] GO:0009898[cytoplasmic side of plasma membrane] GO:0009968[negative regulation of signal transduction] GO:0010519[negative regulation of phospholipase activity] GO:0010614[negative regulation of cardiac muscle hypertrophy] GO:0010855[adenylate cyclase inhibitor activity] GO:0010976[positive regulation of neuron projection development] GO:0016020[membrane] GO:0017148[negative regulation of translation] GO:0030728[ovulation] GO:0043005[neuron projection] GO:0043407[negative regulation of MAP kinase activity] GO:0045471[response to ethanol] GO:0045744[negative regulation of G protein-coupled receptor signaling pathway] GO:0048487[beta-tubulin binding] GO:0050873[brown fat cell differentiation] GO:0055119[relaxation of cardiac muscle] GO:0060087[relaxation of vascular associated smooth muscle] GO:0060135[maternal process involved in female pregnancy] GO:0060452[positive regulation of cardiac muscle contraction] GO:0061052[negative regulation of cell growth involved in cardiac muscle cell development] GO:0140194[negative regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process] GO:1900924[negative regulation of glycine import across plasma membrane]
The Human Protein Atlas project is funded
