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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Plasma proteins Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
1
Cytoband
p34.2
Chromosome location (bp)
43358981 - 43363203
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Involved in the metaphase/anaphase transition of cell cycle 1. Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and confers substrate specificity upon the complex 2. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation. The CDC20-APC/C complex promotes proper dilation formation and radial migration by degrading CCDC41 (By similarity)....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
CDC20 appears to act as a regulatory protein interacting with several other proteins at multiple points in the cell cycle. It is required for two microtubule-dependent processes, nuclear movement prior to anaphase and chromosome separation. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q12834 [Direct mapping] Cell division cycle protein 20 homolog
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Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000922[spindle pole] GO:0005515[protein binding] GO:0005654[nucleoplasm] GO:0005680[anaphase-promoting complex] GO:0005737[cytoplasm] GO:0005813[centrosome] GO:0005815[microtubule organizing center] GO:0005819[spindle] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0007049[cell cycle] GO:0007064[mitotic sister chromatid cohesion] GO:0007094[mitotic spindle assembly checkpoint signaling] GO:0007346[regulation of mitotic cell cycle] GO:0007399[nervous system development] GO:0008022[protein C-terminus binding] GO:0008284[positive regulation of cell population proliferation] GO:0010997[anaphase-promoting complex binding] GO:0016567[protein ubiquitination] GO:0019899[enzyme binding] GO:0030154[cell differentiation] GO:0031145[anaphase-promoting complex-dependent catabolic process] GO:0031915[positive regulation of synaptic plasticity] GO:0032991[protein-containing complex] GO:0033597[mitotic checkpoint complex] GO:0040020[regulation of meiotic nuclear division] GO:0042826[histone deacetylase binding] GO:0048471[perinuclear region of cytoplasm] GO:0050773[regulation of dendrite development] GO:0051301[cell division] GO:0051444[negative regulation of ubiquitin-protein transferase activity] GO:0051445[regulation of meiotic cell cycle] GO:0090129[positive regulation of synapse maturation] GO:0090307[mitotic spindle assembly] GO:0097027[ubiquitin-protein transferase activator activity] GO:1904668[positive regulation of ubiquitin protein ligase activity] GO:1905786[positive regulation of anaphase-promoting complex-dependent catabolic process] GO:1990757[ubiquitin ligase activator activity]
Q12834 [Direct mapping] Cell division cycle protein 20 homolog
Show all
Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
