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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
1
Cytoband
p22.1
Chromosome location (bp)
93345907 - 93369493
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
DNA-binding, Repressor
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Transcription, Transcription regulation
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q658N3 [Target identity:100%; Query identity:100%] Protein Dr1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0001046[core promoter sequence-specific DNA binding] GO:0003677[DNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006338[chromatin remodeling] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0016251[RNA polymerase II general transcription initiation factor activity] GO:0017025[TBP-class protein binding] GO:0017054[negative cofactor 2 complex] GO:0031063[regulation of histone deacetylation] GO:0043966[histone H3 acetylation] GO:0044154[histone H3-K14 acetylation] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0045995[regulation of embryonic development] GO:0046982[protein heterodimerization activity] GO:0051123[RNA polymerase II preinitiation complex assembly] GO:0051302[regulation of cell division] GO:0051726[regulation of cell cycle] GO:0072686[mitotic spindle] GO:0090043[regulation of tubulin deacetylation] GO:0090575[RNA polymerase II transcription regulator complex] GO:0140223[general transcription initiation factor activity] GO:0140672[ATAC complex]
Q658N3 [Target identity:100%; Query identity:100%] Protein Dr1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0001046[core promoter sequence-specific DNA binding] GO:0003677[DNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006338[chromatin remodeling] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0016251[RNA polymerase II general transcription initiation factor activity] GO:0017025[TBP-class protein binding] GO:0017054[negative cofactor 2 complex] GO:0031063[regulation of histone deacetylation] GO:0043966[histone H3 acetylation] GO:0044154[histone H3-K14 acetylation] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0045995[regulation of embryonic development] GO:0046982[protein heterodimerization activity] GO:0051123[RNA polymerase II preinitiation complex assembly] GO:0051302[regulation of cell division] GO:0051726[regulation of cell cycle] GO:0072686[mitotic spindle] GO:0090043[regulation of tubulin deacetylation] GO:0090575[RNA polymerase II transcription regulator complex] GO:0140223[general transcription initiation factor activity] GO:0140672[ATAC complex]
The Human Protein Atlas project is funded
