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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
1
Cytoband
p36.11
Chromosome location (bp)
25884181 - 25906991
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Developmental protein
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Differentiation, Neurogenesis
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene belongs to the stathmin family of genes. It encodes a ubiquitous cytosolic phosphoprotein proposed to function as an intracellular relay integrating regulatory signals of the cellular environment. The encoded protein is involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000281[mitotic cytokinesis] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0005874[microtubule] GO:0007019[microtubule depolymerization] GO:0007052[mitotic spindle organization] GO:0007165[signal transduction] GO:0007399[nervous system development] GO:0009615[response to virus] GO:0015631[tubulin binding] GO:0030154[cell differentiation] GO:0031110[regulation of microtubule polymerization or depolymerization] GO:0031115[negative regulation of microtubule polymerization] GO:0031175[neuron projection development] GO:0035024[negative regulation of Rho protein signal transduction] GO:0035556[intracellular signal transduction] GO:0043005[neuron projection] GO:0048012[hepatocyte growth factor receptor signaling pathway] GO:0051497[negative regulation of stress fiber assembly] GO:0061436[establishment of skin barrier] GO:0070062[extracellular exosome] GO:0070495[negative regulation of thrombin-activated receptor signaling pathway] GO:1905098[negative regulation of guanyl-nucleotide exchange factor activity]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000281[mitotic cytokinesis] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0005874[microtubule] GO:0007019[microtubule depolymerization] GO:0007052[mitotic spindle organization] GO:0007165[signal transduction] GO:0007399[nervous system development] GO:0009615[response to virus] GO:0015631[tubulin binding] GO:0030154[cell differentiation] GO:0031110[regulation of microtubule polymerization or depolymerization] GO:0031115[negative regulation of microtubule polymerization] GO:0031175[neuron projection development] GO:0035024[negative regulation of Rho protein signal transduction] GO:0035556[intracellular signal transduction] GO:0043005[neuron projection] GO:0048012[hepatocyte growth factor receptor signaling pathway] GO:0051497[negative regulation of stress fiber assembly] GO:0061436[establishment of skin barrier] GO:0070062[extracellular exosome] GO:0070495[negative regulation of thrombin-activated receptor signaling pathway] GO:1905098[negative regulation of guanyl-nucleotide exchange factor activity]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000281[mitotic cytokinesis] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0005874[microtubule] GO:0007019[microtubule depolymerization] GO:0007052[mitotic spindle organization] GO:0007165[signal transduction] GO:0007399[nervous system development] GO:0009615[response to virus] GO:0015631[tubulin binding] GO:0030154[cell differentiation] GO:0031110[regulation of microtubule polymerization or depolymerization] GO:0031115[negative regulation of microtubule polymerization] GO:0031175[neuron projection development] GO:0035024[negative regulation of Rho protein signal transduction] GO:0035556[intracellular signal transduction] GO:0043005[neuron projection] GO:0048012[hepatocyte growth factor receptor signaling pathway] GO:0051497[negative regulation of stress fiber assembly] GO:0061436[establishment of skin barrier] GO:0070062[extracellular exosome] GO:0070495[negative regulation of thrombin-activated receptor signaling pathway] GO:1905098[negative regulation of guanyl-nucleotide exchange factor activity]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000281[mitotic cytokinesis] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0005874[microtubule] GO:0007019[microtubule depolymerization] GO:0007052[mitotic spindle organization] GO:0007165[signal transduction] GO:0007399[nervous system development] GO:0009615[response to virus] GO:0015631[tubulin binding] GO:0030154[cell differentiation] GO:0031110[regulation of microtubule polymerization or depolymerization] GO:0031115[negative regulation of microtubule polymerization] GO:0031175[neuron projection development] GO:0035024[negative regulation of Rho protein signal transduction] GO:0035556[intracellular signal transduction] GO:0043005[neuron projection] GO:0048012[hepatocyte growth factor receptor signaling pathway] GO:0051497[negative regulation of stress fiber assembly] GO:0061436[establishment of skin barrier] GO:0070062[extracellular exosome] GO:0070495[negative regulation of thrombin-activated receptor signaling pathway] GO:1905098[negative regulation of guanyl-nucleotide exchange factor activity]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000281[mitotic cytokinesis] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0005874[microtubule] GO:0007019[microtubule depolymerization] GO:0007052[mitotic spindle organization] GO:0007165[signal transduction] GO:0007399[nervous system development] GO:0007409[axonogenesis] GO:0009615[response to virus] GO:0015631[tubulin binding] GO:0016020[membrane] GO:0030154[cell differentiation] GO:0031110[regulation of microtubule polymerization or depolymerization] GO:0031115[negative regulation of microtubule polymerization] GO:0031175[neuron projection development] GO:0035024[negative regulation of Rho protein signal transduction] GO:0035556[intracellular signal transduction] GO:0043005[neuron projection] GO:0048012[hepatocyte growth factor receptor signaling pathway] GO:0051497[negative regulation of stress fiber assembly] GO:0061436[establishment of skin barrier] GO:0070062[extracellular exosome] GO:0070495[negative regulation of thrombin-activated receptor signaling pathway] GO:1905098[negative regulation of guanyl-nucleotide exchange factor activity]
The Human Protein Atlas project is funded
