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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes Enzymes Human disease related genes Metabolic proteins Potential drug targets
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
1
Cytoband
p36.11
Chromosome location (bp)
26432282 - 26471306
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
With NUS1, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Both subunits contribute to enzymatic activity, i.e. condensation of multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol phosphate which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER) 1,2,3. Synthesizes long-chain polyprenols, mostly of C95 and C100 chain length 4. Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol 5....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Transferase
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Lipid metabolism
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Magnesium, Metal-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene catalyzes cis-prenyl chain elongation to produce the polyprenyl backbone of dolichol, a glycosyl carrier lipid required for the biosynthesis of several classes of glycoproteins. Mutations in this gene are associated with retinitis pigmentosa type 59. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Enzymes ENZYME proteins Transferases Metabolic proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Potential drug targets Human disease related genes Congenital disorders of metabolism Congenital disorders of glycan/glycoprotein metabolism Nervous system diseases Eye disease Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Enzymes ENZYME proteins Transferases Metabolic proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Potential drug targets Human disease related genes Congenital disorders of metabolism Congenital disorders of glycan/glycoprotein metabolism Nervous system diseases Eye disease Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Metabolic proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital disorders of metabolism Congenital disorders of glycan/glycoprotein metabolism Nervous system diseases Eye disease Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016740[transferase activity] GO:0016765[transferase activity, transferring alkyl or aryl (other than methyl) groups]
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital disorders of metabolism Congenital disorders of glycan/glycoprotein metabolism Nervous system diseases Eye disease Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016740[transferase activity] GO:0016765[transferase activity, transferring alkyl or aryl (other than methyl) groups]
Metabolic proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital disorders of metabolism Congenital disorders of glycan/glycoprotein metabolism Nervous system diseases Eye disease Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016740[transferase activity] GO:0016765[transferase activity, transferring alkyl or aryl (other than methyl) groups]
Metabolic proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital disorders of metabolism Congenital disorders of glycan/glycoprotein metabolism Nervous system diseases Eye disease Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016740[transferase activity] GO:0016765[transferase activity, transferring alkyl or aryl (other than methyl) groups]
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital disorders of metabolism Congenital disorders of glycan/glycoprotein metabolism Nervous system diseases Eye disease Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016740[transferase activity] GO:0016765[transferase activity, transferring alkyl or aryl (other than methyl) groups]
Metabolic proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital disorders of metabolism Congenital disorders of glycan/glycoprotein metabolism Nervous system diseases Eye disease Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016740[transferase activity] GO:0016765[transferase activity, transferring alkyl or aryl (other than methyl) groups]
Metabolic proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital disorders of metabolism Congenital disorders of glycan/glycoprotein metabolism Nervous system diseases Eye disease Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016740[transferase activity] GO:0016765[transferase activity, transferring alkyl or aryl (other than methyl) groups]
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital disorders of metabolism Congenital disorders of glycan/glycoprotein metabolism Nervous system diseases Eye disease Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016740[transferase activity] GO:0016765[transferase activity, transferring alkyl or aryl (other than methyl) groups]
Metabolic proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital disorders of metabolism Congenital disorders of glycan/glycoprotein metabolism Nervous system diseases Eye disease Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016740[transferase activity] GO:0016765[transferase activity, transferring alkyl or aryl (other than methyl) groups]
Enzymes ENZYME proteins Transferases Metabolic proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Potential drug targets Human disease related genes Congenital disorders of metabolism Congenital disorders of glycan/glycoprotein metabolism Nervous system diseases Eye disease Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Enzymes ENZYME proteins Transferases Metabolic proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Potential drug targets Human disease related genes Congenital disorders of metabolism Congenital disorders of glycan/glycoprotein metabolism Nervous system diseases Eye disease Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Metabolic proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital disorders of metabolism Congenital disorders of glycan/glycoprotein metabolism Nervous system diseases Eye disease Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016765[transferase activity, transferring alkyl or aryl (other than methyl) groups]
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital disorders of metabolism Congenital disorders of glycan/glycoprotein metabolism Nervous system diseases Eye disease Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016740[transferase activity] GO:0016765[transferase activity, transferring alkyl or aryl (other than methyl) groups]
Metabolic proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital disorders of metabolism Congenital disorders of glycan/glycoprotein metabolism Nervous system diseases Eye disease Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016740[transferase activity] GO:0016765[transferase activity, transferring alkyl or aryl (other than methyl) groups]
Metabolic proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital disorders of metabolism Congenital disorders of glycan/glycoprotein metabolism Nervous system diseases Eye disease Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016740[transferase activity] GO:0016765[transferase activity, transferring alkyl or aryl (other than methyl) groups]
Metabolic proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital disorders of metabolism Congenital disorders of glycan/glycoprotein metabolism Nervous system diseases Eye disease Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016765[transferase activity, transferring alkyl or aryl (other than methyl) groups]
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital disorders of metabolism Congenital disorders of glycan/glycoprotein metabolism Nervous system diseases Eye disease Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016765[transferase activity, transferring alkyl or aryl (other than methyl) groups]
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital disorders of metabolism Congenital disorders of glycan/glycoprotein metabolism Nervous system diseases Eye disease Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016765[transferase activity, transferring alkyl or aryl (other than methyl) groups]
Metabolic proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital disorders of metabolism Congenital disorders of glycan/glycoprotein metabolism Nervous system diseases Eye disease Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016765[transferase activity, transferring alkyl or aryl (other than methyl) groups]
The Human Protein Atlas project is funded
