GENERAL INFORMATIONi
Gene namei PROX1
Synonyms
Gene descriptioni Prospero homeobox 1
Protein classi Plasma proteins
Transcription factors
Predicted locationi Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi
Chromosome 1
Cytoband q32.3
Chromosome location (bp) 213983181 - 214041510
Number of transcriptsi 6
Ensembl ENSG00000117707 (version 109)
Entrez gene 5629
HGNC HGNC:9459
UniProt Q92786 (UniProt - Evidence at protein level)
neXtProt NX_Q92786
GeneCards PROX1
Antibodypedia PROX1 antibodies


PROTEIN FUNCTION
Protein function (UniProt)i Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3. show less
Molecular function (UniProt)i Developmental protein, DNA-binding, Repressor
Biological process (UniProt)i Biological rhythms, Transcription, Transcription regulation
Gene summary (Entrez)i The protein encoded by this gene is a member of the homeobox transcription factor family. Members of this family contain a homeobox domain that consists of a 60-amino acid helix-turn-helix structure that binds DNA and RNA. The protein encoded by this gene is conserved across vertebrates and may play an essential role during development. Altered levels of this protein have been reported in cancers of different organs, such as colon, brain, blood, breast, pancreas, liver and esophagus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012] show less
PROTEIN INFORMATIONi
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
PROX1-201
ENSP00000261454
ENST00000261454
Q92786
[Direct mapping] Prospero homeobox protein 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Transcription factors
   Helix-turn-helix domains
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000976 [transcription cis-regulatory region binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001227 [DNA-binding transcription repressor activity, RNA polymerase II-specific]
GO:0001822 [kidney development]
GO:0001889 [liver development]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0001946 [lymphangiogenesis]
GO:0002088 [lens development in camera-type eye]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0007399 [nervous system development]
GO:0007420 [brain development]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008285 [negative regulation of cell population proliferation]
GO:0010468 [regulation of gene expression]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0016922 [nuclear receptor binding]
GO:0021516 [dorsal spinal cord development]
GO:0021542 [dentate gyrus development]
GO:0021707 [cerebellar granule cell differentiation]
GO:0021915 [neural tube development]
GO:0030240 [skeletal muscle thin filament assembly]
GO:0030324 [lung development]
GO:0030910 [olfactory placode formation]
GO:0031016 [pancreas development]
GO:0042752 [regulation of circadian rhythm]
GO:0043049 [otic placode formation]
GO:0043433 [negative regulation of DNA-binding transcription factor activity]
GO:0045071 [negative regulation of viral genome replication]
GO:0045737 [positive regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0045787 [positive regulation of cell cycle]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046619 [lens placode formation involved in camera-type eye formation]
GO:0048468 [cell development]
GO:0048511 [rhythmic process]
GO:0048845 [venous blood vessel morphogenesis]
GO:0050692 [DNA binding domain binding]
GO:0050693 [LBD domain binding]
GO:0055005 [ventricular cardiac myofibril assembly]
GO:0055009 [atrial cardiac muscle tissue morphogenesis]
GO:0055010 [ventricular cardiac muscle tissue morphogenesis]
GO:0060042 [retina morphogenesis in camera-type eye]
GO:0060059 [embryonic retina morphogenesis in camera-type eye]
GO:0060214 [endocardium formation]
GO:0060298 [positive regulation of sarcomere organization]
GO:0060412 [ventricular septum morphogenesis]
GO:0060414 [aorta smooth muscle tissue morphogenesis]
GO:0060421 [positive regulation of heart growth]
GO:0060836 [lymphatic endothelial cell differentiation]
GO:0060838 [lymphatic endothelial cell fate commitment]
GO:0070309 [lens fiber cell morphogenesis]
GO:0070365 [hepatocyte differentiation]
GO:0070858 [negative regulation of bile acid biosynthetic process]
GO:0097150 [neuronal stem cell population maintenance]
GO:1990837 [sequence-specific double-stranded DNA binding]
GO:2000179 [positive regulation of neural precursor cell proliferation]
GO:2000979 [positive regulation of forebrain neuron differentiation]
Show all
 737 aa
83.2 kDa 		No 0
PROX1-202
ENSP00000355925
ENST00000366958
Q92786
[Direct mapping] Prospero homeobox protein 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Transcription factors
   Helix-turn-helix domains
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000976 [transcription cis-regulatory region binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001227 [DNA-binding transcription repressor activity, RNA polymerase II-specific]
GO:0001822 [kidney development]
GO:0001889 [liver development]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0001945 [lymph vessel development]
GO:0001946 [lymphangiogenesis]
GO:0002088 [lens development in camera-type eye]
GO:0002089 [lens morphogenesis in camera-type eye]
GO:0002194 [hepatocyte cell migration]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0006366 [transcription by RNA polymerase II]
GO:0007399 [nervous system development]
GO:0007405 [neuroblast proliferation]
GO:0007406 [negative regulation of neuroblast proliferation]
GO:0007420 [brain development]
GO:0007623 [circadian rhythm]
GO:0008283 [cell population proliferation]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008285 [negative regulation of cell population proliferation]
GO:0010468 [regulation of gene expression]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0010631 [epithelial cell migration]
GO:0016922 [nuclear receptor binding]
GO:0021516 [dorsal spinal cord development]
GO:0021542 [dentate gyrus development]
GO:0021707 [cerebellar granule cell differentiation]
GO:0021915 [neural tube development]
GO:0030240 [skeletal muscle thin filament assembly]
GO:0030324 [lung development]
GO:0030910 [olfactory placode formation]
GO:0031016 [pancreas development]
GO:0031667 [response to nutrient levels]
GO:0042752 [regulation of circadian rhythm]
GO:0043049 [otic placode formation]
GO:0043433 [negative regulation of DNA-binding transcription factor activity]
GO:0043565 [sequence-specific DNA binding]
GO:0045071 [negative regulation of viral genome replication]
GO:0045737 [positive regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0045787 [positive regulation of cell cycle]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046619 [lens placode formation involved in camera-type eye formation]
GO:0048468 [cell development]
GO:0048511 [rhythmic process]
GO:0048664 [neuron fate determination]
GO:0048839 [inner ear development]
GO:0048845 [venous blood vessel morphogenesis]
GO:0050692 [DNA binding domain binding]
GO:0050693 [LBD domain binding]
GO:0055005 [ventricular cardiac myofibril assembly]
GO:0055009 [atrial cardiac muscle tissue morphogenesis]
GO:0055010 [ventricular cardiac muscle tissue morphogenesis]
GO:0060042 [retina morphogenesis in camera-type eye]
GO:0060059 [embryonic retina morphogenesis in camera-type eye]
GO:0060214 [endocardium formation]
GO:0060298 [positive regulation of sarcomere organization]
GO:0060412 [ventricular septum morphogenesis]
GO:0060414 [aorta smooth muscle tissue morphogenesis]
GO:0060421 [positive regulation of heart growth]
GO:0060836 [lymphatic endothelial cell differentiation]
GO:0060837 [blood vessel endothelial cell differentiation]
GO:0060838 [lymphatic endothelial cell fate commitment]
GO:0061114 [branching involved in pancreas morphogenesis]
GO:0070309 [lens fiber cell morphogenesis]
GO:0070365 [hepatocyte differentiation]
GO:0070858 [negative regulation of bile acid biosynthetic process]
GO:0072574 [hepatocyte proliferation]
GO:0090425 [acinar cell differentiation]
GO:0097150 [neuronal stem cell population maintenance]
GO:1901978 [positive regulation of cell cycle checkpoint]
GO:1990837 [sequence-specific double-stranded DNA binding]
GO:2000179 [positive regulation of neural precursor cell proliferation]
GO:2000979 [positive regulation of forebrain neuron differentiation]
Show all
 737 aa
83.2 kDa 		No 0
PROX1-203
ENSP00000400694
ENST00000435016
Q92786
[Direct mapping] Prospero homeobox protein 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Transcription factors
   Helix-turn-helix domains
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000976 [transcription cis-regulatory region binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001227 [DNA-binding transcription repressor activity, RNA polymerase II-specific]
GO:0001822 [kidney development]
GO:0001889 [liver development]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0001946 [lymphangiogenesis]
GO:0002088 [lens development in camera-type eye]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0007399 [nervous system development]
GO:0007420 [brain development]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008285 [negative regulation of cell population proliferation]
GO:0010468 [regulation of gene expression]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0016922 [nuclear receptor binding]
GO:0021516 [dorsal spinal cord development]
GO:0021542 [dentate gyrus development]
GO:0021707 [cerebellar granule cell differentiation]
GO:0021915 [neural tube development]
GO:0030240 [skeletal muscle thin filament assembly]
GO:0030324 [lung development]
GO:0030910 [olfactory placode formation]
GO:0031016 [pancreas development]
GO:0042752 [regulation of circadian rhythm]
GO:0043049 [otic placode formation]
GO:0043433 [negative regulation of DNA-binding transcription factor activity]
GO:0045071 [negative regulation of viral genome replication]
GO:0045737 [positive regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0045787 [positive regulation of cell cycle]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046619 [lens placode formation involved in camera-type eye formation]
GO:0048468 [cell development]
GO:0048511 [rhythmic process]
GO:0048845 [venous blood vessel morphogenesis]
GO:0050692 [DNA binding domain binding]
GO:0050693 [LBD domain binding]
GO:0055005 [ventricular cardiac myofibril assembly]
GO:0055009 [atrial cardiac muscle tissue morphogenesis]
GO:0055010 [ventricular cardiac muscle tissue morphogenesis]
GO:0060042 [retina morphogenesis in camera-type eye]
GO:0060059 [embryonic retina morphogenesis in camera-type eye]
GO:0060214 [endocardium formation]
GO:0060298 [positive regulation of sarcomere organization]
GO:0060412 [ventricular septum morphogenesis]
GO:0060414 [aorta smooth muscle tissue morphogenesis]
GO:0060421 [positive regulation of heart growth]
GO:0060836 [lymphatic endothelial cell differentiation]
GO:0060838 [lymphatic endothelial cell fate commitment]
GO:0070309 [lens fiber cell morphogenesis]
GO:0070365 [hepatocyte differentiation]
GO:0070858 [negative regulation of bile acid biosynthetic process]
GO:0097150 [neuronal stem cell population maintenance]
GO:1990837 [sequence-specific double-stranded DNA binding]
GO:2000179 [positive regulation of neural precursor cell proliferation]
GO:2000979 [positive regulation of forebrain neuron differentiation]
Show all
 737 aa
83.2 kDa 		No 0
PROX1-204
ENSP00000419517
ENST00000471129
C9JU29
[Direct mapping] Prospero homeobox protein 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of DNA-templated transcription]
GO:0007399 [nervous system development]
GO:0048468 [cell development]
Show all
 230 aa
25.8 kDa 		No 0
PROX1-205
ENSP00000420283
ENST00000498508
Q92786
[Direct mapping] Prospero homeobox protein 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Transcription factors
   Helix-turn-helix domains
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000976 [transcription cis-regulatory region binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001227 [DNA-binding transcription repressor activity, RNA polymerase II-specific]
GO:0001822 [kidney development]
GO:0001889 [liver development]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0001946 [lymphangiogenesis]
GO:0002088 [lens development in camera-type eye]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0007399 [nervous system development]
GO:0007420 [brain development]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008285 [negative regulation of cell population proliferation]
GO:0010468 [regulation of gene expression]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0016922 [nuclear receptor binding]
GO:0021516 [dorsal spinal cord development]
GO:0021542 [dentate gyrus development]
GO:0021707 [cerebellar granule cell differentiation]
GO:0021915 [neural tube development]
GO:0030240 [skeletal muscle thin filament assembly]
GO:0030324 [lung development]
GO:0030910 [olfactory placode formation]
GO:0031016 [pancreas development]
GO:0042752 [regulation of circadian rhythm]
GO:0043049 [otic placode formation]
GO:0043433 [negative regulation of DNA-binding transcription factor activity]
GO:0045071 [negative regulation of viral genome replication]
GO:0045737 [positive regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0045787 [positive regulation of cell cycle]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046619 [lens placode formation involved in camera-type eye formation]
GO:0048468 [cell development]
GO:0048511 [rhythmic process]
GO:0048845 [venous blood vessel morphogenesis]
GO:0050692 [DNA binding domain binding]
GO:0050693 [LBD domain binding]
GO:0055005 [ventricular cardiac myofibril assembly]
GO:0055009 [atrial cardiac muscle tissue morphogenesis]
GO:0055010 [ventricular cardiac muscle tissue morphogenesis]
GO:0060042 [retina morphogenesis in camera-type eye]
GO:0060059 [embryonic retina morphogenesis in camera-type eye]
GO:0060214 [endocardium formation]
GO:0060298 [positive regulation of sarcomere organization]
GO:0060412 [ventricular septum morphogenesis]
GO:0060414 [aorta smooth muscle tissue morphogenesis]
GO:0060421 [positive regulation of heart growth]
GO:0060836 [lymphatic endothelial cell differentiation]
GO:0060838 [lymphatic endothelial cell fate commitment]
GO:0070309 [lens fiber cell morphogenesis]
GO:0070365 [hepatocyte differentiation]
GO:0070858 [negative regulation of bile acid biosynthetic process]
GO:0097150 [neuronal stem cell population maintenance]
GO:1990837 [sequence-specific double-stranded DNA binding]
GO:2000179 [positive regulation of neural precursor cell proliferation]
GO:2000979 [positive regulation of forebrain neuron differentiation]
Show all
 737 aa
83.2 kDa 		No 0
PROX1-206
ENSP00000475357
ENST00000607425
U3KPY6
[Direct mapping] Prospero homeobox protein 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of DNA-templated transcription]
GO:0007399 [nervous system development]
GO:0048468 [cell development]
Show all
 143 aa
15.6 kDa 		No 0

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