GENERAL INFORMATIONi
Gene namei KIF14
Synonyms KIAA0042
Gene descriptioni Kinesin family member 14
Protein classi Disease related genes
Human disease related genes
Plasma proteins
Predicted locationi Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi
Chromosome 1
Cytoband q32.1
Chromosome location (bp) 200551497 - 200620751
Number of transcriptsi 2
Ensembl ENSG00000118193 (version 109)
Entrez gene 9928
HGNC HGNC:19181
UniProt Q15058 (UniProt - Evidence at protein level)
neXtProt NX_Q15058
GeneCards KIF14
Antibodypedia KIF14 antibodies


PROTEIN FUNCTION
Protein function (UniProt)i Microtubule motor protein that binds to microtubules with high affinity through each tubulin heterodimer and has an ATPase activity (By similarity). Plays a role in many processes like cell division, cytokinesis and also in cell proliferation and apoptosis 1, 2. During cytokinesis, targets to central spindle and midbody through its interaction with PRC1 and CIT respectively 3. Regulates cell growth through regulation of cell cycle progression and cytokinesis 4. During cell cycle progression acts through SCF-dependent proteasomal ubiquitin-dependent protein catabolic process which controls CDKN1B degradation, resulting in positive regulation of cyclins, including CCNE1, CCND1 and CCNB1 5. During late neurogenesis, regulates the cerebellar, cerebral cortex and olfactory bulb development through regulation of apoptosis, cell proliferation and cell division (By similarity). Also is required for chromosome congression and alignment during mitotic cell cycle process 6. Regulates cell spreading, focal adhesion dynamics, and cell migration through its interaction with RADIL resulting in regulation of RAP1A-mediated inside-out integrin activation by tethering RADIL on microtubules 7. show less
Molecular function (UniProt)i Motor protein
Ligand (UniProt)i ATP-binding, Nucleotide-binding
Gene summary (Entrez)i This gene encodes a member of the kinesin-3 superfamily of microtubule motor proteins. These proteins are involved in numerous processes including vesicle transport, chromosome segregation, mitotic spindle formation, and cytokinesis. In human HeLa-S3 and 293T cells, this protein is localized to the cytoplasm during interphase, to the spindle poles and spindle microtubules during mitosis, and to the midbody during cytokinesis. An internal motor domain displays microtubule-dependent ATPase activity, consistent with its function as a microtubule motor protein. Knockdown of this gene results in failed cytokinesis with endoreplication, which results in multinucleated cells. This gene has been identified as a likely oncogene in breast, lung and ovarian cancers, as well as retinoblastomas and gliomas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015] show less
PROTEIN INFORMATIONi
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
KIF14-201
ENSP00000356319
ENST00000367350
Q15058
[Direct mapping] Kinesin-like protein KIF14
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Disease related genes
Human disease related genes
   Cancers
   Cancers of eye, brain, and central nervous system
   Congenital malformations
   Congenital malformations of the nervous system
   Congenital malformations of the urinary system
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0001558 [regulation of cell growth]
GO:0003777 [microtubule motor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005871 [kinesin complex]
GO:0005874 [microtubule]
GO:0005886 [plasma membrane]
GO:0007018 [microtubule-based movement]
GO:0007080 [mitotic metaphase plate congression]
GO:0008017 [microtubule binding]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008574 [plus-end-directed microtubule motor activity]
GO:0010389 [regulation of G2/M transition of mitotic cell cycle]
GO:0015631 [tubulin binding]
GO:0016020 [membrane]
GO:0016887 [ATP hydrolysis activity]
GO:0019901 [protein kinase binding]
GO:0021685 [cerebellar granular layer structural organization]
GO:0021693 [cerebellar Purkinje cell layer structural organization]
GO:0021695 [cerebellar cortex development]
GO:0021766 [hippocampus development]
GO:0021772 [olfactory bulb development]
GO:0021846 [cell proliferation in forebrain]
GO:0021987 [cerebral cortex development]
GO:0030155 [regulation of cell adhesion]
GO:0030165 [PDZ domain binding]
GO:0030334 [regulation of cell migration]
GO:0030496 [midbody]
GO:0031146 [SCF-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0031641 [regulation of myelination]
GO:0032147 [activation of protein kinase activity]
GO:0032467 [positive regulation of cytokinesis]
GO:0032487 [regulation of Rap protein signal transduction]
GO:0033624 [negative regulation of integrin activation]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0043066 [negative regulation of apoptotic process]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043523 [regulation of neuron apoptotic process]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0045184 [establishment of protein localization]
GO:0051233 [spindle midzone]
GO:0051301 [cell division]
GO:0090543 [Flemming body]
GO:1903429 [regulation of cell maturation]
GO:2000045 [regulation of G1/S transition of mitotic cell cycle]
Show all
 1648 aa
186.5 kDa 		No 0
KIF14-202
ENSP00000483069
ENST00000614960
Q15058
[Direct mapping] Kinesin-like protein KIF14
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Disease related genes
Human disease related genes
   Cancers
   Cancers of eye, brain, and central nervous system
   Congenital malformations
   Congenital malformations of the nervous system
   Congenital malformations of the urinary system
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0001558 [regulation of cell growth]
GO:0003777 [microtubule motor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005871 [kinesin complex]
GO:0005874 [microtubule]
GO:0005886 [plasma membrane]
GO:0007018 [microtubule-based movement]
GO:0007080 [mitotic metaphase plate congression]
GO:0008017 [microtubule binding]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008574 [plus-end-directed microtubule motor activity]
GO:0010389 [regulation of G2/M transition of mitotic cell cycle]
GO:0015631 [tubulin binding]
GO:0016020 [membrane]
GO:0016887 [ATP hydrolysis activity]
GO:0019901 [protein kinase binding]
GO:0021685 [cerebellar granular layer structural organization]
GO:0021693 [cerebellar Purkinje cell layer structural organization]
GO:0021695 [cerebellar cortex development]
GO:0021766 [hippocampus development]
GO:0021772 [olfactory bulb development]
GO:0021846 [cell proliferation in forebrain]
GO:0021987 [cerebral cortex development]
GO:0030155 [regulation of cell adhesion]
GO:0030165 [PDZ domain binding]
GO:0030334 [regulation of cell migration]
GO:0030496 [midbody]
GO:0031146 [SCF-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0031641 [regulation of myelination]
GO:0032147 [activation of protein kinase activity]
GO:0032467 [positive regulation of cytokinesis]
GO:0032487 [regulation of Rap protein signal transduction]
GO:0033624 [negative regulation of integrin activation]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0043066 [negative regulation of apoptotic process]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043523 [regulation of neuron apoptotic process]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0045184 [establishment of protein localization]
GO:0051233 [spindle midzone]
GO:0090543 [Flemming body]
GO:2000045 [regulation of G1/S transition of mitotic cell cycle]
Show all
 1648 aa
186.5 kDa 		No 0

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