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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Disease related genes Transcription factors
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
2
Cytoband
q33.3
Chromosome location (bp)
207529737 - 207605988
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters (By similarity). Transcription activation is enhanced by the TORC coactivators which act independently of Ser-119 phosphorylation 1. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells (By similarity). Regulates the expression of apoptotic and inflammatory response factors in cardiomyocytes in response to ERFE-mediated activation of AKT signaling (By similarity)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Activator, DNA-binding
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in several transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
P16220 [Direct mapping] Cyclic AMP-responsive element-binding protein 1
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Q53X93 [Target identity:100%; Query identity:100%] CREB1 protein; cAMP responsive element binding protein 1; cAMP responsive element binding protein 1, isoform CRA_b; cDNA, FLJ96224, Homo sapiens cAMP responsive element binding protein 1 (CREB1),transcript variant A, mRNA
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Basic domains Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000785[chromatin] GO:0000791[euchromatin] GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005667[transcription regulator complex] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006468[protein phosphorylation] GO:0007165[signal transduction] GO:0007409[axonogenesis] GO:0007595[lactation] GO:0007613[memory] GO:0007623[circadian rhythm] GO:0008361[regulation of cell size] GO:0009410[response to xenobiotic stimulus] GO:0010033[response to organic substance] GO:0010035[response to inorganic substance] GO:0010944[negative regulation of transcription by competitive promoter binding] GO:0014074[response to purine-containing compound] GO:0019899[enzyme binding] GO:0019933[cAMP-mediated signaling] GO:0021983[pituitary gland development] GO:0030154[cell differentiation] GO:0030316[osteoclast differentiation] GO:0030879[mammary gland development] GO:0033363[secretory granule organization] GO:0033762[response to glucagon] GO:0035497[cAMP response element binding] GO:0035729[cellular response to hepatocyte growth factor stimulus] GO:0040018[] GO:0042789[mRNA transcription by RNA polymerase II] GO:0042802[identical protein binding] GO:0043565[sequence-specific DNA binding] GO:0045600[positive regulation of fat cell differentiation] GO:0045672[positive regulation of osteoclast differentiation] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046879[hormone secretion] GO:0046887[positive regulation of hormone secretion] GO:0046889[positive regulation of lipid biosynthetic process] GO:0048511[rhythmic process] GO:0050821[protein stabilization] GO:0050896[response to stimulus] GO:0055025[positive regulation of cardiac muscle tissue development] GO:0060428[lung epithelium development] GO:0060430[lung saccule development] GO:0060509[type I pneumocyte differentiation] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0071294[cellular response to zinc ion] GO:0071300[cellular response to retinoic acid] GO:0071363[cellular response to growth factor stimulus] GO:0090575[RNA polymerase II transcription regulator complex] GO:1904322[cellular response to forskolin] GO:1990589[ATF4-CREB1 transcription factor complex] GO:1990830[cellular response to leukemia inhibitory factor] GO:1990837[sequence-specific double-stranded DNA binding]
C9JCI4 [Direct mapping] Cyclic AMP-responsive element-binding protein 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
C9JBT4 [Direct mapping] Cyclic AMP-responsive element-binding protein 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
P16220 [Direct mapping] Cyclic AMP-responsive element-binding protein 1
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Q53X93 [Target identity:100%; Query identity:100%] CREB1 protein; cAMP responsive element binding protein 1; cAMP responsive element binding protein 1, isoform CRA_b; cDNA, FLJ96224, Homo sapiens cAMP responsive element binding protein 1 (CREB1),transcript variant A, mRNA
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Basic domains Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000785[chromatin] GO:0000791[euchromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005667[transcription regulator complex] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006468[protein phosphorylation] GO:0007165[signal transduction] GO:0007623[circadian rhythm] GO:0010033[response to organic substance] GO:0010944[negative regulation of transcription by competitive promoter binding] GO:0014074[response to purine-containing compound] GO:0019899[enzyme binding] GO:0019933[cAMP-mediated signaling] GO:0030154[cell differentiation] GO:0033762[response to glucagon] GO:0035497[cAMP response element binding] GO:0042789[mRNA transcription by RNA polymerase II] GO:0042802[identical protein binding] GO:0045600[positive regulation of fat cell differentiation] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046889[positive regulation of lipid biosynthetic process] GO:0048511[rhythmic process] GO:0050821[protein stabilization] GO:0050896[response to stimulus] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0071300[cellular response to retinoic acid] GO:0090575[RNA polymerase II transcription regulator complex] GO:1904322[cellular response to forskolin] GO:1990589[ATF4-CREB1 transcription factor complex] GO:1990837[sequence-specific double-stranded DNA binding]
P16220 [Direct mapping] Cyclic AMP-responsive element-binding protein 1
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Q5U0J5 [Target identity:100%; Query identity:100%] cAMP responsive element binding protein 1; cAMP responsive element binding protein 1, isoform CRA_a; cDNA, FLJ93156, Homo sapiens cAMP responsive element binding protein 1 (CREB1),transcript variant B, mRNA
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Basic domains Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000785[chromatin] GO:0000791[euchromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005667[transcription regulator complex] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006468[protein phosphorylation] GO:0007165[signal transduction] GO:0007623[circadian rhythm] GO:0010033[response to organic substance] GO:0010944[negative regulation of transcription by competitive promoter binding] GO:0014074[response to purine-containing compound] GO:0019899[enzyme binding] GO:0019933[cAMP-mediated signaling] GO:0030154[cell differentiation] GO:0033762[response to glucagon] GO:0035497[cAMP response element binding] GO:0042789[mRNA transcription by RNA polymerase II] GO:0042802[identical protein binding] GO:0045600[positive regulation of fat cell differentiation] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046889[positive regulation of lipid biosynthetic process] GO:0048511[rhythmic process] GO:0050821[protein stabilization] GO:0050896[response to stimulus] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0071300[cellular response to retinoic acid] GO:0090575[RNA polymerase II transcription regulator complex] GO:1904322[cellular response to forskolin] GO:1990589[ATF4-CREB1 transcription factor complex] GO:1990837[sequence-specific double-stranded DNA binding]
E7EWP8 [Direct mapping] Cyclic AMP-responsive element-binding protein 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
C9J896 [Direct mapping] Cyclic AMP-responsive element-binding protein 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
C9J276 [Direct mapping] Cyclic AMP-responsive element-binding protein 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
C9J4L5 [Direct mapping] Cyclic AMP-responsive element-binding protein 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
