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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
6
Cytoband
q14.1
Chromosome location (bp)
79201245 - 79234689
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function (By similarity)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Chromatin regulator, DNA-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene binds thyroid hormone receptor beta in the presence of thyroid hormone. The encoded protein, a member of the HMGN protein family, is thought to reduce the compactness of the chromatin fiber in nucleosomes, thereby enhancing transcription from chromatin templates. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. There is a related pseudogene on chromosome 1. [provided by RefSeq, Jan 2016]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q15651 [Direct mapping] High mobility group nucleosome-binding domain-containing protein 3
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Q15651 [Direct mapping] High mobility group nucleosome-binding domain-containing protein 3
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
A0A087WZE9 [Direct mapping] High mobility group nucleosome-binding domain-containing protein 3
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000785[chromatin] GO:0003682[chromatin binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0031492[nucleosomal DNA binding] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0061178[regulation of insulin secretion involved in cellular response to glucose stimulus]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
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GO:0000785[chromatin] GO:0003682[chromatin binding] GO:0005634[nucleus] GO:0031492[nucleosomal DNA binding] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0061178[regulation of insulin secretion involved in cellular response to glucose stimulus]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785[chromatin] GO:0003682[chromatin binding] GO:0005634[nucleus] GO:0031492[nucleosomal DNA binding] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0061178[regulation of insulin secretion involved in cellular response to glucose stimulus]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785[chromatin] GO:0003682[chromatin binding] GO:0005634[nucleus] GO:0031492[nucleosomal DNA binding] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0061178[regulation of insulin secretion involved in cellular response to glucose stimulus]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785[chromatin] GO:0003682[chromatin binding] GO:0005634[nucleus] GO:0031492[nucleosomal DNA binding] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0061178[regulation of insulin secretion involved in cellular response to glucose stimulus]
The Human Protein Atlas project is funded
