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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes Enzymes Human disease related genes Metabolic proteins Plasma proteins Potential drug targets
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
6
Cytoband
q23.2
Chromosome location (bp)
131470832 - 131584332
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell proliferation, respectively; the urea cycle takes place primarily in the liver and, to a lesser extent, in the kidneys....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Hydrolase
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Manganese, Metal-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exist (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type I isoform encoded by this gene, is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Enzymes ENZYME proteins Hydrolases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Disease related genes Potential drug targets Human disease related genes Congenital disorders of metabolism Congenital disorders of amino acid metabolism Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Enzymes ENZYME proteins Hydrolases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Disease related genes Potential drug targets Human disease related genes Congenital disorders of metabolism Congenital disorders of amino acid metabolism Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000050[urea cycle] GO:0001889[liver development] GO:0001938[positive regulation of endothelial cell proliferation] GO:0002250[adaptive immune response] GO:0002376[immune system process] GO:0004053[arginase activity] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005741[mitochondrial outer membrane] GO:0005829[cytosol] GO:0006525[arginine metabolic process] GO:0006527[arginine catabolic process] GO:0007565[female pregnancy] GO:0007568[aging] GO:0009410[response to xenobiotic stimulus] GO:0009611[response to wounding] GO:0009635[response to herbicide] GO:0010042[response to manganese ion] GO:0010043[response to zinc ion] GO:0010269[response to selenium ion] GO:0014075[response to amine] GO:0016787[hydrolase activity] GO:0016813[hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines] GO:0019547[arginine catabolic process to ornithine] GO:0030145[manganese ion binding] GO:0030324[lung development] GO:0032496[response to lipopolysaccharide] GO:0032964[collagen biosynthetic process] GO:0033189[response to vitamin A] GO:0033197[response to vitamin E] GO:0035578[azurophil granule lumen] GO:0035580[specific granule lumen] GO:0042130[negative regulation of T cell proliferation] GO:0042802[identical protein binding] GO:0042832[defense response to protozoan] GO:0043005[neuron projection] GO:0043025[neuronal cell body] GO:0043200[response to amino acid] GO:0043434[response to peptide hormone] GO:0045087[innate immune response] GO:0046007[negative regulation of activated T cell proliferation] GO:0046686[response to cadmium ion] GO:0046872[metal ion binding] GO:0048545[response to steroid hormone] GO:0048678[response to axon injury] GO:0051597[response to methylmercury] GO:0060056[mammary gland involution] GO:0060135[maternal process involved in female pregnancy] GO:0060336[negative regulation of interferon-gamma-mediated signaling pathway] GO:0070301[cellular response to hydrogen peroxide] GO:0070965[positive regulation of neutrophil mediated killing of fungus] GO:0071222[cellular response to lipopolysaccharide] GO:0071353[cellular response to interleukin-4] GO:0071377[cellular response to glucagon stimulus] GO:0071549[cellular response to dexamethasone stimulus] GO:0071560[cellular response to transforming growth factor beta stimulus] GO:1905541[regulation of L-arginine import across plasma membrane] GO:2000552[negative regulation of T-helper 2 cell cytokine production]
Enzymes ENZYME proteins Hydrolases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Disease related genes Potential drug targets Human disease related genes Congenital disorders of metabolism Congenital disorders of amino acid metabolism Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital disorders of metabolism Congenital disorders of amino acid metabolism Protein evidence (Ezkurdia et al 2014)
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GO:0000050[urea cycle] GO:0004053[arginase activity] GO:0006525[arginine metabolic process] GO:0016787[hydrolase activity] GO:0016813[hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines] GO:0046872[metal ion binding]
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital disorders of metabolism Congenital disorders of amino acid metabolism Protein evidence (Ezkurdia et al 2014)
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GO:0016787[hydrolase activity] GO:0016813[hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines] GO:0046872[metal ion binding]
The Human Protein Atlas project is funded
